Antivirulence therapy inhibits bacterial virulence factors, thus preventing the development of infection without affecting bacterial growth. The development of new antibiotics is complicated by the increasing incidenc...Antivirulence therapy inhibits bacterial virulence factors, thus preventing the development of infection without affecting bacterial growth. The development of new antibiotics is complicated by the increasing incidence of antibiotic resistance in pathogenic bacteria. Antiviru-lence therapy is a promising alternative to traditional an-tibiotic therapy for the treatment of infectious disease, either alone or in combination with antibiotic treatment. In this review, we consider patents concerning inhibition of several bacterial virulence factors： adhesion/colonization, secretion systems, cellular signalling systems and antimicrobial resistance mechanisms. Finally, we emphasize the importance of analyzing new targets and/or molecules in this feld and of considering possible resistance mechanisms.展开更多
基金Supported by Instituto de Salud Carlos III FEDER,Spanish Network for the Research in Infectious Diseases,No.REIPIRD12/0015the Spanish Ministry of Health and FEDER funding,No.FIS PI10/00056-PI13/02390(to Tomás M) and PI12/00552(to Bou G)the Miguel Servet Programme(C.H.U.A.Coruna and ISCIII)(to Tomás M)
文摘Antivirulence therapy inhibits bacterial virulence factors, thus preventing the development of infection without affecting bacterial growth. The development of new antibiotics is complicated by the increasing incidence of antibiotic resistance in pathogenic bacteria. Antiviru-lence therapy is a promising alternative to traditional an-tibiotic therapy for the treatment of infectious disease, either alone or in combination with antibiotic treatment. In this review, we consider patents concerning inhibition of several bacterial virulence factors： adhesion/colonization, secretion systems, cellular signalling systems and antimicrobial resistance mechanisms. Finally, we emphasize the importance of analyzing new targets and/or molecules in this feld and of considering possible resistance mechanisms.
