合成了Keggin结构钨硅、钨锗、钨磷、钨砷两电子及四电子稀土钐盐杂多蓝,铈量滴定及元素分析方法确定了化合物的还原电子数及化学组成,采用 IR,UV-Vis,183 W NMR和ESR等对其结构进行了表征.在人T淋巴细胞 MT-4内,对合成的化合...合成了Keggin结构钨硅、钨锗、钨磷、钨砷两电子及四电子稀土钐盐杂多蓝,铈量滴定及元素分析方法确定了化合物的还原电子数及化学组成,采用 IR,UV-Vis,183 W NMR和ESR等对其结构进行了表征.在人T淋巴细胞 MT-4内,对合成的化合物进行了系统的抗艾滋病毒(HIV-1)活性及毒性测定.发现Keggin结构钨硅、钨锗四电子稀土钐盐杂多蓝具有较强的抗HIV-1活性,其中钨锗酸钐四电子杂多蓝(代号HPBR-2)具有较高的治疗指数.展开更多
A C1-C7 fragment of the HIV-active Didemnaketal A analogue was synthesized from (R)-pulegone through 12 steps. Two new chiral centers, C3, C4 were successfully constructed by the steric induction in this approach and ...A C1-C7 fragment of the HIV-active Didemnaketal A analogue was synthesized from (R)-pulegone through 12 steps. Two new chiral centers, C3, C4 were successfully constructed by the steric induction in this approach and the aldehyde was selectively reduced.展开更多
文摘合成了Keggin结构钨硅、钨锗、钨磷、钨砷两电子及四电子稀土钐盐杂多蓝,铈量滴定及元素分析方法确定了化合物的还原电子数及化学组成,采用 IR,UV-Vis,183 W NMR和ESR等对其结构进行了表征.在人T淋巴细胞 MT-4内,对合成的化合物进行了系统的抗艾滋病毒(HIV-1)活性及毒性测定.发现Keggin结构钨硅、钨锗四电子稀土钐盐杂多蓝具有较强的抗HIV-1活性,其中钨锗酸钐四电子杂多蓝(代号HPBR-2)具有较高的治疗指数.
文摘A C1-C7 fragment of the HIV-active Didemnaketal A analogue was synthesized from (R)-pulegone through 12 steps. Two new chiral centers, C3, C4 were successfully constructed by the steric induction in this approach and the aldehyde was selectively reduced.