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花粉对人胚肺二倍体成纤维细胞的抗衰老研究 被引量:1
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作者 陈世义 王淑兰 李淑莲 《老年学杂志》 CSCD 1991年第2期97-99,共3页
本研究选用体外培养的人胚肺二倍体成纤维细胞(2BS株)作为抗衰老研究体外模型,从30代开始在培养液中加入花粉精为实验组,加入氢化可的松为阳性对照组,不加任何药物为空白对照组。结果表明,加入花粉组传至80代,空白对照组细胞传至64.5代... 本研究选用体外培养的人胚肺二倍体成纤维细胞(2BS株)作为抗衰老研究体外模型,从30代开始在培养液中加入花粉精为实验组,加入氢化可的松为阳性对照组,不加任何药物为空白对照组。结果表明,加入花粉组传至80代,空白对照组细胞传至64.5代,阳性对照组传至72代。花粉组细胞的生长形态和增殖速度均优于对照组。本研究证明,花粉对体外培养的人胚肺二倍体成纤维细胞有抗衰老作用。 展开更多
关键词 花粉 二倍细胞株 抗衰体
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An Ac-SDKP analogue resistant to angiotensin converting enzyme exhibits anti-fibrosis effects and improves heart function in mice after myocardial infarction
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作者 陈建辉 马晓雯 +3 位作者 张昭 张英启 苑媛 李萌 《Journal of Chinese Pharmaceutical Sciences》 CAS CSCD 2015年第12期789-800,共12页
To explore the effect of an Ac-SDKP analog on left ventricular remodeling after myocardial infarction,we synthesized the analog Ac-SD_DK_DP by replacing Asp and Lys with their D isomers.The biological activities of Ac... To explore the effect of an Ac-SDKP analog on left ventricular remodeling after myocardial infarction,we synthesized the analog Ac-SD_DK_DP by replacing Asp and Lys with their D isomers.The biological activities of Ac-SD_DK_DP were confirmed using flow cytometry,qRT-PCR,Western blots and fluorescence microscopy.The protective effects of Ac-SD_DK_DP on infarcted hearts were assessed in mice with myocardial infarction(MI).The half-life of Ac-SD_DK_DP was prolonged to over 2 h from a few minutes that Ac-SDKP has.Compared with Ac-SDKP,the analog exhibited stronger inhibition on the differentiation of macrophages,expression of arginase I(ARG I) and TGF-β1 in mature macrophages,proliferation and secretion of collagen type I in cardiac fibroblasts.In MI mice mode,Ac-SD_DK_DP decreased collagen deposition and TGF-β1 expression in myocardium,thus improving the FS(%) to 23.0±7.8 compared with 11.2±6.2 in untreated mice and 11.7±5.3 in Ac-SDKP treated mice(P0.05).This work shows that the Ac-SDKP analogue is potentially useful for protective treatment for heart failure post-MI.In addition,the anti-fibrosis mechanism of Ac-SDKP was correlated with the alternative activation(M2) of macrophages by assessing ARG I and TGF-β1,two important fibrosis-related molecules secreted in M2 macrophages. 展开更多
关键词 Ac-SDKP ANALOGUE ANTI-FIBROSIS Myocardial infarction Heart failure
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