二茂铁基苯甲酸四乙酰葡萄糖酯的合成及其抗贫血活性

Three tetraacetyl glucosyl esters of the ferrocenyl benzoic acids(compounds Ⅱ o,Ⅱ m,Ⅱ p) have been synthesized using a phase transfer catalyst(CTAB) in dichloroethane/water at 50 ℃. Their structures have been confirmed by elemental analysis, IR, 1H NMR and MS. The compounds were found to have antianemic activity. The RBC and HB values of the tested anemic rats were increased by 72 0% and 126 4%, respectively after abdomen injection.

3-二茂铁基-2-丁烯酸糖酯的合成及其抗贫血活性

以二茂铁为起始原料,通过相转移催化法和去乙酰作用合成了2种3-二茂铁基-2-丁烯酸糖酯。它们的结构得到IR、EA和MS确证,其中化合物3-二茂铁基-2-丁烯酸四乙酰葡萄糖酯的抗贫血活性得到测试。初步结果表明该化合物具有一定的抗贫血活性,进一步研究有待进行。