The travel time and amplitude of ground-penetrating radar （GPR） waves are closely related to medium parameters such as water content, porosity, and dielectric permittivity. However, conventional estimation methods, ...The travel time and amplitude of ground-penetrating radar （GPR） waves are closely related to medium parameters such as water content, porosity, and dielectric permittivity. However, conventional estimation methods, which are mostly based on wave velocity, are not suitable for real complex media because of limited resolution. Impedance inversion uses the reflection coefficient of radar waves to directly calculate GPR impedance and other parameters of subsurface media. We construct a 3D multiscale stochastic medium model and use the mixed Gaussian and exponential autocorrelation function to describe the distribution of parameters in real subsurface media. We introduce an elliptical Gaussian function to describe local random anomalies. The tapering function is also introduced to reduce calculation errors caused by the numerical simulation of discrete grids. We derive the impedance inversion workflow and test the calculation precision in complex media. Finally, we use impedance inversion to process GPR field data in a polluted site in Mongolia. The inversion results were constrained using borehole data and validated by resistivity data.展开更多
Herpes simplex virus type 1 （HSV-1） is a commonly occurring human pathogen worldwide. There is an urgent need to discover and develop new alternative agents for the management of HSV-1 infection. Tripterygium hypogl...Herpes simplex virus type 1 （HSV-1） is a commonly occurring human pathogen worldwide. There is an urgent need to discover and develop new alternative agents for the management of HSV-1 infection. Tripterygium hypoglaucum （level） Hutch （Celastraceae） is a traditional Chinese medicine plant with many pharmacological activities such as anti-inflammation, anti-tumor and antifertility. The usual medicinal part is the roots which contain about a 1% yield of alkaloids. A crude total alkaloids extract was prepared from the roots of T. hypoglaucum amd its antiviral activity against HSV-1 in Vero cells was evaluated by cytopathic effect （CPE） assay, plaque reduction assay and by RT-PCR analysis. The alkaloids extract presented low cytotoxicity （CC50 = 46.6μg/mL） and potent CPE inhibition activity, the 50% inhibitory concentration （ICs0） was 6.5 μg/mL, noticeably lower than that of Acyclovir （15.4μg /mL）. Plaque formation was significantly reduced by the alkaloids extract at concentrations of 6.25 μg/mL to 12.5 μg/mL, the plaque reduction ratio reached 55% to 75% which was 35% higher than that of Acyclovir at the same concentration. RT-PCR analysis showed that, the transcription of two important delayed early genes UL30 and UL39, and a late gene US6 of HSV-1 genome all were suppressed by the alkaloids extract, the expression inhibiting efficacy compared to the control was 74.6% （UL30）, 70.9% （UL39） and 62.6% （US6） respectively at the working concentration of 12.5μg/mL. The above results suggest a potent anti-HSV-1 activity of the alkaloids extract in vitro.展开更多
The improvements of anti-jamming performance of modem radar seeker are great threats to military targets. To protect the target from detection and estimation, the novel signal-to-interference-plus-noise ratio （SINR）...The improvements of anti-jamming performance of modem radar seeker are great threats to military targets. To protect the target from detection and estimation, the novel signal-to-interference-plus-noise ratio （SINR）-based and mutual information （Ml）-based jamming design techniques were proposed. To interfere with the target detection, the jamming was designed to minimize the S1NR of the radar seeker. To impair the estimation performance, the mutual information between the radar echo and the random target impulse response was used as the criterion. The spectral of optimal jamming under the two criteria were achieved with the power constraints. Simulation results show the effectiveness of the jamming techniques. SINR and MI of the SINR-based jamming, the MI-based jamming as well as the predefined jamming under the same power constraints were compared. Furthermore, the probability of detection and minimum mean-square error （MMSE） were also utilized to validate the jamming performance. Under the jamming power constraint of I W, the relative decrease of the probability of detection using S1NR-based optimal jamming is about 47%, and the relative increase of MMSE using Ml-based optimal jamming is about 8%. Besides, two useful jamming design principles are concluded which can be used in limited jamming power situations.展开更多
基金supported by the Doctoral Fund Project of the Ministry of Education(No.20130061110060 class tutors)the Post-Doctoral Fund Project(No.2015M571366)+1 种基金the National Natural Science Foundation of China(No.41174097)US DoD ARO Project"Advanced Mathematical Algorithm"(No.W911NF-11-2-0046)
文摘The travel time and amplitude of ground-penetrating radar （GPR） waves are closely related to medium parameters such as water content, porosity, and dielectric permittivity. However, conventional estimation methods, which are mostly based on wave velocity, are not suitable for real complex media because of limited resolution. Impedance inversion uses the reflection coefficient of radar waves to directly calculate GPR impedance and other parameters of subsurface media. We construct a 3D multiscale stochastic medium model and use the mixed Gaussian and exponential autocorrelation function to describe the distribution of parameters in real subsurface media. We introduce an elliptical Gaussian function to describe local random anomalies. The tapering function is also introduced to reduce calculation errors caused by the numerical simulation of discrete grids. We derive the impedance inversion workflow and test the calculation precision in complex media. Finally, we use impedance inversion to process GPR field data in a polluted site in Mongolia. The inversion results were constrained using borehole data and validated by resistivity data.
基金The Joint Funds of National Science Foundation of China (U0632010)The State Key Laboratory of Phytochemistry and Plant Resources in West China+1 种基金Chinese Academy of Sciences (O807B11211, O807E21211)"211 grant of MOE"
文摘Herpes simplex virus type 1 （HSV-1） is a commonly occurring human pathogen worldwide. There is an urgent need to discover and develop new alternative agents for the management of HSV-1 infection. Tripterygium hypoglaucum （level） Hutch （Celastraceae） is a traditional Chinese medicine plant with many pharmacological activities such as anti-inflammation, anti-tumor and antifertility. The usual medicinal part is the roots which contain about a 1% yield of alkaloids. A crude total alkaloids extract was prepared from the roots of T. hypoglaucum amd its antiviral activity against HSV-1 in Vero cells was evaluated by cytopathic effect （CPE） assay, plaque reduction assay and by RT-PCR analysis. The alkaloids extract presented low cytotoxicity （CC50 = 46.6μg/mL） and potent CPE inhibition activity, the 50% inhibitory concentration （ICs0） was 6.5 μg/mL, noticeably lower than that of Acyclovir （15.4μg /mL）. Plaque formation was significantly reduced by the alkaloids extract at concentrations of 6.25 μg/mL to 12.5 μg/mL, the plaque reduction ratio reached 55% to 75% which was 35% higher than that of Acyclovir at the same concentration. RT-PCR analysis showed that, the transcription of two important delayed early genes UL30 and UL39, and a late gene US6 of HSV-1 genome all were suppressed by the alkaloids extract, the expression inhibiting efficacy compared to the control was 74.6% （UL30）, 70.9% （UL39） and 62.6% （US6） respectively at the working concentration of 12.5μg/mL. The above results suggest a potent anti-HSV-1 activity of the alkaloids extract in vitro.
基金Project(61171133)supported by the National Natural Science Foundation of ChinaProject(11JJ1010)supported by the Natural Science Fund for Distinguished Young Scholars of Hunan Province,China
文摘The improvements of anti-jamming performance of modem radar seeker are great threats to military targets. To protect the target from detection and estimation, the novel signal-to-interference-plus-noise ratio （SINR）-based and mutual information （Ml）-based jamming design techniques were proposed. To interfere with the target detection, the jamming was designed to minimize the S1NR of the radar seeker. To impair the estimation performance, the mutual information between the radar echo and the random target impulse response was used as the criterion. The spectral of optimal jamming under the two criteria were achieved with the power constraints. Simulation results show the effectiveness of the jamming techniques. SINR and MI of the SINR-based jamming, the MI-based jamming as well as the predefined jamming under the same power constraints were compared. Furthermore, the probability of detection and minimum mean-square error （MMSE） were also utilized to validate the jamming performance. Under the jamming power constraint of I W, the relative decrease of the probability of detection using S1NR-based optimal jamming is about 47%, and the relative increase of MMSE using Ml-based optimal jamming is about 8%. Besides, two useful jamming design principles are concluded which can be used in limited jamming power situations.
