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免疫调节剂对烫伤大鼠脾细胞抗SRBC抗体及IFN-γ产生的作用
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作者 卓安山 陈爱娟 +2 位作者 申繁星 程国尊 黄强 《基础医学与临床》 CSCD 1998年第3期52-56,共5页
为探讨烧伤对大鼠免疫功能的影响及不同免疫调节剂对它的作用,本研究利用烫伤大鼠实验模型,采用溶血分光光度法和微量细胞病变抑制法,在整体条件下分别测定了各组烫伤大鼠伤后第5、10天时脾细胞产生IFNγ和抗SRBC抗体的... 为探讨烧伤对大鼠免疫功能的影响及不同免疫调节剂对它的作用,本研究利用烫伤大鼠实验模型,采用溶血分光光度法和微量细胞病变抑制法,在整体条件下分别测定了各组烫伤大鼠伤后第5、10天时脾细胞产生IFNγ和抗SRBC抗体的能力。结果发现,①烫伤后大鼠脾细胞产生IFNγ和抗SRBC抗体的能力均明显低于正常组(P<001),至伤后10天时一直处于较低水平。②经不同免疫调节剂治疗后,各组大鼠脾细胞产生IFNγ和抗SRBC抗体的能力均有不同程度的改善,经F检验发现,在用药的三组中,以iRNA作用最明显,其次为黄芪,葡聚糖稍差。这一结果为临床应用免疫调节剂,纠正伤后免疫功能失常,提供了重要的实验依据。 展开更多
关键词 烫伤 脾细胞 抗srbc抗体 IFN-Γ 免疫调节剂
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REGULATION OF ANTI-SRBC ANTIBODY PRODUCTION BY OPIOIDS AND THEIR MECHANISMS
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作者 王慧琴 林嘉友 刘景生 《Chinese Medical Sciences Journal》 CAS CSCD 1995年第3期125-130,共6页
This study focused on the influences of opioids on the generation of antibody against sheep erythrocyte in vitro, It was found that morphine. a-CAO, DADLE, MENK were able to inhibit the capacity of murine spleen cell... This study focused on the influences of opioids on the generation of antibody against sheep erythrocyte in vitro, It was found that morphine. a-CAO, DADLE, MENK were able to inhibit the capacity of murine spleen cells to generate antibody and leukotriene C4 and conversely. dynorphin was able to stimulate the capacity of murine spleen cells to generate antibody and leukotriene C4. Morphine, a-CAO, MENK, DADLE, dynorphin decreased intracellular cAMP level, increased [Ca(2+)]i and calmodulin activity. The effects were completely blocked by naloxone, the specific opioid antagonist. Our results showed that opioids regulate the production of antibody in murine spleen cells, and alter intracellular cAMP, [Ca(2+)]i calmodulin activity. and leukotriene C4 production by way of binding to different receptor types. 展开更多
关键词 OPIOIDS ANTIBODY [Ca ̄(2+)]i
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