Many studies on oxidative stress,insulin resistance,and antioxidant treatment have shown that increased oxidative stress may accelerate the development of diabetic complications through the excessive glucose and free ...Many studies on oxidative stress,insulin resistance,and antioxidant treatment have shown that increased oxidative stress may accelerate the development of diabetic complications through the excessive glucose and free fatty acids metabolism in diabetic and insulin-resistant states.Many pathogenic mechanisms such as insulin receptor substrate phosphorylation are involved in insulin resistance induced by oxidative stress.And antioxidant treatments can show benefits in animal models of diabetes mellitus and insulin resistance.However,negative evidence from large clinical trials suggests that new and more powerful antioxidants need to be studied to demonstrate whether antioxidants can be effective in treating diabetic complications.Furthermore,it appears that oxidative stress is only one of the factors contributing to diabetic complications.Thus,antioxidant treatment would most likely be more effective if it were coupled with other treatments for diabetic complications.展开更多
We have synthesized single crystals of CeZnAl3, which is a new member of family of Ce-based intermetallics CeTX3 （T=transition metal, X=Si, Ge, A1）, crystallizing in the non-centrosymmetric tetragonal BaNiSns-type s...We have synthesized single crystals of CeZnAl3, which is a new member of family of Ce-based intermetallics CeTX3 （T=transition metal, X=Si, Ge, A1）, crystallizing in the non-centrosymmetric tetragonal BaNiSns-type structure. Magnetization, specific heat and resistivity measurements all show that CeZnAls orders magnetically below around 4.4 K. Furthermore, magnetization measurements exhibit a hysteresis loop at low temperatures and fields, indicating the presence of a ferromagnetic component in the magnetic state. This points to a different nature of the magnetism in CeZnAl3 compared to the other isostructural CeTAl3 compounds. Resistivity measurements under pressures up to 1.8 GPa show a moderate suppression of the ordering temperature with pressure, suggesting that measurements to higher pressures are required to look for quantum critical behavior.展开更多
基金Supported by grant from the National Basic Research Program (973Program) (2006CB503903)
文摘Many studies on oxidative stress,insulin resistance,and antioxidant treatment have shown that increased oxidative stress may accelerate the development of diabetic complications through the excessive glucose and free fatty acids metabolism in diabetic and insulin-resistant states.Many pathogenic mechanisms such as insulin receptor substrate phosphorylation are involved in insulin resistance induced by oxidative stress.And antioxidant treatments can show benefits in animal models of diabetes mellitus and insulin resistance.However,negative evidence from large clinical trials suggests that new and more powerful antioxidants need to be studied to demonstrate whether antioxidants can be effective in treating diabetic complications.Furthermore,it appears that oxidative stress is only one of the factors contributing to diabetic complications.Thus,antioxidant treatment would most likely be more effective if it were coupled with other treatments for diabetic complications.
基金supported by the Science Challenge Project of China(Grant No.TZ2016004)the National Natural Science Foundation of China(Grant Nos.11474251,11604291,and U1632275)the National Key R&D Program of China(Grant Nos.2017YFA0303100,and 2016YFA0300202)
文摘We have synthesized single crystals of CeZnAl3, which is a new member of family of Ce-based intermetallics CeTX3 （T=transition metal, X=Si, Ge, A1）, crystallizing in the non-centrosymmetric tetragonal BaNiSns-type structure. Magnetization, specific heat and resistivity measurements all show that CeZnAls orders magnetically below around 4.4 K. Furthermore, magnetization measurements exhibit a hysteresis loop at low temperatures and fields, indicating the presence of a ferromagnetic component in the magnetic state. This points to a different nature of the magnetism in CeZnAl3 compared to the other isostructural CeTAl3 compounds. Resistivity measurements under pressures up to 1.8 GPa show a moderate suppression of the ordering temperature with pressure, suggesting that measurements to higher pressures are required to look for quantum critical behavior.
