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胰岛素抵抗与致抵抗因素
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作者 李梅 高玉琪 《辽宁医学杂志》 1996年第3期113-114,共2页
胰岛素抵抗与致抵抗因素天津医科大学总医院内分泌科(300052)李梅,高玉琪1936年Himsworth最先发现不同个体对胰岛素(INS)的反应性有很大差异。注射等量的INS后,一部分患者出现明显的血糖下降,而另一部... 胰岛素抵抗与致抵抗因素天津医科大学总医院内分泌科(300052)李梅,高玉琪1936年Himsworth最先发现不同个体对胰岛素(INS)的反应性有很大差异。注射等量的INS后,一部分患者出现明显的血糖下降,而另一部分则反应不敏感。前者易发生在瘦型的... 展开更多
关键词 胰岛素抵抗 抵抗因素
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代谢综合征患者胰岛素抵抗的影响因素 被引量:5
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作者 杨冀衡 陆泽元 +2 位作者 许香广 林怿昊 罗国辉 《中国动脉硬化杂志》 CAS CSCD 2004年第4期452-454,共3页
为探讨代谢综合征患者胰岛素抵抗的影响因素。对 12 6 1例年龄在 2 0~ 6 2岁机关职员的调查资料进行分析 ,代谢综合征诊断标准参考NCEP ATPⅢ标准 ,修改腹部肥胖的指标 (腰围男 >90cm ,女 >80cm) ,用稳态模式评估法的胰岛素抵抗... 为探讨代谢综合征患者胰岛素抵抗的影响因素。对 12 6 1例年龄在 2 0~ 6 2岁机关职员的调查资料进行分析 ,代谢综合征诊断标准参考NCEP ATPⅢ标准 ,修改腹部肥胖的指标 (腰围男 >90cm ,女 >80cm) ,用稳态模式评估法的胰岛素抵抗指数 (HOMA IR)评价胰岛素抵抗。男女代谢综合征的患病率分别为 11.4 %和 10 .3% ,男女患病率之间差异无显著性意义 ;男女代谢综合征组的HOMA IR指数均高于非代谢综合征组 ;代谢综合征患者的逐步回归分析发现 ,空腹血糖、甘油三酯和腰围与HOMA IR呈独立相关。空腹血糖、甘油三酯和腰围是影响代谢综合征患者胰岛素抵抗程度的因素。 展开更多
关键词 内科学 代谢综合征患者胰岛素抵抗的影响因素 酶法 代谢综合征 胰岛素抵抗 空腹血糖 甘油三酯
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食品中李斯特氏菌的分布及其对理化因素抵抗力的研究 被引量:4
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作者 戴建华 王为云 封幼玲 《中国卫生检验杂志》 CAS 1997年第5期274-276,共3页
关键词 食品微生物学 李斯特氏菌 分布 理化因素抵抗
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氯吡格雷抵抗在非致残性缺血性脑血管事件患者中的研究价值探讨
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作者 曾培灿 陈玉芳 +2 位作者 蔡蓉菲 郭文雄 李曼佳 《基层医学论坛》 2021年第16期2233-2235,共3页
目的研究非致残性缺血性脑血管事件患者的氯吡格雷抵抗情况。方法选取2018年1月—2020年8月于潮州市人民医院就诊的58例非致残性缺血性脑血管事件患者,依据氯吡格雷治疗后情况分为氯吡格雷抵抗组和非氯吡格雷抵抗组,各29例。比较2组治疗... 目的研究非致残性缺血性脑血管事件患者的氯吡格雷抵抗情况。方法选取2018年1月—2020年8月于潮州市人民医院就诊的58例非致残性缺血性脑血管事件患者,依据氯吡格雷治疗后情况分为氯吡格雷抵抗组和非氯吡格雷抵抗组,各29例。比较2组治疗7 d后血小板聚集率和miR-26a变化,并分析氯吡格雷抵抗因素。结果氯吡格雷抵抗组血小板聚集率、miR-26a为(43.77±8.46)%、(1.89±0.23)%,高于非抵抗组的(25.02±3.68)%、(0.55±0.12)%,有统计学差异(P<0.05);氯吡格雷抵抗组高血压、糖尿病发病率为44.83%、55.17%,高于非抵抗组的13.79%,20.69%,LDL水平为(4.11±0.53)mmol/L,高于非抵抗组的(3.04±0.41)mmol/L,有统计学差异(P<0.05)。结论氯吡格雷抵抗可降低非致残性缺血性脑血管事件患者血小板抑制效果,临床早期应分析患者相关指标,重点评估合并高血压、糖尿病、吸烟等群体氯吡格雷抵抗风险,以合理制定诊疗计划,保障治疗效果。 展开更多
关键词 非致残性缺血性脑血管事件 氯吡格雷抵抗 抵抗因素 血小板聚集率
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A Study on Exon 17 and 20 of the Insulin Receptor Gene Variations in Patients with Acanthosis Nigricans and Their Close Relatives
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作者 沈捷 丁国宪 +5 位作者 陈家伟 庄旻 王华 夏红 马向华 马立隽 《Journal of Nanjing Medical University》 2003年第4期149-158,共10页
Objective: To explore the relationship between the insulin resistance and thedefects or mutations or mutations in insulin receptor (InsR)gene. Methods: Using the single-strandconformation polymorphism(SSCP), mutations... Objective: To explore the relationship between the insulin resistance and thedefects or mutations or mutations in insulin receptor (InsR)gene. Methods: Using the single-strandconformation polymorphism(SSCP), mutations and polymorphisms were detected in nine patients withacan-thosis nigricans (AN) and their first degree relatives in exon 17 and 20 of InsR gene. Thepolymorphisms and mutations were confirmed by DNA direct sequencing. Results: Fourteen variant SSCPpat-terns were detected. Direct sequencing revealed seven point mutations and six silentpolymorphisms. Five of the mutations appeared not to be mentioned in the previous literature. Thesemutations were all located within the domain of tyrokinase in InsR. Conclusion: It seem to us thatalmost all the AN patients with severe insulin resistance in this study have mutations in InsRtyrokinase domain. 展开更多
关键词 insulin receptor GENETICS canthosis nigricans
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Effect of biofilm formation by clinical isolates of Helicobacter pylori on the efflux-mediated resistance to commonly used antibiotics 被引量:13
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作者 Bahareh Attaran Tahereh Falsafi Nassim Ghorbanmehr 《World Journal of Gastroenterology》 SCIE CAS 2017年第7期1163-1170,共8页
To evaluate the role of biofilm formation on the resistance of Helicobacter pylori (H. pylori) to commonly prescribed antibiotics, the expression rates of resistance genes in biofilm-forming and planktonic cells were ... To evaluate the role of biofilm formation on the resistance of Helicobacter pylori (H. pylori) to commonly prescribed antibiotics, the expression rates of resistance genes in biofilm-forming and planktonic cells were compared.METHODSA collection of 33 H. pylori isolates from children and adult patients with chronic infection were taken for the present study. The isolates were screened for biofilm formation ability, as well as for polymerase chain reaction (PCR) reaction with HP1165 and hp1165 efflux pump genes. Susceptibilities of the selected strains to antibiotic and differences between susceptibilities of planktonic and biofilm-forming cell populations were determined. Quantitative real-time PCR (qPCR) analysis was performed using 16S rRNA gene as a H. pylori-specific primer, and two efflux pumps-specific primers, hp1165 and hefA.RESULTSThe strains were resistant to amoxicillin, metronidazole, and erythromycin, except for one strain, but they were all susceptible to tetracycline. Minimum bactericidal concentrations of antibiotics in the biofilm-forming cells were significantly higher than those of planktonic cells. qPCR demonstrated that the expression of efflux pump genes was significantly higher in the biofilm-forming cells as compared to the planktonic ones.CONCLUSIONThe present work demonstrated an association between H. pylori biofilm formation and decreased susceptibility to all the antibiotics tested. This decreased susceptibility to antibiotics was associated with enhanced functional activity of two efflux pumps: hp1165 and hefA. 展开更多
关键词 Helicobacter pylori BIOFILM Antibiotic resistance Efflux genes hp1165 hefA
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PLASMA RESISTIN LEVELS AND SINGLE-NUCLEOTIDE POLYMORPHISMS IN RESISTIN GENE 5 FLANKING REGION IN PATIENTS WITH STROKE 被引量:3
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作者 Xing-jian Lin Ying-dong Zhang Qing-shan Guan Qing Di Jing-ping Shi Wei-guo Liu 《Chinese Medical Sciences Journal》 CAS CSCD 2007年第1期27-32,共6页
Objective To analyze the role of resistin in insulin resistance (IR) through investigating the variation of plasma resistin levels and single-nucleotide polymorphisms (SNPs) in resistin gene 5’ flanking region in str... Objective To analyze the role of resistin in insulin resistance (IR) through investigating the variation of plasma resistin levels and single-nucleotide polymorphisms (SNPs) in resistin gene 5’ flanking region in stroke patients.Methods In 103 atherothrombotic cerebral infarction (ACI) patients, 85 lacunar infarction (LI) patients, 70 intracerebral hemorrhage (ICH) patients, and 86 healthy controls, plasma resistin and insulin levels were measured by ELISA , SNPs in resistin gene 5’ flanking region were detected by PCR and direct DNA sequencing. The subjects’ body height and weight, the body mass index, quantitative insulin sensitivity check index (QUICKI), blood pressure, and the concentration of fasting plasma glucose, triglyceride, total cholesterol, creatinine, low-density lipoprotein, and high-density lipoprotein were also determined. Results QUICKI was significantly lower in the ACI and ICH patients (0.316±0.037 and 0.309±0.032, respectively) than that in the controls (0.342±0.043, P<0.001), while plasma resistin level was significantly higher in the ACI and ICH patients (6.36±3.79 and 7.15±4.27 ng/mL, respectively) than that in the controls (5.28±2.56 ng/mL, P<0.05), but such difference was not observed in the LI patients compared with controls. There was a statistically negative correlation between plasma resistin level with QUICKI (r=-0.228, P<0.001). The distributions of allele and genotype frequencies of resistin gene -420C>G and -537A>C SNPs were not significantly different among the different groups, and those SNPs were not correlated with other clinical and biochemical parameters.Conclusions Plasma resistin is associated with stroke by participating in the development of IR. The SNPs in resistin gene 5’ flanking region has no impact on the plasma resistin level. 展开更多
关键词 RESISTIN insulin resistance single-nucleotide polymorphisms STROKE
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Betaine and nonalcoholic steatohepatitis: Back to the future? 被引量:7
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作者 Sandeep Mukherjee 《World Journal of Gastroenterology》 SCIE CAS CSCD 2011年第32期3663-3664,共2页
Nonalcoholic steatohepatitis (NASH) is an important indication for liver transplantation in many Western countries. Obesity and insulin resistance are the two most common risk factors for NASH, which can lead to recur... Nonalcoholic steatohepatitis (NASH) is an important indication for liver transplantation in many Western countries. Obesity and insulin resistance are the two most common risk factors for NASH, which can lead to recurrent NASH after liver transplantation. There is currently no approved therapy for NASH, and treatment is directed at risk factor modification and lifestyle changes. Betaine has been used for NASH, with mixed results, and may show promise in conjunction with other agents in clinical trials. 展开更多
关键词 BETAINE Nonalcoholic steatohepatitis CIRRHOSIS OBESITY Insulin resistance
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Problems associated with glucose toxicity:Role of hyperglycemia-induced oxidative stress 被引量:46
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作者 Shinji Kawahito Hiroshi Kitahata Shuzo Oshita 《World Journal of Gastroenterology》 SCIE CAS CSCD 2009年第33期4137-4142,共6页
Glucose homeostasis deficiency leads to a chronic increase in blood glucose concentration. In contrast to physiological glucose concentration, chronic super-physiological glucose concentration negatively affects a lar... Glucose homeostasis deficiency leads to a chronic increase in blood glucose concentration. In contrast to physiological glucose concentration, chronic super-physiological glucose concentration negatively affects a large number of organs and tissues. Glucose toxicity means a decrease in insulin secretion and an increase in insulin resistance due to chronic hyperglycemia. It is now generally accepted that glucose toxicity is involved in the worsening of diabetes by affecting the secretion of B-cells. Several mechanisms have been proposed to explain the adverse effects of hyperglycemia. It was found that persistent hyperglycemia caused the functional decline of neutrophils. Infection is thus the main problem resulting from glucose toxicity in the acute phase. In other words, continued hyperglycemia is a life-threatening risk factor, not only in the chronic but also the acute phase, and it becomes a risk factor for infection, particularly in the perioperative period. 展开更多
关键词 Glucose toxicity DIABETES COMPLICATION SURGERY Surgical site infection Emergency medicine Critical care medicine
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Role of Adiponectin and Its Receptors in Cancer 被引量:7
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作者 Stephanie Obeid Lionel Hebbard 《Clinical oncology and cancer researeh》 CAS CSCD 2012年第4期213-220,共8页
Adiponectin(APN),a novel hormone/cytokine derived from adipocyte tissue,is involved in various physiological functions. Genetics,nutrition,and adiposity are factors contributing to circulating plasma concentrations of... Adiponectin(APN),a novel hormone/cytokine derived from adipocyte tissue,is involved in various physiological functions. Genetics,nutrition,and adiposity are factors contributing to circulating plasma concentrations of APN.Clinical correlation studies have shown that lower levels of serum APN are associated with increased malignancy of various cancers,such as breast and colon cancers,suggesting that APN has a role in tumorigenesis.APN affects insulin resistance,thus further influencing cancer development. Tumor cells may express receptors for APN.Cellular signaling is the mechanism by which APN exerts its host-protective responses. These factors suggest that serum APN levels and downstream signaling targets of APN may serve as potential diagnostic markers for malignancies.Further research is necessary to clarify the exact role of APN in cancer diagnosis and therapy. 展开更多
关键词 ADIPONECTIN CANCER SIGNALING
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A prospective study (SCOPE) comparing the cardiometabolic and respiratory effects of air pollution exposure on healthy and pre-diabetic individuals 被引量:5
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作者 Yanwen Wang Yiqun Han +2 位作者 Tong Zhu Weiju Li Hongyin Zhang 《Science China(Life Sciences)》 SCIE CAS CSCD 2018年第1期46-56,共11页
Air pollution is known to be a major risk factor for cardiopulmonary disease, but this is unclear for cardiometabolic disease (e.g.diabetes). This is of considerable public health importance, given the nationwide epid... Air pollution is known to be a major risk factor for cardiopulmonary disease, but this is unclear for cardiometabolic disease (e.g.diabetes). This is of considerable public health importance, given the nationwide epidemic of diabetes, accompanied by severe air pollution, in China. The evidence so far remained inadequate to answer questions of whether individuals with cardiometabolic dysfunctions are susceptible to air pollution and whether air pollution exacerbates diabetes development via certain biological pathways. In this manuscript, we summarize the results and limitations of studies exploring these two topics and elaborate our design of a prospective panel study (SCOPE) as a solution. We assessed and compared the health effect of air pollution among pre-diabetic individuals and matched healthy controls through four repeated clinical visits over 1 year. Comprehensive evaluation was made to both health endpoints and exposure. The primary biomarkers were assessed to reveal the impact on multiple biological pathways, including glycolipid metabolism and insulin resistance, endothelial function, and inflammation. Detailed chemical and size fractional components of particulate matter were measured in this study, along with the application of personal monitors.The work should increase our understanding of how air pollution affects individuals with cardiometabolic dysfunction and the underlying mechanisms. 展开更多
关键词 panel study air pollution diabetes susceptibility cardiometabolic effect
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Identification of PTPRR and JAG1 as key genes in castrationresistant prostate cancer by integrated bioinformatics methods 被引量:1
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作者 Ji-li WANG Yan WANG Guo-ping REN 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2020年第3期246-257,共12页
To identify novel genes in castration-resistant prostate cancer(CRPC),we downloaded three microarray datasets containing CRPC and primary prostate cancer in Gene Expression Omnibus(GEO).R packages affy and limma were ... To identify novel genes in castration-resistant prostate cancer(CRPC),we downloaded three microarray datasets containing CRPC and primary prostate cancer in Gene Expression Omnibus(GEO).R packages affy and limma were performed to identify differentially expressed genes(DEGs)between primary prostate cancer and CRPC.After that,we performed functional enrichment analysis including gene ontology(GO)and Kyoto encyclopedia of genes and genomes(KEGG)pathway.In addition,protein–protein interaction(PPI)analysis was used to search for hub genes.Finally,to validate the significance of these genes,we performed survival analysis.As a result,we identified 53 upregulated genes and 58 downregulated genes that changed in at least two datasets.Functional enrichment analysis showed significant changes in the positive regulation of osteoblast differentiation pathway and aldosteroneregulated sodium reabsorption pathway.PPI network identified hub genes like cortactin-binding protein 2(CTTNBP2),Rho family guanosine triphosphatase(GTPase)3(RND3),protein tyrosine phosphatase receptor-type R(PTPRR),Jagged1(JAG1),and lumican(LUM).Based on PPI network analysis and functional enrichment analysis,we identified two genes(PTPRR and JAG1)as key genes.Further survival analysis indicated a relationship between high expression of the two genes and poor prognosis of prostate cancer.In conclusion,PTPRR and JAG1 are key genes in the CRPC,which may serve as promising biomarkers of diagnosis and prognosis of CRPC. 展开更多
关键词 BIOINFORMATICS Protein tyrosine phosphatase receptor-type R(PTPRR) Jagged1(JAG1) Differentially expressed genes(DEGs) Castration-resistant prostate cancer(CRPC) Functional enrichment
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