The racemic phenylalanine has been separated by (R)-mandelic acid through the formation of diastereomeric molecular complex. The crystal of the title chiral complex (C8H8O3 C9H11NO2, Mr = 317.33) belongs to monoclinic...The racemic phenylalanine has been separated by (R)-mandelic acid through the formation of diastereomeric molecular complex. The crystal of the title chiral complex (C8H8O3 C9H11NO2, Mr = 317.33) belongs to monoclinic, space group C2 with a = 19.391(3), b = 5.715(4), c = 15.755(3) ? b = 115.23(1), V = 1579(1) 3, Z = 4, Dc = 1.335 g/cm3, F(000) = 672, m = 0.099 mm-1, R = 0.033 and wR = 0.060 for 1278 observed reflections (I > 2s(I)). The complex consists of (R)-mandelic acid and (R)-phenylalanine in 1:1 molar ratio, and the complex molecules form layered crystal structure by self-assembly through intermolecular H-bonding between carboxyl and carboxylate of the neighboring molecules.展开更多
This paper presents a new online incremental training algorithm of Gaussian mixture model （GMM）, which aims to perform the expectation-maximization（EM） training incrementally to update GMM model parameters online ...This paper presents a new online incremental training algorithm of Gaussian mixture model （GMM）, which aims to perform the expectation-maximization（EM） training incrementally to update GMM model parameters online sample by sample, instead of waiting for a block of data with the sufficient size to start training as in the traditional EM procedure. The proposed method is extended from the split-and-merge EM procedure, so inherently it is also capable escaping from local maxima and reducing the chances of singularities. In the application domain, the algorithm is optimized in the context of speech processing applications. Experiments on the synthetic data show the advantage and efficiency of the new method and the results in a speech processing task also confirm the improvement of system performance.展开更多
The catalytic synthesis of cyclic carbonates via the cycloaddition of CO2 to epoxides is a standard methodology for CO2 fixation.For this purpose,chiral basket-handle porphyrin-Co complexes were devised,prepared,and f...The catalytic synthesis of cyclic carbonates via the cycloaddition of CO2 to epoxides is a standard methodology for CO2 fixation.For this purpose,chiral basket-handle porphyrin-Co complexes were devised,prepared,and fully characterized by nuclear magnetic resonance,mass spectrometry,Fourier transform infrared spectroscopy,ultraviolet-visible spectroscopy,and specific rotation.The proposed metalloporphyrin catalysts were synthesized with either 1,1'-bi-2-naphthol or L-phenylalanine,which have different chirality,and then applied to the coupling of propylene oxide and CO2 for generating chiral cyclic carbonates with good enantioselectivity under extremely mild conditions in the presence of tetrabutyl ammonium chloride as a co-catalyst.The good enantioselectivity in the cycloaddition reaction is attributed to a synergistic interplay between the chiral porphyrin catalysts and the substrate.The mechanism and enantioselectivity of the asymmetric cycloaddition reaction is discussed.展开更多
Four geometric mer-isomers in the [Co(2,3-tri)(cmen)Cl]2+ system have been synthesized and well separated (2,3-tri = N-(3-aminoethyl)-1,3-propanediamine; cmen = 1,2-di- aminopropane). Their structures in DMSO-d6 solut...Four geometric mer-isomers in the [Co(2,3-tri)(cmen)Cl]2+ system have been synthesized and well separated (2,3-tri = N-(3-aminoethyl)-1,3-propanediamine; cmen = 1,2-di- aminopropane). Their structures in DMSO-d6 solution have been uniquely assigned by using 2D- NMR techniques (gCOSY and NOESY).展开更多
Electrolytic detachable coils (EDC) have been the main embolic materi als for intracranial aneurysms. Liquid aneurysmal embolic materials represented by cellulose acetate polymer (CAP) are still in controversy. In thi...Electrolytic detachable coils (EDC) have been the main embolic materi als for intracranial aneurysms. Liquid aneurysmal embolic materials represented by cellulose acetate polymer (CAP) are still in controversy. In this research, t he embolization results and pathological reactions after embolization of canine aneurysmal models with EDC or CAP were observed and compared. Methods. The canine aneurysmal models constructed by anastomosis of venous pouch es were randomly grouped. The aneurysms were respectively occluded with CAP and electrolytic detachable coils that was named by Wu electrolytic detachable coil (WEDC) and made by us. Angiogram follow ups were performed at 24 hour, 2 week , and 2 month after embolization. The occluded aneurysms were dissected in each stage for light microscopic, electron microscopic, and histochemical research. Results. The effect of embolization was significantly better with WEDC than that with CAP . Post embolized complications such as aneurysm rupture and stenosis of parent arteries could only be found in CAP group. Pathol ogical research showed that CAP mass could packed the aneurysms more densely tha n coils. Acute chemical damage of aneurysmal wall and inflammatory cell infiltra tion was prominently found in early stage after CAP embolization. Organization of thrombus inside aneurysms and formation of endothelial tissue over the orific es of aneurysmal necks could be found in both groups 2 months after embolization . But parts of coils might be exposed outside endothelial layer. Conclusions. EDC are still the most safe, efficient, and reliable instruments to embolize aneurysm. CAP should be improved further to solve the problem of stron g chemical corrosion and difficulty in control before it is widely used.展开更多
Biomacromolecules including protein and nucleic acids are considered as promising chiral selectors in the fields of enantioselective separation, owing to their inherent chirality, polymorphous structures, stable physi...Biomacromolecules including protein and nucleic acids are considered as promising chiral selectors in the fields of enantioselective separation, owing to their inherent chirality, polymorphous structures, stable physicochemical properties, good biocompatibility as well as susceptible modification and regulation. In this review, firstly,enantioselective recognition mechanism of proteins and nucleic acids toward different enantiomers is discussed,as well as their potential applications on the chiral separation of racemic compounds. Secondly, preparative enantioseparation adopting biomolecule-modified hybrid materials including porous microspheres, magnetic nanoparticles and affinity membranes, are introduced respectively. Finally, novel chiroptical materials constructed on the basis of chiral induction, transfer, amplification and transcription, are recognized as promising candidates in future applications.展开更多
Virtual routers are gaining increasing attention in the research field of future networks. As the core network device to achieve network virtualization, virtual routers have multiple virtual instances coexisting on a ...Virtual routers are gaining increasing attention in the research field of future networks. As the core network device to achieve network virtualization, virtual routers have multiple virtual instances coexisting on a physical router platform, and each instance retains its own forwarding information base （FIB）. Thus, memory scalability suffers from the limited on-chip memory. In this paper, we present a splitting-after-merging approach to compress the FIBs, which not only improves the memory efficiency but also offers an ideal split position to achieve system refactoring. Moreover, we propose an improved strategy to save the time used for system rebuilding to achieve fast refactoring. Experiments with 14 real-world routing data sets show that our approach needs only a unibit trie holding 134 188 nodes, while the original number of nodes is 4 569 133. Moreover, our approach has a good performance in scalability, guaranteeing 90 000 000 prefixes and 65 600 FIBs.展开更多
A phonon counting scheme based on the control of polaritons in an optomechanical system is proposed. This approach permits us to measure the number of phonons in a quantum non-demolition(QND) manner for arbitrary mode...A phonon counting scheme based on the control of polaritons in an optomechanical system is proposed. This approach permits us to measure the number of phonons in a quantum non-demolition(QND) manner for arbitrary modes not limited by the frequency matching condition as in usual photon-phonon scattering detections. The performance on phonon number transfer and quantum state transfer of the counter are analyzed and simulated numerically by taking into account all relevant sources of noise.展开更多
基金The work was supported by the National Natural Science Foundation of China (29973036)
文摘The racemic phenylalanine has been separated by (R)-mandelic acid through the formation of diastereomeric molecular complex. The crystal of the title chiral complex (C8H8O3 C9H11NO2, Mr = 317.33) belongs to monoclinic, space group C2 with a = 19.391(3), b = 5.715(4), c = 15.755(3) ? b = 115.23(1), V = 1579(1) 3, Z = 4, Dc = 1.335 g/cm3, F(000) = 672, m = 0.099 mm-1, R = 0.033 and wR = 0.060 for 1278 observed reflections (I > 2s(I)). The complex consists of (R)-mandelic acid and (R)-phenylalanine in 1:1 molar ratio, and the complex molecules form layered crystal structure by self-assembly through intermolecular H-bonding between carboxyl and carboxylate of the neighboring molecules.
文摘This paper presents a new online incremental training algorithm of Gaussian mixture model （GMM）, which aims to perform the expectation-maximization（EM） training incrementally to update GMM model parameters online sample by sample, instead of waiting for a block of data with the sufficient size to start training as in the traditional EM procedure. The proposed method is extended from the split-and-merge EM procedure, so inherently it is also capable escaping from local maxima and reducing the chances of singularities. In the application domain, the algorithm is optimized in the context of speech processing applications. Experiments on the synthetic data show the advantage and efficiency of the new method and the results in a speech processing task also confirm the improvement of system performance.
文摘The catalytic synthesis of cyclic carbonates via the cycloaddition of CO2 to epoxides is a standard methodology for CO2 fixation.For this purpose,chiral basket-handle porphyrin-Co complexes were devised,prepared,and fully characterized by nuclear magnetic resonance,mass spectrometry,Fourier transform infrared spectroscopy,ultraviolet-visible spectroscopy,and specific rotation.The proposed metalloporphyrin catalysts were synthesized with either 1,1'-bi-2-naphthol or L-phenylalanine,which have different chirality,and then applied to the coupling of propylene oxide and CO2 for generating chiral cyclic carbonates with good enantioselectivity under extremely mild conditions in the presence of tetrabutyl ammonium chloride as a co-catalyst.The good enantioselectivity in the cycloaddition reaction is attributed to a synergistic interplay between the chiral porphyrin catalysts and the substrate.The mechanism and enantioselectivity of the asymmetric cycloaddition reaction is discussed.
文摘Four geometric mer-isomers in the [Co(2,3-tri)(cmen)Cl]2+ system have been synthesized and well separated (2,3-tri = N-(3-aminoethyl)-1,3-propanediamine; cmen = 1,2-di- aminopropane). Their structures in DMSO-d6 solution have been uniquely assigned by using 2D- NMR techniques (gCOSY and NOESY).
文摘Electrolytic detachable coils (EDC) have been the main embolic materi als for intracranial aneurysms. Liquid aneurysmal embolic materials represented by cellulose acetate polymer (CAP) are still in controversy. In this research, t he embolization results and pathological reactions after embolization of canine aneurysmal models with EDC or CAP were observed and compared. Methods. The canine aneurysmal models constructed by anastomosis of venous pouch es were randomly grouped. The aneurysms were respectively occluded with CAP and electrolytic detachable coils that was named by Wu electrolytic detachable coil (WEDC) and made by us. Angiogram follow ups were performed at 24 hour, 2 week , and 2 month after embolization. The occluded aneurysms were dissected in each stage for light microscopic, electron microscopic, and histochemical research. Results. The effect of embolization was significantly better with WEDC than that with CAP . Post embolized complications such as aneurysm rupture and stenosis of parent arteries could only be found in CAP group. Pathol ogical research showed that CAP mass could packed the aneurysms more densely tha n coils. Acute chemical damage of aneurysmal wall and inflammatory cell infiltra tion was prominently found in early stage after CAP embolization. Organization of thrombus inside aneurysms and formation of endothelial tissue over the orific es of aneurysmal necks could be found in both groups 2 months after embolization . But parts of coils might be exposed outside endothelial layer. Conclusions. EDC are still the most safe, efficient, and reliable instruments to embolize aneurysm. CAP should be improved further to solve the problem of stron g chemical corrosion and difficulty in control before it is widely used.
基金Supported by the National Natural Science Foundation of China(21206107)the National High-tech R&D Program of China(2012AA03A609)Program for Changjiang Scholars and Innovative Research Team in University(IRT1161)
文摘Biomacromolecules including protein and nucleic acids are considered as promising chiral selectors in the fields of enantioselective separation, owing to their inherent chirality, polymorphous structures, stable physicochemical properties, good biocompatibility as well as susceptible modification and regulation. In this review, firstly,enantioselective recognition mechanism of proteins and nucleic acids toward different enantiomers is discussed,as well as their potential applications on the chiral separation of racemic compounds. Secondly, preparative enantioseparation adopting biomolecule-modified hybrid materials including porous microspheres, magnetic nanoparticles and affinity membranes, are introduced respectively. Finally, novel chiroptical materials constructed on the basis of chiral induction, transfer, amplification and transcription, are recognized as promising candidates in future applications.
基金Project supported by the National Basic Research Program （973） of China （No. 2012CB315805）, the National Natural Science Foundation of China （Nos. 61173167 and 61472130）, the Prospective Research Project on Future Networks of Jiangsu Future Networks Innovation Institute, China （No. 2013095-1-05）, the Hunan Provincial Innovation Foundation for Postgraduate, China （No. CX2014B150）, and the State Scholarship Fund of China （No. 201406130048）
文摘Virtual routers are gaining increasing attention in the research field of future networks. As the core network device to achieve network virtualization, virtual routers have multiple virtual instances coexisting on a physical router platform, and each instance retains its own forwarding information base （FIB）. Thus, memory scalability suffers from the limited on-chip memory. In this paper, we present a splitting-after-merging approach to compress the FIBs, which not only improves the memory efficiency but also offers an ideal split position to achieve system refactoring. Moreover, we propose an improved strategy to save the time used for system rebuilding to achieve fast refactoring. Experiments with 14 real-world routing data sets show that our approach needs only a unibit trie holding 134 188 nodes, while the original number of nodes is 4 569 133. Moreover, our approach has a good performance in scalability, guaranteeing 90 000 000 prefixes and 65 600 FIBs.
基金supported by the National Key Research and Development Program of China(Grant No.2016YFA0302001)the National Natural Science Foundation of China(Grant Nos.11574086,91436211,11234003,and11654005)+1 种基金the Shanghai Rising-Star Program(Grant No.16QA1401600)the Science and Technology Commission of Shanghai Municipality(Grant No.16DZ2260200)
文摘A phonon counting scheme based on the control of polaritons in an optomechanical system is proposed. This approach permits us to measure the number of phonons in a quantum non-demolition(QND) manner for arbitrary modes not limited by the frequency matching condition as in usual photon-phonon scattering detections. The performance on phonon number transfer and quantum state transfer of the counter are analyzed and simulated numerically by taking into account all relevant sources of noise.
