Datong-Qinhuangdao line, as the first electrified double-track heavy-haul line dedicated to coal transport in China, extends from Datong in the west, and reaches Qinhuangdao in the east, opened to traffic in December,...Datong-Qinhuangdao line, as the first electrified double-track heavy-haul line dedicated to coal transport in China, extends from Datong in the west, and reaches Qinhuangdao in the east, opened to traffic in December, 1992, totaling 653 km with the designed annual traffic volume of 1×108 t. In order to meet the demands of national economic development, the transport capacity of the line must be enhanced greatly. Depending on independent innovation, MOR, for the first time in the world,realizes the integration between GSM-R and Locotrol, the integration between 800 MHz digital radio and Locotrol, and the integration between a single set of Locotrol and SS4 locomotive. Meanwhile, CR develops equipment portfolio for heavy-haul through combining 2 high power locomotives of HXD series (means harmony) with controllable EOT. Relying on integration and innovation, it succeeds in operating 20 kt-level combined heavy-haul train on Datong-Qinhuangdao line, which tripled the annual traffic volume of the line from 1×108 t in 2002 to 3×108 t in 2007.展开更多
PGC-1α, a potent transcriptional coactivator, is the major regulator of mitochondrial biogenesis and activity in the cardiac muscle. The dysregulation of PGC-la and its target genes has been reported to be associated...PGC-1α, a potent transcriptional coactivator, is the major regulator of mitochondrial biogenesis and activity in the cardiac muscle. The dysregulation of PGC-la and its target genes has been reported to be associated with congenital and acquired heart diseases. By examining myocardium samples from patients with Tetralogy of Fallot, we show here that PGC-1α expression levels are markedly increased in patients compared with healthy controls and positively correlated with the severity of cyanosis. Furthermore, hypoxia significantly induced the expression of PGC-1α and mitochondrial biogenesis in cultured cardiac myocytes. Mechanistic studies suggest that hypoxia-induced PGC-1α expression is regulated through the AMPK signaling pathway. Together, our data indicate that hypoxia can stimulate the expression of PGC-1α and mitochondrial biogenesis in the cardiac myocytes, and this process might provide a potential adaptive mechanism for cardiac myocytes to increase ATP output and minimize hypoxic damage to the heart.展开更多
The purposes and the types of dams are reviewed in AI-Baha province, on the western south of KSA (Kingdom of Saudi Arabia). Data are collected and tabulated ascending according to the capacity of storing water. The ...The purposes and the types of dams are reviewed in AI-Baha province, on the western south of KSA (Kingdom of Saudi Arabia). Data are collected and tabulated ascending according to the capacity of storing water. The cost (in Saudi Riyal) is plotted versus the capacity (in m3) for the dams. Then a linear regression analysis is done employing Micro Software Excel. An equation is obtained to predict the cost of dams with storage capacities less than or equal 500,000 m3, where the type of dam has no effect on the cost. Taking into consideration the inflation rates along the time, the 2013's costs are estimated and also another equation is obtained to predict the cost.展开更多
In rechargeable wireless sensor networks, a sensor cannot be always benefi cial to conserve energy when a network can harvest excessive energy from the environment due to its energy replenished continually and limited...In rechargeable wireless sensor networks, a sensor cannot be always benefi cial to conserve energy when a network can harvest excessive energy from the environment due to its energy replenished continually and limited energy storage capacity. Therefore, surplus energy of a node can be utilized for strengthening packet delivery efficiency and improving data collection rate. In this work, we propose an algorithm to compute an upper data generation rate that maximizes it as an optimization problem for a network with multiple sinks, which is formulated as a linear programming problem. Subsequently, a dual problem by introducing Lagrange multipliers is constructed, and subgradient algorithms are used to solve it in a distributed manner. The resulting algorithms are guaranteed to converge to an optimal data generation rate, which are illustrated by an example in which an optimum data generation rate is computed for a network of randomly distributed nodes. Through extensive simulation and experiments, we demonstrate our algorithm is efficient to maximize data collection rate in rechargeable wireless sensor networks.展开更多
Most economically important tungsten(W)deposits are of magmatic-hydrothermal origin.The species and partitioning of W during fluid exsolution,considered to be the controlling factors for the formation of ore deposits,...Most economically important tungsten(W)deposits are of magmatic-hydrothermal origin.The species and partitioning of W during fluid exsolution,considered to be the controlling factors for the formation of ore deposits,are thus of great significance to investigate.However,this issue has not been well addressed mainly due to the significant difference in reported partition coefficients(e.g.,from strongly incompatible to strongly compatible)between fluid and melt(D_(W)^(fluid/melt)).Here,we used an in situ Raman spectroscopic approach to describe the W speciation,and to quantitatively determine the Dfluid/melt of individual and total W species in granite melts and coexisting Na2WO4 solutions at elevated temperatures(T;700–800C)and pressures(P;0.35–1.08 GPa).Results show that WO_(4)^(2-)and HWO4are predominant W species,and the fractions of these two species are similar in melt and coexisting fluid.The partitioning behaviors of WO_(4)^(2-)and HWO4are comparable,exhibiting strong enrichment in the fluid.The total DW fluid/melt ranges from 8.6 to 37.1.Specifically,DW fluid/melt decreases with rising T–P,indicating that shallow exsolution favors enrichment of W in evolved fluids.Furthermore,Rayleigh fractionation modeling based on the obtained D_(W)^(fluid/melt)data was used to describe the fluid exsolution processes.Our results strongly support that fluid exsolution can serve as an important mechanism to generate W-rich oreforming fluids.This study also indicates that in situ approach can be used to further investigate the geochemical behavior of ore-forming elements during the magmatic-hydrothermal transition,especially for rare metals associated with granite and pegmatite.展开更多
文摘Datong-Qinhuangdao line, as the first electrified double-track heavy-haul line dedicated to coal transport in China, extends from Datong in the west, and reaches Qinhuangdao in the east, opened to traffic in December, 1992, totaling 653 km with the designed annual traffic volume of 1×108 t. In order to meet the demands of national economic development, the transport capacity of the line must be enhanced greatly. Depending on independent innovation, MOR, for the first time in the world,realizes the integration between GSM-R and Locotrol, the integration between 800 MHz digital radio and Locotrol, and the integration between a single set of Locotrol and SS4 locomotive. Meanwhile, CR develops equipment portfolio for heavy-haul through combining 2 high power locomotives of HXD series (means harmony) with controllable EOT. Relying on integration and innovation, it succeeds in operating 20 kt-level combined heavy-haul train on Datong-Qinhuangdao line, which tripled the annual traffic volume of the line from 1×108 t in 2002 to 3×108 t in 2007.
基金Supplementary information is linked to the online version of the paper on the Cell Research website. Acknowledgments We thank Yun Luo, Jia Jia and Dr Yun Xu at Nanjing University, Nanjing, China, for their scientific discussions and experimental assistance. This work was supported by grants from the National Natural Science Foundation of China (Nos. 30871195, 90813035, 30890044), the National Basic Research Program of China (Nos. 2006CB503909, 2004CB518603), the "111" Project, the Hi-Tech Research and Development Program of China (No. 2006AA02A112,), and the Natural Science Foundation of Jiangsu Province (Nos. BK2004082, BK2006714, BK2008021).
文摘PGC-1α, a potent transcriptional coactivator, is the major regulator of mitochondrial biogenesis and activity in the cardiac muscle. The dysregulation of PGC-la and its target genes has been reported to be associated with congenital and acquired heart diseases. By examining myocardium samples from patients with Tetralogy of Fallot, we show here that PGC-1α expression levels are markedly increased in patients compared with healthy controls and positively correlated with the severity of cyanosis. Furthermore, hypoxia significantly induced the expression of PGC-1α and mitochondrial biogenesis in cultured cardiac myocytes. Mechanistic studies suggest that hypoxia-induced PGC-1α expression is regulated through the AMPK signaling pathway. Together, our data indicate that hypoxia can stimulate the expression of PGC-1α and mitochondrial biogenesis in the cardiac myocytes, and this process might provide a potential adaptive mechanism for cardiac myocytes to increase ATP output and minimize hypoxic damage to the heart.
文摘The purposes and the types of dams are reviewed in AI-Baha province, on the western south of KSA (Kingdom of Saudi Arabia). Data are collected and tabulated ascending according to the capacity of storing water. The cost (in Saudi Riyal) is plotted versus the capacity (in m3) for the dams. Then a linear regression analysis is done employing Micro Software Excel. An equation is obtained to predict the cost of dams with storage capacities less than or equal 500,000 m3, where the type of dam has no effect on the cost. Taking into consideration the inflation rates along the time, the 2013's costs are estimated and also another equation is obtained to predict the cost.
基金supported by The Natural Science Foundation of Jiangsu Province of China(Grant No.BK20141474)funded by China Postdoctoral Science Foundation(Grant No.2015M571639)+3 种基金three Projects Funded by The Jiangsu Planned Projects for Postdoctoral Research Funds(Grant No.1402018C)The Key Laboratory of Computer Network and Information Integration(Southeast University)Ministry of Education(Grant No.K93-9-2015-09C)The Priority Academic Program Development(PAPD)of Jiangsu Higher Education Institutions
文摘In rechargeable wireless sensor networks, a sensor cannot be always benefi cial to conserve energy when a network can harvest excessive energy from the environment due to its energy replenished continually and limited energy storage capacity. Therefore, surplus energy of a node can be utilized for strengthening packet delivery efficiency and improving data collection rate. In this work, we propose an algorithm to compute an upper data generation rate that maximizes it as an optimization problem for a network with multiple sinks, which is formulated as a linear programming problem. Subsequently, a dual problem by introducing Lagrange multipliers is constructed, and subgradient algorithms are used to solve it in a distributed manner. The resulting algorithms are guaranteed to converge to an optimal data generation rate, which are illustrated by an example in which an optimum data generation rate is computed for a network of randomly distributed nodes. Through extensive simulation and experiments, we demonstrate our algorithm is efficient to maximize data collection rate in rechargeable wireless sensor networks.
基金supported by the National Natural Science Foundation of China(41922023,41830428,42173038,41973055,and 42130109)the Research Funds for the Frontiers Science Center for Critical Earth Material Cycling(Nanjing University,China)the Fundamental Research Funds for the Central Universities,China(2022300192).
文摘Most economically important tungsten(W)deposits are of magmatic-hydrothermal origin.The species and partitioning of W during fluid exsolution,considered to be the controlling factors for the formation of ore deposits,are thus of great significance to investigate.However,this issue has not been well addressed mainly due to the significant difference in reported partition coefficients(e.g.,from strongly incompatible to strongly compatible)between fluid and melt(D_(W)^(fluid/melt)).Here,we used an in situ Raman spectroscopic approach to describe the W speciation,and to quantitatively determine the Dfluid/melt of individual and total W species in granite melts and coexisting Na2WO4 solutions at elevated temperatures(T;700–800C)and pressures(P;0.35–1.08 GPa).Results show that WO_(4)^(2-)and HWO4are predominant W species,and the fractions of these two species are similar in melt and coexisting fluid.The partitioning behaviors of WO_(4)^(2-)and HWO4are comparable,exhibiting strong enrichment in the fluid.The total DW fluid/melt ranges from 8.6 to 37.1.Specifically,DW fluid/melt decreases with rising T–P,indicating that shallow exsolution favors enrichment of W in evolved fluids.Furthermore,Rayleigh fractionation modeling based on the obtained D_(W)^(fluid/melt)data was used to describe the fluid exsolution processes.Our results strongly support that fluid exsolution can serve as an important mechanism to generate W-rich oreforming fluids.This study also indicates that in situ approach can be used to further investigate the geochemical behavior of ore-forming elements during the magmatic-hydrothermal transition,especially for rare metals associated with granite and pegmatite.