拓扑替康联合顺铂治疗小细胞肺癌44例疗效观察

目的：研究拓扑替康联合顺铂治疗小细胞肺癌的疗效。方法：对确诊的44例小细胞肺癌患者,应用拓扑替康联合顺铂静滴d1-d5,同时给予止吐治疗。结果：全组共化疗132个周期,44例患者中总有效率为45.5%,临床受益率81.8%,全组无治疗相关性死亡。结论：以拓扑替康联合顺铂的化疗方案对小细胞肺癌具有较好的疗效。

Solution for Output Coordination Equations of Several Typical Parallel Six-Dimensional Acceleration Sensing Mechanisms

Aiming at the problem that it is difficult to generate the dynamic decoupling equation of the parallel six-dimensional acceleration sensing mechanism,two typical parallel six-dimensional acceleration sensing mechanisms are taken as examples.By analyzing the scale constraint relationship between the hinge points on the mass block and the hinge points on the base of the sensing mechanism,a new method for establishing the dynamic equation of the sensing mechanism is proposed.Firstly,based on the scale constraint relationship between the hinge points on the mass block and the hinge points on the base of the sensing mechanism,the expression of the branch rod length is obtained.The inherent constraint relationship between the branches is excavated and the branch coordination closed chain of the“12-6”configuration is constructed.The output coordination equation of the sensing mechanism is successfully derived.Secondly,the dynamic equations of“12-4”and“12-6”configurations are constructed by the Newton-Euler method,and the forward decoupling equations of the two configurations are solved by combining the dynamic equations and the output coordination equations.Finally,the virtual prototype experiment is carried out,and the maximum reference errors of the forward decoupling equations of the two configuration sensing mechanisms are 4.23%and 6.53%,respectively.The results show that the proposed method is effective and feasible,and meets the real-time requirements.

One-pot topotactic synthesis of Ti^(3+) self-doped 3D TiO_2 hollow nanoboxes with enhanced visible light response

Ti^（3＋） self-doped anatase three-dimensional（3D） TiO_2 hollow nanoboxes were synthesized via a topological transformation process involving template participation by a facile one-pot hydrothermal treatment with an ethanol solution of zinc powder and TiOF_2. It is worth noting that the 3D TiO_2 hollow nanoboxes are assembled from six single-crystal nanosheets and have dominant exposure of the {001} facets. It is found from EPR spectra that adding zinc powder is an environment-friendly and effective strategy to introduce Ti^（3＋） and oxygen vacancy（Ov） into the bulk of 3D hollow nanoboxes rather than the surface, which is responsible for their enhanced visible photocatalytic properties.The photocatalytic activity was evaluated by measuring the formation rate of hydroxide free radicals using 7-hydroxycoumarin as a probe. The sample prepared with zinc/TiOF_2 mass ratio of0.25 exhibited the highest RhB photodegradation activity under visible-light irradiation with a degradation rate of 96%, which is 4.0-times higher than that of pure TiO_2. The results suggest a novel approach to construct in-situ 3D hierarchical TiO_2 hollow nanoboxes doped with Ti^（3＋） and Ov without introducing any impurity elements for superior visible-light photocatalytic activity.

~＊X中的Q－拓扑、~＊τ拓扑、F_τ拓扑及其性质

本文对＊Ｘ中的三种常用拓扑进行了研究，得到了一些性质。特别地，通过对＊Ｘ的商拓扑的研究，得到了Ｔｙｃｈｏｎｏｆｆ空间的Ｓｔｏｎｅ－Ｃｅｃｈ紧扩张定理的非标准证明。

Energy-Efficient Multi-Mode Clusters Maintenance(M^2CM) for Hierarchical Wireless Sensor Networks

How to energy-efficiently maintain the topology of wireless sensor networks(WSNs) is still a difficult problem because of their numerous nodes,highly dynamic nature,varied application scenarios and limited resources.An energy-efficient multi-mode clusters maintenance(M2CM) method is proposed based on localized and event-driven mechanism in this work,which is different from the conventional clusters maintenance model with always periodically re-clustered among the whole network style based on time-trigger for hierarchical WSNs.M2 CM can meet such demands of clusters maintenance as adaptive local maintenance for the damaged clusters according to its changes in time and space field.,the triggers of M2 CM include such events as nodes' residual energy being under the threshold,the load imbalance of cluster head,joining in or exiting from any cluster for new node or disable one,etc.Based on neighboring relationship of the damaged clusters,one can start a single cluster(inner-cluster) maintenance or clusters(inter-cluster) maintenance program to meet diverse demands in the topology management of hierarchical WSNs.The experiment results based on NS2 simulation show that the proposed method can significantly save energy used in maintaining a damaged network,effectively narrow down the influenced area of clusters maintenance,and increase transmitted data and prolong lifetime of network compared to the traditional schemes.

The Characterizations of Weighted H^p(w) Spaces on the Certain Groups

The weighted HP(ω) spaces on the homogeneous type spaces have been defined in [1],in this paper we shall show the equivalence of various characterizations of HP (ω) on the certain groups that are the special kind of the homogeneous type spaces.

Remarks on （1, 2）^＊-Generalized Closed Sets with Respect to an Ideal Bitopological Space

In this paper, the authors introduce and study the concept of （1, 2）^＊-generalized closed sets with respect to an ideal in a bitopological space. Also, some characterizations and applications of（1, 2）^＊-generalized closed sets are given.

一类函数的局部凸拓扑

D(Ω)空间是一个基本空间,它的对偶空间D'(Ω)就是我们所熟知的(SCHWARTZ)广义函数空间,很多年来广义函数论在数学的各个分支(特别是偏微分方程理论)和理论物理学中得到越来越广泛的应用,是现代教学中的一个重要的分支.下面我们一起观察D(Ω)空间的一些基本定理的证明,包括它是一个线性的局部凸的拓扑空间,并且是不可度量的.

叶片弯曲对大折转压气机叶栅内分离结构的影响

通过数值模拟,分析了叶片周向弯曲对大折转角压气机叶栅内分离结构的影响。弯角分别为±10°,±20°,±30°。应用壁面流谱的拓扑法则,详细讨论了不同弯角下的分离形态。结果表明,正弯可以有效遏止角区分离,改变吸力面的分离形态,但不能完全消除吸力面的分离。因此一定范围内的叶片正弯可以改善流动,但当弯角大于20°时,流动重新恶化。反弯则使得叶栅内分离趋势增加,气动性能明显降低。

Topology optimization of microstructure and selective laser meltingfabrication for metallic biomaterial scaffolds

The precise design and fabrication of biomaterial scaffolds is necessary to provide a systematic study for bone tissue engineering. Biomaterial scaffolds should have sufficient stiffness and large porosity. These two goals generally contradict since larger porosity results in lower mechanical properties. To seek the microstructure of maximum stiffness with the constraint of volume fraction by topology optimization method, algorithms and programs were built to obtain 2D and 3D optimized microstructure and then they were transferred to CAD models of STL format. Ti scaffolds with 30% volume fraction were fabricated using a selective laser melting （SLM） technology. The architecture and pore shape in the metallic biomaterial scaffolds were relatively precise reproduced and the minimum mean pore size was 231μm. The accurate fabrication of intricate microstructure has verified that the SLM process is suitable for fabrication of metallic biomaterial scaffolds.

An efficient reliability evaluation method for industrial wireless sensor networks

Aimed at the difficulties in accurately, comprehensively and systematically evaluating the reliability of industrial wireless sensor networks （WSNs）, a time-evolving state transition-Monte Carlo （TEST-MC） evaluation method and a novel network function value representation method are proposed to evaluate the reliability of the IWSNs. First, the adjacency matrix method is used to characterize three typical topologies of WSNs including the mesh network, tree network and ribbon network. Secondly, the network function value method is used to evaluate the network connectivity, and the TEST-MC evaluation method is used to evaluate network reliability and availability. Finally, the variations in the reliability, connectivity and availability of these three topologies are presented. Simulation results show that the proposed method can quickly analyze the reliability of the networks containing typical WSN topologies, which provides an effective method for the comprehensive and accurate evaluation of the reliability of WSNs.

TaChord: a Chord system using topology-aware routing and super peers

Due to minimum consideration of an actual network topology, the existing peer-to-peer (P2P) overlay networks, such as CAN, Chord, Pastry and Tapestry, will lead to high latency and low efficiency. In TaChord, a topology-aware routing approach in P2P overlays and an improved design in Chord are presented. TaChord and other algorithms are evaluated by physical hops, interdomain-adjusted latency, and aggregate bandwidth used per message. Experimental results demonstrate that TaChord has the drastic improvement in routing performance where average physical hop is half that of chord, and the impact of cache management strategies in the TaChord overlay cannot be neglected.

3-D SPIDERGON:3-D TOPOLOGY OF DELAY OPTIMIZATION FOR NETWORKS-ON-CHIP

A 3-D topology architeeture based on Spidergon and its generation method are proposed. Aiming at establishing relationships between the topology architecture and the latency, the 3-D topology latency model based on prototype is proposed, and then the optimization topology structure with minimum latency is determined based on it. Meanwhile, in accordance with the structure, the adaptive routing algorithm is designed. The algorithm sets longitudinal direction priority to adaptively searching the equivalent minimum path between the source nodes and the destination nodes in order to increase network throughput. Simulation shows that in case of approximate saturation network, compared with the same scale 3-D mesh structure, 3-D Spidergon has 17% less latency and 16.7% more network throughput.

Plotting and application of predominance area diagram of In-S-O system based on topological rules

The mathematical topological rule was proposed to plot the predominance area diagram.Based on the phase rules,the components of In-S-O system were analyzed and the coexisting points of three condensed phases were determined.Combined with the topological rules and thermody namic calculation,four relation diagrams between the coexisting points of three condensed phases,which were denoted as α,β stable plane-topological diagram and unstable plane-topological diagram,were plotted for the In-S-O system.The results show that α stable plane topological diagram is in accordance with the predominance area diagram of In-S-O system plotted by traditional methods,which indicates that the new method is feasible to plot the predominance area diagram of In-S-O system.Meanwhile,β unstable plane-topological diagram can be used to elucidate the indium production with the bath smelting process.

Calculation connectivity reliability of road networks based on recursive decomposition arithmetic

In order to decrease the calculation complexity of connectivity reliability of road networks, an improved recursive decomposition arithmetic is proposed. First, the basic theory of recursive decomposition arithmetic is reviewed. Then the characteristics of road networks, which are different from general networks, are analyzed. Under this condition, an improved recursive decomposition arithmetic is put forward which fits road networks better. Furthermore, detailed calculation steps are presented which are convenient for the computer, and the advantage of the approximate arithmetic is analyzed based on this improved arithmetic. This improved recursive decomposition arithmetic directly produces disjoint minipaths and avoids the non-polynomial increasing problems. And because the characteristics of road networks are considered, this arithmetic is greatly simplified. Finally, an example is given to prove its validity.

SECURITY ANALYSIS BASED ON OVERSAMPLED CHAOTIC BINARY SEQUENCES

Some chaotic sequences generated from maps conjugated with tent map can be reconstructed precisely by short sequence prediction,since the problem of finite precision degrades the statistical properties of chaotic maps.This paper discusses the topological conjugation properties of the chaotic maps;analyzes in detail the reconstruction process of the chaotic sequences and the security of the oversampled chaotic map (OSCM) binary sequences.The result demonstrates that OSCM binary sequences can sustain the attack of the short sequence prediction,that is,they cant be reconstructed.Furthermore,all attack strategies aiming at the chaotic systems based on synchronization will fail,meaning that they are secure.

MULTI-CLASS TRAFFIC QOS ROUTING FOR LEO SATELLITE NETWORKS

Due to the diversified demands of quality of service（QoS） in volume multimedia application, QoS routings for multiservice are becoming a research hotspot in low earth orbit（LEO） satellite networks. A novel QoS satellite routing algorithm for multi-class traffic is proposed. The goal of the routing algorithm is to provide the distinct QoS for different traffic classes and improve the utilization of network resources. Traffic is classified into three classes and allocated priorities based on their QoS requirements, respectively. A priority queuing mechanism guarantees the algorithm to work better for high-priority classes. In order to control the congestion, a blocking probability analysis model is built up based on the Markov process theory. Finally, according to the classification link-cost metrics, routings for different classes are calculated with the distinct QoS requirments and the status of network resource. Simulations verify the performance of the routing algorithm at different time and in different regions, and results demonstrate that the algorithm has great advantages in terms of the average delay and the blocking probability. Meanwhile, the robustness issue is also discussed.

Novel forward mode AC/AC converters with high frequency link

A circuit configuration and a circuit topologic family of the novel forward mode AC/AC converters with high frequency link are presented. The circuit configuration is constituted of input cycloconverter, high frequency transformer, output cycloconverter, input and output filters. The circuit topologic family includes eight circuit topologies, such as full-bridge-full-wave mode, etc. The bi-polarity phase-shifted control strategy and steady principles are thoroughly investigated. The output characteristics are obtained. By using the bi-polarity phase-shifted control strategy with phase-shifted control between the output cycloconveter and the input cycloconverter, commutation overlap period of the output cycloconverter, and polarity selection of the output filtering inductance current and the input voltage, the leakage inductance energy and the output filtering inductance current are naturally commutated, and surge voltage and surge current of the cycloconverters are overcome. The converters have such advantages as simple topology, two-stage power conversions(LFAC/HFAC/LFAC), bi-directional power flow, high frequency electrical isolation, good output waveforms, and strong ability to stabilize voltage. The converters lay key technical foundation on a new-type of regulated sinusoidal AC power supplies and electronic transformers. The correction and advancement of the converters are well verified by a principle test.

Inverse Halogen Bonds Interactions Involving Br Atom in the Electronic Deficiency Systems of CH3＋… Br-Y （Y--H, CCH, CN, NC）

Inverse halogen bonds interactions involving Br in the electronic deficiency systems of CH3＋...Br-Y （Y=H, CCH, CN, NC） have been investigated by B3LYP/6- 311＋＋G（d, p） and MP2/6-311＋＋G（d, p） methods. The calculated interaction energies with basis set super-position error correction of the four IXBs complexes are 218.87, 219.48, 159.18, and 143.05kJ/mol （MP2/6-311＋＋G（d, p））, respectively. The relative stabilities of the four complexes increased in the order： CH3＋ … BrCN〈CH3＋…- BrNC〈CH3＋… BrH≈CH3＋ …BrCCH. Natural bond orbital theory analysis and the chemical shifts calculation of the related atoms revealed that the charges flow from Br-Y to CH3e. Here, the Br of Br-Y acts as both a halogen bond donor and an electron donor. Therefore, compared with conventional halogen bonds, the IXBs complexes formed between Br-Y and CH3＋. Atoms-in-molecules theory has been used to investigate the topological properties of the critical points of the four IXBs structures which have more covalent content.

STUDY ON MEASURES OF FAULT TOLERANCE FOR DISTRIBUTED SYSTEM

Fault tolerant ability is an important aspect for overall evaluation of distributed system(DS). This paper discusses three measures for the evaluation: node/edge connectivity, number of spanning trees and synthetic connectivity. A numerical example for illustration and analysis is given, and the synthetic connectivity measure presented by this paper is proved to be rational and satisfactory.