Exploring the structural topology of genome-based large-scale metabolic network is essential for in- vestigating possible relations between structure and functionality.Visualization would be helpful for obtaining imme...Exploring the structural topology of genome-based large-scale metabolic network is essential for in- vestigating possible relations between structure and functionality.Visualization would be helpful for obtaining immediate information about structural organization.In this work,metabolic networks of 75 organisms were investigated from a topological point of view.A spread bow-tie model was proposed to give a clear visualization of the bow-tie structure for metabolic networks.The revealed topological pattern helps to design more efficient algorithm specifically for metabolic networks.This coarse- grained graph also visualizes the vulnerable connections in the network,and thus could have important implication for disease studies and drug target identifications.In addition,analysis on the reciprocal links and main cores in the GSC part of bow-tie also reveals that the bow-tie structure of metabolic networks has its own intrinsic and significant features which are significantly different from those of random networks.展开更多
In the past few decades,we have seen the rapid development of bioactive materials which can repair damaged tissues and save human lives.Traditionally,researchers have sought to develop bioactive materials with unique ...In the past few decades,we have seen the rapid development of bioactive materials which can repair damaged tissues and save human lives.Traditionally,researchers have sought to develop bioactive materials with unique physical and chemical properties,such as stiffness,functional groups,nanotopographies and stimulus-responsive properties,to promote tissue regeneration at the biointerface.展开更多
基金Supported in part by the Ministry of Science and Technology of China(Grant Nos.2003CB715900 and 2004CB720103)National Natural Science Foundation of China(Grant Nos.30500107 and 30670953)Science and Technology Commission of Shanghai Municipality(Grant Nos.04DZ19850 and 04DZ14005)
文摘Exploring the structural topology of genome-based large-scale metabolic network is essential for in- vestigating possible relations between structure and functionality.Visualization would be helpful for obtaining immediate information about structural organization.In this work,metabolic networks of 75 organisms were investigated from a topological point of view.A spread bow-tie model was proposed to give a clear visualization of the bow-tie structure for metabolic networks.The revealed topological pattern helps to design more efficient algorithm specifically for metabolic networks.This coarse- grained graph also visualizes the vulnerable connections in the network,and thus could have important implication for disease studies and drug target identifications.In addition,analysis on the reciprocal links and main cores in the GSC part of bow-tie also reveals that the bow-tie structure of metabolic networks has its own intrinsic and significant features which are significantly different from those of random networks.
基金supported by the National Natural Science Foundation of China(51932002,52072127,51773045,21772030,51922032,and 21961160720)the National Natural Science Foundation of China(51773045,21772030,51922032,and 21961160720)for financial support+2 种基金the National Key Research and Development Program of China(2017YFA0206600)the National Key Research and Development Program of China(2017YFA0206600)the Science and Technology Program of Guangzhou(202002030308)。
文摘In the past few decades,we have seen the rapid development of bioactive materials which can repair damaged tissues and save human lives.Traditionally,researchers have sought to develop bioactive materials with unique physical and chemical properties,such as stiffness,functional groups,nanotopographies and stimulus-responsive properties,to promote tissue regeneration at the biointerface.
