自拟化痰通窍熄风定痫方联合德巴金治疗儿童癫痫疗效观察

目的探究自拟化痰通窍熄风定痫方联合德巴金对儿童癫痫的临床疗效。方法选取2019年1月—2022年4月该院风痰闭阻型癫痫患儿150例为研究对象,按随机数字表法,将入组患儿均分为治疗组和对照组,各75例。对照组予德巴金治疗,治疗组予自拟化痰通窍熄风定痫方联合德巴金治疗,两组均持续治疗3个月。比较两组治疗后临床疗效,治疗前后中医症状积分、炎症指标[超敏C-反应蛋白(hypersensitive C-reactive protein,hs-CRP)、红细胞沉降率(erythrocyte sedimentation rate,ESR)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)]、脑电图、青少年癫痫患儿生活质量评定量表(QOLIE-AD-48)变化,及患儿癫痫发作次数、持续时间,记录治疗期间不良反应。结果治疗后,治疗组临床有效率显著高于对照组[93.33%(70/75)vs 82.67%(62/75),P<0.05];治疗后,两组中医各项积分均下降(P<0.05),且治疗组主症、次症积分均低于对照组(P<0.05);治疗后,治疗组脑电图好转总有效率86.67%(65/75)高于对照组72.00%(54/75)(P<0.05);治疗后,两组QOLIE-AD-48评分均升高(P<0.05),且治疗组高于对照组(P<0.05);治疗后,两组血清hs-CR、TNF-α、ESR水平均下降(P<0.05),且治疗组低于对照组(P<0.05);治疗后,两组癫痫发作次数及发作时持续时间均降低(P<0.05),且治疗组上述指标均低于对照组(P<0.05);治疗期间,均未见严重不良反应。结论自拟化痰通窍熄风定痫方联合德巴金可提高风痰闭阻型儿童癫痫的临床疗效,控制其症状,减轻炎症反应,有利于改善患儿脑电图指标,降低发作频率和持续时间,可提高患儿生活质量。

自拟定喘1号方治疗痰湿蕴肺型喘证临床疗效及安全性评估

目的:探究自拟定喘1号方治疗痰湿蕴肺型喘证临床疗效及安全性。方法:选取我院2016年4月~2018年2月收治的78例痰湿蕴肺型喘证患者作为研究对象,采取随机数字表法将其分为观察组与对照组,对照组患者(39例)采取临床西医常规治疗,观察组患者(39例)在对照组治疗基础上联合自拟定喘1号方治疗,对比两组患者治疗效果、治疗前后患者肺功能指标及英国医学研究委员会呼吸困难量表(MRC)、圣乔治呼吸问卷量表(SGRQ)评分、不良反应情况。结果:观察组患者治疗有效率(97.44%)高于对照组(82.05%)(P<0.05);治疗前两组患者一秒用力呼气容积(FEV1)、一秒用力呼气容积/用力肺活量(FEV1/FVC)肺功能指标、MRC及SGRQ量表评分均相当(P>0.05),治疗后各组患者FEV1、FEV1/FVC水平及MRC及SGRQ量表评分均改善(P<0.05),差异具有统计学意义;观察组(2.56%)与对照组(5.13%)不良反应率均较低,两组相当(P>0.05),差异无统计学意义。结论:自拟定喘1号方治疗痰湿蕴肺型喘证临床疗效显著,患者肺功能改善,症状缓解,生活改善,且不良反应率低,安全性高,值得推广与应用。

自拟定喘化痰方辅助治疗支气管哮喘急性发作的临床研究

目的:研究我院自拟定喘化痰方辅助治疗支气管哮喘急性发作的临床效果。方法:以2018年10月至2020年1月于我院接受治疗的78例支气管哮喘急性发作患者为研究对象,随机分为对照组和观察组(n=39)。对照组患者给予布地奈德粉吸入剂Bid进行治疗,观察组患者在此基础上联合使用我院自拟定喘化痰方进行治疗,治疗2 w后,采用哮喘控制测试(Asthma control test,ACT)评价患者哮喘控制情况;同时比较治疗前、后患者中医症状积分(气粗息涌,胸膈烦闷,呛咳频繁)以及用力肺活量(Forced vital capacity,FVC)、最大呼气峰流速(Peak expiratory flow,PEF)、第1秒用力呼气容积Forced expiratory volume in 1􀯗second,FEV1)。结果:治疗2 w后,观察组ACT评级明显低于对照组(P<0.05);两组患者气粗息涌、胸膈烦闷、呛咳频繁等中医症状积分较治疗前均有显著下降,且观察组积分低于同一时间对照组患者(P<0.05);两组患者FVC、PEF、FEV1水平较治疗前均有明显提升,且观察组显著高于同一时间对照组(P<0.05)。结论:自拟定喘化痰方结合常规药物治疗支气管哮喘急性发作效果优良,有利于缓解患者临床症状,具有临床使用价值。

不同方法联合治疗急性期支气管哮喘的效果观察

目的观察自拟定喘方、定喘穴注射甲基强的松龙联合西药治疗支气管哮喘急性发作期的临床疗效,以探索中西医结合治疗支气管哮喘的最佳配组方法。方法将106例慢性支气管哮喘急性发作期患者随机分为观察组52例和对照组54例。对照组以西药常规治疗;观察组在对照组基础上予甲基强的松龙定喘穴药物注射,口服自拟定喘方联合治疗,比较2组患者哮喘临床疗效,肺功能FEV1、FEV1/FEV%及C-反应蛋白、IL-6、IL-8、IgA、IgE的改善情况。结果2组患者哮喘临床喘息、咳嗽、憋气等症状均比治疗前有显著改善,且观察组显著高于对照组(P<0.05);肺功能指标FEV1和FEV1/FEV%均比治疗前显著提高(P<0.05),观察组治疗后的FEV1和FEV1/FEV%均显著高于对照组(P<0.05)。2组C-反应蛋白、IL-6、IL-8、IgA、IgE均有所改善,且观察组显著高于对照组(P<0.05)。结论自拟定喘方、甲基强的松龙定喘穴注射联合西药治疗支气管哮喘急性发作期,能够很好地缓解患者的症状,改善肺功能,提高生活质量。

Stability monitoring and evaluation of the modeled test square for prehistoric earthen sites during excavation period

In order to explore the stability of test square during archaeological excavation for prehistoric earthen sites in Hangzhou, a modeled test square with 2. 3 min depth, inplane dimensions of 5 min width by 5 m in length, and an archaeological column in the middle was excavated by means of a top-down excavation technique. To investigate the stability performance of the modeled test square and the associated effect on the adjacent area, a real-time comprehensive instrumentation program was conducted during the excavation. Field observations included ground settlements, lateral displacement, pore pressure and underground water level. Monitoring data indicates that the ground settlement induced by dewatering and unloading action basically decreases with the increase of the distance away from the pit edge, and the lateral displacements at four sides showa nonlinear variation along the depth. The maximum value is far below the acceptable value regulated by the related standard,which validates the stability of the modeled test square during excavation. Variations of pore pressure and water level suggest that long-term stability should be paid more attention due to the slowconsolidation of soft soil. Meanwhile, it is proved that the step shape of the wall can resist lateral displacement more effectively than the vertical shape of wall. This case study provides insights into the real archaeological excavation in Hangzhou, in particular Liangzhu prehistoric earthen sites.

Infrared thermography for prediction of spontaneous combustion of sulfide ores

The method of infrared thermography to predict the temperature of the sulfide ores has a large error. To solve this problem, the temperature of the sulfide ores is measured by thermal infrared imager and recording thermometric instrument contrastively. The main factors, including emissivity, distance, angle and dust concentration that affect the temperature measurement precision, are analyzed. The regression equations about the individual factors and comprehensive factors are obtained by analyzing test data. The application of the regression equations improves the precision of the thermal infrared imager. The geometric information lost in traditional infrared thermometry is determined by visualization grid method and interpolation method, the relationship between the infrared imager and geometry information is established. The geometry location can be measured exactly.

自拟散结节汤治疗乳腺增生效果观察

目的观察自拟散结节汤治疗乳腺增生的效果。方法2019—2020年间扬州市广陵区沙头社区卫生服务中心收治的160例女性乳腺增生患者,随机分为对照组与观察组各80例,对照组予乳癖散结胶囊治疗,观察组予自拟散结节汤治疗。治疗1个月后评价两组乳房疼痛VAS评分、肿块大小、肿块质地的变化及临床疗效。结果治疗前两组乳房疼痛VAS评分、肿块大小、肿块质地接近(P>0.05);治疗后,两组乳房疼痛VAS评分、肿块大小、肿块质地均有所降低,且观察组明显低于对照组(P<0.05)。观察组临床总有效率显著优于对照组(P<0.05)。结论自拟散结节汤治疗乳腺增生效果显著。

A purely data driven method for European option valuation

An alternative option pricing method is proposed based on a random walk market model. The minimal entropy martingale measure which adopts no arbitrage opportunity in the market, is deduced for this market model and is used as the pricing measure to evaluate European call options by a Monte Carlo simulation method. The proposed method is a purely data driven valuation method without any distributional assumption about the price process of underlying asset. The performance of the proposed method is compared with the canonical valuation method and the historical volatility-based Black-Scholes method in an artificial Black-Scholes world. The simulation results show that the proposed method has merits, and is valuable to financial engineering.

李扬声自拟定眩方治疗眩晕38例临床观察

目的:观察李扬声自拟定眩方联合氟桂嗪胶囊治疗眩晕的临床疗效。方法:将76例眩晕患者随机分为治疗组和对照组,每组各38例。对照组予氟桂嗪(脑灵)胶囊治疗,治疗组在对照组基础上加用李扬声自拟定眩方治疗。比较2组临床疗效,临床症状与功能评分,左侧椎动脉(LVA)、右侧椎动脉(RVA)血流动力学指标,血脂水平。结果:总有效率治疗组为89.47%(34/38),对照组为73.68%(28/38),2组比较,差异有统计学意义(P<0.05)。2组临床症状与功能评分、两侧椎动脉最大血流速度及其口径和血脂各项指标水平治疗前后组内比较及治疗后组间比较,差异均有统计学意义(P<0.05)。结论:李扬声自拟定眩方联合氟桂嗪胶囊治疗眩晕临床疗效显著,能有效缓解患者临床症状,改善椎动脉血流动力学及血脂各项指标水平,值得临床推广应用。

Interaction between anti-shear galleries and surrounding rock in the right-bank slope of Dagangshan hydropower station

The fight-bank slope of the Dagangshan hydropower station located in Southwest China is a highly unloaded rock slope. Moreover, large-scale natural faults were detected in the slope body; some excavation-induced unloading fractures were discovered at elevations between lo75m and 1146m. Because of poor tectonic stability, the excavation work was suspended in September 2009, and six large- scale anti-shear galleries were employed to replace the weak zone in the slope body to reinforce the fight- bank slope. In this study, based on microseismic- monitoring technology and a numerical-simulation method, the stabilities of the slope with and without the reinforcement are analysed. An in-situ microseismic-monitofing system is used to obtain quantitative information about the damage location, extent, energy, and magnitude of the rocks. Thus, any potential sliding block in the fight-bank slope can be identified. By incorporating the numerical results along with the microseismic-monitoring data, the stress concentration is found to largely occur aroundthe anti-shear galleries, and the seismic deformation near the anti-shear galleries is apparent, particularly at elevations of 121o, 118o, 115o, and 112om. To understand the interaction mechanism between the anti-shear gallery and the surrounding rock, a 2D simulation of the potential damage process occurring in an anti-shear gallery is performed. The numerical simulation helps in obtaining additional information about the stress distribution and failure-induced stress re-distribution in the vicinity of the anti-shear galleries that cannot be directly observed in the field. Finally, the potential sliding surface of the right-bank slope is numerically obtained, which generally agrees with the spatial distribution of the in-situ monitored microseismic events. The safety factor of the slope reinforced with the anti-shear gallery increases by approximately 36.2%. Both the numerical results and microseismic data show that the anti-shear galleries have a good reinforcement effect.

Simulation of Kelvin-Helmholtz Instability with Flux-Corrected Transport Method

The sixth-order accurate phase error flux-corrected transport numerical algorithm is introduced, and used to simulate Kelvin-Helmholtz instability. Linear growth rates of the simulation agree with the linear theories of Kelvin Helmholtz instability. It indicates the validity and accuracy of this simulation method. The method also has good capturing ability of the instability interface deformation.

Analytic solution of phreatic surface in the slope of reservoir bank

In most cases, the slope stability of reservoir bank is analyzed on the premise that the location of phreatic surface is obtained. But many designers generalize a line as the phreatie surface through their experience to analyze the stability, which is unsafe in the project. To find a solution of the phreatic surface which is convenient to put into use and in accordance with the practice, the article, based on Boussinesq equation, infers analytic solutions suitable to the water level at different ratios and achieves an analytic solution equation through fitting curves. The correctness of the equation is also proved by the experiments of sand and sand-clay models and the inaccuracy of empirical generalization is analyzed quantitatively. The calculation results show that the inaccuracy through the method of experiential generalizing is so large that the designers should be awake to it.

Two Unconditional Stable Schemes for Simulation of Heat Equation on Manifold Using DEC

To predict the heat diffusion in a given region over time, it is often necessary to find the numerical solution for heat equation. However, the computational domain of classical numerical methods are limited to fiat spacetime. With the techniques of discrete differential calculus, we propose two unconditional stable numerical schemes for simulation heat equation on space manifold and time. The analysis of their stability and error is accomplished by the use of maximum principle.

Study on Unsteady Hydrodynamic Performance of Propeller in Waves

The speed of a ship sailing in waves always slows down due to the decrease in efficiency of the propeller. So it is necessary and essential to analyze the unsteady hydrodynamic performance of propeller in waves. This paper is based on the numerical simulation and experimental research of hydrodynamics performance when the propeller is under wave conditions. Open-water propeller performance in calm water is calculated by commercial codes and the results are compared to experimental values to evaluate the accuracy of the numerical simulation method. The first-order Volume of Fluid(VOF) wave method in STAR CCM+ is utilized to simulate the three-dimensional numerical wave. According to the above prerequisite, the numerical calculation of hydrodynamic performance of the propeller under wave conditions is conducted, and the results reveal that both thrust and torque of the propeller under wave conditions reveal intense unsteady behavior. With the periodic variation of waves, ventilation, and even an effluent phenomenon appears on the propeller. Calculation results indicate, when ventilation or effluent appears, the numerical calculation model can capture the dynamic characteristics of the propeller accurately, thus providing a significant theory foundation forfurther studying the hydrodynamic performance of a propeller in waves.

Building Vulnerability Evaluation in Landslide Deformation Phase

Building vulnerability evaluation is important in the risk assessment on earthquake and flood hazards. But for landslide hazard, it is also a very important part for the people in buildings. Most discussions or researches about building vulnerability are for landslide failure, few for landslide in deformation phase. For this objective, this paper discussed about building vulnerability evaluation using Zhaoshuling landslide as an example Zhaoshuling landslide named located in the Three Gorges Reservoir Area, China. After a field survey on the geological condition of landslide, detailed field investigation on the buildings' location and structure is carried out. To get landslide surface deformation, numerical simulation method is used under the combining condition of water fluctuation and rainfall. Then building deformation and probable damage degree is analyzed according to landslide surface deformation and the relative theory in mining. Based on the national standard building damage classification system, the vulnerability of all the buildings on the landslide is semi-quantitatively evaluated.

A Defined Process to Digitally Reproduce in 3D a Wide Set of Archaeological Artifacts for Virtual Investigation and Display

This paper contributes to depict the current pattern of applications of digital 3D models for professional research and practice, and for broader dissemination of cultural heritage. Passing from a general review to the illustration of the background project, named MUSINT, the authors underline the objectives. The present case study primarily aims to share information about valuable archaeological collections which have little visibility. To enhance the project＇s contents, which include a whole set of different artifacts, the authors have reproduced high resolution, faithful and measurable digital models on one side, and on the other, lower resolution and geometrically simplified models are yet completed and very close to reality. The former are meant to implement a scholars＇ archive for further scientific activity. The latter to provide content for virtual exhibitions on the Web or on stand-alone interfaces situated in the actual physical museum spaces. The data acquisition and post-processing methods which have been tested and chosen are here briefly described. Hence, the authors then give an account of the most recurrent problematic issues of the established work-flow and how they should be solved. Touched instances are the delicate placing of the artifacts, which must be digitized, in relation to the triangulation-based laser scanner＇s functionality, the refining operations in order to build a coherent single polygon mesh, the most effective ways to deal with unavoidable missing parts or defected textures in the generated model and so on.

Numerical Simulation of the Water Entry of a Structure in Free Fall Motion

To solve the problems concerning water entry of a structure, the RANS equations and volume of fluid （VOF） method are used. Combining the user-defined function （UDF） procedure with dynamic grids, the water impact on a structure in free fall is simulated, and the velocity, displacement and the pressure distribution on the structure are investigated. The results of the numerical simulation were compared with the experimental data, and solidly consistent results have been achieved, which validates the numerical model. Therefore, this method can be used to study the water impact problems of a structure.

Model identification of hydraulic flight simulator based on improved particle swarm optimization and wavelet analysis

A new model identification method of hydraulic flight simulator adopting improved panicle swarm optimization （PSO） and wavelet analysis is proposed for achieving higher identification precision. Input-output data of hydraulic flight simulator were decomposed by wavelet muhiresolution to get the information of different frequency bands. The reconstructed input-output data were used to build the model of hydraulic flight simulator with improved particle swarm optimization with mutation （IPSOM） to avoid the premature convergence of traditional optimization techniques effectively. Simulation results show that the proposed method is more precise than traditional system identification methods in operating frequency bands because of the consideration of design index of control system for identification.

Deformation tests and failure process analysis of an anchorage structure

In order to study the failure process of an anchorage structure and the evolution law of the body＇s defor- mation field, anchor push-out tests were carried out based on digital speckle correlation methods （DSCM）. The stress distribution of the anchorage interface was investigated using the particle flow numerical simulation method. The results indicate that there are three stages in the deformation and fail- ure process of an anchorage structure： elastic bonding stage, a de-bonding stage and a failure stage. The stress distribution in the interface controls the stability of the structure. In the elastic bonding stage, the shear stress peak point of the interface is close to the loading end, and the displacement field gradually develops into a ＂V＂ shape, in the de-bonding stage, there is a shear stress plateau in the center of the anchorage section, and shear strain localization begins to form in the deformation field. In the failure stage, the bonding of the interface fails rapidly and the shear stress peak point moves to the anchorage free end. The anchorage structure moves integrally along the macro-cracl~ The de-bonding stage is a research focus in the deformation and failure process of an anchorage structure, and plays an important guiding role in roadway support design and prediction of the stability of the surrounding rock.

Numerical simulation of the influence of ground effect on the performance of multi section wings

the establishment of multi-element airfoil in steady and unsteady ground effect N-S equation turbulence model, the S-A model of multi element airfoils during takeoff and landing high attack angle change numerical simulation analysis, the calculation results show that the lower altitude, lift and drag wing angle decreased; the greater the ground the effect is more obvious, the greater the loss of lift. The simulation results show that the lift coefficient is slightly less than that of unsteady numerical simulation, and the drag coefficient is slightly less than that of unsteady numerical simulation. The ground disturbance to the wing not only affects the steady state flow field, but also is closely related to the unsteady aerodynamic performance. The results of this study can provide a reference for the design and flight control of large aircraft wings.