Similar to Hepatitis C virus (HCV) infection in humans, HCVcc infection can also result in persistent and chronic infection. The core protein is a variable protein and exists in several sizes. Some sizes of core prote...Similar to Hepatitis C virus (HCV) infection in humans, HCVcc infection can also result in persistent and chronic infection. The core protein is a variable protein and exists in several sizes. Some sizes of core proteins have been reported to be related to chronic HCV infection. To study the possible role of the core protein in persistent HCV infection, a persistent HCVcc infection was established, and the expression of the core protein was analysed over the course of the infection. The results show that there are three sizes of core proteins (p24, p21 and p19) expressed during the establishment of persistent HCVcc infection. Of these, the p21 core protein is the mature form of the HCV core protein. The p24 core protein is the phosphorylated form of p21. The p19 core protein appears to be a functional by-product generated during the course of infection. These three core proteins are all localized in the cytoplasm and can be encapsidated into the HCV virion. The appearance of the p19 and p24 core proteins might be related to acute HCVcc infection and chronic infection respectively and may play an important role in the pathology of a HCV infection.展开更多
Although bacterial persistence was first observed in 1944,its underlying mechanism is just beginning to be understood and many fundamental questions remain.In this review,we summarize studies in order to chart the ful...Although bacterial persistence was first observed in 1944,its underlying mechanism is just beginning to be understood and many fundamental questions remain.In this review,we summarize studies in order to chart the full map of bacterial persistence.Because persistence significantly contributes to disease recalcitrance,we also elucidate the probable relationships between bacterial persistence and prolonged chronic infections,with some comments on future research directions and therapeutic strategies.展开更多
In the real world, quite a few infectious diseases like schistosomiasis spread seasonally. In this paper, a nonautonomous schistosomiasis system is established, in which the saturation incidence rate and the coefficie...In the real world, quite a few infectious diseases like schistosomiasis spread seasonally. In this paper, a nonautonomous schistosomiasis system is established, in which the saturation incidence rate and the coefficients varying with time are taken into account. The long-time behavior of the model is studied. Under quite weak assumptions, sufficient conditions for the permanence and extinction of infectious population of disease are obtained. Finally, numerical simulations illustrate the validity of our results.展开更多
基金funded by the National Basic Research Program of China (2009CB522504)
文摘Similar to Hepatitis C virus (HCV) infection in humans, HCVcc infection can also result in persistent and chronic infection. The core protein is a variable protein and exists in several sizes. Some sizes of core proteins have been reported to be related to chronic HCV infection. To study the possible role of the core protein in persistent HCV infection, a persistent HCVcc infection was established, and the expression of the core protein was analysed over the course of the infection. The results show that there are three sizes of core proteins (p24, p21 and p19) expressed during the establishment of persistent HCVcc infection. Of these, the p21 core protein is the mature form of the HCV core protein. The p24 core protein is the phosphorylated form of p21. The p19 core protein appears to be a functional by-product generated during the course of infection. These three core proteins are all localized in the cytoplasm and can be encapsidated into the HCV virion. The appearance of the p19 and p24 core proteins might be related to acute HCVcc infection and chronic infection respectively and may play an important role in the pathology of a HCV infection.
基金supported by the National Natural Science Foundation of China(31370847)the Recruitment Program of Global Youth Experts
文摘Although bacterial persistence was first observed in 1944,its underlying mechanism is just beginning to be understood and many fundamental questions remain.In this review,we summarize studies in order to chart the full map of bacterial persistence.Because persistence significantly contributes to disease recalcitrance,we also elucidate the probable relationships between bacterial persistence and prolonged chronic infections,with some comments on future research directions and therapeutic strategies.
基金Special thanks to the anonymous referees who have given us very useful suggestions. The research has been supported by the Natural Science Foundation of China （11261004）, the National Key Technologies R＆D Program of China （2009BAI78B01） and the Science and Technology Plan Projects of Jiangxi Provincial Education Department （GJJ14665, GJJ14673）.
文摘In the real world, quite a few infectious diseases like schistosomiasis spread seasonally. In this paper, a nonautonomous schistosomiasis system is established, in which the saturation incidence rate and the coefficients varying with time are taken into account. The long-time behavior of the model is studied. Under quite weak assumptions, sufficient conditions for the permanence and extinction of infectious population of disease are obtained. Finally, numerical simulations illustrate the validity of our results.
