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重组(酵母)乙型肝炎疫苗免疫后8年的抗体持久性研究 被引量:9
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作者 翟如方 邢秀生 +5 位作者 闫以让 李国英 安建会 李太生 常少英 范富云 《中国计划免疫》 2005年第2期86-88,共3页
目的 重组(酵母)乙型肝炎(乙肝)疫苗(YDV)已纳入儿童计划免疫,为观察其免疫效果的持久性及免疫记忆反应。方法 对山西省晋中、阳泉市1995年出生,并按照免疫程序全程免疫的儿童,进行了8年的免疫持久性观察。同时在该年龄组儿童免疫5年... 目的 重组(酵母)乙型肝炎(乙肝)疫苗(YDV)已纳入儿童计划免疫,为观察其免疫效果的持久性及免疫记忆反应。方法 对山西省晋中、阳泉市1995年出生,并按照免疫程序全程免疫的儿童,进行了8年的免疫持久性观察。同时在该年龄组儿童免疫5年后,对乙肝病毒表面抗体(抗-HBs) <2 1mIU/ml者,加强免疫YDV 1针(5 μg) ,观察其免疫反应。结果 基础免疫后,抗 HBs阳性率、有效阳性率、几何平均滴度(GMT)分别达到92 . 0 8%、84. 16 %、2 9. 2 1mIU/ml,以后逐年下降,免疫后8年时分别降低为6 5 . 6 3%、4 0 . 6 3%、5 . 89mIU/ml。抗 HBs阳性率下降速率较慢,年均3 .78% ,有效阳性率的下降速率较快,年均降低6 . 2 2 % ,GMT每年平均下降3. 33mIU/ml,免疫后8年较1年时降低79 .84 %。免疫后5年抗HBs <2. 1mIU/ml的儿童,加强免疫1针后其抗 HBs阳性率和有效阳性率均达到10 0 % ,GMT达基础免疫1年时的8 .33倍。结论 YDV免疫后,机体同样产生特异性体液和细胞免疫记忆。由于YDV与血源乙肝疫苗的理化性质等方面的不同,其免疫的长期记忆和保护效果如何,需否加强免疫等问题,尚需进一步研究。 展开更多
关键词 重组(酵母)乙型肝炎疫苗 乙型肝炎病毒表面抗体 持久性研究
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Violence in Partnership and Persisting Problems of Assistance
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作者 Hermina Marekova 《Sociology Study》 2016年第9期553-564,共12页
The paper focuses on an attempt to answer questions concerning domestic violence in accordance with the epistemology in contemporary scientific research. The phenomenology of violence is defined with respect to the su... The paper focuses on an attempt to answer questions concerning domestic violence in accordance with the epistemology in contemporary scientific research. The phenomenology of violence is defined with respect to the superficial as well as the essential side of the phenomena. The problems are covered with respect to interdisciplinary relations. We endeavor to open a broader view. The underlying research represents an alternative approach, attempting to reach a cumulative view based on the data acquired from various contexts. In social science research, it is important to look at the social reality not only through the numbers of quantitative research, because social reality is constructed in various ways. The issues of elimination of violence against women in Slovakia are entrenched in the program of various institutions. Based on the performed analysis, inconsistencies in the approach to providing assistance are identified as the most important problem. The paper deals with the institutional issues persisting in dealing with situations and identifies the fundamental failures of social intervention that still exist, among other reasons, due to the stereotypical, discriminatory perceptions of the issues by the competency. 展开更多
关键词 Gender-Based violence ABUSE competencies LEGISLATION REPORTING
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