The long-term goal of the 2015 Paris Agreement is to limit global warming to well below 2 ℃above pre-industrial levels and to pursue efforts to limit it to 1.5 ℃. However, for climate mitigation and adaption efforts...The long-term goal of the 2015 Paris Agreement is to limit global warming to well below 2 ℃above pre-industrial levels and to pursue efforts to limit it to 1.5 ℃. However, for climate mitigation and adaption efforts, further studies are still needed to understand the regional consequences between the two global warming limits. Here we provide an assessment of changes in temperature extremes over China (relative to 1986-2005) at 1.5 ℃ and 2 ℃ warming levels (relative to 1861-1900) by using the 5th phase of the Coupled Model Intercomparison Project (CMIP5) models under three RCP scenarios (RCP2.6, RCP4.5, RCP8.5). Results show that the increases in mean temperature and temperature extremes over China are greater than that in global mean temperature. With respect to 1986-2005, the temperature of hottest day (TXx) and coldest night (TNn) are projected to increase about 1/1.6 ℃ and 1.1/1.8 ℃, whereas warm days (TX90p) and warm spell duration (WSDI) will increase about 7.5/13.8% and 15/30 d for the 1.5/2 ℃ global warming target, respectively. Under an additional 0.5 ℃ global warming, the projected increases of temperature in warmest day/night and coldest day/night are both more than 0.5 ℃ across almost the whole China. In Northwest China, Northeast China and the Tibetan Plateau, the projected changes are particularly sensitive to the additional 0.5 ℃ global warming, for example, multi-model mean increase in coldest day (TXn) and coldest night (TNn) will be about 2 times higher than a change of 0.5 ℃ global warming. Although the area-averaged changes in temperature extremes are very similar for different scenarios, spatial hotspot still exists, such as in Northwest China and North China, the increases in temperatures are apparently larger in RCP8.5 than that in RCP4.5.展开更多
Asian options are the popular second generation derivative products and embedded in many structured notes to enhance upside performance.The embedded options,as a result,usually have a long duration.The movement of int...Asian options are the popular second generation derivative products and embedded in many structured notes to enhance upside performance.The embedded options,as a result,usually have a long duration.The movement of interest rates becomes more important in pricing such long-dated options.In this paper,the pricing of Asian options under stochastic interest rates is studied.Assuming Hull and White model for the interest rates,a closed-form formula for geometric-average options is derived.As a by-product,pricing formula is also given for plan-vanilla options under stochastic interest rates.展开更多
Early warning model of debris flow is important for providing local residents with reliable and accurate warning information to escape from debris flow hazards. This research studied the debris flow initiation in the ...Early warning model of debris flow is important for providing local residents with reliable and accurate warning information to escape from debris flow hazards. This research studied the debris flow initiation in the Yindongzi gully in Dujiangyan City, Sichuan province, China with scaled-down model experiments. We set rainfall intensity and slope angle as dominating parameters and carried out 20 scaled-down model tests under artificial rainfall conditions. The experiments set four slope angles(32°, 34°, 37°, 42°) and five rainfall intensities(60 mm/h, 90 mm/h, 120 mm/h, 150 mm/h, and 180 mm/h) treatments. The characteristic variables in the experiments, such as, rainfall duration, pore water pressure, moisture content, surface inclination, and volume were monitored. The experimental results revealed the failure mode of loose slope material and the process of slope debris flow initiation, as well as the relationship between the surface deformation and the physical parameters of experimental model. A traditional rainfall intensity-duration early warning model(I-D model) was firstly established by using a mathematical regression analysis, and it was then improved into ISD model and ISM model(Here, I is rainfall Intensity, S is Slope angle, D is rainfall Duration, and M is Moisture content). The warning model can provide reliable early warning of slope debris flow initiation.展开更多
Protoplasts from Candida tropicalis and Candida lipolytica were fused under an optimized electrofusion (electrical pulse strength 6 kV/cm, pulse duration time 40μs and pulse times 5) and then regenerated on YEPD me...Protoplasts from Candida tropicalis and Candida lipolytica were fused under an optimized electrofusion (electrical pulse strength 6 kV/cm, pulse duration time 40μs and pulse times 5) and then regenerated on YEPD media for achieving new genotypes with higher chromium loading capacity. A target fusant RHJ-004 was screened out by its chromium resistance and chromium-sorbing capacity tests for further research. The comparative study of applicability shows that the fusant has better performance than its parent strains in respect of solution pH, biomass concentration and chromium loading capacity. Especially for treating low concentration Cr(VI) (〈20 mg/L), above 80% chromium is sequestered from the aqueous phase at pH 1-9. Atomic force microscopy (AFM) visualizes the distribution of chromium on the binding sites of the cells, suggesting that the altered surface structure and intracellular constitutes of the fusant associate with its increased biosorption capacity. The rapid biosorption processes of chromium foUow the Langmuir model well.展开更多
The latest financial crisis has been impressive for strength, impact, duration, and reduced efficacy of the economic and financial policies adopted by the authorities. We use an original information risk model to cont...The latest financial crisis has been impressive for strength, impact, duration, and reduced efficacy of the economic and financial policies adopted by the authorities. We use an original information risk model to contribute to the analysis of the crisis and to suggest some approaches for a possible early diagnosis. Using data referred to the three main financial markets and comparing the latest crisis with the previous one and with long-term quantitative evidence, we find out that the 2007-2009 crisis was very different in the information risk quality. That gap affected the market risk aversion and its equilibrium, reducing the efficacy of the authorities' intervention tools mainly based on payoff risk control and efficient market restoration. Since information risk is an endogenous element of the market dynamics that can be independent form contingent levels of market efficiency. Drivers of information risk in the European Markets differed strongly from the US and Japanese ones; that is why some global decisions had low impact while opportunities of local intervention were missed.展开更多
According to the chaotic and non-linear characters of power load data,the time series matrix is established with the theory of phase-space reconstruction,and then Lyapunov exponents with chaotic time series are comput...According to the chaotic and non-linear characters of power load data,the time series matrix is established with the theory of phase-space reconstruction,and then Lyapunov exponents with chaotic time series are computed to determine the time delay and the embedding dimension.Due to different features of the data,data mining algorithm is conducted to classify the data into different groups.Redundant information is eliminated by the advantage of data mining technology,and the historical loads that have highly similar features with the forecasting day are searched by the system.As a result,the training data can be decreased and the computing speed can also be improved when constructing support vector machine(SVM) model.Then,SVM algorithm is used to predict power load with parameters that get in pretreatment.In order to prove the effectiveness of the new model,the calculation with data mining SVM algorithm is compared with that of single SVM and back propagation network.It can be seen that the new DSVM algorithm effectively improves the forecast accuracy by 0.75%,1.10% and 1.73% compared with SVM for two random dimensions of 11-dimension,14-dimension and BP network,respectively.This indicates that the DSVM gains perfect improvement effect in the short-term power load forecasting.展开更多
Mergers & acquisitions (M&As) are important strategic instruments, yet nearly half of all transactions fail, often resulting in disastrous write-offs and losses for corporations and financing institutions alike - ...Mergers & acquisitions (M&As) are important strategic instruments, yet nearly half of all transactions fail, often resulting in disastrous write-offs and losses for corporations and financing institutions alike - despite promising prospects upfront. Applied research has been trying to find a "panacea" to prevent or at least predict M&A failure, investigating motives, synergies and performance. Despite the growing unease with the stationary explanatory models in literature, research has only marginally focused on the concept of time, with inquiries into market timing and integration speed. Yet other timing concepts have been neglected in concepts so far despite early empirical evidence for their existence. The purpose of this paper is thus to identify and elaborate on the importance of further relevant theories of timing. For this, and true to the exploratory nature of the topic, the authors have chosen a qualitative comparative case study design based on existing case reports which are investigated for narrations highlighting timing concepts. This study reveals six factors which have a crucial impact on the M&A outcome: time of acquisition, M&A duration in its entirety, M&A sequence, synergy chronology, frequency of acquisitions and time to step back. It contributes to theory and practice in outlining the careful attention that needs to be paid in planning in these factors to enhance the chances of a successful M&A transaction.展开更多
The paper considers the problem of representing non-Markovian systems that evolve stochastically over time. It is often necessary to use approximations in the case the system is non-Markovian. Phase type distribution ...The paper considers the problem of representing non-Markovian systems that evolve stochastically over time. It is often necessary to use approximations in the case the system is non-Markovian. Phase type distribution is by now indispensable tool in creation of stochastic system models. The paper suggests a method and software for evaluating stochastic systems approximations by Markov chains with continuous time and countable state space. The performance of a system is described in the event language used for generating the set of states and transition matrix between them. The example of a numerical model is presented.展开更多
The author considers a three-species ratio-dependent predator-prey model with time delay in a two-patch environments. This model is of periodic coefficients, which incorporates the periodicity of the environment. By m...The author considers a three-species ratio-dependent predator-prey model with time delay in a two-patch environments. This model is of periodic coefficients, which incorporates the periodicity of the environment. By means of the coincidence degree theory, sufficient conditions for the existence of at least one positive periodic solution of this model are established. Moreover, The author shows that the system is uniformly persistent under the conditions.展开更多
In order to uncover a possible influence on the Earth's climate, we need a much longer time series, i.e., the total solar irradiance (TSI) which is also an interesting issue in its own right in solar physics. By c...In order to uncover a possible influence on the Earth's climate, we need a much longer time series, i.e., the total solar irradiance (TSI) which is also an interesting issue in its own right in solar physics. By comparing different solar indices associated with TSI during the period 1979 to 2009, several empirical models in the TSI are presented. We verify that the reconstruction model based on the three variables: sunspot number, sunspot area, and solar 10.7 cm radio flux, is the best one. As demonstrated by model calculations, the history of TSI was reconstructed back to 1947 based on 3-indices and to 1874 based on 2-indices, respectively. The reason that the reduced irradiance on the trough during 2006 to 2009 lasts long may be due to the about 85-year cycle of solar activity, which modulates the intensity of the 11-year cycle (Schwabe cycles), possesses a considerable potential to produce an effective reducing, and holds on a steadily lower level of irradiance.展开更多
OBJECTIVE: To investigate the antidepressant-likeeffect of active fraction of Polyrhachis vicina Roger(AFPR) in a rat depression model, and to elucidate the underlying mechanism.METHODS: AFPR was extracted with ethano...OBJECTIVE: To investigate the antidepressant-likeeffect of active fraction of Polyrhachis vicina Roger(AFPR) in a rat depression model, and to elucidate the underlying mechanism.METHODS: AFPR was extracted with ethanol followed by petroleum ether. Its antidepressant-like effect was investigated in mice by tail suspension test(TST), forced swimming test(FST) and open field test(OPT). A repeated dose of reserpine(0.5 mg/kg, daily for 14 d) was used to establish a rat depression model. Fluoxetine was used as positive control agent. The effect of AFPR on reserpine-induced ptosis, hypothermia and akinesia, the levels of monoamines and their metabolites, and the activity of monoamine oxidase(MAO) in hippocampus and prefrontal cortex were determined.RESULTS: Administration of AFPR by gavage at 160 and 320 mg/kg significantly reduced the duration of immobility in the FST and TST, and did not affect locomotor activity in the OPT. In the reserpine-induced depression model, AFPR attenuated anhedonia, demonstrated by reversing hypothermia, akinesia and sucrose consumption. AFPR significantly increased the concentration of monoamines, including dopamine, serotonin, noradrenaline and acetylcholine.CONCLUSION: AFPR normalized the metabolism rates of noradrenaline, serotonin and dopamine,and the activity of MAO, which were altered by chronic reserpine exposure. The findings suggest that modulation of the monoaminergic neurotransmitter system likely underlies the antidepressant-like effect of AFPR.展开更多
This paper demonstrates that the susceptible-infected-removed (SIR) model applied to the early phase of an epidemic can be used to determine epidemic parameters reliably. As a case study, the SIR model is applied to...This paper demonstrates that the susceptible-infected-removed (SIR) model applied to the early phase of an epidemic can be used to determine epidemic parameters reliably. As a case study, the SIR model is applied to the fatality data of the 2009 fall wave cycle of the A(H1N1) pandemic in 12 European countries. It is observed that the best estimates of the basic reproduction number R0 and the mean duration of the infection period l/r/ lie on a curve in the scatterplots, indicating the existence of a nearly-invariant quantity which corresponds to the duration of the epidemic. Spline interpolation applied to the early phase of the epidemic, an approximately 10-week period, together with a future control point in the stabilization region, is sufficient to estimate model parameters. The SIR model is run over a wide range of parameters and estimates of R0 in the range 1.2- 2.0 match the values in the literature. The duration of the infection period, 1/η is estimated to be in the range 2.0-7.0 days. Longer infection periods are tied to spatial characteristics of the spread of the epidemic.展开更多
An integrated approach is proposed to predict the chromatographic retention time of oligonucleotides based on quantitative structure-retention relationships (QSRR) models. First, the primary base sequences of oligon...An integrated approach is proposed to predict the chromatographic retention time of oligonucleotides based on quantitative structure-retention relationships (QSRR) models. First, the primary base sequences of oligonucleotides are translated into vectors based on scores of generalized base properties (SGBP), involving physicochemical, quantum chemical, topological, spatial structural properties, etc.; thereafter, the sequence data are transformed into a uniform matrix by auto cross covariance (ACC). ACC accounts for the interactions between bases at a certain distance apart in an oligonucleotide sequence; hence, this method adequately takes the neighboring effect into account. Then, a genetic algorithm is used to select the variables related to chromatographic retention behavior of oligonuclcotides. Finally, a support vector machine is used to develop QSRR models to predict chromatographic retention behavior. The whole dataset is divided into pairs of training sets and test sets with different proportions; as a result, it has been found that the QSRR models using more than 26 training samples have an appropriate external power, and can accurately represent the relationship between the features of sequences and structures, and the retention times. The results indicate that the SGBP-ACC approach is a useful structural representation method in QSRR of oligonucleotides due to its many advantages such as plentiful structural information, easy manipulation and high characterization competence. Moreover, the method can further be applied to predict chromatographic retention behavior of oligonucleotides.展开更多
The aim of this study is to build two mathematical models of canine ionic currents specific to right atria and left atria.The canine left atria mathematical model was firstly modified from the Ramirez-Nattel-Courteman...The aim of this study is to build two mathematical models of canine ionic currents specific to right atria and left atria.The canine left atria mathematical model was firstly modified from the Ramirez-Nattel-Courtemanche(RNC) model using the recently available experimental data of ionic currents and was further developed based on our own experimental data.A model of right atria was then built by considering the differences between right atria and left atria.The two developed models well reproduced the experimental data on action potential morphology,the rate dependence,and action potential duration restitution.They are useful for investigating the mechanisms underlying the het-erogeneity of canine regional action potentials and would help the simulation of whole heart excitation propagation and cardiac arrhythmia in the near future.展开更多
基金We acknowledge the World Climate Research Programme's Working Group on Coupled Modelling, which is responsible for CMIP, and we thank the climate modeling groups (listed in Table l) for producing and making available their model output. This research is supported by the National Key Research and Development Program of China (2017YFA0603804) and the State Key Program of National Natural Science Foundation of China (41230528).
文摘The long-term goal of the 2015 Paris Agreement is to limit global warming to well below 2 ℃above pre-industrial levels and to pursue efforts to limit it to 1.5 ℃. However, for climate mitigation and adaption efforts, further studies are still needed to understand the regional consequences between the two global warming limits. Here we provide an assessment of changes in temperature extremes over China (relative to 1986-2005) at 1.5 ℃ and 2 ℃ warming levels (relative to 1861-1900) by using the 5th phase of the Coupled Model Intercomparison Project (CMIP5) models under three RCP scenarios (RCP2.6, RCP4.5, RCP8.5). Results show that the increases in mean temperature and temperature extremes over China are greater than that in global mean temperature. With respect to 1986-2005, the temperature of hottest day (TXx) and coldest night (TNn) are projected to increase about 1/1.6 ℃ and 1.1/1.8 ℃, whereas warm days (TX90p) and warm spell duration (WSDI) will increase about 7.5/13.8% and 15/30 d for the 1.5/2 ℃ global warming target, respectively. Under an additional 0.5 ℃ global warming, the projected increases of temperature in warmest day/night and coldest day/night are both more than 0.5 ℃ across almost the whole China. In Northwest China, Northeast China and the Tibetan Plateau, the projected changes are particularly sensitive to the additional 0.5 ℃ global warming, for example, multi-model mean increase in coldest day (TXn) and coldest night (TNn) will be about 2 times higher than a change of 0.5 ℃ global warming. Although the area-averaged changes in temperature extremes are very similar for different scenarios, spatial hotspot still exists, such as in Northwest China and North China, the increases in temperatures are apparently larger in RCP8.5 than that in RCP4.5.
文摘Asian options are the popular second generation derivative products and embedded in many structured notes to enhance upside performance.The embedded options,as a result,usually have a long duration.The movement of interest rates becomes more important in pricing such long-dated options.In this paper,the pricing of Asian options under stochastic interest rates is studied.Assuming Hull and White model for the interest rates,a closed-form formula for geometric-average options is derived.As a by-product,pricing formula is also given for plan-vanilla options under stochastic interest rates.
基金financially supported by the CAS Pioneer Hundred Talents Programpthe Institute of Mountain Hazards and Environment(Grant No.SDS-135-1705)+1 种基金support from the National Natural Science Foundation of China(Grant No.41771021,41471429,and 41790443)the National Key Research and Development Program of China(Grant No.2017YFD0800501)
文摘Early warning model of debris flow is important for providing local residents with reliable and accurate warning information to escape from debris flow hazards. This research studied the debris flow initiation in the Yindongzi gully in Dujiangyan City, Sichuan province, China with scaled-down model experiments. We set rainfall intensity and slope angle as dominating parameters and carried out 20 scaled-down model tests under artificial rainfall conditions. The experiments set four slope angles(32°, 34°, 37°, 42°) and five rainfall intensities(60 mm/h, 90 mm/h, 120 mm/h, 150 mm/h, and 180 mm/h) treatments. The characteristic variables in the experiments, such as, rainfall duration, pore water pressure, moisture content, surface inclination, and volume were monitored. The experimental results revealed the failure mode of loose slope material and the process of slope debris flow initiation, as well as the relationship between the surface deformation and the physical parameters of experimental model. A traditional rainfall intensity-duration early warning model(I-D model) was firstly established by using a mathematical regression analysis, and it was then improved into ISD model and ISM model(Here, I is rainfall Intensity, S is Slope angle, D is rainfall Duration, and M is Moisture content). The warning model can provide reliable early warning of slope debris flow initiation.
基金Project(NSFC-GDNSF U0933002) supported by the Joint Funds of the National Natural Science Foundation of China and the Natural Science Foundation of Guangdong Province,ChinaProject(50978122) supported by the National Natural Science Foundation of China
文摘Protoplasts from Candida tropicalis and Candida lipolytica were fused under an optimized electrofusion (electrical pulse strength 6 kV/cm, pulse duration time 40μs and pulse times 5) and then regenerated on YEPD media for achieving new genotypes with higher chromium loading capacity. A target fusant RHJ-004 was screened out by its chromium resistance and chromium-sorbing capacity tests for further research. The comparative study of applicability shows that the fusant has better performance than its parent strains in respect of solution pH, biomass concentration and chromium loading capacity. Especially for treating low concentration Cr(VI) (〈20 mg/L), above 80% chromium is sequestered from the aqueous phase at pH 1-9. Atomic force microscopy (AFM) visualizes the distribution of chromium on the binding sites of the cells, suggesting that the altered surface structure and intracellular constitutes of the fusant associate with its increased biosorption capacity. The rapid biosorption processes of chromium foUow the Langmuir model well.
文摘The latest financial crisis has been impressive for strength, impact, duration, and reduced efficacy of the economic and financial policies adopted by the authorities. We use an original information risk model to contribute to the analysis of the crisis and to suggest some approaches for a possible early diagnosis. Using data referred to the three main financial markets and comparing the latest crisis with the previous one and with long-term quantitative evidence, we find out that the 2007-2009 crisis was very different in the information risk quality. That gap affected the market risk aversion and its equilibrium, reducing the efficacy of the authorities' intervention tools mainly based on payoff risk control and efficient market restoration. Since information risk is an endogenous element of the market dynamics that can be independent form contingent levels of market efficiency. Drivers of information risk in the European Markets differed strongly from the US and Japanese ones; that is why some global decisions had low impact while opportunities of local intervention were missed.
基金Project(70671039) supported by the National Natural Science Foundation of China
文摘According to the chaotic and non-linear characters of power load data,the time series matrix is established with the theory of phase-space reconstruction,and then Lyapunov exponents with chaotic time series are computed to determine the time delay and the embedding dimension.Due to different features of the data,data mining algorithm is conducted to classify the data into different groups.Redundant information is eliminated by the advantage of data mining technology,and the historical loads that have highly similar features with the forecasting day are searched by the system.As a result,the training data can be decreased and the computing speed can also be improved when constructing support vector machine(SVM) model.Then,SVM algorithm is used to predict power load with parameters that get in pretreatment.In order to prove the effectiveness of the new model,the calculation with data mining SVM algorithm is compared with that of single SVM and back propagation network.It can be seen that the new DSVM algorithm effectively improves the forecast accuracy by 0.75%,1.10% and 1.73% compared with SVM for two random dimensions of 11-dimension,14-dimension and BP network,respectively.This indicates that the DSVM gains perfect improvement effect in the short-term power load forecasting.
文摘Mergers & acquisitions (M&As) are important strategic instruments, yet nearly half of all transactions fail, often resulting in disastrous write-offs and losses for corporations and financing institutions alike - despite promising prospects upfront. Applied research has been trying to find a "panacea" to prevent or at least predict M&A failure, investigating motives, synergies and performance. Despite the growing unease with the stationary explanatory models in literature, research has only marginally focused on the concept of time, with inquiries into market timing and integration speed. Yet other timing concepts have been neglected in concepts so far despite early empirical evidence for their existence. The purpose of this paper is thus to identify and elaborate on the importance of further relevant theories of timing. For this, and true to the exploratory nature of the topic, the authors have chosen a qualitative comparative case study design based on existing case reports which are investigated for narrations highlighting timing concepts. This study reveals six factors which have a crucial impact on the M&A outcome: time of acquisition, M&A duration in its entirety, M&A sequence, synergy chronology, frequency of acquisitions and time to step back. It contributes to theory and practice in outlining the careful attention that needs to be paid in planning in these factors to enhance the chances of a successful M&A transaction.
文摘The paper considers the problem of representing non-Markovian systems that evolve stochastically over time. It is often necessary to use approximations in the case the system is non-Markovian. Phase type distribution is by now indispensable tool in creation of stochastic system models. The paper suggests a method and software for evaluating stochastic systems approximations by Markov chains with continuous time and countable state space. The performance of a system is described in the event language used for generating the set of states and transition matrix between them. The example of a numerical model is presented.
基金The research is supported by the Scientific Research Foundation of the Doctor Department of Hubei University of Technology.
文摘The author considers a three-species ratio-dependent predator-prey model with time delay in a two-patch environments. This model is of periodic coefficients, which incorporates the periodicity of the environment. By means of the coincidence degree theory, sufficient conditions for the existence of at least one positive periodic solution of this model are established. Moreover, The author shows that the system is uniformly persistent under the conditions.
基金supported by the National Natural Science Foundation of China (Grant No. 10978007)the Excellent Scientists Training Program of Beijing
文摘In order to uncover a possible influence on the Earth's climate, we need a much longer time series, i.e., the total solar irradiance (TSI) which is also an interesting issue in its own right in solar physics. By comparing different solar indices associated with TSI during the period 1979 to 2009, several empirical models in the TSI are presented. We verify that the reconstruction model based on the three variables: sunspot number, sunspot area, and solar 10.7 cm radio flux, is the best one. As demonstrated by model calculations, the history of TSI was reconstructed back to 1947 based on 3-indices and to 1874 based on 2-indices, respectively. The reason that the reduced irradiance on the trough during 2006 to 2009 lasts long may be due to the about 85-year cycle of solar activity, which modulates the intensity of the 11-year cycle (Schwabe cycles), possesses a considerable potential to produce an effective reducing, and holds on a steadily lower level of irradiance.
基金Supported by Grants from the National Natural Science Foundation of China(No.81560663,81773924,U1402221,81573636)Beijing Natural Science Foundation(7182114)+7 种基金PUMC Youth Fund(3332016058)CAMS Innovation Fund for Medical Sciences(CIFMS)(2016-I2M-1-004)the Scientific Research Foundation of the Higher Education Institutions of Hunan Province(15K091)Project of NDRC and State Administration of Traditional Chinese Medicine(60011000)Hunan Provincial Key Laboratory for Standardization of Important Chinese Herbal Pieces(BG201701,4981-0901020)The State Key Laboratory Fund Open Project(GTZK201610)China Postdoctoral Science Foundation(2013M540066)Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study(BZ0150)
文摘OBJECTIVE: To investigate the antidepressant-likeeffect of active fraction of Polyrhachis vicina Roger(AFPR) in a rat depression model, and to elucidate the underlying mechanism.METHODS: AFPR was extracted with ethanol followed by petroleum ether. Its antidepressant-like effect was investigated in mice by tail suspension test(TST), forced swimming test(FST) and open field test(OPT). A repeated dose of reserpine(0.5 mg/kg, daily for 14 d) was used to establish a rat depression model. Fluoxetine was used as positive control agent. The effect of AFPR on reserpine-induced ptosis, hypothermia and akinesia, the levels of monoamines and their metabolites, and the activity of monoamine oxidase(MAO) in hippocampus and prefrontal cortex were determined.RESULTS: Administration of AFPR by gavage at 160 and 320 mg/kg significantly reduced the duration of immobility in the FST and TST, and did not affect locomotor activity in the OPT. In the reserpine-induced depression model, AFPR attenuated anhedonia, demonstrated by reversing hypothermia, akinesia and sucrose consumption. AFPR significantly increased the concentration of monoamines, including dopamine, serotonin, noradrenaline and acetylcholine.CONCLUSION: AFPR normalized the metabolism rates of noradrenaline, serotonin and dopamine,and the activity of MAO, which were altered by chronic reserpine exposure. The findings suggest that modulation of the monoaminergic neurotransmitter system likely underlies the antidepressant-like effect of AFPR.
文摘This paper demonstrates that the susceptible-infected-removed (SIR) model applied to the early phase of an epidemic can be used to determine epidemic parameters reliably. As a case study, the SIR model is applied to the fatality data of the 2009 fall wave cycle of the A(H1N1) pandemic in 12 European countries. It is observed that the best estimates of the basic reproduction number R0 and the mean duration of the infection period l/r/ lie on a curve in the scatterplots, indicating the existence of a nearly-invariant quantity which corresponds to the duration of the epidemic. Spline interpolation applied to the early phase of the epidemic, an approximately 10-week period, together with a future control point in the stabilization region, is sufficient to estimate model parameters. The SIR model is run over a wide range of parameters and estimates of R0 in the range 1.2- 2.0 match the values in the literature. The duration of the infection period, 1/η is estimated to be in the range 2.0-7.0 days. Longer infection periods are tied to spatial characteristics of the spread of the epidemic.
基金supported by the National Natural Science Foundation of China (10901169)National 111 Programme of Introducing Talents of Discipline to Universities (0507111106)+2 种基金Innovation Ability Training Foundation of Chongqing University (CDCX008)Innovative Group Program for Graduates of Chongqing University,ScienceInnovation Fund (200711C1A0010260)
文摘An integrated approach is proposed to predict the chromatographic retention time of oligonucleotides based on quantitative structure-retention relationships (QSRR) models. First, the primary base sequences of oligonucleotides are translated into vectors based on scores of generalized base properties (SGBP), involving physicochemical, quantum chemical, topological, spatial structural properties, etc.; thereafter, the sequence data are transformed into a uniform matrix by auto cross covariance (ACC). ACC accounts for the interactions between bases at a certain distance apart in an oligonucleotide sequence; hence, this method adequately takes the neighboring effect into account. Then, a genetic algorithm is used to select the variables related to chromatographic retention behavior of oligonuclcotides. Finally, a support vector machine is used to develop QSRR models to predict chromatographic retention behavior. The whole dataset is divided into pairs of training sets and test sets with different proportions; as a result, it has been found that the QSRR models using more than 26 training samples have an appropriate external power, and can accurately represent the relationship between the features of sequences and structures, and the retention times. The results indicate that the SGBP-ACC approach is a useful structural representation method in QSRR of oligonucleotides due to its many advantages such as plentiful structural information, easy manipulation and high characterization competence. Moreover, the method can further be applied to predict chromatographic retention behavior of oligonucleotides.
基金supported by the National Basic Research Program (973) of China (No.2007CB512100)the National High-Tech R & D Program (863) of China (No.2006AA02Z307)the National Natural Science Foundation of China (No.30570484)
文摘The aim of this study is to build two mathematical models of canine ionic currents specific to right atria and left atria.The canine left atria mathematical model was firstly modified from the Ramirez-Nattel-Courtemanche(RNC) model using the recently available experimental data of ionic currents and was further developed based on our own experimental data.A model of right atria was then built by considering the differences between right atria and left atria.The two developed models well reproduced the experimental data on action potential morphology,the rate dependence,and action potential duration restitution.They are useful for investigating the mechanisms underlying the het-erogeneity of canine regional action potentials and would help the simulation of whole heart excitation propagation and cardiac arrhythmia in the near future.