海绿石成因类型及其对沉积环境的指相分析

海绿石不仅可以作为地层对比的标志矿物,而且可以作为指相矿物反映沉积环境,它包含了丰富的地质信息。通过对海绿石形成条件及成因类型划分进行再认识,对其不同划分类型与沉积环境关系进行分析,认为对海绿石成因类型划分理论主要有两种:溶液胶体沉积理论和海绿石化作用理论。在这两种理论基础上提出的淀胶沉积及粘土矿物交代理论等,均反映了海绿石化学成因类型的本质,为以颗粒状、团粒状、碎屑胶结物、孔隙充填等多种产出形态的海绿石从成因上提供依据。基于成因分析,根据海绿石搬运与否、产出形态以及成熟度类型的综合分析,利用显微镜观测,扫描电镜、电子探针、X衍射分析、红外光谱分析、拉曼光谱等方法对海绿石类型进行辅助确定,认为原地自生海绿石能作为指相矿物,反映沉积环境,原地次生、异地自生及异地次生海绿石均无法作为沉积环境的直接指相证据,但仍可以反映沉积古水流及沉积环境能量信息,为综合确定沉积环境提供依据。

Correlation analysis between the HPLC fingerprints and in vitro antibacterial activity of ethyl acetate extracts from Radix isatidis

Aim To study the correlation between the HPLC fingerprints and in vitro antibacterial activities of EtOAc extracts of Radix isatidis from various sources. Methods Ten batches of Radix isatidis EtOAc extracts were analyzed with HPLC and the fingerprints were established. The influence of EtOAc extracts on the thermogenic curve of growth of Escherchia coli was obtained by microcalorimetry. The chemical differences of EtOAc extracts of Radix isatidis from various sources in the HPLC fingerprints were probed with hierarchical clustering analysis and similarity analysis. The correlation between the HPLC fingerprints and in vitro antibacterial activities was analyzed with multivafiant correlation analysis. Results Close correlation existed between the HPLC fingerprints and in vitro antibacterial activities of EtOAc extracts of Radix isatidis. Conlusion The combination of HPLC fingerprints and antibacterial activities can be used to discover principle components of Radix isatidis on bioactivity.

Diagnosis of uremia patients based on color space

Since traditional nail diagnosis is susceptible to objective factors such as illumination,medical experience,etc.,a nail diagnosis system of traditional Chinese medicine which combines objective nail image acquisition with information analysis is proposed and applied to the clinical research of nail diagnosis of uremia patients.Fifteen nail pictures of uremic patients were collected and segmented.The color information of nails was extracted.The relationship between the hemoglobin values of uremic patients and the values of color space before and after maintenance hemodialysis was analyzed by correlation analysis and multiple regression analysis.The experimental results show that the hemoglobin value of uremic patients have certain correlations with multiple color channels;before and after dialysis,there are significant changes in multiple channels;and the related multiple regression equation is established.

Nonlinear dynamics analysis of a new autonomous chaotic system

In this paper,a new nonlinear autonomous system introduced by Chlouverakis and Sprott is studied further,to present very rich and complex nonlinear dynamical behaviors. Some basic dynamical properties are studied either analytically or nu-merically,such as Poincaré map,Lyapunov exponents and Lyapunov dimension. Based on this flow,a new almost-Hamilton chaotic system with very high Lyapunov dimensions is constructed and investigated. Two new nonlinear autonomous systems can be changed into one another by adding or omitting some constant coefficients.

Identification of Volatile Compounds in Codfish(Gadus) by a Combination of Two Extraction Methods Coupled with GC-MS Analysis

Codfish is a kind of abyssal fish species with a great value in food industry. However, the flavor of codfish, especially the unpleasant odor, has caused serious problems in its processing. To accurately identify the volatile compounds in codfish, a combination of solid phase micro-extraction(SPME) method and simultaneous distillation extraction(SDE) method was used to extract the volatiles. Gas chromatography-mass spectrometry(GC-MS) along with Kovats indices(KI) and authentic standard compounds were used to identify the volatiles. The results showed that a total of 86 volatile compounds were identified in codfish, of them 24 were extracted by SDE, 69 compounds by SPME, and 10 compounds by both SDE and SPME. Seventy volatile compounds were found to have specific odors, of them 7 typical compounds contributed significantly to the flavor of codfish. Alcohols(i.e.,(E)-2-penten-1-ol and 2-octanol), esters(i.e., ethyl butyrate and methyl geranate), aldehydes(i.e., 2-dodecenal and pentadecanal) contributed the most to fresh flavor while nitrogen compounds, sulphur compounds, furans, as well as some ketones(i.e., 2-hydroxy-3-pentanone) brought unpleasant odor, such as fishy and earthy odor. It was indicated that the combination of multiple extraction methods and GC-MS analysis can enhance the accuracy of identification, and provide a reference for the further study on flavor of aquatic products.

Quantitative structure-activity relationship of 2-alkyl-4-(biphenylylmethoxy) pyridine derivatives with AT1 receptor antagonistic activity

The quantitative structure-activity relationship(QSAR) of 2-alkyl-4-(biphenylylmethoxy) pyridine derivatives was studied.Three different alignment methods were used to get the models of the comparative molecular field analysis(CoMFA),the comparative molecular similarity indices analysis(CoMSIA),and the hologram quantitative structure?activity relationship(HQSAR).The statistical results from the established models show believable predictivity based on the cross-validated value(q2>0.5) and the non-validated value(r2>0.9),The analysis on contour maps of CoMFA and CoMSIA models suggests that hydrophobic and hydrogen-bond acceptor fields are important factors that affect the AT1 antagonistic activity of 2-alkyl-4-(biphenylylmethoxy) pyridine derivatives besides the steric and electrostatic fields,The structural modification information from different atom contributions in the HQSAR model is in agreement with that in the 3D-QSAR models.

Direct Fingerprinting Polycyclic Aromatic Hydrocarbons in Heavy Oils by PY-GC/MS and Its Application to Hydrotreating Processes

An efficient analytical method combining pyrolysis and capillary GC/MS has been developed for determination and quantitation of targeted polycyclic aromatic hydrocarbons.The limit of detection ranged from 0.29 μg/g to 43.46 μg/g,and repeatability values were between 0.1% and 8.2% for blank spiked samples and between 0.1 % and 9.8% for real samples of heavy oils.Through application of the proposed method in hydrotreating processes,it has been found out that heavy oils before and after the specified hydroprocessing treatment exhibited a diverse PAHs distribution which might be determined by the discrepancy in their intrinsic contents and hydrogenation reactivity.Furthermore,the hydrogenation reactivity of different polycyclic aromatic hydrocarbons was further investigated and discovered to be more interrelated to molecular structure and rings alignment or conjugation mode.

3D-QSAR and action mechanism of potential dual inhibitors towards AP-1 and NF-κB

Three-dimensional quantitative structure-activity relationship （3D-QSAR） and docking studies of a series of novel dioxopyrrolinyl-amino-pyrimidine derivatives, which are potential dual inhibitors mediating a transcriptional activation towards protein-1 （AP-1） and nuclear factor kappa B （NF-κB）, have been carried out. The QS, AR models established by comparative molecular field analysis （CoMFA） and comparative molecular similarity index analysis （CoMSIA） show a good predictive ability with cross-validated coefficients q2 of 0.644 and 0.636, respectively. The docking result shows that there are quite lower average values of the flexible and rigid energy scores on the selected binding sites, meanwhile, it further shows that the binding sites just fall on the joint regions between AP-1 （and NF-κB） and DNA. The reason that these analogues have inhibition function towards AP-I and NF-κB is that their existence on these joint regions can effectively prevent free AP-I and NF-κB from binding to DNA. These results can offer a valuable theoretical reference to the pharmaceutical molecular design as well as the action mechanism analysis.

Chromatographic fingerprint analysis of Fructus Aurantii Immaturus by HPLC-DAD and chemometric methods

An efficient method for quality control of Fructus Aurantii Immaturus (FAI),a famous traditional Chinese medicine (TCM) was established. A simple and reliable high-performance liquid chromatography-photodiode array detector (HPLC-DAD) procedure coupled with chemometric methods was developed for fingerprint analysis,qualitative analysis and quantitative determination of this herb. In qualitative and quantitative analyses,heuristic evolving latent projection (HELP) method was employed to resolve the overlapping peaks of the tested samples. Two bioactive components,namely hesperidin and naringin,are confirmed and determined,together with four flavonoids compounds tentatively identified including two new ones. From fingerprint analysis,the fingerprint data were processed with correlation coefficients for quantitative expression of their similarity and dissimilarity. The developed method based on an integration of chromatographic fingerprint and quantitative analysis is scientific,and the obtained results can be applied to the quality control of herb medicine.

Variability and correlation analysis of physical and mechanical indexes of loess in western Liaoning

Based on the method of probability and statistics, the authors analyzed the physical and mechanical properties of loess in specified area, and discussed its main indexes, the coefficient of variation, and the corre- lation among the physical and mechanical indexes. Regression equations are built among those indexes, the re- suits show that the variability of mechanical indexes is higher than that of the physical indexes, and the physical indexes have better correlation than the relation between physical and mechanical indexes. The conclusions of this study would contribute to further research about loess in western Liaoning.

Projections of the 21st Century Changjiang-Huaihe River Basin Extreme Precipitation Events

Based on the 1961-1990 observed daily precipitation in the Changjiang-Huaihe River Basin, the NCEP/NCAR reanalysis data, and the HadCM3 model data for IPCC SRES A1B climate projections, the simulation capabilities of the BP-CCA downscaling approach for extreme precipitation indices of the current climate are assessed by applying canonical correlation analysis (CCA). In addition, future extreme precipitation indices in the middle and late 21st century are projected. The results show that simulation capability of the HadCM3 for regional climate characteristics can be effectively improved by the downscaling approach, with 30%-100% reduction of the relative errors of the climatological mean state of extreme precipitation indices. However, the downscaling results still show wetter winter and dryer summer than the observation. Under the SRES A1B emission scenario, frequency and intensity of extreme precipitation events are projected to increase, and the estimated increasing rate is higher for extreme precipitation indices than for mean precipitation index; and in summer than in winter. Extreme precipitations in the middle and late 21st century are expected to increase by 14% and 25% respectively in winter, and by 24% and 32% respectively in summer.

Characteristics of Spatial and Temporal Vegetation Index Variability and Its Responses to Temperature and Precipitation in Mongolia

The Mongolian Plateau,a vital ecological barrier in northern China,is of great importance for studying vegetation dynamics in Mongolia against the background of climate warming.Such studies can enhance our understanding of regional vegetation responses to global warming and contribute to the establishment of a stronger ecological barrier in northern China.Here,we analyzed the spatial and temporal characteristics of the NDVI(normalized difference vegetation index)in Mongolia using 8 km resolution GIMMS NDVI3g data from 1990 to 2022,along with temperature,precipitation,and elevation data.Trend analysis and correlation methods were used to examine the relationships between the NDVI and temperature,as well as precipitation.The results showed four important aspects of these relationships.(1)The NDVI in Mongolia increased significantly from 1990 to 2022 at a rate of 0.0015 yr^(-1)(P<0.05).(2)Mongolia’s NDVI increased from 1990 to 2022 in 60.73%of the country.Of this total,the area with a significant increase accounted for 31.67%and was concentrated on the eastern and western edges.The area experiencing a significant decrease accounted for 15.67%and was mainly located on the southwestern edges.(3)The NDVI analysis revealed significant increasing trends in all regions except for those at elevations of 1500-2000 m.The greatest rate of increase was observed between 500 and 1000 m,and the increasing trend weakened as elevation continued to increase before gradually becoming significant again.Additionally,the NDVI increased significantly across different slopes,and the rate of increase decreased as the slope increased.(4)From 1990 to 2022,Mongolia’s NDVI was mostly negatively correlated with temperature.This occurred over 66.75%of the total land area,with 17.21%of the region exhibiting a significant negative correlation,mainly in the southwest.Conversely,the NDVI demonstrated a positive correlation with precipitation,encompassing 86.71%of the total land area.Approximately 40.44%of the region had a significant positive correlation,primarily in the southwest.In conclusion,throughout the experimental period,the vegetation state in Mongolia improved.However,due to the warming and drying climate,more attention should be paid to vegetation degradation in the south-central region.

High-performance liquid chromatographic fingerprint analysis of Oxytropis falcata Bunge and Oxytropis chiliophylla Royle

A simple, sensible and reliable HPLC-DAD fingerprint analysis method for the raw materials of Oxytropisfalcata and Oxytropis chiliophylla, both of which were used as ＂Er-Da-Xia＂ in Tibetan medicines, was developed and then subsequently applied to analyze samples collected from different locations or times. 19 common fingerprint peaks for O. falcata, 24 for O. chiliophylla, and 11 for the two herbs were designated respectively, including 7 identified characteristic peaks existing in both herbs and 1 uniquely presenting in O. chiliophylla. Although there were some slight differences in the chemicals of O. falcata and O. chiliophylla, the main components of both herbs were consistent generally. The results provided scientific basis, at least from the chemical point of view, for the reasonablity of two herbs being used as the same drug in Tibetan medicines and for the necessary of further investigation on their detailed chemical and pharmacological differences.

CONFIDENCE INDEX AND ORAL PROFICIENCY

Many researchers confirm that confidence factor plays a significant role in oral English training. However, lack of reliable evaluation methods renders teachers impotent in measuring individual confidence variation. They can do little more than form a rough impression on the basis of students' test scores and their personality traits, which proves deceptive and misleading. This paper introduces the notion of confidence index as an evaluation criterion, and empirical investigation reveals the wide variation in individual confidence index. Finally this paper explores the correlation between confidence factor and proficiency.

3D-QSAR and docking studies on 2-arylbenzoxazole and linker-Y transthyretin amyloidogenesis inhibitors

Transthyretin(TTR),a plasma protein with a tetramer structure,could form amyloid fibril associated with several human diseases through the dissociation of tetramer and the misfolding of monomer.These amyloidogenesis can be inhibited by small molecules which bind to the central channel of TTR.A number of small molecules like 2-arylbenzoxazoles(ABZ)analogues are proposed as promising therapeutic strategy to treat amyloidosis.In this work,comparative molecular field analysis(CoMFA)and comparative molecular similarity indices analysis(CoMSIA)three-dimensional quantitative structure-activity relationship(3D-QSAR)and docking studies were performed on series of 2-arylbenzoxazoles(ABZ)and linker-Y analogues to investigate the inhibitory activities of TTR amyloidogenesis at atomic level.Significant correlation coefficients for ABZ series(CoMFA,r2=0.877,q2=0.431;CoMSIA,r2=0.836,q2=0.447)and those for linker-Y series(CoMFA,r2=0.828,q2=0.522;CoMSIA,r2=0.800,q2=0.493)were obtained,and the generated models were validated using test sets.In addition,docking studies on 6 compounds binding to TTR were performed to analyze the forward or reverse binding mode and interactions between molecules and TTR.These results from 3D-QSAR and docking studies have great significance for designing novel TTR amyloidogenesis inhibitors in the future.