5-Fluorouracil （5-FU） is the most frequently used chemotherapy agent concomitant with radiotherapy in the management of patients with rectal cancer. Capecitabine is an oral fluoropyrimidine that mimics the pharmacon...5-Fluorouracil （5-FU） is the most frequently used chemotherapy agent concomitant with radiotherapy in the management of patients with rectal cancer. Capecitabine is an oral fluoropyrimidine that mimics the pharmaconkinetics of infusional 5-FU. This new drug is replacing 5-FU as a part of the combined-modality treatment of a number of gastrointestinal cancers. While cardiac events associated with the use of 5-FU are a well known side effect, capecitabine-induced cardiotoxicity has been only rarely reported. Here, we reviewed the case of a patient with rectal cancer who had a capecitabine-induced coronary vasospasm. The most prominent mutation of the dihydropyrimidine dehydrogenase gene was also analyzed.展开更多
Coronary artery spasm （CAS） is found not only in Asian but also in white patients. CAS can lead to angina pecto- ris, myocardial infarction, ventricular arrhythmias and sud- den cardiac death. But CAS diagnosis is n...Coronary artery spasm （CAS） is found not only in Asian but also in white patients. CAS can lead to angina pecto- ris, myocardial infarction, ventricular arrhythmias and sud- den cardiac death. But CAS diagnosis is not necessarily easy, and it also remains highly challenging to therapy and prevention. We present a spontaneous extensive-CAS case with typical clinical features of acute myocardial infarction, despite the regular vasodilator treatment.展开更多
Objective： To observe the effect of combining Chinese medicine and tuina along the meridians on motor function and activities of daily living （ADL） in patient with post-stroke upper limb spasticity. Methods： A tot...Objective： To observe the effect of combining Chinese medicine and tuina along the meridians on motor function and activities of daily living （ADL） in patient with post-stroke upper limb spasticity. Methods： A total of 220 patients with post-stroke upper limb spasticity were randomly allocated into a treatment group （n=120） and a control group （n=110）. Patients in the treatment group received tuina along the meridians combined with spasticity-alleviating and collateral-unblocking Chinese medicine, whereas patients in the control group received routine rehabilitation therapy. Patients in both groups were treated for 3 weeks. Then the patients＇ motor function, ADL and muscle tone were evaluated before and after treatment using the FugI-Meyer assessment scale （FMA）, modified Barthel index （MBI） and modified Ashworth scale （MAS）. Results： After treatment, the FMA scores, MBI scores, and muscle （shoulder intortor, elbow flexors and wrist flexors） tones were significantly improved （P〈0.05）, but the improvement was more significant in the treatment group than that in the control group （P〈0.05）. Conclusion： Tuina along the meridians combined with spasticity-alleviating and collateral-unblocking Chinese medicine can substantially alleviate muscle tone on the affected side and remarkably improve the patients＇ motor function and ADL.展开更多
文摘5-Fluorouracil （5-FU） is the most frequently used chemotherapy agent concomitant with radiotherapy in the management of patients with rectal cancer. Capecitabine is an oral fluoropyrimidine that mimics the pharmaconkinetics of infusional 5-FU. This new drug is replacing 5-FU as a part of the combined-modality treatment of a number of gastrointestinal cancers. While cardiac events associated with the use of 5-FU are a well known side effect, capecitabine-induced cardiotoxicity has been only rarely reported. Here, we reviewed the case of a patient with rectal cancer who had a capecitabine-induced coronary vasospasm. The most prominent mutation of the dihydropyrimidine dehydrogenase gene was also analyzed.
文摘Coronary artery spasm （CAS） is found not only in Asian but also in white patients. CAS can lead to angina pecto- ris, myocardial infarction, ventricular arrhythmias and sud- den cardiac death. But CAS diagnosis is not necessarily easy, and it also remains highly challenging to therapy and prevention. We present a spontaneous extensive-CAS case with typical clinical features of acute myocardial infarction, despite the regular vasodilator treatment.
基金supported by Scientific Research Fund Project of Hebei Provincial Administration Bureau of Traditional Chinese Medicine~~
文摘Objective： To observe the effect of combining Chinese medicine and tuina along the meridians on motor function and activities of daily living （ADL） in patient with post-stroke upper limb spasticity. Methods： A total of 220 patients with post-stroke upper limb spasticity were randomly allocated into a treatment group （n=120） and a control group （n=110）. Patients in the treatment group received tuina along the meridians combined with spasticity-alleviating and collateral-unblocking Chinese medicine, whereas patients in the control group received routine rehabilitation therapy. Patients in both groups were treated for 3 weeks. Then the patients＇ motor function, ADL and muscle tone were evaluated before and after treatment using the FugI-Meyer assessment scale （FMA）, modified Barthel index （MBI） and modified Ashworth scale （MAS）. Results： After treatment, the FMA scores, MBI scores, and muscle （shoulder intortor, elbow flexors and wrist flexors） tones were significantly improved （P〈0.05）, but the improvement was more significant in the treatment group than that in the control group （P〈0.05）. Conclusion： Tuina along the meridians combined with spasticity-alleviating and collateral-unblocking Chinese medicine can substantially alleviate muscle tone on the affected side and remarkably improve the patients＇ motor function and ADL.
