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运用Poser软件制作橄榄球运动中颈部损伤动作模型 被引量:2
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作者 华宏 于亮 《中国运动医学杂志》 CAS CSCD 北大核心 2011年第5期470-472,共3页
橄榄球运动中球员之间身体接触频繁,尽管大多数球员身体条件出众,但因比赛时球员不使用任何护具,易引起各种运动损伤的发生[1]。这些损伤中,颈部损伤对球员的危害最大,不仅造成颈部及周围肌肉僵硬,关节活动度减小,影响训练和比赛的质... 橄榄球运动中球员之间身体接触频繁,尽管大多数球员身体条件出众,但因比赛时球员不使用任何护具,易引起各种运动损伤的发生[1]。这些损伤中,颈部损伤对球员的危害最大,不仅造成颈部及周围肌肉僵硬,关节活动度减小,影响训练和比赛的质量,颈椎骨折、脱位等严重损伤甚至危及生命。 展开更多
关键词 运动损伤 颈部损伤 损伤动作 软件制作 橄榄 模型 身体接触 关节活动度
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基于篮球技术动作造成的损伤因素分析
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作者 温武 《文体用品与科技》 2019年第9期217-218,共2页
(1)目的:探讨篮球技术动作损伤的风险因素及解决对策,为降低损伤发生率提供依据;(2)方法:采用自拟问卷调查表对篮球运动员一般资料进行统计,内容包括:患者年龄、性别、损伤部位、损伤原因等最终选定87分有效问卷,对相关因素进行单因素分... (1)目的:探讨篮球技术动作损伤的风险因素及解决对策,为降低损伤发生率提供依据;(2)方法:采用自拟问卷调查表对篮球运动员一般资料进行统计,内容包括:患者年龄、性别、损伤部位、损伤原因等最终选定87分有效问卷,对相关因素进行单因素分析,并根据危险因素提出针对性的解决对策;(3)结果:入选的87例篮球技术动作损伤中,损伤排在前三位的分别为:踝关节、膝关节、大腿,分别占:27.6%、20.7%和12.6%;篮球技术动作损伤的风险因素相对较多,排在前三位的分别为:准备活动不充分、动作粗野、技术动作错误等,分别占:28.7%、20.7%以及18.4%;(4)结论:篮球技术动作损伤的风险因素相对较多,应该加强易损伤部位练习,对运动员进行定期身体检查,在篮球技术动作上应遵循先易后难、由简单到复杂原则。 展开更多
关键词 篮球技术 动作损伤 风险因素 解决对策
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篮球运动员运动损伤的特点及预防 被引量:15
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作者 蒋桂凤 《南华大学学报(理工版)》 2003年第2期87-90,93,共5页
通过对我国部分省、市男子篮球队运动员运动损伤的调查分析 ,提出预防措施 ,以期减少运动损伤的发生 .
关键词 篮球运动员 运动损伤 年龄 训练年限 损伤场所 损伤动作 损伤部位 损伤原因 对抗性 预防措施
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Protective effect of ascorbic acid in experimental gastric cancer: reduction of oxidative stress 被引量:2
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作者 Claudia P.M.S.Oliveira Paulo Kassab +5 位作者 Fabio P.Lopasso Heraldo P.Souza Mariano Janiszewski Francisco R.M.Laurindo Kioshi Iriya Antonio A.Laudanna 《World Journal of Gastroenterology》 SCIE CAS CSCD 2003年第3期446-448,共3页
AIM;Oxidative stress participates in the cell carcinogenesis by inducing DNA mutations.Our aim was to assess whether ascorbic acid,an antioxidant,could have a role in preventing ROS(Reactive Oxygen Species)generation ... AIM;Oxidative stress participates in the cell carcinogenesis by inducing DNA mutations.Our aim was to assess whether ascorbic acid,an antioxidant,could have a role in preventing ROS(Reactive Oxygen Species)generation in experimental gastric carcinoma in a rat model. METHODS:Experimental gastric cancer was induced in twelve Wistar male rats(weighting 250-350 g)by profound duodeno-gastric reflux throught split gastrojenunostomy.The rats were allocated to the following groups:Group Ⅰ(n=6) was the control;Group Ⅱ(n=6)which was mantained with daily intake of tape water with Vitamin C(30 mg/Kg).After 6 or 12 months,samples of gastric tumor or non tumor mucosa were taken from the anastomosis of both groups. Oxidative stress was measured by superoxide quantification through lucigenin-amplified chemiluminescence base and by staining with Nitrobluetetrazolium.The histopathologic confirmation of adenocarcinoma was made by eosin- hemathoxilin method. RESULTS:The intestinal type of gastric adenocarcinoma was microscopically identified in all animals of group Ⅰ whereas only 3 rats of group Ⅱ showed an adenocarcinoma without macroscopic evidence of them.The cancers were located in the anastomosis in all cases.Basal luminescence from tumor gastric tissue generated 38.4±6.8 count per minute/mg/×10~6(mean±SD)and 14.9±4.0 count per minute/mg/×10~6,respectively,in group Ⅰ and Ⅱ animals(P <0.05).The Nitrobluetetrazolium method showed intense staining in tumor tissues but not in non neoplasic mucosa. CONCLUSION:Experimental gastric tumors seem to produce more reactive oxygen species than non neoplasic gastric tissue.The reduction of oxidative stress and gastric tumor incidence in rats were induced by the intake of ascorbic acid.Therefore,it may have a role in the prevention of gastric carcinoma. Oliveira CPMS Kassab P Lopasso FP Souza HP Janiszewski M Laurindo FRM Iriya K Laudanna AA.Protective effect of ascorbic acid in experimental gastric cancer:reduction of oxidative stress.World J Gastroenterol 2003;9(3):446-448 http://www.wjgnet.com/1007-9327/9/446.htm 展开更多
关键词 ANIMALS ANTIOXIDANTS Ascorbic Acid Male Oxidative Stress RATS Rats Wistar Stomach Neoplasms control
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Cell and gene therapy for arrhythmias: Repair of cardiac conduction damage 被引量:3
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作者 Yong-Fu Xiao 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2011年第3期147-158,共12页
Action potentials generated in the sinoatrial node (SAN) dominate the rhythm and rate of a healthy human heart. Subsequently, these action potentials propagate to the whole heart via its conduction system. Abnormali... Action potentials generated in the sinoatrial node (SAN) dominate the rhythm and rate of a healthy human heart. Subsequently, these action potentials propagate to the whole heart via its conduction system. Abnormalities of impulse generation and/or propagation in a heart can cause arrhythmias. For example, SAN dysfunction or conduction block of the atrioventricular node can lead to serious bradycardia which is currently treated with an implanted electronic pacemaker. On the other hand, conduction damage may cause reentrant tachyarrhythmias which are primarily treated pharmacologically or by medical device-based therapies, including defibrillation and tissue ablation. However, drug therapies sometimes may not be effective or are associated with serious side effects. Device-based therapies for cardiac arrhythmias, even with well developed technology, still face inadequacies, limitations, hardware complications, and other challenges. Therefore, scientists are actively seeking other alternatives for antiarrhythmic therapy. In particular, cells and genes used for repairing cardiac conduction damage/defect have been investigated in various studies both in vitro and in vivo. Despite the complexities of the excitation and conduction systems of the heart, cell and gene-based strategies provide novel alternatives for treatment or cure of cardiac arrhythmias. This review summarizes some highlights of recent research progress in this field. 展开更多
关键词 cell therapy gene therapy conduction repair ARRHYTHMIA
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EXPRESSION OF TISSUE-TYPE PLASMINOGENACTIVATOR IN SMOOTH MUSCLE CELLS OF INJUREDILIAC ARTERIES IN RABBITS
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作者 马晓莉 黄文英 +2 位作者 佘铭鹏 李晓惠 笪冀平 《Chinese Medical Sciences Journal》 CAS CSCD 1996年第2期84-88,共5页
In this experiment, expression of tissue-type plasminogen activator (t-PA) in smooth muscle cells (SMCs) was measured at different intervals after the arterial injury. In the normal iliac arteries, only low levels of ... In this experiment, expression of tissue-type plasminogen activator (t-PA) in smooth muscle cells (SMCs) was measured at different intervals after the arterial injury. In the normal iliac arteries, only low levels of t-PA activity were estimated. t-PA activity in extracts of the iliac arteries increased significantlyat the 4th day after the injury, equivalent to the process that SMCs migrated from the media to the intima,and the t-PA activity was then decreased approximately to the normal level at the 7th day. Coexistent to the above data, results from in situ hybridization showed that the expression of t-PA mRNA in the intima as well as media increased also significantly at the 4th day after the arterial injury, and at the 7th day, tPA mRNA was detected only in those SMCs locating closely adjacent to the internal elastic lamina. These results suggest that t-PA might play an important role in SMC migration following endothelial injury, andantagonism of t-PA expression and/or activity within the vessel wall might be helpful in intervening the de velopment of restenosis following angioplasty. 展开更多
关键词 tissue-type plasminogen activator smooth muscle cell PROLIFERATION
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PROTECTIVE EFFECTS OF MELATONIN ON CULTURED RAT CARDIOMYOCYTES DAMAGED BY H_2O_2
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作者 李源 郑延松 +1 位作者 龚卫琴 王晓明 《Chinese Medical Sciences Journal》 CAS CSCD 2003年第4期260-264,共5页
Objective.To investigate the protective effects of melatonin(MT )on cardiomyocytes against the ox-idative injury induced by H 2 O 2 .Methods.Ventricular myocytes were isolated from neonatal rats and cultured for3~5da... Objective.To investigate the protective effects of melatonin(MT )on cardiomyocytes against the ox-idative injury induced by H 2 O 2 .Methods.Ventricular myocytes were isolated from neonatal rats and cultured for3~5days.Cells were divided into4groups:control group,H 2 O 2 (100μmol/L H 2 O 2 )group,MT group(100μmol/L MT )and MT preconditioning group(100μmol/L MT+100μmol/L H 2 O 2 ).The fluorescent probe,DCFH?DA,was used to detect intracellular levels of reactive oxygen species(ROS)and another fluorescent probe,Fluo-3?AM,was used to detect[Ca 2+ ] i by using a laser scanning confocal microscopy(LSCM).The malondi-aldehyde(MDA)content in cardiomyocytes was determined by measuring thiobarbituric acid?reactive sub-stances to monitor lipid peroxidation.The activity of cytoplasmic enzyme lactate dehydrogenase(LDH)that was released into the culture media was assayed to indicate alternation in the integrity of the cellular membrane.Trypan blue exclusion was used to detect the cell viability.Results.Compared with the control group,intracellular ROS,[Ca 2+ ] i ,MDA content ,LDH leakage and cell death were significantly elevated when cells were treated by100μmol/L H 2 O 2 for60minutes(P<0.01).However,those changes were significantly attenuated in MT preconditioning group.Conclusion.MT has very good antioxidant effect and can protect the cardiomyocytes against H 2 O 2 -in-duced injury. 展开更多
关键词 MELATONIN CARDIOMYOCYTE oxidative injury
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An Application of Damage Detection Methods to A Real World Structure Subjected to Ground Motion Excitation
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作者 Francesco Cavalieri Maura Imbimbo Raimondo Betti 《Journal of Civil Engineering and Architecture》 2012年第3期280-299,共20页
This paper aims at investigating the efficacy of different state-of-art damage detection methods when applied to real worm structures subjected to ground motion excitations, for which the literature contributions are,... This paper aims at investigating the efficacy of different state-of-art damage detection methods when applied to real worm structures subjected to ground motion excitations, for which the literature contributions are, at present, still not fully comprehensive. To this purpose the paper analyses two test structures: (1) a four-story scaled steel frame tested on a shake table in a controlled laboratory conditions, and (2) a seven-story reinforced concrete building monitored during the seismic excitations of the 1999 Chi-Chi (Taiwan) Earthquake main shock and numerous fore and afiershocks. Some model based damage approaches and statistics based damage indexes are reviewed. The different methodologies and indexes are, then, applied to the two test structures with the final aim of analysing their performance and validity within the case of a laboratory scaled model and a real world structure subjected to input ground motion. 展开更多
关键词 Identification DAMAGE model STATISTICAL data-driven.
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Effects of nerve growth factor on neuronal nitric oxide production after spinal cord injury in rats 被引量:8
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作者 汤长华 曹晓建 王道新 《Chinese Journal of Traumatology》 CAS 2002年第3期165-168,共4页
Objective: To explore the protective effects of nerve growth factor (NGF) on injured spinal cord. Methods: The spinal cord injury (SCI) model of Wistar rats was established by a 10 g× 2.5 cm impact force on the T... Objective: To explore the protective effects of nerve growth factor (NGF) on injured spinal cord. Methods: The spinal cord injury (SCI) model of Wistar rats was established by a 10 g× 2.5 cm impact force on the T 8 spinal cord. NGF (60 μg/20 μl) was given to the rats of the treatment group immediately and at 2, 4, 8, 12, 24 hours after SCI. The level of neuronal constitutive nitric oxide synthase (ncNOS) and the expression of ncNOS mRNA in the spinal cord were detected by the immunohistochemistry assay and in situ hybridization method. Results: Abnormal expression of ncNOS was detected in the spinal ventral horn motorneuron in injured rats. The levels of ncNOS protein in the NGF group were significantly lower than those in the normal saline group (P< 0.05 ). The ncNOS mRNA expression was found in the spinal ventral horn motorneuron in injured rats and the expression in the NGF group was significantly decreased compared with that in the normal saline group (P< 0.01 ). Conclusions: NGF can protect the injured tissue of the spinal cord by prohibiting abnormal expression of nitric oxide synthase and the neurotoxicity of nitric oxide. 展开更多
关键词 Spinal cord injuries Nerve growth factor Nitric oxide IMMUNOHISTOCHEMISTRY In situ hybridization
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Effects of magnesium sulfate on traumatic brain edema in rats 被引量:2
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作者 冯东福 朱志安 卢亦成 《Chinese Journal of Traumatology》 CAS 2004年第3期148-152,共5页
Objective: To investigate the effects of magnesium sulfate on traumatic brain edema and explore its possible mechanism. Methods: Forty-eight Sprague-Dawley (SD) rats were randomly divided into three groups: Control, T... Objective: To investigate the effects of magnesium sulfate on traumatic brain edema and explore its possible mechanism. Methods: Forty-eight Sprague-Dawley (SD) rats were randomly divided into three groups: Control, Trauma and Treatment groups. In Treatment group, magnesium sulfate was intraperitoneally administered immediately after the induction of brain trauma. At 24 h after trauma, total tissue water content and Na +, K +, Ca 2+, Mg 2+ contents were measured. Permeability of blood-brain barrier (BBB) was assessed quantitatively by Evans Blue (EB) dye technique. The pathological changes were also studied. Results: Water, Na +, Ca 2+ and EB contents in Treatment group were significantly lower than those in Trauma group (P< 0.05). Results of light microscopy and electron microscopy confirmed that magnesium sulfate can attenuate traumatic brain injury and relieve BBB injury. Conclusions: Treatment with MgSO 4 in the early stage can attenuate traumatic brain edema and prevent BBB injury. 展开更多
关键词 Brain injuries Brain edema Magnesium sulfate
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Therapeutic effect of nimodipine on experimental brain injury
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作者 杨树源 王增光 《Chinese Journal of Traumatology》 CAS 2003年第6期326-331,共6页
Objective: To study the therapeutic effect of nimodipine on experimental brain injury. Methods: Experimental and control rabbits were subjected to a closed head injury. In one group nimodipine was given intravenously ... Objective: To study the therapeutic effect of nimodipine on experimental brain injury. Methods: Experimental and control rabbits were subjected to a closed head injury. In one group nimodipine was given intravenously and the effect evaluated by electron microscopy, brain water content, calcium levels, transcranial Doppler, and intracranial pressure monitoring. Results: In rabbits treated with nimodipine the level of neuronal cytosolic free calcium was markedly decreased. There were less cellular damage and less spasm of the middle cerebral artery seen on electron microscopy. No difference regarding intracranial pressure changes between the two groups was noted. Conclusions: Nimodipine has a protective action on brain injury by blocking a series of pathological reactions induced by neuronal calcium overload, and by reducing the spasm of brain vessels and improving cerebral blood flow. 展开更多
关键词 Brain injuries Models animal CALCIUM NIMODIPINE
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Effect of methylprednisolone on reperfusion injury in severe uncontrolled hemorrhagic shock
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作者 夏芳 曹经山 +3 位作者 詹丽英 夏中元 夏正远 黄海波 《Chinese Journal of Traumatology》 CAS 2003年第6期359-362,共4页
Objective: To study the effect of methylprednisolone (MP) on reperfusion injury in severe uncontrolled hemorrhagic shock and explore the possible mechanism involved. Methods: Twelve dogs were randomly divided into two... Objective: To study the effect of methylprednisolone (MP) on reperfusion injury in severe uncontrolled hemorrhagic shock and explore the possible mechanism involved. Methods: Twelve dogs were randomly divided into two groups, control group (Group I, n=6) and MP group (Group II, n=6). The animals were bled continuously from a femoral artery catheter to produce uncontrolled hemorrhagic shock models. Resuscitation with lactated Ringer’s (LR) solution was initiated when mean arterial pressure (MAP) decreased to 20 mm Hg, and MAP was maintained at 30-40 mm Hg. MP (4 mg/kg) was injected intravenously in Group II when resuscitation began. While in Group I, normal saline (NS) was injected instead. The levels of superoxide dismutase (SOD) and malondialdehyde (MDA) were measured before exsanguination (T 1), when MAP decreased to 20 mm Hg (T 2), 60 min (T 3) and 120 min (T 4) after resuscitation. Heart rate, MAP and cardiac output (CO) levels were recorded concomitantly. Results: Infusion volume and hemorrhage volume shed from the superior mesenteric artery in Group I were higher than those in Group II (P< 0.01 and P< 0.05). After reperfusion, blood SOD levels decreased progressively and MDA levels increased rapidly in Group I. In Group II, blood SOD levels at T 3 and T 4 decreased as compared with that at T 1 but a stepwise increase was present. At T 4, blood SOD level was significantly higher in Group II than in Group I (P< 0.01). At T 3 and T 4, MDA levels were markedly lower in Group II than in Group I. During reperfusion, MAP was more steady in Group II than in Group I and survival rate after 120 min (at T 4) was higher in Group II than in Group I (P< 0.05). Conclusions: MP has a protective effect on severe uncontrolled hemorrhagic shock and subsequent reperfusion injury. The mechanism mainly involves the anti-lipid peroxidation activity of MP. 展开更多
关键词 METHYLPREDNISOLONE Reperfusion injury Lipid peroxidation Shock hemorrhagic
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Neuroprotective effect of sodium ferulate on transient focal cerebral ischemia by weakening activation of postsynaptic density-95 in rats 被引量:2
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作者 王强 陈绍洋 +2 位作者 熊利泽 金卫林 杨静 《Chinese Journal of Traumatology》 CAS 2005年第5期297-302,共6页
Objective: To investigate the effects of sodium ferulate (SF), an intravenous drug made from traditional Chinese herbs, on activation of postsynaptic density-95 (PSD-95) and neuroprotection after transient cerebr... Objective: To investigate the effects of sodium ferulate (SF), an intravenous drug made from traditional Chinese herbs, on activation of postsynaptic density-95 (PSD-95) and neuroprotection after transient cerebral artery occlusion in rats. Methods: Forty-six male Sprague-Dawley rats were randomized into 2 groups ( n = 23 in each group) : the control group and the SF group. After anesthesia, the middle cerebral artery occlusion (MCAO) was conducted with the intraluminal filament technique. The neurological deficit was assessed with the method devised by Bederson et al.^ 8 The 2, 3, 4-triphenyltetrazolium chloride staining was used to assess the infarct volume. We adopted a modified six-point scale to conduct neurobehavioral evaluation. Immediately the activation of postsynaptic density-95 ( PSD- 95 ) was studied with Western blot analysis system in the cortex and striatum of rat brain. Results : The neurologic deficit score of the SF group decreased substantially compared with that of the control group ( P 〈0.05). The infarct volume of the control group (168.1 mm^3 ± 42.2 mm^3) was significantly larger than that of the SF group (61.5 mm^3 ± 28.7 mm^3 ) at 24 hours after reperfusion (P 〈 0.01 ). And the rats showed some neurological deficit. The activity of PSD-95 in the SF group at most timepoints was less than that in the control group. No upregulation of PSD-95 protein could be detected in the contralateral cortex. Conclusions : Sodium ferulate can induce a neuroproteetive effect against the transient focal cerebral isehemie injury and weaken the activation of PSD-95 in isehemie area after MCAO. 展开更多
关键词 Brain ischemia RATS Sodium ferulate Postsynaptic density-95 PSD-95
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