Nowadays, resistance to rituximab has become a major issue in clinical practice. And loss of CD20 may contribute to it. Here we presented a case of loss of CD20 expression in relapsed diffuse large B cell lymphoma tre...Nowadays, resistance to rituximab has become a major issue in clinical practice. And loss of CD20 may contribute to it. Here we presented a case of loss of CD20 expression in relapsed diffuse large B cell lymphoma treated with rituximab and discuss the incidence, mechanism, influence factors, specific markers, prognosis and treatment of this disease. These results suggested that a post-relapse biopsy after rituximab treatment shguld be performed. CD79a and Pax-5 should be used as the first-line B lineage-specific markers for these patients. Though mechanisms of CD20 decrement are not fully elucidated, the down-regulation of CD20 mRNA is the most probable hypothesis. Recently various new agents are developed, but the prognosis is still poor. Further studies for new treatments are needed.展开更多
Purpose： The purpose of this review was to critically analyse the cun;ent evidence investigating the effect of an athlete＇s hydration status on physical performance. Methods： A literature search of multiple databas...Purpose： The purpose of this review was to critically analyse the cun;ent evidence investigating the effect of an athlete＇s hydration status on physical performance. Methods： A literature search of multiple databases was used to identify studies that met the inclusion criteria for this review. The included studies were then critically appraised using the Downs and Black protocol. Results： Nine articles were found to meet the inclusion criteria, with an average score of 79% for methodological quality representative of a ＂high＂ standard of research. Conclusion： The evidence suggests that dehydration has a negative impact on physical performance for activities lasting more than 30 s in duration. However dehydration was found to have no significant impact on physical performance for activities lasting less than 15 s in duration.展开更多
文摘Nowadays, resistance to rituximab has become a major issue in clinical practice. And loss of CD20 may contribute to it. Here we presented a case of loss of CD20 expression in relapsed diffuse large B cell lymphoma treated with rituximab and discuss the incidence, mechanism, influence factors, specific markers, prognosis and treatment of this disease. These results suggested that a post-relapse biopsy after rituximab treatment shguld be performed. CD79a and Pax-5 should be used as the first-line B lineage-specific markers for these patients. Though mechanisms of CD20 decrement are not fully elucidated, the down-regulation of CD20 mRNA is the most probable hypothesis. Recently various new agents are developed, but the prognosis is still poor. Further studies for new treatments are needed.
文摘Purpose： The purpose of this review was to critically analyse the cun;ent evidence investigating the effect of an athlete＇s hydration status on physical performance. Methods： A literature search of multiple databases was used to identify studies that met the inclusion criteria for this review. The included studies were then critically appraised using the Downs and Black protocol. Results： Nine articles were found to meet the inclusion criteria, with an average score of 79% for methodological quality representative of a ＂high＂ standard of research. Conclusion： The evidence suggests that dehydration has a negative impact on physical performance for activities lasting more than 30 s in duration. However dehydration was found to have no significant impact on physical performance for activities lasting less than 15 s in duration.
