This article presents a new method to calculate the composition differences (e) for tar g.etin.g the minimum total annualized cost (TAC) of a mass exchange network (MEN),which is based on the combination of comp...This article presents a new method to calculate the composition differences (e) for tar g.etin.g the minimum total annualized cost (TAC) of a mass exchange network (MEN),which is based on the combination of composition interval diagram (CID) with mathematical programming.The total cost target consists of the capital cost of the process units and the operating cost for mass separating agents (MS.As). The value of total cost varies considerablv with the composition differences, so the values of e should be optimized in order to obtain minimum TAC of a MEN. This articleconsiders ε as a set of unequal variables for each equilibrium equation of a rich-lean stream pair, employing them to build the CID and mathematical model, which optimizes the structure and composition differences simultaneously. Two examples are applied to illustrate the proposed method and the results demonstrate that the approach introduced by this article is simpler and more convenient than the methods in previous literatures.展开更多
A sequential three-step programming method is proposed for determining the minimum flowrate of fresh water and corresponding regenerated water in water-using system of single contaminant with regeneration reuse. In st...A sequential three-step programming method is proposed for determining the minimum flowrate of fresh water and corresponding regenerated water in water-using system of single contaminant with regeneration reuse. In step 1, a programming with the objective of min fws is used to determine the minimum flowrate of fresh water, in which the mathematical representation is a mixed integer nonlinear programming (MINLP1). Then under the same constraints with step 1, a programming with the objective of min freg in step 2 and a programming with the objective of min Cr in step 3 are subsequently used to determine the minimum flowrate of regenerated water and the minimum inlet concentration to regeneration process corresponding to the minimum flowrate of fresh water based on step 1. The method is easy to apply because we only need to change the objective function but keep the constraints constant to go along the following steps after step 1. In addition, the relationship between the fresh water flowrate required, fws and inlet concentration to regeneration process, Cr, is investigated. It is found that there exist three relationships between fws and Cr, which indicate three possibilities for C\>: below the pinch, above the pinch or at the pinch. Therefore, a new conclusion is drawn, which differs from that 'regeneration of water at pinch minimizes fresh water flowrate' derived in literature and indicates that in some cases, regeneration at other point also minimizes fresh water flowrate.展开更多
This paper presents a superstructure-based formulation for the synthesis of mass-exchange networks (MENs) considering multiple components. The superstructure is simplified by directly using the mass separation agents ...This paper presents a superstructure-based formulation for the synthesis of mass-exchange networks (MENs) considering multiple components. The superstructure is simplified by directly using the mass separation agents (MSA) from their sources, and therefore the automatic synthesis of the multi-component system involved in the MENs can be achieved without choosing a 'key-component' either for the whole process or the mass exchangers. A mathematical model is proposed to carry out the optimization process. The concentrations, flow rates, matches and unit operation displayed in the obtained network constitute the exact representation of the mass exchange process in terms of all species in the system. An example is used to illustrate and demonstrate the application of the proposed method.展开更多
State space approach is an effective method to mass-exchange network (MEN) synthesis. By decomposing the network into two interactive parts, a distribution network and a process operator, the synthesis problem can be ...State space approach is an effective method to mass-exchange network (MEN) synthesis. By decomposing the network into two interactive parts, a distribution network and a process operator, the synthesis problem can be formulated into a mixed integer nonlinear programming (MINLP) model. In this article, a generalized state space model based on typical MEN is established and verified in two cases. A new asymmetrical operator and cost index are also adopted to speed up the solution process. The results demonstrate the efficiency of the proposed approach.展开更多
The retromer is a protein complex that mediates retrograde transport of transmembrane cargoes from endosomes to the trans-Golgi network (TGN). It is comprised of a cargo-selection subcomplex of Vps26, Vps29 and Vps3...The retromer is a protein complex that mediates retrograde transport of transmembrane cargoes from endosomes to the trans-Golgi network (TGN). It is comprised of a cargo-selection subcomplex of Vps26, Vps29 and Vps35 and a membrane-binding coat subcomplex of sorting nexins (SNXs). Previous studies identified SNX1/2 as one of the components of the SNX subcomplex, and SNX5/6 as candidates for the second SNX. How the retromer-associated cargoes are recognized and transported by molecular motors are largely unknown. In this study, we found that one of SNX1/2's dimerization partners, SNX6, interacts with the p150Gued subunit of the dynein/dynactin motor complex. We present evidence that SNX6 is a component of the retromer, and that recruitment of the motor complex to the membrane-associated retromer requires the SNX6-pl50Gued interaction. Disruption of the SNX6-pl50Glued interaction causes failure in formation and detachment of the tubulovesicular sorting structures from endosomes and results in block of CI-MPR retrieval from endosomes to the TGN. These observations indicate that in addition to SNX1/2, SNX6 in association with the dynein/dynactin complex drives the formation and movement of tubular retrograde intermediates.展开更多
Integrating multiple systems into one has become an important trend in Process Systems Engineering research field since there is strong demand from the modern industries. In this study, a stage-wise superstructurebase...Integrating multiple systems into one has become an important trend in Process Systems Engineering research field since there is strong demand from the modern industries. In this study, a stage-wise superstructurebased method is proposed to synthesize a combined mass and heat exchange network(CM&HEN) which has two parts as the mass exchange network(MEN) and heat exchange network(HEN) involved. To express the possible heat exchange requirements resulted from mass exchange operations, a so called "indistinct HEN superstructure(IHS)", which can contain the all potential matches between streams, is constructed at first. Then, a non-linear programming(NLP) mathematical model is established for the simultaneous synthesis and optimization of networks. Therein, the interaction between mass exchange and heat exchange is modeling formulated.The NLP model has later been examined using an example from literature, and the effectiveness of the proposed method has been demonstrated with the results.展开更多
Hybrid optical switching networks make full use of the advantages of Optical Circuit Switching(OCS)and Optical Burst Switching(OBS).In parallel hybrid optical switching networks,edge nodes choose a switching mode for ...Hybrid optical switching networks make full use of the advantages of Optical Circuit Switching(OCS)and Optical Burst Switching(OBS).In parallel hybrid optical switching networks,edge nodes choose a switching mode for traffic and no longer change.The inflexible decision making of the traffic transfer mode leads to low resource utilization when the arrival rate of the OCS traffic is lower than the capacity of the light path.In this paper,a new transmission scheme is proposed to improve resource utilization for hybrid optical switching networks.When the traffic arrival rate of the light path is lower than the transmission rate of the light path,the OCS traffic flow is reshaped at the edge nodes to generate a series of voids.Then,several message packets are sent along the light path to inform the core nodes of the voids of the light paths that represent the unused bandwidth resources.To improve the resource utilization,the voids can be filled with data bursts by core nodes.The simulation results show that the new scheme can effectively reduce the burst loss rate and improve the link utilization of the hybrid optical switching network on the premise of a providing service quality guarantee for OCS traffic.展开更多
文摘This article presents a new method to calculate the composition differences (e) for tar g.etin.g the minimum total annualized cost (TAC) of a mass exchange network (MEN),which is based on the combination of composition interval diagram (CID) with mathematical programming.The total cost target consists of the capital cost of the process units and the operating cost for mass separating agents (MS.As). The value of total cost varies considerablv with the composition differences, so the values of e should be optimized in order to obtain minimum TAC of a MEN. This articleconsiders ε as a set of unequal variables for each equilibrium equation of a rich-lean stream pair, employing them to build the CID and mathematical model, which optimizes the structure and composition differences simultaneously. Two examples are applied to illustrate the proposed method and the results demonstrate that the approach introduced by this article is simpler and more convenient than the methods in previous literatures.
基金Supported by the National Fundamental Research Development Program of China(No.2000026308).
文摘A sequential three-step programming method is proposed for determining the minimum flowrate of fresh water and corresponding regenerated water in water-using system of single contaminant with regeneration reuse. In step 1, a programming with the objective of min fws is used to determine the minimum flowrate of fresh water, in which the mathematical representation is a mixed integer nonlinear programming (MINLP1). Then under the same constraints with step 1, a programming with the objective of min freg in step 2 and a programming with the objective of min Cr in step 3 are subsequently used to determine the minimum flowrate of regenerated water and the minimum inlet concentration to regeneration process corresponding to the minimum flowrate of fresh water based on step 1. The method is easy to apply because we only need to change the objective function but keep the constraints constant to go along the following steps after step 1. In addition, the relationship between the fresh water flowrate required, fws and inlet concentration to regeneration process, Cr, is investigated. It is found that there exist three relationships between fws and Cr, which indicate three possibilities for C\>: below the pinch, above the pinch or at the pinch. Therefore, a new conclusion is drawn, which differs from that 'regeneration of water at pinch minimizes fresh water flowrate' derived in literature and indicates that in some cases, regeneration at other point also minimizes fresh water flowrate.
基金Supported by the National Natural Science Foundation of China (20976022)
文摘This paper presents a superstructure-based formulation for the synthesis of mass-exchange networks (MENs) considering multiple components. The superstructure is simplified by directly using the mass separation agents (MSA) from their sources, and therefore the automatic synthesis of the multi-component system involved in the MENs can be achieved without choosing a 'key-component' either for the whole process or the mass exchangers. A mathematical model is proposed to carry out the optimization process. The concentrations, flow rates, matches and unit operation displayed in the obtained network constitute the exact representation of the mass exchange process in terms of all species in the system. An example is used to illustrate and demonstrate the application of the proposed method.
基金Supported by the National Natural Science Foundation of China (NSF 29836140).
文摘State space approach is an effective method to mass-exchange network (MEN) synthesis. By decomposing the network into two interactive parts, a distribution network and a process operator, the synthesis problem can be formulated into a mixed integer nonlinear programming (MINLP) model. In this article, a generalized state space model based on typical MEN is established and verified in two cases. A new asymmetrical operator and cost index are also adopted to speed up the solution process. The results demonstrate the efficiency of the proposed approach.
基金We thank Yingfang Liu (Institute of Biophysics, Chinese Acad- emy of Sciences) for advice on PX domain structure and SNX6 mutations. We are particularly grateful to Yanmin Yang (Stanford University, USA) for insightful discussions and the Flag-MAP1B LC construct. We also thank Juan S Bonifacino (NIH, USA) for the rabbit anti-CI-MPR antibody, Hiroyoshi Ariga (Hokkaido University, Japan) for Flag- and HA-tagged human SNX6 overexpression constructs, and Li Yu (Tsinghua University, China) for the YFP-EEA1 expression construct. We thank Chonglin Yang (Institute of Genetics and Developmental Biology, Chinese Academy of Sciences), Dahua Chen (Institute of Zoology, Chinese Academy of Sciences) and Li Yu for critical reading of the manuscript. This work was supported by grants from the National Natural Science Foundation of China (30770675) and Chinese Academy of Sciences (KSCX1-YW-R-37). J-J Liu is supported by the CAS 100-Tal- ents Program.
文摘The retromer is a protein complex that mediates retrograde transport of transmembrane cargoes from endosomes to the trans-Golgi network (TGN). It is comprised of a cargo-selection subcomplex of Vps26, Vps29 and Vps35 and a membrane-binding coat subcomplex of sorting nexins (SNXs). Previous studies identified SNX1/2 as one of the components of the SNX subcomplex, and SNX5/6 as candidates for the second SNX. How the retromer-associated cargoes are recognized and transported by molecular motors are largely unknown. In this study, we found that one of SNX1/2's dimerization partners, SNX6, interacts with the p150Gued subunit of the dynein/dynactin motor complex. We present evidence that SNX6 is a component of the retromer, and that recruitment of the motor complex to the membrane-associated retromer requires the SNX6-pl50Gued interaction. Disruption of the SNX6-pl50Glued interaction causes failure in formation and detachment of the tubulovesicular sorting structures from endosomes and results in block of CI-MPR retrieval from endosomes to the TGN. These observations indicate that in addition to SNX1/2, SNX6 in association with the dynein/dynactin complex drives the formation and movement of tubular retrograde intermediates.
基金Supported by the Fundamental Research Funds for the Central Universities of China(DUT14RC(3)046)China Postdoctoral Science Foundation(2014M551091)the National Natural Science Foundation of China(21406026)
文摘Integrating multiple systems into one has become an important trend in Process Systems Engineering research field since there is strong demand from the modern industries. In this study, a stage-wise superstructurebased method is proposed to synthesize a combined mass and heat exchange network(CM&HEN) which has two parts as the mass exchange network(MEN) and heat exchange network(HEN) involved. To express the possible heat exchange requirements resulted from mass exchange operations, a so called "indistinct HEN superstructure(IHS)", which can contain the all potential matches between streams, is constructed at first. Then, a non-linear programming(NLP) mathematical model is established for the simultaneous synthesis and optimization of networks. Therein, the interaction between mass exchange and heat exchange is modeling formulated.The NLP model has later been examined using an example from literature, and the effectiveness of the proposed method has been demonstrated with the results.
基金supported by the National Basic Research Program of China(973 Program)under Grant No.2012CB315800the National Natural Science Foundation of China under Grants No.61275077,No.61071117,No.61171158,No.61102131+1 种基金the Natural Science Foundation Project of CQ,CSTC under GrantsNo.2009BB2285,No.2008BB2414,No.2010BB2413,No.2010BB2409,No.2010BB2413the Projects of the Education Council of Chongqing under Grants No.KJ080513,No.KJ080522,No.KJ110519,No.KJ110527
文摘Hybrid optical switching networks make full use of the advantages of Optical Circuit Switching(OCS)and Optical Burst Switching(OBS).In parallel hybrid optical switching networks,edge nodes choose a switching mode for traffic and no longer change.The inflexible decision making of the traffic transfer mode leads to low resource utilization when the arrival rate of the OCS traffic is lower than the capacity of the light path.In this paper,a new transmission scheme is proposed to improve resource utilization for hybrid optical switching networks.When the traffic arrival rate of the light path is lower than the transmission rate of the light path,the OCS traffic flow is reshaped at the edge nodes to generate a series of voids.Then,several message packets are sent along the light path to inform the core nodes of the voids of the light paths that represent the unused bandwidth resources.To improve the resource utilization,the voids can be filled with data bursts by core nodes.The simulation results show that the new scheme can effectively reduce the burst loss rate and improve the link utilization of the hybrid optical switching network on the premise of a providing service quality guarantee for OCS traffic.