OBJECTIVE:To investigate the dynamic changes of urinary nephrin,and the relationship between it and urinary albumin excretion rate(UAER) in a diabetic rat model,as well the effects of yiqiyangyinhuayutongluo recipe.ME...OBJECTIVE:To investigate the dynamic changes of urinary nephrin,and the relationship between it and urinary albumin excretion rate(UAER) in a diabetic rat model,as well the effects of yiqiyangyinhuayutongluo recipe.METHODS:Diabetic model was induced by high fat diet combined with low-dose Streptozotocin(STZ) in rats.Normal group(NG),model group(MG),and yiqiyangyinhuayutongluo recipe treated group(YHTG) were set.Gastrointestinal Yiqiyangyinhuayutongluo recipe was administered once daily for 32 w.At the end of the 2nd w(2w),8w,16w,and 32w,fasting blood glucose(FBG),UAER and 24h urinary nephrin(U-nephrin) were detected.RESULTS:Compared with NG,FBG in MG increased notably(P<0.05).Compared with MG,FBG of YHTG reduced slowly,and the difference was significant(P<0.05) since 16w.U-nephrin and UAER in MG increased significantly from 2w,peaked at 16w,lessened in different degree at 32w,but were still higher than NG.The correlation analysis showed that there was a significant positive correlation between U-nephrin and UAER at different time,the correlation coefficient as r>0.9,and P<0.05.Compared with MG,U-nephrin and UAER in YHTG decreased markedly(P<0.05) except for U-nephrin at 8w.CONCLUSIONS:U-nephrin and UAER in diabetic rat model have a positive linear correlation.Yiqiyangyinhuayutongluo recipe can reduce UAER markedly,and preventing the lose of nephrin in urine maybe one of the mechanisms.展开更多
Scale pig production is an effective approach to improve farmers＇ income. Many pig feeding villages and intensive pig farms has presented rapidly in Center China in recent years, the focus of large quantity of manure...Scale pig production is an effective approach to improve farmers＇ income. Many pig feeding villages and intensive pig farms has presented rapidly in Center China in recent years, the focus of large quantity of manure and sewage discharged by pig farms has become the leading source of pollution in vast rural areas. How to dissolve the contravention between the development of scale pig production and the serious pollution caused by swine excreta in rural area is a complex systematic problem. An approach named Systems Dynamic Digraph Analysis Approach is presented in this paper. And the approach is applied to analyze the scale pig breeding system in small hill watershed area systematically. A case of Pingxiang Taihua pig farm in the west region of Jinggang Mountain, which is a typical intensive pig farm in small hill watershed area in Center China, was studied, after the systematical analyses with its system dynamic digraph, three common management policies are presented at the end of the paper.展开更多
基金Supported by the Natural Science Foundation of Hebei (No.C2008001074)
文摘OBJECTIVE:To investigate the dynamic changes of urinary nephrin,and the relationship between it and urinary albumin excretion rate(UAER) in a diabetic rat model,as well the effects of yiqiyangyinhuayutongluo recipe.METHODS:Diabetic model was induced by high fat diet combined with low-dose Streptozotocin(STZ) in rats.Normal group(NG),model group(MG),and yiqiyangyinhuayutongluo recipe treated group(YHTG) were set.Gastrointestinal Yiqiyangyinhuayutongluo recipe was administered once daily for 32 w.At the end of the 2nd w(2w),8w,16w,and 32w,fasting blood glucose(FBG),UAER and 24h urinary nephrin(U-nephrin) were detected.RESULTS:Compared with NG,FBG in MG increased notably(P<0.05).Compared with MG,FBG of YHTG reduced slowly,and the difference was significant(P<0.05) since 16w.U-nephrin and UAER in MG increased significantly from 2w,peaked at 16w,lessened in different degree at 32w,but were still higher than NG.The correlation analysis showed that there was a significant positive correlation between U-nephrin and UAER at different time,the correlation coefficient as r>0.9,and P<0.05.Compared with MG,U-nephrin and UAER in YHTG decreased markedly(P<0.05) except for U-nephrin at 8w.CONCLUSIONS:U-nephrin and UAER in diabetic rat model have a positive linear correlation.Yiqiyangyinhuayutongluo recipe can reduce UAER markedly,and preventing the lose of nephrin in urine maybe one of the mechanisms.
基金The research is supported by National Natural Science Foundation of China（70361002）.
文摘Scale pig production is an effective approach to improve farmers＇ income. Many pig feeding villages and intensive pig farms has presented rapidly in Center China in recent years, the focus of large quantity of manure and sewage discharged by pig farms has become the leading source of pollution in vast rural areas. How to dissolve the contravention between the development of scale pig production and the serious pollution caused by swine excreta in rural area is a complex systematic problem. An approach named Systems Dynamic Digraph Analysis Approach is presented in this paper. And the approach is applied to analyze the scale pig breeding system in small hill watershed area systematically. A case of Pingxiang Taihua pig farm in the west region of Jinggang Mountain, which is a typical intensive pig farm in small hill watershed area in Center China, was studied, after the systematical analyses with its system dynamic digraph, three common management policies are presented at the end of the paper.
