Lot scheduling problem with idle time transfer between processes to minimize mean flow time is very important because to minimize mean flow time is to minimize work in process. But the problem is NP hard and no polyn...Lot scheduling problem with idle time transfer between processes to minimize mean flow time is very important because to minimize mean flow time is to minimize work in process. But the problem is NP hard and no polynomial algorithm exists to guarantee optimal solution. Based the analysis the mathematical structure of the problem, the paper presents a new heuristic algorithm. Computer simulation shows that the proposed heuristic algorithm performs well in terms of both quality of solution and execution speed.展开更多
The water and sediment discharge regulation （WSDR） project, which has been performed since 2002 before flood season every year, is of great significance to the river management in China. Until 2007, six experiments ...The water and sediment discharge regulation （WSDR） project, which has been performed since 2002 before flood season every year, is of great significance to the river management in China. Until 2007, six experiments have been fulfilled to evaluate the effect of the project on the natural environment. To fill the gap of investigations, a study on flood and suspended sediment transportation and channel changing along the distributary channel of the Huanghe （Yellow） River was conducted during the WSDR project period in 2007. The lower channel was scoured rapidly and the channel became unobstructed gradually several days after the flood peak water was discharged from the Xiaolangdi Reservoir. Within four days after the flood peak at 3 000 m3/s entered the distributary, the channel in the river mouth area was eroded quickly. Both the mean values of area and depth of the main channel were tripled, and the maximum flood carrying capacity increased to 5 500 m3/s or more. Then, the river channel was silted anew in a very short time after completion of the WSDR. Favored by the WSDR project, the fiver status in April 2008 became better than that of the year before. The adjustment ranges of main channel parameters were about 30%, 10%, and 10% at sections C2, Q4, and Q7, respectively. The process of rapid erosion-deposition was more active 15 km away in the channel from the fiver mouth due to the marine influence. It is reasonable for discharging sediment at concentration peak from Xiaolangdi Reservoir at the end of the flood peak. As a result, the sediment peak reached the river mouth about two days later than that of the water current. In addition, the WSDR project has improved the development of the estuarine wetland. Wetland vegetation planted along the river banks restrained the water flow as a strainer and improved the main channel stability. It is suggested to draw water at mean rate of 150 m3/s from the Huanghe River during flood periods, because at the rate the water in the wetland would be stored and replenished in balance. Moreover, we believe that cropland on the river shoal of the lower Huanghe River should be replaced by wetland. These activities should achieve the Huanghe River management strategy of ＂To concentrate flow to scour sediment, stabilize the main channel, and regulate water and sediment＂.展开更多
To determine the onset and duration of contraflow evacuation, a multi-objective optimization(MOO) model is proposed to explicitly consider both the total system evacuation time and the operation cost. A solution algor...To determine the onset and duration of contraflow evacuation, a multi-objective optimization(MOO) model is proposed to explicitly consider both the total system evacuation time and the operation cost. A solution algorithm that enhances the popular evolutionary algorithm NSGA-II is proposed to solve the model. The algorithm incorporates preliminary results as prior information and includes a meta-model as an alternative to evaluation by simulation. Numerical analysis of a case study suggests that the proposed formulation and solution algorithm are valid, and the enhanced NSGA-II outperforms the original algorithm in both convergence to the true Pareto-optimal set and solution diversity.展开更多
Objective: In this paper we compared the two methods of cell sorting (magnetic cell sorting and flow cytometry sorting) for the isolation and function analysis of mouse CD4+ CD25+ regulatory T (Treg) cells, in order t...Objective: In this paper we compared the two methods of cell sorting (magnetic cell sorting and flow cytometry sorting) for the isolation and function analysis of mouse CD4+ CD25+ regulatory T (Treg) cells, in order to inform further studies in Treg cell function. Methods: We separately used magnetic cell sorting and flow cytometry sorting to identify CD4+ CD25+ Treg cells. After magnetic cell separation, we further used flow cytometry to analyze the purity of CD4+ CD25+ Treg cells, trypan blue staining to detect cell viability, and propidium iodide (PI) staining to assess the cell viability. We detected the immune inhibition of CD4+ CD25+ Treg cells in the in vitro proliferation experiments. Results: The results showed that compared to flow cytometry sorting, magnetic cell sorting took more time and effort, but fewer live cells were obtained than with flow cytometry sorting. The CD4+ CD25+ Treg cells, however, obtained with both methods have similar immunosuppressive capacities. Conclusion: The result suggests that both methods can be used in isolating CD4+ CD25+ Treg cells, and one can select the best method according to specific needs and availability of the methodologies.展开更多
By using Schwarz alternating method, this paper presents asimplified alternating algorithm for the problems of two holes having arbitrary shapes and arrangements in an isotropic homogeneous linear elastic infinite reg...By using Schwarz alternating method, this paper presents asimplified alternating algorithm for the problems of two holes having arbitrary shapes and arrangements in an isotropic homogeneous linear elastic infinite region, and obtains stress and displacement fields for random times of iteration. After precision analysis it is found that the results for twenty times of iteration are of very high precision, and those with higher precision can be acquired if the iteration solving is further conducted. The comparison of the results from FEM further proves the reliability of the simplified alternating algorithm presented by this paper.展开更多
With the level of short-circuit current of power systems growing increasingly higher,optimal allocation of current limiters has received considerable attention in recent years,especially in China.This paper analyzes t...With the level of short-circuit current of power systems growing increasingly higher,optimal allocation of current limiters has received considerable attention in recent years,especially in China.This paper analyzes two kinds of common used current limiters based on the increment of bus impedance matrix and proposes a multi-objective current limiters configuration model considering the investment of limiters,the level of short-circuit current,as well as the transient stability of power system.An innovative search space reduction technique based on sensitivity factor is introduced to choose better candidate locations for current limiters so as to avoid the curse of dimensionality.The elitist non-dominated sorting genetic algorithm II is used to search the Pareto-optimal solutions of the proposed model.In order to further improve optimization efficiency,master-slave parallel modification of NSGA-II program structure is implemented.The satisfactory case study results demonstrate the feasibility of the proposed multi-objective method in power system current limiters allocation associated with cost,security and stability.展开更多
As the running speed of high-speed trains increases, aerodynamic drag becomes the key factor which limits the further increase of the running speed and energy consumption. Aerodynamic lift of the trailing car also bec...As the running speed of high-speed trains increases, aerodynamic drag becomes the key factor which limits the further increase of the running speed and energy consumption. Aerodynamic lift of the trailing car also becomes the key force which affects the amenity and safety of the train. In the present paper, a simplified CRH380A high-speed train with three carriages is chosen as the model in order to optimize aerodynamic drag of the total train and aerodynamic lift of the trailing car. A constrained mul- ti-objective optimization design of the aerodynamic head shape of high-speed trains based on adaptive non-dominated sorting genetic algorithm is also developed combining local function three-dimensional parametric approach and central Latin hypercube sampling method with maximin criteria based on the iterative local search algorithm. The results show that local function parametric approach can be well applied to optimal design of complex three-dimensional aerodynamic shape, and the adaptive non-dominated sorting genetic algorithm can be more accurate and efficient to find the Pareto front. After optimization the aerodynamic drag of the simplified train with three carriages is reduced by 3.2%, and the lift coefficient of the trailing car by 8.24%, the volume of the streamlined head by 2.16%; the aerodynamic drag of the real prototype CRH380A is reduced by 2.26%, lift coefficient of the trailing car by 19.67%. The variation of aerodynamic performance between the simplified train and the true train is mainly concentrated in the deformation region of the nose cone and tail cone. The optimization approach proposed in the present paper is simple yet efficient, and sheds lights on the constrained multi-objective engineering optimization design of aerodynamic shape of high-speed trains.展开更多
文摘Lot scheduling problem with idle time transfer between processes to minimize mean flow time is very important because to minimize mean flow time is to minimize work in process. But the problem is NP hard and no polynomial algorithm exists to guarantee optimal solution. Based the analysis the mathematical structure of the problem, the paper presents a new heuristic algorithm. Computer simulation shows that the proposed heuristic algorithm performs well in terms of both quality of solution and execution speed.
基金Supported by National Key Basic Research Program of China (No. 2005CB422304)National Natural Science Foundation of China (No.40872167)
文摘The water and sediment discharge regulation （WSDR） project, which has been performed since 2002 before flood season every year, is of great significance to the river management in China. Until 2007, six experiments have been fulfilled to evaluate the effect of the project on the natural environment. To fill the gap of investigations, a study on flood and suspended sediment transportation and channel changing along the distributary channel of the Huanghe （Yellow） River was conducted during the WSDR project period in 2007. The lower channel was scoured rapidly and the channel became unobstructed gradually several days after the flood peak water was discharged from the Xiaolangdi Reservoir. Within four days after the flood peak at 3 000 m3/s entered the distributary, the channel in the river mouth area was eroded quickly. Both the mean values of area and depth of the main channel were tripled, and the maximum flood carrying capacity increased to 5 500 m3/s or more. Then, the river channel was silted anew in a very short time after completion of the WSDR. Favored by the WSDR project, the fiver status in April 2008 became better than that of the year before. The adjustment ranges of main channel parameters were about 30%, 10%, and 10% at sections C2, Q4, and Q7, respectively. The process of rapid erosion-deposition was more active 15 km away in the channel from the fiver mouth due to the marine influence. It is reasonable for discharging sediment at concentration peak from Xiaolangdi Reservoir at the end of the flood peak. As a result, the sediment peak reached the river mouth about two days later than that of the water current. In addition, the WSDR project has improved the development of the estuarine wetland. Wetland vegetation planted along the river banks restrained the water flow as a strainer and improved the main channel stability. It is suggested to draw water at mean rate of 150 m3/s from the Huanghe River during flood periods, because at the rate the water in the wetland would be stored and replenished in balance. Moreover, we believe that cropland on the river shoal of the lower Huanghe River should be replaced by wetland. These activities should achieve the Huanghe River management strategy of ＂To concentrate flow to scour sediment, stabilize the main channel, and regulate water and sediment＂.
基金Project(ADLT 930-809R)supported by the Alabama Department of Transportation,USA
文摘To determine the onset and duration of contraflow evacuation, a multi-objective optimization(MOO) model is proposed to explicitly consider both the total system evacuation time and the operation cost. A solution algorithm that enhances the popular evolutionary algorithm NSGA-II is proposed to solve the model. The algorithm incorporates preliminary results as prior information and includes a meta-model as an alternative to evaluation by simulation. Numerical analysis of a case study suggests that the proposed formulation and solution algorithm are valid, and the enhanced NSGA-II outperforms the original algorithm in both convergence to the true Pareto-optimal set and solution diversity.
基金Project supported by the National Natural Science Foundation of China (Nos. 30872578 and 30753761)the Natural Science Founda-tion of Shanxi Province (No. SJ08C201)+1 种基金the Science and Technology Key Projects Foundation of Shanxi Province (No. 2008K13-04)the Science and Technology Plan Projects Foundation of Xi’an (No. SF08006-2), China
文摘Objective: In this paper we compared the two methods of cell sorting (magnetic cell sorting and flow cytometry sorting) for the isolation and function analysis of mouse CD4+ CD25+ regulatory T (Treg) cells, in order to inform further studies in Treg cell function. Methods: We separately used magnetic cell sorting and flow cytometry sorting to identify CD4+ CD25+ Treg cells. After magnetic cell separation, we further used flow cytometry to analyze the purity of CD4+ CD25+ Treg cells, trypan blue staining to detect cell viability, and propidium iodide (PI) staining to assess the cell viability. We detected the immune inhibition of CD4+ CD25+ Treg cells in the in vitro proliferation experiments. Results: The results showed that compared to flow cytometry sorting, magnetic cell sorting took more time and effort, but fewer live cells were obtained than with flow cytometry sorting. The CD4+ CD25+ Treg cells, however, obtained with both methods have similar immunosuppressive capacities. Conclusion: The result suggests that both methods can be used in isolating CD4+ CD25+ Treg cells, and one can select the best method according to specific needs and availability of the methodologies.
基金the National Natural Science Foundation of China (Grant No. 49772166).
文摘By using Schwarz alternating method, this paper presents asimplified alternating algorithm for the problems of two holes having arbitrary shapes and arrangements in an isotropic homogeneous linear elastic infinite region, and obtains stress and displacement fields for random times of iteration. After precision analysis it is found that the results for twenty times of iteration are of very high precision, and those with higher precision can be acquired if the iteration solving is further conducted. The comparison of the results from FEM further proves the reliability of the simplified alternating algorithm presented by this paper.
文摘With the level of short-circuit current of power systems growing increasingly higher,optimal allocation of current limiters has received considerable attention in recent years,especially in China.This paper analyzes two kinds of common used current limiters based on the increment of bus impedance matrix and proposes a multi-objective current limiters configuration model considering the investment of limiters,the level of short-circuit current,as well as the transient stability of power system.An innovative search space reduction technique based on sensitivity factor is introduced to choose better candidate locations for current limiters so as to avoid the curse of dimensionality.The elitist non-dominated sorting genetic algorithm II is used to search the Pareto-optimal solutions of the proposed model.In order to further improve optimization efficiency,master-slave parallel modification of NSGA-II program structure is implemented.The satisfactory case study results demonstrate the feasibility of the proposed multi-objective method in power system current limiters allocation associated with cost,security and stability.
基金supported by the Major State Basic Research Development Program of China ("973" Program) (Grant No. 2011CB711100) National Key Technology R&D Program (Grant No. 2009BAQG12A03)
文摘As the running speed of high-speed trains increases, aerodynamic drag becomes the key factor which limits the further increase of the running speed and energy consumption. Aerodynamic lift of the trailing car also becomes the key force which affects the amenity and safety of the train. In the present paper, a simplified CRH380A high-speed train with three carriages is chosen as the model in order to optimize aerodynamic drag of the total train and aerodynamic lift of the trailing car. A constrained mul- ti-objective optimization design of the aerodynamic head shape of high-speed trains based on adaptive non-dominated sorting genetic algorithm is also developed combining local function three-dimensional parametric approach and central Latin hypercube sampling method with maximin criteria based on the iterative local search algorithm. The results show that local function parametric approach can be well applied to optimal design of complex three-dimensional aerodynamic shape, and the adaptive non-dominated sorting genetic algorithm can be more accurate and efficient to find the Pareto front. After optimization the aerodynamic drag of the simplified train with three carriages is reduced by 3.2%, and the lift coefficient of the trailing car by 8.24%, the volume of the streamlined head by 2.16%; the aerodynamic drag of the real prototype CRH380A is reduced by 2.26%, lift coefficient of the trailing car by 19.67%. The variation of aerodynamic performance between the simplified train and the true train is mainly concentrated in the deformation region of the nose cone and tail cone. The optimization approach proposed in the present paper is simple yet efficient, and sheds lights on the constrained multi-objective engineering optimization design of aerodynamic shape of high-speed trains.
