Let A={A_1, A_2,…, A_(n+1)} be a simplex in E^n which its center O of circumscribed sphere is in inside of A. If R and R_i are radiuses of A_i respectively (A_i={A_1, A_2,…, A_(i-1), O, A_(i+1),…,A_(n+1)} ,i=1,2,…...Let A={A_1, A_2,…, A_(n+1)} be a simplex in E^n which its center O of circumscribed sphere is in inside of A. If R and R_i are radiuses of A_i respectively (A_i={A_1, A_2,…, A_(i-1), O, A_(i+1),…,A_(n+1)} ,i=1,2,…,n+1),then we have The equality holds if and only if A is a regular simplex.展开更多
Chronic diseases have become a focal point of public health worldwide with estimates of trillions of dollars in annual health care cost and causing more than 36 million deaths a year. Lifestyle factors such as physica...Chronic diseases have become a focal point of public health worldwide with estimates of trillions of dollars in annual health care cost and causing more than 36 million deaths a year. Lifestyle factors such as physical inactivity are heavily correlated with the development of many chronic diseases. New strategies for primary and secondary disease prevention are desperately needed to aid in blunting the negative economic and social impact of these diseases. Physical activity (PA) and exercise are now considered principal interventions for use in primary and secondary prevention of chronic diseases. Currently, more emphasis in primary prevention of disease is necessary to reduce disease risk in youth and adults; however with chronic disease prevalence so high, similar emphasis is also necessary for secondary prevention in those children and adults already inflicted with chronic diseases. Conditions such as cardiovascular disease, type 2 diabetes, obesity, and cancer are drastically improved when PA and exercise are part of a medical management plan. In addition, the national PA guidelines in conjunction with PA promotion tools like Exercise is MedicineTM are needed to promote increased PA and exercise levels worldwide.展开更多
To extend the service life of the clinched joint,a reconditioning process conducted with an additional tubular rivet was proposed in this work.Different reconditioning forces were employed to produce dissimilar recond...To extend the service life of the clinched joint,a reconditioning process conducted with an additional tubular rivet was proposed in this work.Different reconditioning forces were employed to produce dissimilar reconditioned joints by experimental method.The experimental results indicated that the neck fracture was the common failure mode of both original clinched and reconditioned joints.Compared with the original clinched joint,the shearing strength of the reconditioned joint produced by a reconditioning force of 40 kN increased from 1810.5 to 1986.47 N,and the energy absorption increased from 2.34 to 3.46 J.The range of effective reconditioning force was from 35 to 40 kN and 40 kN was the best choice for reconditioning the AA5052 failed joints.The mechanical properties of the reconditioned joints are obviously better than those of the original clinched joints,which fully demonstrates that the reconditioning method proposed in this work has a broad prospect of industrial application.展开更多
Objective:To assess the effect of angiotensin II type 1(AT1)receptor antagonist losartan on myocardium con- nexin43(Cx43)gap junction(GJ)expression in spontaneously hypertensive rats(SHRs)and investigate possible mech...Objective:To assess the effect of angiotensin II type 1(AT1)receptor antagonist losartan on myocardium con- nexin43(Cx43)gap junction(GJ)expression in spontaneously hypertensive rats(SHRs)and investigate possible mechanisms. Methods:Sixteen 9-week-old male SHRs and 8 age-matched male Wistar-Kyoto(WKY)rats were included in this study.SHRs were randomly divided into two groups to receive losartan at 30 mg/(kg·d)by oral gavage once daily for 8 weeks(SHR-L)or vehicle(0.9%saline)to act as controls(SHR-V);WKY rats receiving vehicle for 8 weeks served as normotensive controls.At the end of the experiment,rats were sacrificed and the hearts were removed.Expressions of Cx43 and nuclear factor-kappaB p65 (NF-κB p65)proteins in all three groups were observed and further investigations on the effect of angiotensin II type 1 receptor antagonist losartan(30 mg/(kg·d),8 weeks)on Cx43 expression were conducted with Western blot and immunohistochemistry. NF-κB p65 protein in nuclear extracts was determined by Western blot.Results:Left ventricular(LV)hypertrophy was prominent in SHRs,Cx43 and NF-κB p65 protein expressions were obviously upregulated and Cx43 distribution was dispersed over the cell surface.Treatment with losarton reduced the over-expressions of Cx43 and NF-κB p65 in LV myocardium.The distribution of Cx43 gap junction also became much regular and confined to intercalated disk after losartan treatment.Conclu- sion:Cx43 level was upregulated in LV myocardium of SHR during early stage of hypertrophy.Angiotensin II type 1 receptor antagonist losartan prevented Cx43 gap junction remodeling in hypertrophied left ventricles,possibly through the NF-κB pathway.展开更多
In order to reveal the constant-fatigue fracture form and mechanism of the welded cross plate-hollow sphere joints(WCPHSJs)and establish its formula,the WCPHSJs were fatigue tested.A total of 19 specimens were tested ...In order to reveal the constant-fatigue fracture form and mechanism of the welded cross plate-hollow sphere joints(WCPHSJs)and establish its formula,the WCPHSJs were fatigue tested.A total of 19 specimens were tested under constant amplitude fatigue loads using a specially designed test rig.The joint was analyzed statically by t e finite element analysis(F3A),and metallographic analysis of fatigue fracture was done by the electron scanning microscope.Numerical simulation and experimental results show that the hot-spot of WCPHSJ lies at the weld toe location where severe stress is concentrated.Fatigue cracks initiate at the weld toe and then propagate circumferentially around the sphere with a diameter equivalent to the width of the cross plate up to the fatigue facture.The initial welding defects and constructional detail constitute the main factor of fatigue failure.The S-N curves for the joints were developed through a linear regession analysis of fatigue data.A formula for calculating constant amplitude fatigue,base on the concept of the hot spot stress amplitude,is proposed.展开更多
ObjectiveToinvestigate whether depression, anxiety and stress increase the risk for delirium and poor quality of life (QOL) after co-ronary artery bypass (CABG) surgery.MethodsA total of 180 CABG patients (mean a...ObjectiveToinvestigate whether depression, anxiety and stress increase the risk for delirium and poor quality of life (QOL) after co-ronary artery bypass (CABG) surgery.MethodsA total of 180 CABG patients (mean age of 63.5 ± 10.1 years, 82.2% males) completed baseline and postoperative self-report questionnaires to assess distress and QOL. Incident delirium was diagnosed postoperatively with a structured clinical interview and patients were monitored every day post-operatively for confusion and disturbance in consciousness.Results Delirium developed in 63 persons (35% of sample). After adjustment for covariates, delirium was significantly associated with depression [odds ratio (OR): 1.08; 95% confidence interval (CI): 1.03-1.13,P = 0.003], anxiety (OR: 1.07; 95% CI: 1.02-1.13,P= 0.01) and stress (OR: 1.05; 95% CI: 1.00-1.09,P= 0.03). Preoperative depression scores were associated with poorer QOL including bodily pain (β =-0.39,P = 0.013), vitality (β=-0.32,P = 0.020), social functioning (β=-0.51,P≤0.001), emotional role function (β=-0.44,P = 0.003) and general health (β=-0.33,P = 0.038). Among the covariates, harmful levels of alcohol use was consistently associated with poorer QOL.Conclusions Depression and harmful levels of alcohol use were consistently associated with poorer QOL whereas depression, anxiety and stress were associated with delirium risk. These findings point to further research examining depression and harmful levels of alcohol use in coronary heart disease populations undergoing coronary revascularization.展开更多
Some large-conductance Ca^2+ and voltage-activated K^+(BK) channels are activated by membrane stretch. However, the mechanism of mechano-gating of the BK channels is still not well understood. Previous studies hav...Some large-conductance Ca^2+ and voltage-activated K^+(BK) channels are activated by membrane stretch. However, the mechanism of mechano-gating of the BK channels is still not well understood. Previous studies have led to the proposal that the linker-gating ring complex functions as a passive spring, transducing the force generated by intracellular Ca^2+ to the gate to open the channel. This raises the question as to whether membrane stretch is also transmitted to the gate of mechanosensitive (MS) BK channels via the linker-gating complex. To study this, we changed the linker length in the stretch-activated BK channel (SAKCaC), and examined the effect of membrane stretch on the gating of the resultant mutant channels. Shortening the linker increased, whereas extending the linker reduced, the channel mechanosensitivity both in the presence and in the absence of intracellular Ca^2+. However, the voltage and Ca^2+ sensitivities were not significantly altered by membrane stretch. Furthermore, the SAKCaC became less sensitive to membrane stretch at relatively high intracellular Ca^2+ concentrations or membrane depolarization. These observations suggest that once the channel is in the open-state conformation, tension on the spring is partially released and membrane stretch is less effective. Our results are consistent with the idea that membrane stretch is transferred to the gate via the linker-gating ring complex of the MS BK channels.展开更多
The hollow spherical joints welded with circular pipes applied to the National Swimming Center of China are subjected to large bending moments, but the influence of bending moments is not considered in the design equa...The hollow spherical joints welded with circular pipes applied to the National Swimming Center of China are subjected to large bending moments, but the influence of bending moments is not considered in the design equations in Technical Specification for Latticed Shells. Based on the von Mises yield criterion, multilinear isotropic hardening rule and associated flow rule, the elasto-plastic finite element model is put forward to analyze the behavior of the joints, and a calculation method for the joints under bending moments or eccentric loads is proposed. It is shown by the analytical results of joint that the stiffening rib can improve the ultimate bearing capacity by 10% for joints under axial tensile load, by 40% for joints under axial compressive load, and by 50% for joints under bending moment. The unified calculation equations for joints with or without stiffening rib are put forward, which can be applied to calculating the ultimate bearing capacity of the hollow spherical joints with circular pipes under eccentric loads.展开更多
Objectives: To explore possible mechanisms of connexin40 (Cx40) remodeling by detecting Cx40 mRNA expression of the crista terminalis and left atrium (LA) in patients with rheumatic heart disease (RHD) associat...Objectives: To explore possible mechanisms of connexin40 (Cx40) remodeling by detecting Cx40 mRNA expression of the crista terminalis and left atrium (LA) in patients with rheumatic heart disease (RHD) associated chronic atrial fibrillation (AF). Methods: Twenty patients were enrolled in this study, who underwent surgical operation for RHD-associated mitral disease, including l0 with sinus rhythms (rhythm group) and l0 with AF (AF group). Another 6 patients with non-RHD sinus rhythms were divided into the control group. A small amount of myocardial tissue was cut from the crista terminalis and the LA posterior wall during the valvular replacement operation. Cx40 mRNA expression was assayed by real-time fluorescent quantitation polymerase chain reaction (RT-PCR). Results: There was no significant difference in Cx40 mRNA expression in the crista terminalis and LA posterior wall between the 3 groups, and there was no significant difference in Cx40 mRNA expression between the crista terminalis and LA within each group. Conclusion: Based on the finding in previous studies that there existed evident remodeling of atrial Cx40 protein in patients with chronic RHD, the results of the present study suggest that the mechanism of Cx40 remodeling probably lies in the post transcriptional level.展开更多
An experimental study was undertaken to express the hardening Swift law according to friction stir welding (FSW) aluminum alloy 2017. Tensile tests of welded joints were run in accordance with face centered composit...An experimental study was undertaken to express the hardening Swift law according to friction stir welding (FSW) aluminum alloy 2017. Tensile tests of welded joints were run in accordance with face centered composite design. Two types of identified models based on least square method and response surface method were used to assess the contribution of FSW independent factors on the hardening parameters. These models were introduced into finite-element code "Abaqus" to simulate tensile tests of welded joints. The relative average deviation criterion, between the experimental data and the numerical simulations of tension-elongation of tensile tests, shows good agreement between the experimental results and the predicted hardening models. These results can be used to perform multi-criteria optimization for carrying out specific welds or conducting numerical simulation of plastic deformation of forming process of FSW parts such as hydroforming, bending and forging.展开更多
Recent interest in mobile-based heahhcare has driven significant demands on researching non-contact electrodes for electrocardiogram (ECG) measurement. While the conductive gel achieves the requirement in making a g...Recent interest in mobile-based heahhcare has driven significant demands on researching non-contact electrodes for electrocardiogram (ECG) measurement. While the conductive gel achieves the requirement in making a good contact between the electrodes and skin, several problems appear. A gel-free, non-contact electrode based on capacitive coupling theory was provided in this paper, which was integrated on the print circuit board (PCB). The experimental results showed that clear ECG signals could be acquired in the laboratory conditions by coupling the electrodes to the chest of patients through cotton belts.展开更多
In many circumstances,dissimilar metals have to be bonded together and the resulting joint interfaces must typically sustain mechanical and/or electrical forces without failure,which is not possible by fusion welding ...In many circumstances,dissimilar metals have to be bonded together and the resulting joint interfaces must typically sustain mechanical and/or electrical forces without failure,which is not possible by fusion welding processes.The melting points of magnesium(Mg)and copper(Cu)have a significant difference(nearly 400℃)and this may lead to a large difference in the microstructure and joint performance of Mg-Cu joints.However,diffusion bonding can be used to join these alloys without much difficulty.This work analyses the effect of parameters on diffusion layer thickness,hardness and strength of magnesium-copper dissimilar joints.The experiments were conducted using three-factor,five-level,central composite rotatable design matrix.Empirical relationships were developed to predict diffusion layer thickness,hardness and strength using response surface methodology.It is found that bonding temperature has predominant effect on bond characteristics.Joints fabricated at a bonding temperature of 450℃, bonding pressure of 12 MPa and bonding time of 30 min exhibited maximum shear strength and bonding strength of 66 and 81 MPa, respectively.展开更多
In this paper stresses at joints forming by hollow steel tube and concrete filled steel tube (CFST) are calculated, analyzed and compared. It is founded that the stress concentration at joints of CFST is a quite dif...In this paper stresses at joints forming by hollow steel tube and concrete filled steel tube (CFST) are calculated, analyzed and compared. It is founded that the stress concentration at joints of CFST is a quite different from that of hollow steel tube. A conclusion can be made that analysis of fatigue at the joints of CFST truss arch bridge can not apply the results developed from analyzing at joints of hollow steel tube in marine structure.展开更多
The purpose of the present research was to investigate the predictors to Chinese college students seeking psychological help from professionals. By surveying 1,408 Chinese college students at five universities in Chin...The purpose of the present research was to investigate the predictors to Chinese college students seeking psychological help from professionals. By surveying 1,408 Chinese college students at five universities in China's Mainland, the results showed that among the factors examined, problem severity and help-seeking attitudes directly predicted help-seeking intention, while gender and subjective norms had a significant effect on college students' professional psychological help-seeking intention through help-seeking attitudes. Overall, the model explained 25% and 38.0% (for half-1 and half-2 data sets, respectively) of the variances of help-seeking intention. The results indicated that mainland Chinese college students rationally knew that they should choose to seek such professional help when the problem got severer enough, although they were emotionally reluctant to seek professional psychological help due to negative subjective norms around them. The implications and limitations were discussed.展开更多
ANGIOSARCOMA is the most common primary malignant cardiac tumor. Until recently, the diagnosis is often not established until the tumor is advanced with vital cardiac structure involved or distal metastasis, mainly be...ANGIOSARCOMA is the most common primary malignant cardiac tumor. Until recently, the diagnosis is often not established until the tumor is advanced with vital cardiac structure involved or distal metastasis, mainly because the symptoms are initially nonspecific. The natural history of cardiac angiosarcoma is characterized by a short clinical course and a fatal outcome. Surgical resection remains the preferential therapy for palliation or cure, whereas irradiation and chemotherapy have only limited use. We herein reported a successful radical resection of cardiac angiosarcoma with concomitant reconstruction of right coronary artery, tricuspid leaflet, and atrial wall. The literature on cardiac angiosarcomas is reviewed extensively, with emphasis on presentation and surgical management.展开更多
文摘Let A={A_1, A_2,…, A_(n+1)} be a simplex in E^n which its center O of circumscribed sphere is in inside of A. If R and R_i are radiuses of A_i respectively (A_i={A_1, A_2,…, A_(i-1), O, A_(i+1),…,A_(n+1)} ,i=1,2,…,n+1),then we have The equality holds if and only if A is a regular simplex.
文摘Chronic diseases have become a focal point of public health worldwide with estimates of trillions of dollars in annual health care cost and causing more than 36 million deaths a year. Lifestyle factors such as physical inactivity are heavily correlated with the development of many chronic diseases. New strategies for primary and secondary disease prevention are desperately needed to aid in blunting the negative economic and social impact of these diseases. Physical activity (PA) and exercise are now considered principal interventions for use in primary and secondary prevention of chronic diseases. Currently, more emphasis in primary prevention of disease is necessary to reduce disease risk in youth and adults; however with chronic disease prevalence so high, similar emphasis is also necessary for secondary prevention in those children and adults already inflicted with chronic diseases. Conditions such as cardiovascular disease, type 2 diabetes, obesity, and cancer are drastically improved when PA and exercise are part of a medical management plan. In addition, the national PA guidelines in conjunction with PA promotion tools like Exercise is MedicineTM are needed to promote increased PA and exercise levels worldwide.
基金financial supports from the National Natural Science Foundation of China (No. 51805416)the Young Elite Scientists Sponsorship Program by CAST, China (No. YESS20200279)+3 种基金the Natural Science Foundation of Hunan Province, China (No. 2020JJ5716)the Project of State Key Laboratory of High Performance Complex Manufacturing, Central South University, China (No. ZZYJKT2019-01)the Hunan Provincial Natural Science Foundation for Excellent Young Scholars, China (No. 2021JJ20059)the Huxiang High-Level Talent Gathering Project of Hunan Province, China (No. 2019RS1002)。
文摘To extend the service life of the clinched joint,a reconditioning process conducted with an additional tubular rivet was proposed in this work.Different reconditioning forces were employed to produce dissimilar reconditioned joints by experimental method.The experimental results indicated that the neck fracture was the common failure mode of both original clinched and reconditioned joints.Compared with the original clinched joint,the shearing strength of the reconditioned joint produced by a reconditioning force of 40 kN increased from 1810.5 to 1986.47 N,and the energy absorption increased from 2.34 to 3.46 J.The range of effective reconditioning force was from 35 to 40 kN and 40 kN was the best choice for reconditioning the AA5052 failed joints.The mechanical properties of the reconditioned joints are obviously better than those of the original clinched joints,which fully demonstrates that the reconditioning method proposed in this work has a broad prospect of industrial application.
文摘Objective:To assess the effect of angiotensin II type 1(AT1)receptor antagonist losartan on myocardium con- nexin43(Cx43)gap junction(GJ)expression in spontaneously hypertensive rats(SHRs)and investigate possible mechanisms. Methods:Sixteen 9-week-old male SHRs and 8 age-matched male Wistar-Kyoto(WKY)rats were included in this study.SHRs were randomly divided into two groups to receive losartan at 30 mg/(kg·d)by oral gavage once daily for 8 weeks(SHR-L)or vehicle(0.9%saline)to act as controls(SHR-V);WKY rats receiving vehicle for 8 weeks served as normotensive controls.At the end of the experiment,rats were sacrificed and the hearts were removed.Expressions of Cx43 and nuclear factor-kappaB p65 (NF-κB p65)proteins in all three groups were observed and further investigations on the effect of angiotensin II type 1 receptor antagonist losartan(30 mg/(kg·d),8 weeks)on Cx43 expression were conducted with Western blot and immunohistochemistry. NF-κB p65 protein in nuclear extracts was determined by Western blot.Results:Left ventricular(LV)hypertrophy was prominent in SHRs,Cx43 and NF-κB p65 protein expressions were obviously upregulated and Cx43 distribution was dispersed over the cell surface.Treatment with losarton reduced the over-expressions of Cx43 and NF-κB p65 in LV myocardium.The distribution of Cx43 gap junction also became much regular and confined to intercalated disk after losartan treatment.Conclu- sion:Cx43 level was upregulated in LV myocardium of SHR during early stage of hypertrophy.Angiotensin II type 1 receptor antagonist losartan prevented Cx43 gap junction remodeling in hypertrophied left ventricles,possibly through the NF-κB pathway.
基金The National Natural Science Foundation of China(No.51578357)the Natural Science Foundation of Shanxi Province(No.2015011062)Talent Training Program in the Postgraduate Joint Training Base of Shanxi Province(No.2016JD11)
文摘In order to reveal the constant-fatigue fracture form and mechanism of the welded cross plate-hollow sphere joints(WCPHSJs)and establish its formula,the WCPHSJs were fatigue tested.A total of 19 specimens were tested under constant amplitude fatigue loads using a specially designed test rig.The joint was analyzed statically by t e finite element analysis(F3A),and metallographic analysis of fatigue fracture was done by the electron scanning microscope.Numerical simulation and experimental results show that the hot-spot of WCPHSJ lies at the weld toe location where severe stress is concentrated.Fatigue cracks initiate at the weld toe and then propagate circumferentially around the sphere with a diameter equivalent to the width of the cross plate up to the fatigue facture.The initial welding defects and constructional detail constitute the main factor of fatigue failure.The S-N curves for the joints were developed through a linear regession analysis of fatigue data.A formula for calculating constant amplitude fatigue,base on the concept of the hot spot stress amplitude,is proposed.
文摘ObjectiveToinvestigate whether depression, anxiety and stress increase the risk for delirium and poor quality of life (QOL) after co-ronary artery bypass (CABG) surgery.MethodsA total of 180 CABG patients (mean age of 63.5 ± 10.1 years, 82.2% males) completed baseline and postoperative self-report questionnaires to assess distress and QOL. Incident delirium was diagnosed postoperatively with a structured clinical interview and patients were monitored every day post-operatively for confusion and disturbance in consciousness.Results Delirium developed in 63 persons (35% of sample). After adjustment for covariates, delirium was significantly associated with depression [odds ratio (OR): 1.08; 95% confidence interval (CI): 1.03-1.13,P = 0.003], anxiety (OR: 1.07; 95% CI: 1.02-1.13,P= 0.01) and stress (OR: 1.05; 95% CI: 1.00-1.09,P= 0.03). Preoperative depression scores were associated with poorer QOL including bodily pain (β =-0.39,P = 0.013), vitality (β=-0.32,P = 0.020), social functioning (β=-0.51,P≤0.001), emotional role function (β=-0.44,P = 0.003) and general health (β=-0.33,P = 0.038). Among the covariates, harmful levels of alcohol use was consistently associated with poorer QOL.Conclusions Depression and harmful levels of alcohol use were consistently associated with poorer QOL whereas depression, anxiety and stress were associated with delirium risk. These findings point to further research examining depression and harmful levels of alcohol use in coronary heart disease populations undergoing coronary revascularization.
基金Acknowledgments We thank Ms Mekie Takahashi, Ms Ritsuko Kanda (Nagaya University, Japan), Dr Changliang Fu and Dr Shouqing Lu (Institute of Mechanics, Chinese Academy of Sciences) for technical assistance. This work was partly supported by research grants from the National Natural Science Foundation of China (10602031) and Grants-in-aid for Scientific Research on Priority Areas (#15086270 to M.S.) and Creative Research (# 16GS0308 to M.S.) from the Ministry of Education Science Sports and Culture, Japan.
文摘Some large-conductance Ca^2+ and voltage-activated K^+(BK) channels are activated by membrane stretch. However, the mechanism of mechano-gating of the BK channels is still not well understood. Previous studies have led to the proposal that the linker-gating ring complex functions as a passive spring, transducing the force generated by intracellular Ca^2+ to the gate to open the channel. This raises the question as to whether membrane stretch is also transmitted to the gate of mechanosensitive (MS) BK channels via the linker-gating complex. To study this, we changed the linker length in the stretch-activated BK channel (SAKCaC), and examined the effect of membrane stretch on the gating of the resultant mutant channels. Shortening the linker increased, whereas extending the linker reduced, the channel mechanosensitivity both in the presence and in the absence of intracellular Ca^2+. However, the voltage and Ca^2+ sensitivities were not significantly altered by membrane stretch. Furthermore, the SAKCaC became less sensitive to membrane stretch at relatively high intracellular Ca^2+ concentrations or membrane depolarization. These observations suggest that once the channel is in the open-state conformation, tension on the spring is partially released and membrane stretch is less effective. Our results are consistent with the idea that membrane stretch is transferred to the gate via the linker-gating ring complex of the MS BK channels.
基金National Natural Science Foundation of China (No 50608054)
文摘The hollow spherical joints welded with circular pipes applied to the National Swimming Center of China are subjected to large bending moments, but the influence of bending moments is not considered in the design equations in Technical Specification for Latticed Shells. Based on the von Mises yield criterion, multilinear isotropic hardening rule and associated flow rule, the elasto-plastic finite element model is put forward to analyze the behavior of the joints, and a calculation method for the joints under bending moments or eccentric loads is proposed. It is shown by the analytical results of joint that the stiffening rib can improve the ultimate bearing capacity by 10% for joints under axial tensile load, by 40% for joints under axial compressive load, and by 50% for joints under bending moment. The unified calculation equations for joints with or without stiffening rib are put forward, which can be applied to calculating the ultimate bearing capacity of the hollow spherical joints with circular pipes under eccentric loads.
基金Supported by the National Natural Science Foundation of China(30070749).
文摘Objectives: To explore possible mechanisms of connexin40 (Cx40) remodeling by detecting Cx40 mRNA expression of the crista terminalis and left atrium (LA) in patients with rheumatic heart disease (RHD) associated chronic atrial fibrillation (AF). Methods: Twenty patients were enrolled in this study, who underwent surgical operation for RHD-associated mitral disease, including l0 with sinus rhythms (rhythm group) and l0 with AF (AF group). Another 6 patients with non-RHD sinus rhythms were divided into the control group. A small amount of myocardial tissue was cut from the crista terminalis and the LA posterior wall during the valvular replacement operation. Cx40 mRNA expression was assayed by real-time fluorescent quantitation polymerase chain reaction (RT-PCR). Results: There was no significant difference in Cx40 mRNA expression in the crista terminalis and LA posterior wall between the 3 groups, and there was no significant difference in Cx40 mRNA expression between the crista terminalis and LA within each group. Conclusion: Based on the finding in previous studies that there existed evident remodeling of atrial Cx40 protein in patients with chronic RHD, the results of the present study suggest that the mechanism of Cx40 remodeling probably lies in the post transcriptional level.
文摘An experimental study was undertaken to express the hardening Swift law according to friction stir welding (FSW) aluminum alloy 2017. Tensile tests of welded joints were run in accordance with face centered composite design. Two types of identified models based on least square method and response surface method were used to assess the contribution of FSW independent factors on the hardening parameters. These models were introduced into finite-element code "Abaqus" to simulate tensile tests of welded joints. The relative average deviation criterion, between the experimental data and the numerical simulations of tension-elongation of tensile tests, shows good agreement between the experimental results and the predicted hardening models. These results can be used to perform multi-criteria optimization for carrying out specific welds or conducting numerical simulation of plastic deformation of forming process of FSW parts such as hydroforming, bending and forging.
文摘Recent interest in mobile-based heahhcare has driven significant demands on researching non-contact electrodes for electrocardiogram (ECG) measurement. While the conductive gel achieves the requirement in making a good contact between the electrodes and skin, several problems appear. A gel-free, non-contact electrode based on capacitive coupling theory was provided in this paper, which was integrated on the print circuit board (PCB). The experimental results showed that clear ECG signals could be acquired in the laboratory conditions by coupling the electrodes to the chest of patients through cotton belts.
基金support rendered through a Major Research Project No. F-31-51/2005(SR)
文摘In many circumstances,dissimilar metals have to be bonded together and the resulting joint interfaces must typically sustain mechanical and/or electrical forces without failure,which is not possible by fusion welding processes.The melting points of magnesium(Mg)and copper(Cu)have a significant difference(nearly 400℃)and this may lead to a large difference in the microstructure and joint performance of Mg-Cu joints.However,diffusion bonding can be used to join these alloys without much difficulty.This work analyses the effect of parameters on diffusion layer thickness,hardness and strength of magnesium-copper dissimilar joints.The experiments were conducted using three-factor,five-level,central composite rotatable design matrix.Empirical relationships were developed to predict diffusion layer thickness,hardness and strength using response surface methodology.It is found that bonding temperature has predominant effect on bond characteristics.Joints fabricated at a bonding temperature of 450℃, bonding pressure of 12 MPa and bonding time of 30 min exhibited maximum shear strength and bonding strength of 66 and 81 MPa, respectively.
文摘In this paper stresses at joints forming by hollow steel tube and concrete filled steel tube (CFST) are calculated, analyzed and compared. It is founded that the stress concentration at joints of CFST is a quite different from that of hollow steel tube. A conclusion can be made that analysis of fatigue at the joints of CFST truss arch bridge can not apply the results developed from analyzing at joints of hollow steel tube in marine structure.
文摘The purpose of the present research was to investigate the predictors to Chinese college students seeking psychological help from professionals. By surveying 1,408 Chinese college students at five universities in China's Mainland, the results showed that among the factors examined, problem severity and help-seeking attitudes directly predicted help-seeking intention, while gender and subjective norms had a significant effect on college students' professional psychological help-seeking intention through help-seeking attitudes. Overall, the model explained 25% and 38.0% (for half-1 and half-2 data sets, respectively) of the variances of help-seeking intention. The results indicated that mainland Chinese college students rationally knew that they should choose to seek such professional help when the problem got severer enough, although they were emotionally reluctant to seek professional psychological help due to negative subjective norms around them. The implications and limitations were discussed.
文摘ANGIOSARCOMA is the most common primary malignant cardiac tumor. Until recently, the diagnosis is often not established until the tumor is advanced with vital cardiac structure involved or distal metastasis, mainly because the symptoms are initially nonspecific. The natural history of cardiac angiosarcoma is characterized by a short clinical course and a fatal outcome. Surgical resection remains the preferential therapy for palliation or cure, whereas irradiation and chemotherapy have only limited use. We herein reported a successful radical resection of cardiac angiosarcoma with concomitant reconstruction of right coronary artery, tricuspid leaflet, and atrial wall. The literature on cardiac angiosarcomas is reviewed extensively, with emphasis on presentation and surgical management.