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鼠伤寒沙门氏杆菌减毒疫苗
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作者 李秉鸿 《畜牧兽医科技信息》 1998年第7期7-7,共1页
这种减毒的活苗使用鼠伤寒沙门氏杆菌△cya、△crp双突变株×3985株可以阻止同种、异种血清型的沙门氏杆菌对鸡的侵袭和体内定居,可产生长效的保持作用。2和4周龄鸡口服接种后抵抗野外型鼠伤寒和肠炎沙门氏杆菌在3、6、9和12月龄时... 这种减毒的活苗使用鼠伤寒沙门氏杆菌△cya、△crp双突变株×3985株可以阻止同种、异种血清型的沙门氏杆菌对鸡的侵袭和体内定居,可产生长效的保持作用。2和4周龄鸡口服接种后抵抗野外型鼠伤寒和肠炎沙门氏杆菌在3、6、9和12月龄时经口攻击,攻击后对接种鸡和非接种鸡作对比,显示△cya、△crp双突变株×3985株能诱导良好的保护力,抗沙门氏菌对肠道、内脏、生殖道和蛋内定居、入侵和污染。接种保护期长达11个月。非接种鸡用沙门氏菌攻击可从卵黄。 展开更多
关键词 肠炎沙门氏杆菌 鼠伤寒 肠炎沙门氏菌 突变株 接种保护 异种血清 口服接种 产蛋鸡 肠道沙门氏菌 鼠伤寒杆菌
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Protection Efficacy of Recombinant Infectious Laryngotracheitis Vaccine in Chicks
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作者 K. Chumpolbanchorn P. Anankeatikul +2 位作者 R. Thampisarn S. Jittakhot S. Leethochawalit 《Journal of Agricultural Science and Technology(A)》 2011年第8期1112-1114,共3页
A commercial recombinant fowl pox vectored infectious laryngotracheitis (ILT) vaccine was examined its protection efficacy in one-day-old chicks by subcutaneous route with various dose-strength. The treatment groups... A commercial recombinant fowl pox vectored infectious laryngotracheitis (ILT) vaccine was examined its protection efficacy in one-day-old chicks by subcutaneous route with various dose-strength. The treatment groups I-III birds were vaccinated with a full, 1/2 and 1/3 dose of recommendation dose, respectively. Thereafter, at 6 wk post vaccination, they were challenged with 5x labeled dose of live ILT vaccine. Protection efficacy of the vaccine was compared among groups based on antibody production and eye lesion score. The results of eye lesion score showed that there was a significant difference between control and treatment groups, whereas the difference was not found among the treatment groups. For seroconversion, there was no significant difference between birds in group I and II. However, higher number of seroconversion birds in groups I and II than group III was observed (P 〈 0.05). It was concluded that a half dose of recommendation dose had the same protection efficacy as a full dose of recombinant YP-LT vaccine. 展开更多
关键词 Recombinant vaccine infectious laryngotracheitis fowl pox vectored SEROCONVERSION eye lesion score
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Immunization with Cytomegalovirus Envelope Glycoprotein M and Glycoprotein N DNA Vaccines can Provide Mice with Complete Protection against a Lethal Murine Cytomegalovirus Challenge 被引量:1
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作者 Huadong Wang Yanfeng Yao +3 位作者 Chaoyang Huang Quanjiao Chen Jianjun Chen Ze Chen 《Virologica Sinica》 SCIE CAS CSCD 2013年第3期174-182,共9页
Human cytomegalovirus virions contain three major glycoprotein complexes (gC I, II, III), all of which are required for CMV infectivity. These complexes also represent major antigenic targets for anti-viral immune res... Human cytomegalovirus virions contain three major glycoprotein complexes (gC I, II, III), all of which are required for CMV infectivity. These complexes also represent major antigenic targets for anti-viral immune responses. The gC II complex consists of two glycoproteins, gM and gN. In the current study, DNA vaccines expressing the murine cytomegalovirus (MCMV) homologs of the gM and gN proteins were evaluated for protection against lethal MCMV infection in a mouse model. Humoral and cellular immune responses, spleen viral titers, and mice survival and body-weight changes were examined. The results showed that immunization with gM or gN DNA vaccine alone was not able to offer good protection, whereas co-immunization with both gM and gN induced an effective neutralizing antibody response and cellular immune response, and provided mice with complete protection against a lethal MCMV challenge. This study provides the first in vivo evidence that the gC II (gM-gN) complex may be able to serve as a protective subunit antigen for future HCMV vaccine development. 展开更多
关键词 CYTOMEGALOVIRUS Envelope glycoprotein complex gM/gN DNA vaccine
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Immunogenic and Protective Properties of the First Kazakhstan Vaccine against Pandemic Influenza А(Н1N1) pdm09 in Ferrets
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作者 Kaissar Tabynov Zhailaubai Kydyrbayev +5 位作者 Abylai Sansyzbay Berik Khairullin Sholpan Ryskeldinova Nurika Assanzhanova Yerken Kozhamkulov Dulat Inkarbekov 《Virologica Sinica》 SCIE CAS CSCD 2012年第6期345-352,共8页
This paper presents the results of a pre-clinical study of the immunogenicity and efficacy of an egg-derived, inactivated, whole-virion adjuvanted vaccine (Refluvac) on ferret models. For this purpose, groups of eig... This paper presents the results of a pre-clinical study of the immunogenicity and efficacy of an egg-derived, inactivated, whole-virion adjuvanted vaccine (Refluvac) on ferret models. For this purpose, groups of eight ferrets (6 to 7 months old) were injected with 0.5 mL of vaccine specimens containing 3.75, 7.5 or 15.0 μg of virus hemagglutinin. Administration was intramuscular and given either as a single dose or as two doses 14 days apart. All vaccine specimens manifested immunogenicity in ferrets for single (HI titer, from 51 ± 7 to 160 ± 23) and double (HI titer, from 697± 120 to 829 ± 117) administrations. To assess the protective effects of the vaccine, ferrets from the vaccinated and control groups were infected intranasally with pandemic virus A/California/7/09 (H1N1) pdm09 at a dose of 106 106/0.5 mL. Fourteen days post-infection, the ferrets inoculated with single or double vaccines containing 3.75, 7.5 or 15.0 ~g of hemagglutinin per dose showed no signs of influenza infection, weight loss, or body temperature rise, and no premature deaths occurred. The number of vaccinated ferrets shedding the virus via the upper airway, as well as the amount of virus shed after infection, was significantly reduced in comparison with animals from the control group. Based on our results, we suggest that a single vaccination at a dose of 3.75 or 7.5 μg hemagglutinin be used for Phase I clinical trials. 展开更多
关键词 VACCINE Pandemic Influenza A (H1N1) pdm09 Immunogenic and Protective Properties FERRETS
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