A 31- year- old man presented with a long history of rhino conjunctivitis and sneezing that lasted from March to May. The man kept a chameleon (Chamaeleo calyptratus) as a pet and reported about recurrent urticarial l...A 31- year- old man presented with a long history of rhino conjunctivitis and sneezing that lasted from March to May. The man kept a chameleon (Chamaeleo calyptratus) as a pet and reported about recurrent urticarial lesions, erythema, and itch after skin contact with the animal. The reactions started within a few minutes and were restricted specifically to the contact sites with the animal’ s claws. No comparable reactions occurred in other subjects. Allergy testing confirmed allergy to hazel, alder, birch, and ash pollen, and additionally revealed sensitization to house dust mite, cat, and Ficus benjamina. Apparently the contact dermatitis originated from passive transfer of Ficus benjamina allergens to the patient’ s skin by the reptile which habitually climbed on a big Ficus benjamina tree in the patient’ s home, thereby contaminating its claws with the plant’ s allergenic milky sap. Careful examination revealed strong perforation of many leaves by the pointed claws. The patient denied respiratory symptoms from Ficus benjamina and intolerance of Ficus- associated fruits.展开更多
We report the first case of immediate-type hypersensitivity caused by Emla. c ream. A 55-year-old woman, after using Emlacream, went on to develop urticar ia. An open test was positive to Emlacream. Patch tests an...We report the first case of immediate-type hypersensitivity caused by Emla. c ream. A 55-year-old woman, after using Emlacream, went on to develop urticar ia. An open test was positive to Emlacream. Patch tests and prick tests were p erformed with Emlacream, the components of Emlacream (lidocaine, prilocaine and castor oil) and other local anaesthetic s. The patch test with lidocaine and the prick test with Emlacream were both p ositive. An intradermal test and subcutaneous administration of 3 anaesthetics t hat had negative patch tests and prick tests were performed and well tolerated,a llowing their use. In the literature, anaphylactic reactions to lidocaine inject ions, delayed-type hypersensitivity after lidocaine subcutaneous injections and contact dermatitis from Emlacream have all been described. This first case of contact urticaria from Emlacream was due to lidocaine and did not show any cr oss-reaction with other local anaesthetics.展开更多
Among the cereals,wheat,rye,barley and oats,have been reported to cause protein contact dermatitis. However,in these cases neither the involvement of an immunological mechanism nor the role of specific protein(s) has ...Among the cereals,wheat,rye,barley and oats,have been reported to cause protein contact dermatitis. However,in these cases neither the involvement of an immunological mechanism nor the role of specific protein(s) has been demonstrated. We present a case of protein contact dermatitis from corn. The patient presented with a Type I sensitization to corn,as shown by the presence of specific immunoglobulin (Ig)E and positivity to prick tests with both a flour suspension and the salt-soluble protein fraction of this cereal. The same corn preparations induced a strong urticarial reaction on scratch testing. This reaction was followed several days later by the appearance of erythema and then eczema at the site of application. When boiled,these preparations became inactive on both prick and scratch testing. Patch tests were negative in all cases. Immunoblotting performed with the patient’s serum showed the presence of a unique IgE-binding protein band with a molecular weight of around 14 kDa,belonging to the salt-soluble corn protein fraction. Our results give the first clear evidence that cornflour can induce protein contact dermatitis. The IgE binding 14-kDa protein has characteristics identical to those of the trypsin/α-amylase inhibitors from cereals.展开更多
We report the first case of a life-threatening immediate-type hypersensitivity caused by Dynexan., a local anaesthetic gel. After mucosal application by his dentist, a 63-year-old man rapidly developed urticaria, dysp...We report the first case of a life-threatening immediate-type hypersensitivity caused by Dynexan., a local anaesthetic gel. After mucosal application by his dentist, a 63-year-old man rapidly developed urticaria, dyspnea and, at last, he collapsed and remained unconscious for 2 hr despite emergency care. While the standard prick tests were negative to all local anaesthetics tested including lidocaine, a 1-fold positive reaction was detected to Meyprogat 60., an ingredient of Dynexan.. As the gelling agent Meyprogat 60. represents a derivative of guar (synonymous guar gum, guaran, E-412), we subsequently tested different guar products derived from Cyamopsis tetragonolobabeansand,ascontrol,thecloselyrelatedlocustbeangum E-410. In the prick-to-prick tests, the guar-derived food additive Provigel. NAG 905 provoked a 1-fold positive reaction. Native guar beans pounded and resuspended in water showed a 2-fold positive reaction, whereas no reaction was found to derivatives of locust bean gum. Specific immunoglobulin E were negative in all cases. Despite the common use of guar as versatile food additive or gelling agent, this is the first case of a severe immediate-type hypersensitivity after mucosal contact.展开更多
文摘A 31- year- old man presented with a long history of rhino conjunctivitis and sneezing that lasted from March to May. The man kept a chameleon (Chamaeleo calyptratus) as a pet and reported about recurrent urticarial lesions, erythema, and itch after skin contact with the animal. The reactions started within a few minutes and were restricted specifically to the contact sites with the animal’ s claws. No comparable reactions occurred in other subjects. Allergy testing confirmed allergy to hazel, alder, birch, and ash pollen, and additionally revealed sensitization to house dust mite, cat, and Ficus benjamina. Apparently the contact dermatitis originated from passive transfer of Ficus benjamina allergens to the patient’ s skin by the reptile which habitually climbed on a big Ficus benjamina tree in the patient’ s home, thereby contaminating its claws with the plant’ s allergenic milky sap. Careful examination revealed strong perforation of many leaves by the pointed claws. The patient denied respiratory symptoms from Ficus benjamina and intolerance of Ficus- associated fruits.
文摘We report the first case of immediate-type hypersensitivity caused by Emla. c ream. A 55-year-old woman, after using Emlacream, went on to develop urticar ia. An open test was positive to Emlacream. Patch tests and prick tests were p erformed with Emlacream, the components of Emlacream (lidocaine, prilocaine and castor oil) and other local anaesthetic s. The patch test with lidocaine and the prick test with Emlacream were both p ositive. An intradermal test and subcutaneous administration of 3 anaesthetics t hat had negative patch tests and prick tests were performed and well tolerated,a llowing their use. In the literature, anaphylactic reactions to lidocaine inject ions, delayed-type hypersensitivity after lidocaine subcutaneous injections and contact dermatitis from Emlacream have all been described. This first case of contact urticaria from Emlacream was due to lidocaine and did not show any cr oss-reaction with other local anaesthetics.
文摘Among the cereals,wheat,rye,barley and oats,have been reported to cause protein contact dermatitis. However,in these cases neither the involvement of an immunological mechanism nor the role of specific protein(s) has been demonstrated. We present a case of protein contact dermatitis from corn. The patient presented with a Type I sensitization to corn,as shown by the presence of specific immunoglobulin (Ig)E and positivity to prick tests with both a flour suspension and the salt-soluble protein fraction of this cereal. The same corn preparations induced a strong urticarial reaction on scratch testing. This reaction was followed several days later by the appearance of erythema and then eczema at the site of application. When boiled,these preparations became inactive on both prick and scratch testing. Patch tests were negative in all cases. Immunoblotting performed with the patient’s serum showed the presence of a unique IgE-binding protein band with a molecular weight of around 14 kDa,belonging to the salt-soluble corn protein fraction. Our results give the first clear evidence that cornflour can induce protein contact dermatitis. The IgE binding 14-kDa protein has characteristics identical to those of the trypsin/α-amylase inhibitors from cereals.
文摘We report the first case of a life-threatening immediate-type hypersensitivity caused by Dynexan., a local anaesthetic gel. After mucosal application by his dentist, a 63-year-old man rapidly developed urticaria, dyspnea and, at last, he collapsed and remained unconscious for 2 hr despite emergency care. While the standard prick tests were negative to all local anaesthetics tested including lidocaine, a 1-fold positive reaction was detected to Meyprogat 60., an ingredient of Dynexan.. As the gelling agent Meyprogat 60. represents a derivative of guar (synonymous guar gum, guaran, E-412), we subsequently tested different guar products derived from Cyamopsis tetragonolobabeansand,ascontrol,thecloselyrelatedlocustbeangum E-410. In the prick-to-prick tests, the guar-derived food additive Provigel. NAG 905 provoked a 1-fold positive reaction. Native guar beans pounded and resuspended in water showed a 2-fold positive reaction, whereas no reaction was found to derivatives of locust bean gum. Specific immunoglobulin E were negative in all cases. Despite the common use of guar as versatile food additive or gelling agent, this is the first case of a severe immediate-type hypersensitivity after mucosal contact.
