接触性超敏反应(CHS)是研究体内免疫活化和调节的重要模型之一。分泌IL-17的CD4+Th(Th17)细胞亚群在CHS发展过程中发挥重要作用。CD4+CD25+FoxP3+调节性T细胞(Treg)是具有较强免疫调控作用的T细胞亚群。在氯化苦咪酸(TNCB)诱导的接触性...接触性超敏反应(CHS)是研究体内免疫活化和调节的重要模型之一。分泌IL-17的CD4+Th(Th17)细胞亚群在CHS发展过程中发挥重要作用。CD4+CD25+FoxP3+调节性T细胞(Treg)是具有较强免疫调控作用的T细胞亚群。在氯化苦咪酸(TNCB)诱导的接触性超敏反应小鼠模型中,TNCB攻击后小鼠Treg占CD4+T细胞的百分比显著增高,于24～48 h达到峰值,72 h开始回落。进一步利用抗-CD25 mAb 7D4在小鼠体内消除Treg后,小鼠的受攻击皮肤增厚明显高于对照组。尽管CD4+T细胞在淋巴细胞中总的比例没有显著变化,但CD4+IL-17+T细胞比例显著增加。由此提示,CD4+CD25+FoxP3+Treg可能通过影响效应性Th17的功能,进而抑制CHS的发生。展开更多
The delayed hypersensitivity development against topical corticosteroids which are used in allergic contact dermatitis (ACD) treatment is an important clinical problem. In our study, 41 ACD patients who did not show a...The delayed hypersensitivity development against topical corticosteroids which are used in allergic contact dermatitis (ACD) treatment is an important clinical problem. In our study, 41 ACD patients who did not show any response to topical corticosteroid treatment were patch tested with corticosteroid series and the commercial preparations of corticosteroids and their vehicles. In corticosteroid series, there were budesonide, bethametasone-17-valerate, triamcinolone acetonide, tixocortol pivalate, alclomethasone-17-21-dipropionate, clobetasole-17-propionate, dexamethasone-21-phosphate disodium and hydrocortisone-17-butyrate. We detected positive reaction to corticosteroids in 9 of our cases (22%) (5 single and 4 multiple). The sensitivity was mostly produced by tixocortol pivalate (6 patients). This was followed by triamcinolone acetonide (2 patients) budesonide (2 patients), alclomethasone dipropionate (2 patients), dexamethasone 21 phosphate disodium (2 patients) and betamethasone-17-valerate (1 patient). As a result, it should not be forgotten that the corticosteroids used to treat ACD patients may cause ACD themselves. In ACD patients who did not respond to corticosteroid treatment, routinely applying patch test with corticosteroids should be helpful in directing the treatment.展开更多
文摘接触性超敏反应(CHS)是研究体内免疫活化和调节的重要模型之一。分泌IL-17的CD4+Th(Th17)细胞亚群在CHS发展过程中发挥重要作用。CD4+CD25+FoxP3+调节性T细胞(Treg)是具有较强免疫调控作用的T细胞亚群。在氯化苦咪酸(TNCB)诱导的接触性超敏反应小鼠模型中,TNCB攻击后小鼠Treg占CD4+T细胞的百分比显著增高,于24～48 h达到峰值,72 h开始回落。进一步利用抗-CD25 mAb 7D4在小鼠体内消除Treg后,小鼠的受攻击皮肤增厚明显高于对照组。尽管CD4+T细胞在淋巴细胞中总的比例没有显著变化,但CD4+IL-17+T细胞比例显著增加。由此提示,CD4+CD25+FoxP3+Treg可能通过影响效应性Th17的功能,进而抑制CHS的发生。
文摘The delayed hypersensitivity development against topical corticosteroids which are used in allergic contact dermatitis (ACD) treatment is an important clinical problem. In our study, 41 ACD patients who did not show any response to topical corticosteroid treatment were patch tested with corticosteroid series and the commercial preparations of corticosteroids and their vehicles. In corticosteroid series, there were budesonide, bethametasone-17-valerate, triamcinolone acetonide, tixocortol pivalate, alclomethasone-17-21-dipropionate, clobetasole-17-propionate, dexamethasone-21-phosphate disodium and hydrocortisone-17-butyrate. We detected positive reaction to corticosteroids in 9 of our cases (22%) (5 single and 4 multiple). The sensitivity was mostly produced by tixocortol pivalate (6 patients). This was followed by triamcinolone acetonide (2 patients) budesonide (2 patients), alclomethasone dipropionate (2 patients), dexamethasone 21 phosphate disodium (2 patients) and betamethasone-17-valerate (1 patient). As a result, it should not be forgotten that the corticosteroids used to treat ACD patients may cause ACD themselves. In ACD patients who did not respond to corticosteroid treatment, routinely applying patch test with corticosteroids should be helpful in directing the treatment.
