基于控制岛的数控机床远程控制系统研究

基于INTERNET网络通信技术和数控机床控制技术的发展,提出控制岛的概念。设计了基于控制岛的远程监控系统的C/S和B/S混合模式的4层网络结构;设计了硬件配置及软件的Java技术实现方案。

基于控制岛的数控机床远程控制系统研究

基于INTERNET网络通信技术和数控机床控制技术的发展,提出控制岛的概念。设计了基于控制岛的远程监控系统的C/S和B/S混合模式的4层网络结构;设计了硬件配置及软件的Java技术实现方案。

一体化大型压铸模具温度控制方法

新能源汽车的发展使一体化压铸完成了从0到1的突破,给压铸模具发展带来了新的机遇。压铸模具是一个热交换器,压铸模具成型中的热平衡问题至关重要。以压铸模具的温度控制为基础,介绍了压铸模具的基本概况与压铸成型加工过程中热平衡的重要性,阐述了目前一体化压铸模模温控制所采用的模温控制岛、异形水路、红外线成像技术、模内传感器、一体化压铸模模温控制集成化等方案。模具温度的控制有利于提高铸件质量,延长模具使用寿命,提高压铸效率。

基于单片机阀岛控制系统的硬件设计

在现代科学技术迅猛发展的今天,单片机以其优越的高可靠性以及高性价比,在诸多领域中有着广泛的应用,如工业控制系统、办公自动化系统,移动通信系统等,也给社会带来了巨大的经济效益。现在,将计算机技术与信息技术、气动技术等经过整合,就形成了一个智能化的气动系统。而智能化的气动系统已经在自动化领域崭露头角并仍在对其进行大规模的探讨及研发。本文主要针对基于单片机阀岛控制系统中的硬件工作的基本原理进行了详细的分析。

一种基于AT89C51单片机阀岛控制系统的电路设计

阀岛是一类由不同电控阀组成的控制元器件,其高性价比和安全性显著,广泛应用于电气一体化控制过程中。AT89C95单片机集成了存储器、处理器等多方面功能,相当于一个微型计算机系统,将其嵌入到阀岛控制系统电路中来实现两者的有效结合很有必要,为系统调试、检测和维修提供更方便快捷的途径。本文深入了解了阀岛控制系统中按键输入电路、检测电路和输出电路的构造情况,研究RS232接口电路、复位电路的运行步骤,提出了该系统硬件防干扰的措施,通过整合现场总线技术、阀岛技术来实现系统的优化提升。

埕岛油田馆上段储层非均质与沉积微相关系研究

埕岛油田馆上段储层为曲流河沉积,并细分为7种沉积微相,储层非均质研究表明馆上段层内、层间和平面均表现出较强的非均质性。研究认为,沉积微相对储层非均质有明显的控制作用,主要表现在沉积微相对砂体和油层的展布、孔渗的变化、层内非均质性、夹层和微观孔喉分布上。此研究为埕岛油田调整方案的制定提供了地质依据。

ISO9001质量保证体系在鄂州工程控制系统中的应用

在东方电气集团公司承担的鄂州电厂汽机岛仪表和控制系统的设计和供货过程中，我们按照ＩＳＯ９００１标准，建立并遵循了较为完善的质量保证体系，从而保证了整个工程项目的质量。

Prevalence and determinants of delayed gastric emptying in hospitalised Type 2 diabetic patients

AIM: To determine the prevalence of delayed gastric emptying (GE) in older patients with Type 2 diabetes mellitus. METHODS: One hundred and forty seven patients with Type 2 diabetes, of whom 140 had been hospitalised, mean age 62.3 ± 8.0 years, HbA1c 9.1% ± 1.9%, treated with either oral hypoglycemic drugs or insulin were studied. GE of a solid meal (scintigraphy), autonomic nerve function, upper gastrointestinal symptoms, acute and chronic glycemic control were evaluated. Gastric emptying results were compared to a control range of hospitalised patients who did not have diabetes. RESULTS: Gastric emptying was delayed (T50 > 85 min) in 17.7% patients. Mean gastric emptying was slower in females (T50 72.1 ± 72.1 min vs 56.9 ± 68.1 min, P = 0.02) and in those reporting nausea (112.3 ± 67.3 vs 62.7 ± 70.0 min, P < 0.01) and early satiety (114.0 ± 135.2 vs 61.1 ± 62.6 min, P = 0.02). There was no correlation between GE with age, body weight, duration of diabetes, neuropathy, current glycemia or the total score for upper gastrointestinal symptoms. CONCLUSION: Prolonged GE occurs in about 20% of hospitalised elderly patients with Type 2 diabetes when compared to hospitalised patients who do not have diabetes. Female gender, nausea and early satiety areassociated with higher probability of delayed GE.

Effects of the Dietary Probiotic Clostridium butyricum on Intestine Digestive and Metabolic Capacities, SCFA Content and Body Composition in Marsupenaeus japonicus

A 56-day feeding trial was performed to evaluate the effects of dietary probiotic Clostridium butyricum(CB) on intestine digestive and metabolic capacities, intestine short-chain fatty acids(SCFA) content and body composition of kuruma shrimp Marsupenaeus japonicus. Shrimp s were randomly allocated into 9 tanks, 30 each, and f ed with diets containing different levels of C. butyricum(1×10~9 cfug^(-1)): 0 mgg^(-1) feed(Control), 100 mgg^(-1) feed(CB-100), 200 mgg^(-1) feed(CB-200), while each level was triplicated. The results indicated that compared with the control group, the intestine pepsin(Pep) activity and 5-hydroxytryptamine(5-HT) concentration of two C. butyricum group s were both increased. Amylase(AM Y) and lipase(LPS) activities wer e only induced in CB-200 group. Alanine aminotransferase(ALT) and aspartate aminotransferase(A ST) activities of two C. butyricum group s showed no significant change. The α-amylase(AM Y) gene expression was induced in CB-200 group, and tryp sin gene expression of two C. butyricum treated group s were both induced. Intestine SCFA content and body composition analysis showed that the contents of propionic acid, butyric acid and the crude protein of two C. butyricum group s were all higher than those of control. These results revealed that C. butyricum can modulate intestine digestive and metabolic capacities, improve intestine SCFA content and body crude protein content in M. japonicus.

Characteristics of Growth Rate of Coral Porites from Sanya Bay,Hainan Island and its Relationship to Environmental Variables

The time series of annual and seasonal growth rate of two coral Porites, collected at different sites of fringe reef in the Sanya Bay, Hainan Island have been obtained by analyzing X-radiograph of skeletal band. There are obvious seasonal variations of the growth rate in two corals, the average low rate in winter and the average high rate from spring to autumn. Compared with the time series of environmental variables, the coral growth rate is only correlated statistically with seawater temperature and not related to rainfall and sunshine. Furthermore, the growth rate in spring and summer is correlated directly with seawater temperature of the winter-early spring ( between December and March ) and the other seasonal growth rate has no relationship with seasonal variations of seawater temperature. We propose that seawater temperature is one of the factors affecting the coral growth rate in the area and the low seawater temperature is a primary control of the seasonal growth rate.

A SINGLE TETRACYCLINE-REGULATED VECTOR DEVISED FOR CONTROLLED INSULIN GENE EXPRESSION

Objective To construct a single plasmid vector mediating doxycycline-inducible recombined human insulin gene expr-ession in myotube cell line. Methods An expression cassette of rtTAnls driven by promoter of human cytomegalovirus and a furin-cuttable recom-bined human insulin expression cassette driven by a reverse poly-tetO DNA motif were cloned into a single plasmid vector (prTR-tetO-mINS). The prTR-tetO-mINS and pLNCX were co-transfected into a myotube cell line (C2C12) and pLNCX vector were used as a control. After selection with G418, the transfected cells were induced with doxycycline at concentra-tions of 0, 2, and 10 μg/mL. RT-PCR was used to determine expression levels of recombinant insulin mRNA at the 5th day. Insulin production in cell cultures medium (at different incubation time) and cell extracts (at the 7th day) were analyzed with human pro/insulin RIA kits. Results Immune reactive insulin (IRI) level in cell medium was found increased at 24 hours of doxycycline incubation, and still increased at the 5th day. After withdrawn of doxycycline, IRI decreased sharply and was at baseline three days later. IRI and human insulin mRNA levels were positively related to different levels of doxycycline. A 25-fold increase in IRI was found against background expression at the 7th day. Conclusion Human insulin expression can be successfully regulated by doxycycline and the background was very low. This single tet-on insulin expression system may provide a new approach to a controlled insulin gene therapy in skeletal muscle.

Tests of new in-situ seabed acoustic measurement system in Qingdao

A new in-situ seabed acoustic measurement system is developed for direct in-situ measurement of sediment geoacoustic properties （compressional wave velocity and attenuation）. The new in-situ system consists of two parts： the deck control unit and the underwater measurement unit. The underwater measurement unit emits sonic waves that propagate through the seafloor sediment, receives the returning signals, and transmits them to the deck control unit for waveform display and analysis. The entire operation is controlled and monitored in real time by the deck control unit on the research vessel and can provide recording of full waveforms to determine the sound velocity and attenuation. This paper outlines the design of the system, the measurement process, and demonstrates its application in tests carded out on seabed sediment off the Qingdao coast, China. The test results show that the system performed well and rapidly provided accurate in-situ acoustic velocity and attenuation estimates of the seafloor sediment.

纳米岛控制响应时间

德国斯图加特马克斯·普朗克固体物理研究所的研究人员和美国圣巴巴拉的加州大学合作．通过剪裁半导体矩阵中光学非激活ErAs纳米岛层间的距离，证实光电导开关的电学响应速度可调他们认为这种方法对通信波长上接收器和太赫技术可能有用．

BRCA1 affects global DNA methylation through regulation of DNMT1

Global DNA hypomethylation at CpG islands coupled with local hypermethylation is a hallmark for breast cancer, yet the mechanism underlying this change remains elusive. In this study, we showed that DNMT1, which encodes a methylation maintenance enzyme, is a transcriptional target of BRCA1. BRCA1 binds to the promoter of the DNMT1 gene through a potential OCT1 site and the binding is required for maintaining a transcriptional active configuration of the promoter in both mouse and human cells. We further demonstrated that impaired function of BRCA1 leads to global DNA hypomethylation, loss of genomic imprinting, and an open chromatin configuration in several types of tissues examined in a BRCA1 mutant mouse model at premaligant stages. BRCA1 deficiency is also associated with significantly increased expression levels of several protooncogenes, including c-Fos, Ha-Ras, and c-Myc, with a higher expression in tumors, while premalignant mammary epithelial cells displayed an intermediate state between tumors and controls. In human clinical samples, reduced expression of BRCA1 correlates with decreased levels of DNMT1, and reduced methylation of CpG islands. Thus, BRCA1 prevents global DNA hypomethylation through positively regulating DNMT1 expression, and this provides one of mechanisms for BRCAl-associated breast cancer formation.

FRT Control Method Including Islanding Detection in PCS Model for Photovoltaic Generation

The experimental results by the simulated PV （photovoltaic） system for understanding the cause of disconnection when instantaneous voltage sag occurs are reported in this study. Moreover, it is understood that the PCS with the voltage phase jump detection method which is one of the main causes of the disconnection. We modeled it in the simulation. When fault occurs, even though the residual voltage is more than 20% and the voltage sag time is within 1.0 s, the PCS disconnected by the voltage phase jump detection was confirmed in the simulation results. Ifa large number of PV systems are interconnected in the power system, this study is verified through the simulation that the interaction caused by the disconnection which generated by the voltage phase jump detection. This study is proposed threshold limit value of islanding detection. The validity of proposed method was verified through the simulation in this study.

Innovative Control Strategy for Islanded Small Hydro Power Plant

In many developing countries, there are regions where the electrical grid is weak or nonexistent. However, in these areas, large amounts of distributed energy sources, such as hydro, are often available and could be suitably exploited. To this aim, the low head hydro power plants can play a significant role. In fact, recent technological advances in mini-hydro turbines and decreasing costs of static electricity conversion devices enable to realize suitable power plants for an efficient and profitable exploitation of these sites. One of the major challenges is the integration of the above-mentioned power plants into autonomous electrical systems, islanded and/or disconnectable from the main distribution network. In this paper, an innovative control strategy for a low head hydro power plant supplying users in small clusters of villages is proposed.

Cidea controls lipid droplet fusion and lipid storage in brown and white adipose tissue

Excess lipid storage in adipose tissue results in the development of obesity and other metabolic disorders including diabetes,fatty liver and cardiovascular diseases.The lipid droplet(LD)is an important subcellular organelle responsible for lipid storage.We previously observed that Fsp27,a member of the CIDE family proteins,is localized to LD-contact sites and promotes atypical LD fusion and growth.Cidea,a close homolog of Fsp27,is expressed at high levels in brown adipose tissue.However,the exact role of Cidea in promoting LD fusion and lipid storage in adipose tissue remains unknown.Here,we expressed Cidea in Fsp27-knockdown adipocytes and observed that Cidea has similar activity to Fsp27 in promoting lipid storage and LD fusion and growth.Next,we generated Cidea and Fsp27 double-deficient mice and observed that these animals had drastically reduced adipose tissue mass and a strong lean phenotype.In addition,Cidea/Fsp27 double-deficient mice had improved insulin sensitivity and were intolerant to cold.Furthermore,we observed that the brown and white adipose tissues of Cidea/Fsp27double-deficient mice had significantly reduced lipid storage and contained smaller LDs compared to those of Cidea or Fsp27single deficient mice.Overall,these data reveal an important role of Cidea in controlling lipid droplet fusion,lipid storage in brown and white adipose tissue,and the development of obesity.

miR-29b upregulates miR-195 by targeting DNMT3B in tongue squamous cell carcinoma

MicroRNAs play important roles in the devel- opment and progression of various cancers, including tongue squamous cell carcinoma （TSCC）. miR-29b and miR-195 have been reported to be tumor suppressors in TSCC. Here, we investigated the expression of miR-29b and miR- 195 and their relationship in TSCC. Our data showed that miR-29b and miR-195 were significantly downregulated in TSCC com- pared with their matched nonmalignant tissues in 60 paired samples. The level of miR-29b was positively correlated with that of miR-195 in TSCC and the matched nonmalignant tissues. Moreover, miR-29b overexpression induced the demethylation of CpG islands upstream of miR-195 via targeting DNMT3B, leading to the upregulation of miR-195 in TSCC cell lines. Following DNMT3B silencing, the expression of miR-195 was increased and the methylation of CpG islands upstream of miR-195 was reduced. Although overexpression of miR-29b alone significantly increased miR- 195 expression, co-transfection of miR-29b with DNMT3B resulted in no change in miR-195 expression. Taken together, our results demonstrated that miR-29b could upregulate miR- 195 by directly targeting DNMT3B in TSCC. The interaction between miR-29b and miR-195 might provide new insights in developing novel therapeutic approaches of TSCC.

A new power coordination method for islanded micro-grid basing on multi-agent system

Multi-agent system (MAS) can provide flexible and intelligent control for micro-grid (MG). In this paper, a new power coordination method of MAS is presented for MG. New way for dispatching controllable generations (CGs) and direct cooperation between storages and CGs are designed. Real-time emulations of the coordination, including the usage of both CGs and storages, have been carried out in islanded situation basing on this method, and much higher performance than conventional method is found.