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人绒毛膜促性腺激素注射时机与超排卵方案 被引量:1
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作者 胡琳莉 孙莹璞 《生殖医学杂志》 CAS 2013年第10期785-791,共7页
选择最佳的人绒毛膜促性腺激素(HCG)时机是体外受精(IVF)成功的关键因素之一。HCG注射过早导致卵丘小而紧附卵泡壁,直接影响卵母细胞的回收率及卵母细胞的成熟度,受精率低。而HCG注射过晚导致卵母细胞受内源性LH峰的影响,过早的... 选择最佳的人绒毛膜促性腺激素(HCG)时机是体外受精(IVF)成功的关键因素之一。HCG注射过早导致卵丘小而紧附卵泡壁,直接影响卵母细胞的回收率及卵母细胞的成熟度,受精率低。而HCG注射过晚导致卵母细胞受内源性LH峰的影响,过早的恢复了有丝分裂,错过受精的最佳时机;卵母细胞过熟可致卵母细胞超微结构异常,以至于受精、卵裂和妊娠率均受到影响;子宫内膜暴露雌孕激素时间延长,子宫内膜容受性改变,影响胚胎着床。因此,正确掌握合适的HCG时机是获得高质量卵母细胞,提高临床妊娠结局的关键。 展开更多
关键词 HCG时机 卵泡径线 控制超排卵方案 体外受精胚胎移植
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早卵泡期超长方案结合选择性单囊胚移植在体外受精中的应用 被引量:6
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作者 赵军招 应映芬 《浙江医学》 CAS 2018年第12期1287-1290,1294,共5页
体外受精-胚胎移植(IVF-ET)已成为世界各国治疗不孕症的重要手段。IVF-ET治疗需要借助不同的促排卵方案。促性腺激素释放激素激动剂(GnRH-a)进行垂体脱敏,可使卵泡发育同步,增加获卵数,降低周期取消率,避免在促排卵过程中出现内源性黄... 体外受精-胚胎移植(IVF-ET)已成为世界各国治疗不孕症的重要手段。IVF-ET治疗需要借助不同的促排卵方案。促性腺激素释放激素激动剂(GnRH-a)进行垂体脱敏,可使卵泡发育同步,增加获卵数,降低周期取消率,避免在促排卵过程中出现内源性黄体生成素峰,改善卵子及胚胎质量,为提高IVF-ET的临床结局做出了巨大贡献。GnRH-a降调节的促排卵方案,包括黄体期标准长方案、超长方案、改良超长方案等。本文着重谈谈早卵泡期超长方案结合选择性单囊胚移植在体外受精中的应用。 展开更多
关键词 控制超促排卵方案 早卵泡期超长方案 体外受精 选择单囊胚移植
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不同剂型、剂量促性腺激素释放激素激动剂用于长方案降调节的效果比较 被引量:9
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作者 代愉恒 陆秀娥 《医学研究杂志》 2017年第12期132-136,共5页
目的笔者单位探索使用不同剂量长效Gn RH-a用于长方案促排卵治疗,与常规使用每日注射短效Gn RH-a长方案的IVF-ET患者进行相互对照比较其临床疗效,以期寻求最优剂量的Gn RH-a降调节。方法回顾性分析214例在笔者医院接受体外受精-胚胎移... 目的笔者单位探索使用不同剂量长效Gn RH-a用于长方案促排卵治疗,与常规使用每日注射短效Gn RH-a长方案的IVF-ET患者进行相互对照比较其临床疗效,以期寻求最优剂量的Gn RH-a降调节。方法回顾性分析214例在笔者医院接受体外受精-胚胎移植辅助生育的患者,根据患者使用Gn RH-a的不同剂量、剂型分为4组,A组:106例于黄体中期开始每日注射0.1mg Gn RH-a至HCG日。B组:18例于黄体中期一次性注射长效Gn RH-a 3.75mg。C组:35例于黄体中期一次性注射长效Gn RH-a 2.0mg。D组:55例于黄体中期一次性注射长效Gn RH-a 0.9mg,降调节后予以Gn促排卵。经阴道B超监测当双侧卵巢内至少2个卵泡直径16~20mm时,停用促性腺激素并测定血清E2、P、LH水平。当晚使用人绒毛膜促性腺激素注射,36h后经阴道超声引导下行穿刺取卵术,采用常规IVF受精。结果 4组在降调节时的LH水平、获卵数、受精数、优质胚胎数、临床妊娠率比较,差异无统计学意义。在Gn使用量上:A组与D组差异无统计学意义,B组和C组比较,差异无统计学意义,A、D组较B、C组使用量少。在促排卵时间上:A组与C组比较,差异有统计学意义(P<0.005),A组较C组使用时间长,其余各组间比较,差异无统计学意义;在受精率上B组较其余各组受精率低,差异有统计学意义(P<0.005),其余各组间受精率比较,差异无统计学意义(P>0.05)。结论长效长方案与短效长方案均能达到垂体降调的效果,且在临床妊娠率上比较,差异无统计学意义(P>0.05)。然而,使用0.9mg Gn RH-a组较其余各组有显著优势,与其他长效组比较可以减少Gn注射剂量,减轻患者经济压力;与短效组比较,可以减少注射次数,值得推广。 展开更多
关键词 腺激素激动剂 体外受精-胚胎移植 垂体降调节 控制超促排卵长方案
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促性腺激素释放激素(GnRH)类似物在辅助生殖治疗领域中的研究进展
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作者 周郁恬 孟艳 +1 位作者 刁飞扬 刘金勇 《南京师大学报(自然科学版)》 CAS 北大核心 2023年第4期68-73,共6页
促性腺激素释放激素(GnRH)类似物主要包括GnRH激动剂(gonadotropin-releasing hormone agonist,GnRH-a)和GnRH拮抗剂(gonadotropin-releasing hormone antagonist,GnRH-A),在辅助生殖技术多个治疗环节均发挥着重要作用.近年来,针对不同... 促性腺激素释放激素(GnRH)类似物主要包括GnRH激动剂(gonadotropin-releasing hormone agonist,GnRH-a)和GnRH拮抗剂(gonadotropin-releasing hormone antagonist,GnRH-A),在辅助生殖技术多个治疗环节均发挥着重要作用.近年来,针对不同适宜人群进行的、基于GnRH的控制性卵巢刺激改良策略,在不同适宜人群中的使用显著提高了体外受精成功率.GnRH-a在扳机方案中使用的适宜人群选择及对临床结局的影响已在近年临床研究中有深入探讨.而GnRH-a在黄体支持方案中的使用,适宜人群的选择及使用剂量、时机仍需进一步探索.本文就GnRH类似物在辅助生殖领域中的应用机制及相关临床研究的最新进展进行回顾总结. 展开更多
关键词 腺激素释放激素类似物 辅助生殖 控制卵巢刺激方案 扳机方案 黄体支持方案
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不同促排卵方案在波塞冬低预后患者IVF/ICSI治疗中的应用进展
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作者 祝婷 周郁恬 +1 位作者 王超仪 孟艳 《中华生殖与避孕杂志》 CAS CSCD 北大核心 2024年第3期304-309,共6页
接受辅助生殖技术治疗中的低预后患者主要表现为卵巢对外源性促性腺激素刺激反应不良、临床妊娠率低于同龄正常反应者,既往此类人群采用博洛尼亚标准定义和诊断。为了提高研究人群的同质性,2016年波塞冬小组提出了新的低预后人群细分标... 接受辅助生殖技术治疗中的低预后患者主要表现为卵巢对外源性促性腺激素刺激反应不良、临床妊娠率低于同龄正常反应者,既往此类人群采用博洛尼亚标准定义和诊断。为了提高研究人群的同质性,2016年波塞冬小组提出了新的低预后人群细分标准即波塞冬标准,概念上从"低反应"转向"低预后",为低预后患者提供了临床咨询和治疗建议的分类依据。现有多种控制性促排卵方案应用于不同亚组的波塞冬低预后人群,在不同亚组人群中的临床应用各有利弊。本文将对波塞冬分组标准下的低预后患者接受不同控制性超促排卵方案及辅助用药的临床应用进展进行阐述及总结。 展开更多
关键词 生殖技术 辅助 卵巢刺激 控制超促排卵方案 波塞冬标准 低预后 卵巢低反应
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铁路客站站房照明设计的整体思路与方法 被引量:1
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作者 宋海涛 《山西建筑》 2014年第1期39-42,共4页
以铁道部关于铁路客站站房的照明设计细则为基础,具体介绍了照明控制性方案设计的准备工作及设计流程,使电气技术人员对铁路站房照明工程的设计进行系统的认识,为站房照明工程的施工管理提供一定的借鉴。
关键词 站房 照明设计 控制性方案
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The Design and Control of Distillation Column with Side Reactors for Chlorobenzene Production 被引量:6
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作者 薄翠梅 汤吉海 +3 位作者 柏杨进 乔旭 丁良辉 张湜 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2012年第6期1113-1120,共8页
The distillation column with side reactors (SRC) can overcome the temperature/pressure mismatch in the traditional reactive distillation, the column operates at temperature/pressure favorable for vapor-liquid separati... The distillation column with side reactors (SRC) can overcome the temperature/pressure mismatch in the traditional reactive distillation, the column operates at temperature/pressure favorable for vapor-liquid separation, while the reactors operate at temperatures/pressures favorable for reaction kinetics. According to the smooth operation and automatic control problem of the distillation column with side reactors (SRC), the design, simulation calculation and dynamic control of the SCR process for chlorobenzene production are discussed in the paper. Firstly, the mechanism models, the integrated structure optimal design and process simulation systems are established, respectively. And then multivariable control schemes are designed, the controllability of SRC process based on the optimal steady-state integrated structure is explored. The dynamic response performances of closed-loop system against several disturbances are discussed to verify the effectiveness of control schemes for the SRC process. The simulating results show that the control structure using conventional control strategies can effectively overcome feeding disturbances in a specific range. 展开更多
关键词 distillation column with side reactors (SRC) mechanism models multivariable control schemes simula- tion system chlorobenzene production
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Prestiction friction compensation in direct-drive mechatronics systems 被引量:2
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作者 黎志强 周擎坤 +2 位作者 张智永 张连超 范大鹏 《Journal of Central South University》 SCIE EI CAS 2013年第11期3031-3041,共11页
LuGre model has been widely used in friction modeling and compensation.However,the new friction regime,named prestiction regime,cannot be accurately characterized by LuGre model in the latest research.With the extensi... LuGre model has been widely used in friction modeling and compensation.However,the new friction regime,named prestiction regime,cannot be accurately characterized by LuGre model in the latest research.With the extensive experimental observations of friction behaviors in the prestiction,some variables were abstracted to depict the rules in the prestiction regime.Based upon the knowledge of friction modeling,a novel friction model including the presliding regime,the gross sliding regime and the prestiction regime was then presented to overcome the shortcomings of the LuGre model.The reason that LuGre model cannot estimate the prestiction friction was analyzed in theory.Feasibility analysis of the proposed model in modeling the prestiction friction was also addressed.A parameter identification method for the proposed model based on multilevel coordinate search algorithm was presented.The proposed friction compensation strategy was composed of a nonlinear friction observer and a feedforward mechanism.The friction observer was designed to estimate the friction force in the presliding and the gross sliding regimes.And the friction force was estimated based on the model in the prestiction regime.The comparative trajectory tracking experiments were conducted on a simulator of inertially stabilization platforms among three control schemes:the single proportional–derivative(PD)control,the PD with LuGre model-based compensation and the PD with compensator based on the presented model.The experimental results reveal that the control scheme based on the proposed model has the best tracking performance.It reduces the peak-to-peak value(PPV)of tracking error to 0.2 mrad,which is improved almost 50%compared with the PD with LuGre model-based compensation.Compared to the single PD control,it reduces the PPV of error by 66.7%. 展开更多
关键词 prestiction friction LuGre model multilevel coordinate search friction compensation inertially stabilization platforms
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Attribute-Based Access Control Scheme with Efficient Revocation in Cloud Computing 被引量:6
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作者 Zhihua Xia Liangao Zhang Dandan Liu 《China Communications》 SCIE CSCD 2016年第7期92-99,共8页
Attribute-based encryption(ABE) supports the fine-grained sharing of encrypted data.In some common designs,attributes are managed by an attribute authority that is supposed to be fully trustworthy.This concept implies... Attribute-based encryption(ABE) supports the fine-grained sharing of encrypted data.In some common designs,attributes are managed by an attribute authority that is supposed to be fully trustworthy.This concept implies that the attribute authority can access all encrypted data,which is known as the key escrow problem.In addition,because all access privileges are defined over a single attribute universe and attributes are shared among multiple data users,the revocation of users is inefficient for the existing ABE scheme.In this paper,we propose a novel scheme that solves the key escrow problem and supports efficient user revocation.First,an access controller is introduced into the existing scheme,and then,secret keys are generated corporately by the attribute authority and access controller.Second,an efficient user revocation mechanism is achieved using a version key that supports forward and backward security.The analysis proves that our scheme is secure and efficient in user authorization and revocation. 展开更多
关键词 access control ABE efficient revocation removing escrow cloud computing
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A practical nonlinear controller for levitation system with magnetic flux feedback 被引量:4
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作者 李金辉 李杰 《Journal of Central South University》 SCIE EI CAS CSCD 2016年第7期1729-1739,共11页
This work proposes a practical nonlinear controller for the MIMO levitation system. Firstly, the mathematical model of levitation modules is developed and the advantages of the control scheme with magnetic flux feedba... This work proposes a practical nonlinear controller for the MIMO levitation system. Firstly, the mathematical model of levitation modules is developed and the advantages of the control scheme with magnetic flux feedback are analyzed when compared with the current feedback. Then, a backstepping controller with magnetic flux feedback based on the mathematical model of levitation module is developed. To obtain magnetic flux signals for full-size maglev system, a physical method with induction coils installed to winding of the electromagnet is developed. Furthermore, to avoid its hardware addition, a novel conception of virtual magnetic flux feedback is proposed. To demonstrate the feasibility of the proposed controller, the nonlinear dynamic model of full-size maglev train with quintessential details is developed. Based on the nonlinear model, the numerical comparisons and related experimental validations are carried out. Finally, results illustrating closed-loop performance are provided. 展开更多
关键词 MAGLEV levitation system BACKSTEPPING magnetic flux
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MAVP-FE:Multi-Authority Vector Policy Functional Encryption with Efficient Encryption and Decryption 被引量:1
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作者 WANG Jing HUANG Chuanhe +3 位作者 YANG Kan WANG Jinhai WANG Xiaomao CHEN Xi 《China Communications》 SCIE CSCD 2015年第6期126-140,共15页
In cloud,data access control is a crucial way to ensure data security.Functional encryption(FE) is a novel cryptographic primitive supporting fine-grained access control of encrypted data in cloud.In FE,every cipherte... In cloud,data access control is a crucial way to ensure data security.Functional encryption(FE) is a novel cryptographic primitive supporting fine-grained access control of encrypted data in cloud.In FE,every ciphertext is specified with an access policy,a decryptor can access the data if and only if his secret key matches with the access policy.However,the FE cannot be directly applied to construct access control scheme due to the exposure of the access policy which may contain sensitive information.In this paper,we deal with the policy privacy issue and present a mechanism named multi-authority vector policy(MAVP) which provides hidden and expressive access policy for FE.Firstly,each access policy is encoded as a matrix and decryptors can only obtain the matched result from the matrix in MAVP.Then,we design a novel function encryption scheme based on the multi-authority spatial policy(MAVPFE),which can support privacy-preserving yet non-monotone access policy.Moreover,we greatly improve the efficiency of encryption and decryption in MAVP-FE by shifting the major computation of clients to the outsourced server.Finally,the security and performance analysis show that our MAVP-FE is secure and efficient in practice. 展开更多
关键词 cloud storage data access control functional encryption hidden access policy efficiency
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Synchronization of perturbed chaotic systems via nonlinear control
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作者 郭凌 年晓红 潘欢 《Journal of Central South University》 SCIE EI CAS 2012年第10期2803-2809,共7页
Chaos synchronization of systems with perturbations was investigated.A generic nonlinear control scheme to realize chaos synchronization of systems was proposed.This control scheme is flexible and practicable,and give... Chaos synchronization of systems with perturbations was investigated.A generic nonlinear control scheme to realize chaos synchronization of systems was proposed.This control scheme is flexible and practicable,and gives more freedom in designing controllers in order to achieve some desired performance.With the aid of Lyapunov stability theorem and partial stability theory,two cases were presented:1) Chaos synchronization of the system without perturbation or with vanishing perturbations;2) The boundness of the error state for the system with nonvanishing perturbations satisfying some conditions.Finally,several simulations for Lorenz system were provided to verify the effectiveness and feasibility of our method.Compared numerically with the existing results of linear feedback control scheme,the results are sharper than the existing ones. 展开更多
关键词 chaotic system SYNCHRONIZATION PERTURBATIONS nonlinear control scheme linear feedback scheme
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Whole process control and precision therapy in lung cancer 被引量:2
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作者 Zhaozhe Liu Xiaodong Xie 《Oncology and Translational Medicine》 2017年第3期91-92,共2页
Lung cancer is one of the most common malignant tumors in the world. Non-small cell lung cancer (NSCLC) accounts for approximately 80% of lung cancer cases, and approximately 75% of patients are diagnosed in the mid... Lung cancer is one of the most common malignant tumors in the world. Non-small cell lung cancer (NSCLC) accounts for approximately 80% of lung cancer cases, and approximately 75% of patients are diagnosed in the middle and late stages. The treatment methods mainly include surgery, chemotherapy, radiotherapy, molecular targeted therapy, traditional Chinese medicine therapy, and immune therapy. We summarize the current status of lung cancer-related treatment options and targets. 展开更多
关键词 Cisplatin administration radiotherapy chemotherapy emetic thalidomide maintenance satisfactory Thalidomide sequencing
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Design of the PLC-based burner Control System
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作者 HU Hai-dong DIAO Jin-xia SUN Shao-hua 《International Journal of Technology Management》 2013年第3期69-71,共3页
With consideration to the acid gas incinerator burned and the problems identified during its application, renovation program has been proposed. According to the new design, draught burners with automatic control syste... With consideration to the acid gas incinerator burned and the problems identified during its application, renovation program has been proposed. According to the new design, draught burners with automatic control system shall be used to eliminate problems encountered during application of original burner. In addition to implement automatic control of combustion processes, the new system may minimize labor intensity and enhance safety of facilities. 展开更多
关键词 INCINERATOR BURNER configuration remote control Proportion Integration Differentiation
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Stabilization of Delayed Networks with Different Nodes
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作者 徐君群 唐万生 张建雄 《Transactions of Tianjin University》 EI CAS 2011年第2期151-156,共6页
In this paper,the control of complex delayed networks with different nodes is proposed.Firstly,the stabilization of coupled networks with time delay is investigated.By constructing a Lyapunov function,a linear feedbac... In this paper,the control of complex delayed networks with different nodes is proposed.Firstly,the stabilization of coupled networks with time delay is investigated.By constructing a Lyapunov function,a linear feedback controller design procedure for the networks is converted to the problem of solving a set of linear matrix inequalities.Then the results are extended to networks with both delayed dynamical nodes and delayed couplings.It is shown that the stabilization of complex networks is determined by the dynamics of each uncoupled node,coupling matrix and feedback gain matrix of networks.Two examples are simulated.In the first example,a network with 10 nodes consisting of Lorenz systems and systems proposed by Zhang in 2009 is given.It is found that the network states are divergent without control,and convergent under designed linear feedback controllers.In the second example,a larger network with 100 nodes consisting of delayed Chen systems and delayed Lorenz systems is given.The proposed method is also effective for large scale networks. 展开更多
关键词 complex network time delay linear feedback linear matrix inequalities
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IVF-ET促排卵方案在多囊卵巢综合征患者中的应用进展 被引量:10
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作者 刘丹 李丽 童国庆 《大连医科大学学报》 CAS 2019年第4期361-365,共5页
多囊卵巢综合征(PCOS)患者的亚生育状态困扰着许多夫妇,随着辅助生殖技术的不断发展,越来越多的PCOS不孕患者选择接受体外受精-胚胎移植(IVF-ET)助孕。IVF-ET作为一种不孕症的治疗方式,为PCOS患者带来了希望,但PCOS患者病情复杂、多样,... 多囊卵巢综合征(PCOS)患者的亚生育状态困扰着许多夫妇,随着辅助生殖技术的不断发展,越来越多的PCOS不孕患者选择接受体外受精-胚胎移植(IVF-ET)助孕。IVF-ET作为一种不孕症的治疗方式,为PCOS患者带来了希望,但PCOS患者病情复杂、多样,促使卵泡发育的促性腺激素(Gn)剂量和导致卵巢过度刺激(OHSS)发生的剂量非常接近,使得临床工作极富挑战。因此,临床上治疗PCOS不孕症患者需要选择一种合适的促排卵方案,以获得高的妊娠率和低并发症发生率。促排卵方案各有其优缺点,目前没有哪一种方案能够推广成为公认最适宜PCOS患者的促排卵方案。本文综述了较适宜的五种促排方案的优缺点,以期指导临床。 展开更多
关键词 多囊卵巢综合征 不孕 控制促排卵方案
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波塞冬分类标准下的不同卵巢刺激方案对卵巢低反应患者的疗效分析 被引量:3
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作者 李飞 牛爱琴 +4 位作者 冯建兵 王晨晨 冯兴梅 张亚莉 陈莹 《中华生殖与避孕杂志》 CSCD 北大核心 2021年第9期770-775,共6页
目的探讨基于波塞冬分类标准下的卵泡期长效长方案、黄体期短效长方案和拮抗剂方案在卵巢低反应人群中的治疗效果,为卵巢低反应患者提供合适的治疗方案。方法回顾性队列研究分析2013年3月至2018年12月期间在郑州大学第一临床学院生殖医... 目的探讨基于波塞冬分类标准下的卵泡期长效长方案、黄体期短效长方案和拮抗剂方案在卵巢低反应人群中的治疗效果,为卵巢低反应患者提供合适的治疗方案。方法回顾性队列研究分析2013年3月至2018年12月期间在郑州大学第一临床学院生殖医学中心行体外受精(in vitro fertilization,IVF)/卵胞质内单精子注射(intracytoplasmic sperm injection,ICSI)治疗的,且根据波塞冬分类标准筛选卵巢低反应预期患者的临床资料,按年龄因素分为低年龄组(<35岁组)和高年龄组(≥35岁组),进行不同治疗方案的临床疗效对比。结果本研究共纳入患者1249例,其中低年龄组410例,高年龄组839例。在低年龄组中,卵泡期长效长方案相对比于黄体期短效长方案和拮抗剂方案,可获得更多的卵母细胞数[(5.6±3.6)枚比(4.6±3.2)枚比(2.4±1.7)枚,P<0.001]和可移植胚胎数[(2.2±1.6)枚比(1.6±1.6)枚比(1.1±1.1)枚,P<0.001],更低的移植周期取消率[20.8%(33/159)比39.5%(49/124)比69.3%(88/127),P<0.001],更高的妊娠率[40.9%(65/159)比29.0%(36/124)比15.7%(20/127),P<0.001]和活产率[31.4%(50/159)比23.4%(29/124)比12.6%(16/127),P<0.001],三种治疗方案的种植率和流产率差异均无统计学意义(P>0.05)。在高年龄组中,卵泡期长效长方案相对比于黄体期短效长方案和拮抗剂方案,可获得更多的卵母细胞数[(3.9±2.8)枚比(3.1±2.3)枚比(2.5±1.8)枚,P<0.001]和可移植胚胎数[(2.8±2.0)枚比(2.4±2.0)枚比(2.1±1.7)枚,P<0.001],但三种治疗方案在种植率、妊娠率、流产率和活产率方面差异均无统计学意义(P>0.05)。结论对于预期卵巢低反应的年轻患者,卵泡期长效长方案比黄体期短效长方案和拮抗剂方案拥有更好的临床结局。值得强调的是年龄越大,妊娠结局越差,另外应根据卵巢低反应患者的特点和个体差异针对性制定治疗方案。 展开更多
关键词 波塞冬标准 卵巢低反应 控制卵巢刺激方案 受精 体外 活产
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年龄对体外受精-胚胎移植患者累积活产率的影响 被引量:4
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作者 杨洋 初子琪 +3 位作者 李丽 王小玲 张武文 童国庆 《中华中医药杂志》 CAS CSCD 北大核心 2021年第9期5505-5509,共5页
目的:探讨年龄对体外受精-胚胎移植(IVF-ET)患者累积活产率的影响,为指导个体化的治疗提供临床依据。方法:回顾性分析2017年1月至2018年9月在上海中医药大学附属曙光医院生殖医学中心进行IVF的患者338例,共1 169周期。比较不同年龄段(&l... 目的:探讨年龄对体外受精-胚胎移植(IVF-ET)患者累积活产率的影响,为指导个体化的治疗提供临床依据。方法:回顾性分析2017年1月至2018年9月在上海中医药大学附属曙光医院生殖医学中心进行IVF的患者338例,共1 169周期。比较不同年龄段(<30岁、30~34岁、35~39岁、≥40岁)的获卵数及妊娠结局,Logistic多因素分析影响累积活产率的相关因素,并以年龄为分层分析控制性卵巢刺激(COS)方案的优劣。结果:(1)随着年龄增加,获卵数、减数分裂中期(MⅡ)卵母细胞数、优胚数、临床妊娠率、活产率、累积活产率逐渐下降(P<0.01);(2)Logistic多因素分析显示:30~34岁患者累积活产的概率是<30岁患者的0.55倍,35~39岁患者是<30岁患者的0.41倍,≥40岁患者是<30岁患者的0.06倍(P<0.01);(3)<30岁患者和30~34岁患者,拮抗剂方案的累积活产率显著高于温和/微刺激(P<0.01,P<0.05);35~39岁患者,温和/微刺激方案累积活产率显著高于拮抗剂方案(P<0.05)。结论:累积活产率随着年龄增加而降低,年龄是影响IVF结局的重要因素。为获得更好妊娠结局,结合患者综合情况,<35岁患者优先考虑拮抗剂方案,≥35岁患者优先考虑温和/微刺激方案。 展开更多
关键词 年龄 累积活产率 体外受精-胚胎移植 控制卵巢刺激方案
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Global Output-Feedback Tracking for Nonlinear Cascade Systems with Unknown Growth Rate and Control Coefficients 被引量:1
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作者 YAN Xuehua LIU Yungang WANG Qingguo 《Journal of Systems Science & Complexity》 SCIE EI CSCD 2015年第1期30-46,共17页
This paper deals with the global practical tracking problem by output-feedback for a class of uncertain cascade systems with zero-dynamics and unmeasured states dependent growth.The systems investigated are substantia... This paper deals with the global practical tracking problem by output-feedback for a class of uncertain cascade systems with zero-dynamics and unmeasured states dependent growth.The systems investigated are substantially different from the closely related works,and have zero-dynamics,unknown growth rate,and unknown time-varying control coefficients.This makes the problem much more difficult to solve.Motivated by the authors' recent works,this paper proposes a new adaptive control scheme to achieve the global practical tracking.It is shown that the designed controller guarantees that the state of the resulting closed-loop system is globally bounded and the tracking error converges to a prescribed arbitrarily small neighborhood of the origin after a finite time.This is achieved by combining the methods of universal control and dead zone with backstepping technique,and using the framework of performance analysis in the closely related works.A numerical example demonstrates the effectiveness of the theoretical results. 展开更多
关键词 Adaptive control dynamic high-gain global practical tracking OUTPUT-FEEDBACK uncertain nonlinear systems.
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L_1 adaptive controller design for hypersonic formation flight 被引量:4
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作者 CHEN Qi WAN Jing AI JianLiang 《Science China(Technological Sciences)》 SCIE EI CAS CSCD 2016年第10期1597-1608,共12页
The design of an L_1 adaptive controller for hypersonic formation flight is presented. The traditional leader/wingman formation control problem is considered, with focused attention on dealing with the input disturban... The design of an L_1 adaptive controller for hypersonic formation flight is presented. The traditional leader/wingman formation control problem is considered, with focused attention on dealing with the input disturbance and parametric variations, both of which are intrinsic properties of the system that result in undesired control performance. A proportional-derivative control scheme based on nonlinear dynamic inversion is implemented as the baseline controller, and an L_1 adaptive controller is augmented to the baseline controller to attenuate the effects of input disturbance and parametric variations. Simulation results illustrate the effectiveness of the proposed control scheme. 展开更多
关键词 hypersonic flight control nonlinear dynamic inversion L1 adaptive control input disturbance parametric variation
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