Urbanization is the dominant form of land-use change in terms of impacts on water quality, hydrology, physical proper- ties of watersheds and their nonpoint source (NPS) pollution po- tential at present. Urbanization ...Urbanization is the dominant form of land-use change in terms of impacts on water quality, hydrology, physical proper- ties of watersheds and their nonpoint source (NPS) pollution po- tential at present. Urbanization has changed the source, process and sink of urban NPS pollution, especially raised the pollution load of urban runoff NPS in receiving water. Urban runoff pollu- tion is a hot spot of research on NPS. This paper analyzed type, source and harm of the NPS pollutants of urban runoff and its influence on the receiving water. Through estimating NPS pollu- tion load of urban runoff and summarizing the law and character- istics of urban runoff NPS systemically, study on management and control of urban runoff NPS pollution was focused on the applica- tion of BMPs (best management practices). It is a fresh method- ology that management and control on NPS pollution from urban surface runoff was analyzed by methods of landscape ecology, environmental economics and environmental management. The paper provided a scientific reference for mitigating urban water environment pressure and an effective method for management and control of NPS pollution from urban surface runoff..展开更多
Assembly variation analysis of parts that have flexible curved surfaces is much more difficult than that of solid bodies, because of structural deformations in the assembly process. Most of the current variation analy...Assembly variation analysis of parts that have flexible curved surfaces is much more difficult than that of solid bodies, because of structural deformations in the assembly process. Most of the current variation analysis methods either neglect the relationships among feature points on part surfaces or regard the distribution of all feature points as the same. In this study, the problem of flexible curved surface assembly is simplified to the matching of side lines. A methodology based on Bézier curves is proposed to represent the side lines of surfaces. It solves the variation analysis problem of flexible curved surface assembly when considering surface continuity through the relations between control points and data points. The deviations of feature points on side lines are obtained through control point distribution and are then regarded as inputs in commercial finite element analysis software to calculate the final product deformations. Finally, the proposed method is illustrated in two cases of antenna surface assembly.展开更多
A key control point in gene expression is the initiation of protein translation, with a universal stress response being constituted by in- hibitory phosphoryiation of the eukaryotic initiation factor 2α （el F2oL）. ...A key control point in gene expression is the initiation of protein translation, with a universal stress response being constituted by in- hibitory phosphoryiation of the eukaryotic initiation factor 2α （el F2oL）. In humans, four kinases sense diverse physiological stresses to regulate elF2α to control cell differentiation, adaptation, and survival. Here we develop a computational molecular model of elF2α and one of its kinases, the protein kinase R, to simulate the dynamics of their interaction. Predictions generated by coarse-grained dynamics simulations suggest a novel mode of action. Experimentation substantiates these predictions, identifying a previously unrecognized interface in the protein complex, which is constituted by dynamic residues in both elF2α and its kinases that are crucial to regulate protein translation. These findings call for a reinterpretation of the current mechanism of action of the el F2α kinases and demonstrate the value of conducting computational analysis to evaluate protein function.展开更多
基金Key Program of Natural Science Foundation of China(No. 40576024).
文摘Urbanization is the dominant form of land-use change in terms of impacts on water quality, hydrology, physical proper- ties of watersheds and their nonpoint source (NPS) pollution po- tential at present. Urbanization has changed the source, process and sink of urban NPS pollution, especially raised the pollution load of urban runoff NPS in receiving water. Urban runoff pollu- tion is a hot spot of research on NPS. This paper analyzed type, source and harm of the NPS pollutants of urban runoff and its influence on the receiving water. Through estimating NPS pollu- tion load of urban runoff and summarizing the law and character- istics of urban runoff NPS systemically, study on management and control of urban runoff NPS pollution was focused on the applica- tion of BMPs (best management practices). It is a fresh method- ology that management and control on NPS pollution from urban surface runoff was analyzed by methods of landscape ecology, environmental economics and environmental management. The paper provided a scientific reference for mitigating urban water environment pressure and an effective method for management and control of NPS pollution from urban surface runoff..
基金supported by the National Natural Science Foundation of China(Nos.51490663,51475418,and U1608256)the National Basic Research Program(973)of China(No.2015CB058100)
文摘Assembly variation analysis of parts that have flexible curved surfaces is much more difficult than that of solid bodies, because of structural deformations in the assembly process. Most of the current variation analysis methods either neglect the relationships among feature points on part surfaces or regard the distribution of all feature points as the same. In this study, the problem of flexible curved surface assembly is simplified to the matching of side lines. A methodology based on Bézier curves is proposed to represent the side lines of surfaces. It solves the variation analysis problem of flexible curved surface assembly when considering surface continuity through the relations between control points and data points. The deviations of feature points on side lines are obtained through control point distribution and are then regarded as inputs in commercial finite element analysis software to calculate the final product deformations. Finally, the proposed method is illustrated in two cases of antenna surface assembly.
文摘A key control point in gene expression is the initiation of protein translation, with a universal stress response being constituted by in- hibitory phosphoryiation of the eukaryotic initiation factor 2α （el F2oL）. In humans, four kinases sense diverse physiological stresses to regulate elF2α to control cell differentiation, adaptation, and survival. Here we develop a computational molecular model of elF2α and one of its kinases, the protein kinase R, to simulate the dynamics of their interaction. Predictions generated by coarse-grained dynamics simulations suggest a novel mode of action. Experimentation substantiates these predictions, identifying a previously unrecognized interface in the protein complex, which is constituted by dynamic residues in both elF2α and its kinases that are crucial to regulate protein translation. These findings call for a reinterpretation of the current mechanism of action of the el F2α kinases and demonstrate the value of conducting computational analysis to evaluate protein function.
