目的:研究温度-时间曲线下面积(Area under temperature-time curve,AUT)与中药活性成分提取率间的相关性,探讨温度-时间曲线下面积参数控制中药提取过程的可行性。方法:以水提丹参为模型药物,建立丹参水溶性成分指纹图谱;采取两种不同...目的:研究温度-时间曲线下面积(Area under temperature-time curve,AUT)与中药活性成分提取率间的相关性,探讨温度-时间曲线下面积参数控制中药提取过程的可行性。方法:以水提丹参为模型药物,建立丹参水溶性成分指纹图谱;采取两种不同的升温速度水提丹参,记录各时间点的温度,不同时间点在线取样并检测指纹图谱,找出六个主要峰,求出AUT。运用线形回归法建立AUT与六个主要峰峰面积的函数相关性,考察其相关程度。结果:各主要峰峰面积与AUT1/2的相关性较好,绝大部分的相关系数大于0.97。结论:温度-时间曲线下面积参数用于控制中药提取过程具有可行性。展开更多
Considering that the on-line measurement and automatic control of element component content(ECC) are difficult to perform in rare earth cascade extraction process, the ECC distribution profile is dynamically regulated...Considering that the on-line measurement and automatic control of element component content(ECC) are difficult to perform in rare earth cascade extraction process, the ECC distribution profile is dynamically regulated at all stages to assess the effect of product purity control. Focusing on the theory of countercurrent extraction, the technology parameters and pre-setting flow-rates during the extract process are designed. Under varying process parameters, a novel step by step model is also proposed for each stage to analyze the impact on the distribution profile change. Combining the mass balance model and ECC changing trend at the monitoring stage, the ECC distribution profile can be automatically regulated by dynamically compensating the related extract or scrubbing liquid flow-rate. To this end, the required product purity at the two outlets is achieved. Based on Wincc and Matlab dynamic simulators, a specific Pr/Nd cascade extraction process is used to illustrate and demonstrate the application of the present approach.展开更多
文摘目的:研究温度-时间曲线下面积(Area under temperature-time curve,AUT)与中药活性成分提取率间的相关性,探讨温度-时间曲线下面积参数控制中药提取过程的可行性。方法:以水提丹参为模型药物,建立丹参水溶性成分指纹图谱;采取两种不同的升温速度水提丹参,记录各时间点的温度,不同时间点在线取样并检测指纹图谱,找出六个主要峰,求出AUT。运用线形回归法建立AUT与六个主要峰峰面积的函数相关性,考察其相关程度。结果:各主要峰峰面积与AUT1/2的相关性较好,绝大部分的相关系数大于0.97。结论:温度-时间曲线下面积参数用于控制中药提取过程具有可行性。
基金Supported by the National Natural Science Foundation of China(51174091,61164013,61364013)
文摘Considering that the on-line measurement and automatic control of element component content(ECC) are difficult to perform in rare earth cascade extraction process, the ECC distribution profile is dynamically regulated at all stages to assess the effect of product purity control. Focusing on the theory of countercurrent extraction, the technology parameters and pre-setting flow-rates during the extract process are designed. Under varying process parameters, a novel step by step model is also proposed for each stage to analyze the impact on the distribution profile change. Combining the mass balance model and ECC changing trend at the monitoring stage, the ECC distribution profile can be automatically regulated by dynamically compensating the related extract or scrubbing liquid flow-rate. To this end, the required product purity at the two outlets is achieved. Based on Wincc and Matlab dynamic simulators, a specific Pr/Nd cascade extraction process is used to illustrate and demonstrate the application of the present approach.
