Based on the interfacial ligand exchange model and the law of conservation of mass, the multi-stage enantioselective liquid-liquid extraction model has been established to analyze and discuss on multi-stage centrifuga...Based on the interfacial ligand exchange model and the law of conservation of mass, the multi-stage enantioselective liquid-liquid extraction model has been established to analyze and discuss on multi-stage centrifugal fractional extraction process of4-nitrobenzene glycine （PGL） enantiomers. The influence of phase ratio, extractant concentra- tion, and PFff concentration on the concentrations of enantiomers in the extract and raffinate was investigated by experiment and simulation. A good agreement between model and experiment was obtained. On this basis, the influence of many parameters such as location of stage, concentration levels, extractant excess, and number of stages on the symmetric separation performance was simulated. The optimal location of feed stage is the middle of fractional extraction equipment. The feed flow must satisfy a restricted relationship on flow ratios and the liquid throughout of centrifugal device. For desired purity specification, the required flow ratios decrease with extractant concentration and increase with PFff concentration. When the number of stages is 18 stages at extractant excess of 1.0 or 14 stages at extractant excess of 2.0, the eeeo （equal enantiomeric excess） can reach to 99%展开更多
基金Supported by the National Natural Science Foundation of China(21176062)the Natural Science Foundation of Hunan Province(12JJ2007)+2 种基金Scientific Research Fund of Hunan Provincial Education Department(12B053)Science and Technology Planning Project of Hunan Province(2012GK3107)Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province
文摘Based on the interfacial ligand exchange model and the law of conservation of mass, the multi-stage enantioselective liquid-liquid extraction model has been established to analyze and discuss on multi-stage centrifugal fractional extraction process of4-nitrobenzene glycine （PGL） enantiomers. The influence of phase ratio, extractant concentra- tion, and PFff concentration on the concentrations of enantiomers in the extract and raffinate was investigated by experiment and simulation. A good agreement between model and experiment was obtained. On this basis, the influence of many parameters such as location of stage, concentration levels, extractant excess, and number of stages on the symmetric separation performance was simulated. The optimal location of feed stage is the middle of fractional extraction equipment. The feed flow must satisfy a restricted relationship on flow ratios and the liquid throughout of centrifugal device. For desired purity specification, the required flow ratios decrease with extractant concentration and increase with PFff concentration. When the number of stages is 18 stages at extractant excess of 1.0 or 14 stages at extractant excess of 2.0, the eeeo （equal enantiomeric excess） can reach to 99%
