目的探索卤泛群自微乳给药系统(halofantrine self-microemulsifying drug delivery system,HF-SMEDDS)通过改善淋巴转运增加HF口服生物利用度的可能性。方法以亚油酸乙酯为油相,吐温80为乳化剂,无水乙醇为助乳化剂,制备并筛选HF-SMEDD...目的探索卤泛群自微乳给药系统(halofantrine self-microemulsifying drug delivery system,HF-SMEDDS)通过改善淋巴转运增加HF口服生物利用度的可能性。方法以亚油酸乙酯为油相,吐温80为乳化剂,无水乙醇为助乳化剂,制备并筛选HF-SMEDDS处方,以油相和混合乳化剂(吐温80和无水乙醇)的比例及乳化剂与助乳化剂的比例为考察因素,以静脉给药组为对照,以二插管大鼠为动物模型,考察不同HF-SMEDDS处方口服给药后在大鼠体内的生物利用度。结果9组处方HF-SMEDDS粒径分布在20.6~336.5 nm,经淋巴转运药量可达到总给药量的2.25%~19.6%。结论HF-SMEDDS能有效提高药物的生物利用度,为HF口服制剂开发提供一定研究思路与基础。展开更多
Objective： The aim of this study was to compare the efficacy in alleviating the endotracheal tube related discomfort and the safetyof intracufflidocaine （in different forms） with air and/or normal saline （NS） dur...Objective： The aim of this study was to compare the efficacy in alleviating the endotracheal tube related discomfort and the safetyof intracufflidocaine （in different forms） with air and/or normal saline （NS） during general anesthesia with tracheal intubation. Methods： Cochrane Central Register of Controlled Trials, PubMed and Embase were searched for relevant studies. Thirteen randomized, controlled trials involving 1 010 patients were ultimately identified. A meta-analysis of all randomized controlled trials fulfilling the predefined criteria was performed. Random-effect model and subgroup studies were used when significant heterogeneity existed among those trials. Results： Compared with air and NS, intracufflidocaine could significantly alleviate the severity of sore throat at different time points （15min, 30min, lh, 2h, 3h, 6h, 12h and 24h aiter extubation） and the occurrence of cough, restlessness, postoperative nausea and vomiting, dysphonia and hoarseness. Besides intracufflidocaine brought about a significant prolongation of spontaneous ventilation time. It was worth mentioning that, compared withlidocaine or its hydrochloride form, alkalinized lidocainewas much more efficient in reducing the severity of sore throat and prolonging spontaneous ventilation time. Conclusion： The present meta-analysis indicates that intracuttlidocaine can significantly improve endotracheal tube tolerance and this improvement can be strengthened by alkalinization of lidocaine.展开更多
To shorten operation time and improve survival rate of rats with myocardial ischemia or myocardial infarction,we use a novel device comprised of a face mask and a head/neck retainer in this study.We report the basic d...To shorten operation time and improve survival rate of rats with myocardial ischemia or myocardial infarction,we use a novel device comprised of a face mask and a head/neck retainer in this study.We report the basic design of the novel respiratory face mask(RFM) and evaluate its performance in a rat model of myocardial ischemia.The device is cost-effective and easier to handle than other devices,such as tracheal intubation.Compared with conventional tracheal intubation,we found that RFM shortens operation time significantly while keeping blood indices normal;the mean operation time for rats in the mask group was(32±3) min,and that for the intubation group was(45±7) min(P<0.05).Moreover,the size and shape of the RFM can be changed according to the body weight of rats.In conclusion,RFM is an appropriate device for the establishment of myocardial infarction or ischemia-reperfusion in rats.展开更多
In this paper, the flow of blood through catheterized artery with mild constriction at the outer wall is considered. The closed form solutions are obtained for velocity and microrotation components. The impedance （re...In this paper, the flow of blood through catheterized artery with mild constriction at the outer wall is considered. The closed form solutions are obtained for velocity and microrotation components. The impedance （resistance to the flow） and wall shear stress are calculated. The effects of catheterization, coupling number, micropolar parameter, and height of the stenosis on impedance and wall shear stresses are discussed.展开更多
文摘Objective： The aim of this study was to compare the efficacy in alleviating the endotracheal tube related discomfort and the safetyof intracufflidocaine （in different forms） with air and/or normal saline （NS） during general anesthesia with tracheal intubation. Methods： Cochrane Central Register of Controlled Trials, PubMed and Embase were searched for relevant studies. Thirteen randomized, controlled trials involving 1 010 patients were ultimately identified. A meta-analysis of all randomized controlled trials fulfilling the predefined criteria was performed. Random-effect model and subgroup studies were used when significant heterogeneity existed among those trials. Results： Compared with air and NS, intracufflidocaine could significantly alleviate the severity of sore throat at different time points （15min, 30min, lh, 2h, 3h, 6h, 12h and 24h aiter extubation） and the occurrence of cough, restlessness, postoperative nausea and vomiting, dysphonia and hoarseness. Besides intracufflidocaine brought about a significant prolongation of spontaneous ventilation time. It was worth mentioning that, compared withlidocaine or its hydrochloride form, alkalinized lidocainewas much more efficient in reducing the severity of sore throat and prolonging spontaneous ventilation time. Conclusion： The present meta-analysis indicates that intracuttlidocaine can significantly improve endotracheal tube tolerance and this improvement can be strengthened by alkalinization of lidocaine.
基金(No.30600580) supported by the National Natural Science Foundation of China
文摘To shorten operation time and improve survival rate of rats with myocardial ischemia or myocardial infarction,we use a novel device comprised of a face mask and a head/neck retainer in this study.We report the basic design of the novel respiratory face mask(RFM) and evaluate its performance in a rat model of myocardial ischemia.The device is cost-effective and easier to handle than other devices,such as tracheal intubation.Compared with conventional tracheal intubation,we found that RFM shortens operation time significantly while keeping blood indices normal;the mean operation time for rats in the mask group was(32±3) min,and that for the intubation group was(45±7) min(P<0.05).Moreover,the size and shape of the RFM can be changed according to the body weight of rats.In conclusion,RFM is an appropriate device for the establishment of myocardial infarction or ischemia-reperfusion in rats.
文摘In this paper, the flow of blood through catheterized artery with mild constriction at the outer wall is considered. The closed form solutions are obtained for velocity and microrotation components. The impedance （resistance to the flow） and wall shear stress are calculated. The effects of catheterization, coupling number, micropolar parameter, and height of the stenosis on impedance and wall shear stresses are discussed.
