Background： Research interest in both partnered Latin dance and non-partnered Latin-themed aerobic dance has increased in recent years, likely a result of the gaining popularity of these types of instructor-led group...Background： Research interest in both partnered Latin dance and non-partnered Latin-themed aerobic dance has increased in recent years, likely a result of the gaining popularity of these types of instructor-led group classes among the mainstream dance and fitness audiences; however, the efficacy of these activities for the purposes of health promotion currently remains unclear. The purpose of this study was to simultaneously assess the physiological responses and psychological experiences during salsa dance and Zumba fitness in a community sample of physically inactive women. Methods： Twenty-four participants, aged 22-56 years, visited the laboratory to perform a graded exercise test for determination of maximal oxygen uptake and maximal heart rate. The participants then attended 2 partnered salsa dance and 2 non-partnered Zumba fitness classes each in a counterbalanced order over a 2-week period. The 1-h classes were taught by certified instructors in established venues in the Royal Borough of Kingston and the surrounding communities of London, UK. Physiological data were collected using a wrist-worn ActiGraph wGT3X＋ acceler- ometer with accompanying heart rate monitor and were processed using previously validated dance-specific techniques. Psychological experiences were measured via the Subjective Exercise Experiences Scale. Results： There was a significantly higher （p 〈 0.001） total time spent in moderate-to-vigorous physical activity （51.2± 3.1 vs. 32.6 ±5.9 min）, total energy expenditure （411±66 vs. 210 ± 46 kcal）, and total step count （6773 ± 556 vs. 4108 ±781 steps） during Zumba fitness when compared to salsa dance. Significant pre- to post-class improvements in positive well-being （p 〈 0.01, partial 7/2 = 0.4l） and psychological distress （p 〈 0.001, partial 02 = 0.72） were simultaneously observed for both salsa dance and Zumba fitness. Conclusion： The acute responses to classes of partnered Latin dance and non-partnered Latin-themed aerobic dance suggest that in physically inactive women participation is indeed efficacious in terms of community-based physical activity and psychosocial health promotion.展开更多
Objective Clinical evidence has suggested that AT1 receptor blocker （ARB） could prevent the development of heart failure. Decreased sarcoplasmic reticulum（SR） Ca2＋ content, which is due to reduced SR calcium reup...Objective Clinical evidence has suggested that AT1 receptor blocker （ARB） could prevent the development of heart failure. Decreased sarcoplasmic reticulum（SR） Ca2＋ content, which is due to reduced SR calcium reuptake by SERCA2a, is responsible for defective systolic function in failing heart. To better understand how ARB could improve cardiac systolic dysfunction, we studied the effects of Valsartan on calcium reuptake of SR and its regulatory proteins in heart failure rabbits. Methods Thirty rabbits were divided into three groups： sham rabbits（controls, n=11）, rabbits with heart failure treated with Valsartan （n=11） and rabbits with heart failure but without Valsartan treatment （n=8）.Rabbit heart failure model was established by volume plus pressure overload. Cardiac function was measured by echocardiography, SR calcium uptake was determined by measuring extra vesicular free [Ca2＋] changes in a fluorescence spectrophotometer. SERCA2a, Ser 16-phosphorylated phospholamban （p-PLB）, PKA and PP 1 a protein abundance were determined by use of Western blot analysis. Results Compared to control rabbits, the ejection fractions in the HF rabbits were significantly decreased （P〈0.05）, these changes could be significantly attenuated by Valsartan treatment （P〈0.05）.Calcium reuptake of SR, activity of SERCA2a and PKA decreased in heart failing myocytes （P〈0.05）, with down regulations of p-PLB, SERCA2a and PKA, but up regulation ofPP la in ventricular samples from the failing rabbits （P〈0.05）. All of these changes were attenuated by Valsartan treatment （all P〈0.05）. Conclusion Valsartan improved cardiac function in volume plus pressure overload induced heart failure of rabbits possibly by restoring the SR calcium uptake resulted from attenuating the activities and expressions of SERCA2a and its regulatory proteins （J Geriatr Cardio12009; 6：173-177）.展开更多
Objective To compare contrast-enhanced magnetic resonance imaging （ceMRI） with nuclear metabolic imaging for the assessment of myocardial viability in patients with chronic ischemic heart disease. Methods Twenty pa...Objective To compare contrast-enhanced magnetic resonance imaging （ceMRI） with nuclear metabolic imaging for the assessment of myocardial viability in patients with chronic ischemic heart disease. Methods Twenty patients with suspected chronic ischemic heart disease underwent ceMRI and technetium-99m sestamibi single-photon emission computed tomography （SPECT）. Patients with positive SPECT results also underwent 18 F-fluorodeoxyglucose （FDG） SPECT. In a 17-segment model, the segmental extent of hyperenhancement （SEH） by ceMRI was compared with segmental FDG and sestamibi uptake by SPECT. Correlation between the extent of hyperenhancement by ceMRI and left ventricular function was analyzed. Seven patients got negative results both in ceMRI and technetium-99m sestamibi SPECT. The rest 13 patients with positive results then underwent ^18F-FDG SPECT. In 221 segments of 13 patients, SEH was （2. 1±8.2）%, （25.0±13.7 ）%, and （57. 7±23.6 ）% in segments with normal metabolism/perfusion, metabolism/perfusion mismatch, and matched defects, respectively, and there were significant differences between either two of them （ all P 〈 0.05）. By receiver operating characteristic curve analysis, the area under the curve was 0. 95 for the differentiation between viable and non-viable segments. At the cutoff value of 34%, SEH optimally differentiated viable from non-viable segments defined by SPECT. Using this threshold, the sensitivity and specificity of ceMRI to detect non-viable myocardium as defined by SPECT were 92% and 93%, respectively. Hyperenhancement size by ceMRI was correlated negatively with the left ventricular ejection fraction （ r = - 0.90, P 〈 0.01 ） and positively with left ventricular volumes （ r = 0. 62 for end-diastolic volume, r = 0.75 for end-systolic volume, both P 〈 0.05 ）. Conclusion CeMRI allows assessment of myocardial viability with a high accuracy in patients with chronic ischemic heart disease.展开更多
文摘Background： Research interest in both partnered Latin dance and non-partnered Latin-themed aerobic dance has increased in recent years, likely a result of the gaining popularity of these types of instructor-led group classes among the mainstream dance and fitness audiences; however, the efficacy of these activities for the purposes of health promotion currently remains unclear. The purpose of this study was to simultaneously assess the physiological responses and psychological experiences during salsa dance and Zumba fitness in a community sample of physically inactive women. Methods： Twenty-four participants, aged 22-56 years, visited the laboratory to perform a graded exercise test for determination of maximal oxygen uptake and maximal heart rate. The participants then attended 2 partnered salsa dance and 2 non-partnered Zumba fitness classes each in a counterbalanced order over a 2-week period. The 1-h classes were taught by certified instructors in established venues in the Royal Borough of Kingston and the surrounding communities of London, UK. Physiological data were collected using a wrist-worn ActiGraph wGT3X＋ acceler- ometer with accompanying heart rate monitor and were processed using previously validated dance-specific techniques. Psychological experiences were measured via the Subjective Exercise Experiences Scale. Results： There was a significantly higher （p 〈 0.001） total time spent in moderate-to-vigorous physical activity （51.2± 3.1 vs. 32.6 ±5.9 min）, total energy expenditure （411±66 vs. 210 ± 46 kcal）, and total step count （6773 ± 556 vs. 4108 ±781 steps） during Zumba fitness when compared to salsa dance. Significant pre- to post-class improvements in positive well-being （p 〈 0.01, partial 7/2 = 0.4l） and psychological distress （p 〈 0.001, partial 02 = 0.72） were simultaneously observed for both salsa dance and Zumba fitness. Conclusion： The acute responses to classes of partnered Latin dance and non-partnered Latin-themed aerobic dance suggest that in physically inactive women participation is indeed efficacious in terms of community-based physical activity and psychosocial health promotion.
基金This work was supported by National Natural Science Foundation of China （No 30800460）.
文摘Objective Clinical evidence has suggested that AT1 receptor blocker （ARB） could prevent the development of heart failure. Decreased sarcoplasmic reticulum（SR） Ca2＋ content, which is due to reduced SR calcium reuptake by SERCA2a, is responsible for defective systolic function in failing heart. To better understand how ARB could improve cardiac systolic dysfunction, we studied the effects of Valsartan on calcium reuptake of SR and its regulatory proteins in heart failure rabbits. Methods Thirty rabbits were divided into three groups： sham rabbits（controls, n=11）, rabbits with heart failure treated with Valsartan （n=11） and rabbits with heart failure but without Valsartan treatment （n=8）.Rabbit heart failure model was established by volume plus pressure overload. Cardiac function was measured by echocardiography, SR calcium uptake was determined by measuring extra vesicular free [Ca2＋] changes in a fluorescence spectrophotometer. SERCA2a, Ser 16-phosphorylated phospholamban （p-PLB）, PKA and PP 1 a protein abundance were determined by use of Western blot analysis. Results Compared to control rabbits, the ejection fractions in the HF rabbits were significantly decreased （P〈0.05）, these changes could be significantly attenuated by Valsartan treatment （P〈0.05）.Calcium reuptake of SR, activity of SERCA2a and PKA decreased in heart failing myocytes （P〈0.05）, with down regulations of p-PLB, SERCA2a and PKA, but up regulation ofPP la in ventricular samples from the failing rabbits （P〈0.05）. All of these changes were attenuated by Valsartan treatment （all P〈0.05）. Conclusion Valsartan improved cardiac function in volume plus pressure overload induced heart failure of rabbits possibly by restoring the SR calcium uptake resulted from attenuating the activities and expressions of SERCA2a and its regulatory proteins （J Geriatr Cardio12009; 6：173-177）.
文摘Objective To compare contrast-enhanced magnetic resonance imaging （ceMRI） with nuclear metabolic imaging for the assessment of myocardial viability in patients with chronic ischemic heart disease. Methods Twenty patients with suspected chronic ischemic heart disease underwent ceMRI and technetium-99m sestamibi single-photon emission computed tomography （SPECT）. Patients with positive SPECT results also underwent 18 F-fluorodeoxyglucose （FDG） SPECT. In a 17-segment model, the segmental extent of hyperenhancement （SEH） by ceMRI was compared with segmental FDG and sestamibi uptake by SPECT. Correlation between the extent of hyperenhancement by ceMRI and left ventricular function was analyzed. Seven patients got negative results both in ceMRI and technetium-99m sestamibi SPECT. The rest 13 patients with positive results then underwent ^18F-FDG SPECT. In 221 segments of 13 patients, SEH was （2. 1±8.2）%, （25.0±13.7 ）%, and （57. 7±23.6 ）% in segments with normal metabolism/perfusion, metabolism/perfusion mismatch, and matched defects, respectively, and there were significant differences between either two of them （ all P 〈 0.05）. By receiver operating characteristic curve analysis, the area under the curve was 0. 95 for the differentiation between viable and non-viable segments. At the cutoff value of 34%, SEH optimally differentiated viable from non-viable segments defined by SPECT. Using this threshold, the sensitivity and specificity of ceMRI to detect non-viable myocardium as defined by SPECT were 92% and 93%, respectively. Hyperenhancement size by ceMRI was correlated negatively with the left ventricular ejection fraction （ r = - 0.90, P 〈 0.01 ） and positively with left ventricular volumes （ r = 0. 62 for end-diastolic volume, r = 0.75 for end-systolic volume, both P 〈 0.05 ）. Conclusion CeMRI allows assessment of myocardial viability with a high accuracy in patients with chronic ischemic heart disease.
