We propose a general multigroup model for cholera dynamics that involves both direct and indirect transmission pathways and that incorporates spatial heterogeneity. Under biologically feasible conditions, we show that...We propose a general multigroup model for cholera dynamics that involves both direct and indirect transmission pathways and that incorporates spatial heterogeneity. Under biologically feasible conditions, we show that the basic reproduction number R0 remains a sharp threshold for cholera dynamics in multigroup settings. We verify the analysis by numerical simulation results. We also perform an optimal control study to explore optimal vaccination strategy for cholera outbreaks.展开更多
文摘We propose a general multigroup model for cholera dynamics that involves both direct and indirect transmission pathways and that incorporates spatial heterogeneity. Under biologically feasible conditions, we show that the basic reproduction number R0 remains a sharp threshold for cholera dynamics in multigroup settings. We verify the analysis by numerical simulation results. We also perform an optimal control study to explore optimal vaccination strategy for cholera outbreaks.