阿奇霉素治疗儿童支原体肺炎38例

目的 :比较静脉注射阿奇霉素与红霉素治疗儿童支原体肺炎的疗效及安全性。方法 :儿童支原体肺炎 72例 ,随机分为 2组 ,治疗组 3 8例 ,静脉滴注阿奇霉素 10mg·kg 1 ·d 1 ,qd ,连用 5d ;对照组 3 4例 ,静脉滴注红霉素 2 0～ 3 0mg·kg 1 ·d 1 ,分 3或 4次滴注 ,连用 14d。结果 :治疗组和对照组的有效率分别为 97.4%和 94.1% (P >0 .0 5 ) ,复发率分别为 5 .3 %和 5 .8% (P >0 .0 5 )。结论 :静脉注射阿奇霉素与红霉素治疗儿童支原体肺炎的疗效相当 ,但阿奇霉素疗程短 ,不良反应小。

阿奇霉素联合孟鲁司特钠对肺炎支原体肺炎患儿免疫功能及肺功能的影响

目的探讨阿奇霉素联合孟鲁司特钠对肺炎支原体肺炎患儿免疫球蛋白、T细胞亚群及肺功能的影响。方法肺炎支原体肺炎患儿112例,随机分为治疗组与对照组,各56例。对照组采用阿奇霉素治疗,治疗组在对照组的基础上联合使用孟鲁司特钠4~5 mg,po,qd,连续14 d,检测并比较两组的免疫球蛋白、T细胞亚群及肺功能指标。结果治疗后,两组患者的Ig A、Ig G、Ig M、CD+8水平均显著降低,且治疗组低于对照组(P<0.05)。两组患者的CD+3、CD+4、CD+4/CD+8均升高,且治疗组高于对照组(P<0.05);两组患儿的第1秒最大呼气量(FEV1)、用力肺活量(FVC)和最大呼气峰流速值(PEF)均升高,且治疗组高于对照组(P<0.05)。治疗组和对照组的总有效率分别为94.64%,80.36%(P<0.05)。结论阿奇霉素联合孟鲁司特钠可有效改善肺炎支原体肺炎患儿免疫功能及肺功能,临床疗效较好。

健脾益气活血汤治疗小儿支原体肺炎30例观察

为观察健脾益气活血汤治疗小儿支原体肺炎疗效。将60例支原体肺炎患儿随机分成两组,对照组用阿奇霉素10mg/(kg.d)静滴,治疗组在对照组基础上加用健脾益气活血汤治疗。治疗1周观察比较疗效及副作用。结果:治疗组住院天数、胃肠道反应时间明显少于对照组(P<0.01),咳嗽消失时间及X线炎症吸收时间均少于对照组(P<0.05),显效率优于对照组。表明本法可增强疗效、减少阿奇霉素胃肠道反应。

Progression of anti-mycoplasma drug therapy in children with refractory mycoplasma pneumonia

The incidence of refractory mycoplasma pneumoniae pneumonia(RMPP)in children is increasing year by year,and the disease is progressing rapidly.It is accompanied by serious complications and legacy effects,seriously affecting the quality of life of children.The selection,dosage,and course of anti-MP drugs in children with RMPP have brought a lot of troubles to pediatric hospitals.In the present study,the characteristics,usage and dosage,drug resistance mechanism,and treatment progress of anti-MP drugs for the treatment of RMPP in children were reviewed.Collectively,our findings provided ideas for the treatment of children with RMPP using anti-MP drugs.