The stent was a major breakthrough in the treatment of atherosclerotic vascular disease. The permanent vascular implant of a stent, however, changes the intra-stent blood flow hemodynamics. There is a growing consensu...The stent was a major breakthrough in the treatment of atherosclerotic vascular disease. The permanent vascular implant of a stent, however, changes the intra-stent blood flow hemodynamics. There is a growing consensus that the stent implant may change the artery wall shear stress distribution and hence lead to the restenosis process. Computational fluid dynamics （CFD） has been widely used to analyze hemodynamics in stented arteries. In this paper, two CFD models （the axisymmetric model and the 3-D stent model） were developed to investigate the effects of strut geometry and blood rheology on the intra-stent hemodynamics. The velocity profile, flow recirculation, and wall shear stress distribution of various stent strut geometries were studied. Results show strong correlations between the intra-stent hemodynamics and strut geometry. The intra-stent blood flow is very sensitive to the strut height and fillet size. A round strut with a large fillet size shows 36% and 34% reductions in key parameters evaluating the restenosis risk for the axisymmetric model and the 3-D stent model, respectively. This suggests that electrochemical polishing, a surface-improving process during stent manufacturing, strongly influences the hemodynamic behavior in stented arteries and should be controlled precisely in order to achieve the best clinical outcome. Rheological effects on the wall shear stress are minor in both axisymmetric and 3-D stent models for the vessel diameter of 4 mm, with Newtonian flow simulation tending to give more conservative estimates ofrestenosis risk. Therefore, it is reasonable to simulate the blood flow as a Newtonian flow in stented arteries using the simpler axisymmetric model. These findings will provide great insights for stent design optimization for potential restenosis improvement.展开更多
The hoist bracket links the rescue hoist with the helicopter cabin, and its structure design greatly affects the operation convenience and safety of the hoistman and lifeguard in the rescue process with a helicopter.T...The hoist bracket links the rescue hoist with the helicopter cabin, and its structure design greatly affects the operation convenience and safety of the hoistman and lifeguard in the rescue process with a helicopter.This paper firstly builds the force model of the hoist and bracket, and gives five kinds of typical working conditions as the design ones of the bracket. Then this paper puts forward a design process of the hoist bracket based on the topology optimization and strength analysis with the 3D modeling and finite element analysis. This design process can make the bracket's structure lightweight by achieving the optimal material layout under the conditions of maximizing the static stiffness or minimizing the compliance of the bracket. And this improves the dynamic performance of the helicopter, and reduces the fuel consumption and cost under the strength constraints. Finally,taking the design of the hoist bracket used in a rescue helicopter as an example, this paper illustrates the proposed model and method. The analysis results show that the mass of the hoist bracket decreases by 12.5% while the static stiffness of the hoist bracket is achieved. The optimization design results meet the strength requirements of the hoist.展开更多
文摘The stent was a major breakthrough in the treatment of atherosclerotic vascular disease. The permanent vascular implant of a stent, however, changes the intra-stent blood flow hemodynamics. There is a growing consensus that the stent implant may change the artery wall shear stress distribution and hence lead to the restenosis process. Computational fluid dynamics （CFD） has been widely used to analyze hemodynamics in stented arteries. In this paper, two CFD models （the axisymmetric model and the 3-D stent model） were developed to investigate the effects of strut geometry and blood rheology on the intra-stent hemodynamics. The velocity profile, flow recirculation, and wall shear stress distribution of various stent strut geometries were studied. Results show strong correlations between the intra-stent hemodynamics and strut geometry. The intra-stent blood flow is very sensitive to the strut height and fillet size. A round strut with a large fillet size shows 36% and 34% reductions in key parameters evaluating the restenosis risk for the axisymmetric model and the 3-D stent model, respectively. This suggests that electrochemical polishing, a surface-improving process during stent manufacturing, strongly influences the hemodynamic behavior in stented arteries and should be controlled precisely in order to achieve the best clinical outcome. Rheological effects on the wall shear stress are minor in both axisymmetric and 3-D stent models for the vessel diameter of 4 mm, with Newtonian flow simulation tending to give more conservative estimates ofrestenosis risk. Therefore, it is reasonable to simulate the blood flow as a Newtonian flow in stented arteries using the simpler axisymmetric model. These findings will provide great insights for stent design optimization for potential restenosis improvement.
基金the Science and Technology Project of Ministry of Transport of China(No.2013328225080)the Natural Science Foundation of Liaoning Province of China(No.2015020121)+1 种基金the Research Fund for the Doctoral Program of Higher Education of China(No.20122125120013)the Fundamental Research Funds for the Central Universities of China(Nos.3132016069 and 3132016354)
文摘The hoist bracket links the rescue hoist with the helicopter cabin, and its structure design greatly affects the operation convenience and safety of the hoistman and lifeguard in the rescue process with a helicopter.This paper firstly builds the force model of the hoist and bracket, and gives five kinds of typical working conditions as the design ones of the bracket. Then this paper puts forward a design process of the hoist bracket based on the topology optimization and strength analysis with the 3D modeling and finite element analysis. This design process can make the bracket's structure lightweight by achieving the optimal material layout under the conditions of maximizing the static stiffness or minimizing the compliance of the bracket. And this improves the dynamic performance of the helicopter, and reduces the fuel consumption and cost under the strength constraints. Finally,taking the design of the hoist bracket used in a rescue helicopter as an example, this paper illustrates the proposed model and method. The analysis results show that the mass of the hoist bracket decreases by 12.5% while the static stiffness of the hoist bracket is achieved. The optimization design results meet the strength requirements of the hoist.
