Objective: To explore whether the deletion (D) allele of angiotensin-converting enzyme (ACE) is associated with the risk or severity of bronchopulmonary dysplasia (BPD) among very low birth weight (BW) infants. Study ...Objective: To explore whether the deletion (D) allele of angiotensin-converting enzyme (ACE) is associated with the risk or severity of bronchopulmonary dysplasia (BPD) among very low birth weight (BW) infants. Study design: Infants with a BW ≤1250 g were prospectively recruited. The D and I (insertion) alleles of ACE were determined using a polymerase chain reaction followed by restriction fragment length polymorphism analysis. Results: Infants with DDDI genotype of ACE had a (mean ±SD) birth weight (938 ±204 g vs 925 ±196 g) and gestational age (28 ±3 weeks vs 28 ±2 weeks), similar to infants with II genotype of ACE (P > .05). Infants with DDDI genotype of ACE were more likely to have BPD than infants with II genotype (47%vs 22%, P = .025). Among infants with BPD, ACE DDDI genotype was more common among infants with moderate or severe BPD compared with infants with mild BPD (74%vs 26%, P = .012). The number of D alleles of ACE correlated directly and positively with the severity of BPD (R = 0.23, P = .045). Conclusion: The D allele of ACE is associated with an increased risk and severity of BPD among preterm infants.展开更多
文摘Objective: To explore whether the deletion (D) allele of angiotensin-converting enzyme (ACE) is associated with the risk or severity of bronchopulmonary dysplasia (BPD) among very low birth weight (BW) infants. Study design: Infants with a BW ≤1250 g were prospectively recruited. The D and I (insertion) alleles of ACE were determined using a polymerase chain reaction followed by restriction fragment length polymorphism analysis. Results: Infants with DDDI genotype of ACE had a (mean ±SD) birth weight (938 ±204 g vs 925 ±196 g) and gestational age (28 ±3 weeks vs 28 ±2 weeks), similar to infants with II genotype of ACE (P > .05). Infants with DDDI genotype of ACE were more likely to have BPD than infants with II genotype (47%vs 22%, P = .025). Among infants with BPD, ACE DDDI genotype was more common among infants with moderate or severe BPD compared with infants with mild BPD (74%vs 26%, P = .012). The number of D alleles of ACE correlated directly and positively with the severity of BPD (R = 0.23, P = .045). Conclusion: The D allele of ACE is associated with an increased risk and severity of BPD among preterm infants.
