Langevin simulation of the particles multi-passing over the saddle point is proposed to calculate thermal fission rate. Due to finite friction and the corresponding thermal fluctuation, a backstreaming exists in the p...Langevin simulation of the particles multi-passing over the saddle point is proposed to calculate thermal fission rate. Due to finite friction and the corresponding thermal fluctuation, a backstreaming exists in the process of the particle descent from the saddle to the scission. This leads to that the diffusion behind the saddle point has influence upon the stationary flow across the saddle point. A dynamical correction factor, as a ratio of the flows of multi- and first-overpassing the saddle point, is evaluated analytically. The results show that the fission rate calculated by the particles multi-passing over the saddle point is lower than the one calculated by the particle firstly passing over the saddle point, and the former approaches the results at the scission point.展开更多
In Gengcun Colliery, Yima Coal Group Co. Ltd.the characteristics of the gateways of thick coal seam and the coal seam is with fully mechanized sublevel caving mining are that the thickness of roof coal seam of gateway...In Gengcun Colliery, Yima Coal Group Co. Ltd.the characteristics of the gateways of thick coal seam and the coal seam is with fully mechanized sublevel caving mining are that the thickness of roof coal seam of gateways is larger, their surrounding rocks are the whole-coal mass and the coal seam is prone to Spontaneous Combustion. With the natural equilibrium arch theory, the reasonable adjacent distance of No.11 mine-type metal supports was calculated in trapezoidal gateways based on these characteristics. Then, in-situ supporting experiments were carried out. The results indicate that under the action of virgin rock stress, the width of broken rocks zone of surrounding rocks is 1.7–2.0 m in return heading and 1.1–1.3 m in going headway. And their surrounding rocks belong to the Ⅳ-type soften rock and the Ⅲ-type common surrounding rock respectively. Therefore, under the movable abutment pressure, the gateways deformation is serious. It is suggested that the designed gateways have to use pre-broadened cross section to suit their deformation. At the same time, the accumulated water on gateway floor must be drained in time. These measures were taken in the 1302 and 1304 coal faces in Gengcun Colliery, and the satisfactory results have been obtained.展开更多
To ensure running safety,the secondary spring loads of railway vehicles must be well equalized.Due to the coupling interactive effects of these hyper static suspended structures,the equalization adjustment through shi...To ensure running safety,the secondary spring loads of railway vehicles must be well equalized.Due to the coupling interactive effects of these hyper static suspended structures,the equalization adjustment through shimming procedure is quite complex.Therefore,an effective and reliable method in application is developed in this paper.Firstly,the best regulation of spring load is solved based on a mechanical model of the secondary suspension system,providing a target for actual adjustment.To reveal the relationship between secondary spring load distribution and shim quantity sequence,a forecasting model is constructed and then modified experimentally with consideration of car body’s elastic deformation.Further,a gradient-based algorithm with a momentum operation is proposed for the load optimization.Effectiveness of the whole method has been verified on a test rig.It is experimentally confirmed that this research provides an important basis for achieving an optimal regulation of spring load distribution for multiple types of railway vehicles.展开更多
PARASOL(Polarization & Anisotropy of Reflectances for Atmospheric Sciences coupled with Observations from a Lidar) multi-channel and multi-directional polarized data for different aerosol types were compared.The P...PARASOL(Polarization & Anisotropy of Reflectances for Atmospheric Sciences coupled with Observations from a Lidar) multi-channel and multi-directional polarized data for different aerosol types were compared.The PARASOL polarized radiance data at 490 nm,670 nm,and 865 nm increased with aerosol optical thickness(AOT) for fine-mode aerosols;however,the polarized radiances at 490 nm and 670 nm decreased as AOT increased for coarse dust aerosols.Thus,the variation of the polarized radiance with AOT can be used to identify fine or coarse particle-dominated aerosols.Polarized radiances at three wavelengths for fine-and coarse-mode aerosols were analyzed and fitted by linear regression.The slope of the line for 670 nm and 490 nm wavelength pairs is less than 0.35 for dust aerosols.However,the value for fine-mode aerosols is greater than 0.60.The Support Vector Machine method(SVM) based on 12 vector features was used to discriminate clear sky,coarse dust aerosols,fine-mode aerosols,and cloud.Two cases were given and validated by AErosol RObotic NETwork(AERONET) measurements,MODIS(Moderate Resolution Imaging Spectroradiometer) FMF(Fine Mode Fraction at 550 nm) images,PARASOL RGB(Red Green Blue) images,and CALIOP(Cloud-Aerosol Lidar with Orthogonal Polarization) VFM(Vertical Feature Mask) data.展开更多
Biomaterial scaffolds play an important role in maintaining the viability and biological functions of highly metabolic hepatocytes in liver tissue engineering. One of the major challenges involves building a complex m...Biomaterial scaffolds play an important role in maintaining the viability and biological functions of highly metabolic hepatocytes in liver tissue engineering. One of the major challenges involves building a complex microchannel network inside three-dimensional （3D） scaffolds for efficient mass transportation. Here we presented a biomimetic strategy to generate a mi- crochannel network within porous biomaterial scaffolds by mimicking the vascular tree of rat liver. The typical parameters of the blood vessels were incorporated into the biomimetic design of the microchannel network such as branching angle and diameter. Silk fibroin-gelatin scaffolds with biomimetic vascular tree were fabricated by combining micromolding, freeze drying and 3D rolling techniques. The relationship between the micro-channeled design and flow pattern was revealed by a flow experiment, which indicated that the scaffolds with biomimetic vascular tree exhibited unique capability in improving mass transportation inside the 3D scaffold. The 3D scaffolds, preseeded with primary hepatocytes, were dynamically cultured in a bioreactor system. The results confirmed that the pre-designed biomimetic microchannel network facilitated the generation and expansion of hepatocytes.展开更多
The human ether-a-go-go related gene （hERG） channel is responsible for the repolarization during the action potential, and blockage of that may result in severe cardiotoxicity and sudden death. In this study, a data...The human ether-a-go-go related gene （hERG） channel is responsible for the repolarization during the action potential, and blockage of that may result in severe cardiotoxicity and sudden death. In this study, a dataset containing 1969 compounds was compiled from literature and FDA-approved drugs. Using a support vector machine （SVM）, two groups of computational models were built to distinguish whether a compound is a blocker or non-blocker of hERG potassium ion channel. These mod- els fit generally satisfactory. The 100 models built with MACCS fingerprints （Model Group A） showed an average accuracy of 90% and an average matthews correlation coefficient （MCC） value of 0.77 on the test sets. The 100 models built with selected MOE descriptors （Model Group B） showed an average accuracy of 89% and an average MCC value of 0.74 on the test sets. Molecular hydrophobicity and lipophilicity were found to be very important factors which lead to block the hERG potassium ion channel. Some other molecular properties such as electrostatic properties, features based on van der Waals surface area, the number of rigid bonds and molecular surface rugosity also played important roles in blocking bERG potassium ion channel.展开更多
基金The project supported by National Natural Science Foundation of China under Grant Nos.10075007 and 10235020
文摘Langevin simulation of the particles multi-passing over the saddle point is proposed to calculate thermal fission rate. Due to finite friction and the corresponding thermal fluctuation, a backstreaming exists in the process of the particle descent from the saddle to the scission. This leads to that the diffusion behind the saddle point has influence upon the stationary flow across the saddle point. A dynamical correction factor, as a ratio of the flows of multi- and first-overpassing the saddle point, is evaluated analytically. The results show that the fission rate calculated by the particles multi-passing over the saddle point is lower than the one calculated by the particle firstly passing over the saddle point, and the former approaches the results at the scission point.
基金Project 0511051900 supported by Natural Science Foundation of Henan Province
文摘In Gengcun Colliery, Yima Coal Group Co. Ltd.the characteristics of the gateways of thick coal seam and the coal seam is with fully mechanized sublevel caving mining are that the thickness of roof coal seam of gateways is larger, their surrounding rocks are the whole-coal mass and the coal seam is prone to Spontaneous Combustion. With the natural equilibrium arch theory, the reasonable adjacent distance of No.11 mine-type metal supports was calculated in trapezoidal gateways based on these characteristics. Then, in-situ supporting experiments were carried out. The results indicate that under the action of virgin rock stress, the width of broken rocks zone of surrounding rocks is 1.7–2.0 m in return heading and 1.1–1.3 m in going headway. And their surrounding rocks belong to the Ⅳ-type soften rock and the Ⅲ-type common surrounding rock respectively. Therefore, under the movable abutment pressure, the gateways deformation is serious. It is suggested that the designed gateways have to use pre-broadened cross section to suit their deformation. At the same time, the accumulated water on gateway floor must be drained in time. These measures were taken in the 1302 and 1304 coal faces in Gengcun Colliery, and the satisfactory results have been obtained.
基金Project(51305467)supported by the National Natural Science Foundation of ChinaProject(12JJ4050)supported by the Natural Science Foundation of Hunan Province,China
文摘To ensure running safety,the secondary spring loads of railway vehicles must be well equalized.Due to the coupling interactive effects of these hyper static suspended structures,the equalization adjustment through shimming procedure is quite complex.Therefore,an effective and reliable method in application is developed in this paper.Firstly,the best regulation of spring load is solved based on a mechanical model of the secondary suspension system,providing a target for actual adjustment.To reveal the relationship between secondary spring load distribution and shim quantity sequence,a forecasting model is constructed and then modified experimentally with consideration of car body’s elastic deformation.Further,a gradient-based algorithm with a momentum operation is proposed for the load optimization.Effectiveness of the whole method has been verified on a test rig.It is experimentally confirmed that this research provides an important basis for achieving an optimal regulation of spring load distribution for multiple types of railway vehicles.
基金supported by the National Basic Research Program of China (Grant Nos.2010CB950804 and 2013CB955801)the Strategic Priority Research Program-Climate Change:Carbon Budget and Relevant Issues (Grant No.XDA05040202)
文摘PARASOL(Polarization & Anisotropy of Reflectances for Atmospheric Sciences coupled with Observations from a Lidar) multi-channel and multi-directional polarized data for different aerosol types were compared.The PARASOL polarized radiance data at 490 nm,670 nm,and 865 nm increased with aerosol optical thickness(AOT) for fine-mode aerosols;however,the polarized radiances at 490 nm and 670 nm decreased as AOT increased for coarse dust aerosols.Thus,the variation of the polarized radiance with AOT can be used to identify fine or coarse particle-dominated aerosols.Polarized radiances at three wavelengths for fine-and coarse-mode aerosols were analyzed and fitted by linear regression.The slope of the line for 670 nm and 490 nm wavelength pairs is less than 0.35 for dust aerosols.However,the value for fine-mode aerosols is greater than 0.60.The Support Vector Machine method(SVM) based on 12 vector features was used to discriminate clear sky,coarse dust aerosols,fine-mode aerosols,and cloud.Two cases were given and validated by AErosol RObotic NETwork(AERONET) measurements,MODIS(Moderate Resolution Imaging Spectroradiometer) FMF(Fine Mode Fraction at 550 nm) images,PARASOL RGB(Red Green Blue) images,and CALIOP(Cloud-Aerosol Lidar with Orthogonal Polarization) VFM(Vertical Feature Mask) data.
基金This work was funded by the National High Technology Research and Development Program，the Natural Science Foundation of China
文摘Biomaterial scaffolds play an important role in maintaining the viability and biological functions of highly metabolic hepatocytes in liver tissue engineering. One of the major challenges involves building a complex microchannel network inside three-dimensional （3D） scaffolds for efficient mass transportation. Here we presented a biomimetic strategy to generate a mi- crochannel network within porous biomaterial scaffolds by mimicking the vascular tree of rat liver. The typical parameters of the blood vessels were incorporated into the biomimetic design of the microchannel network such as branching angle and diameter. Silk fibroin-gelatin scaffolds with biomimetic vascular tree were fabricated by combining micromolding, freeze drying and 3D rolling techniques. The relationship between the micro-channeled design and flow pattern was revealed by a flow experiment, which indicated that the scaffolds with biomimetic vascular tree exhibited unique capability in improving mass transportation inside the 3D scaffold. The 3D scaffolds, preseeded with primary hepatocytes, were dynamically cultured in a bioreactor system. The results confirmed that the pre-designed biomimetic microchannel network facilitated the generation and expansion of hepatocytes.
基金supported by the National Natural Science Foundation of China(20975011)"Chemical Grid Project"of Beijing University of Chemical Technology
文摘The human ether-a-go-go related gene （hERG） channel is responsible for the repolarization during the action potential, and blockage of that may result in severe cardiotoxicity and sudden death. In this study, a dataset containing 1969 compounds was compiled from literature and FDA-approved drugs. Using a support vector machine （SVM）, two groups of computational models were built to distinguish whether a compound is a blocker or non-blocker of hERG potassium ion channel. These mod- els fit generally satisfactory. The 100 models built with MACCS fingerprints （Model Group A） showed an average accuracy of 90% and an average matthews correlation coefficient （MCC） value of 0.77 on the test sets. The 100 models built with selected MOE descriptors （Model Group B） showed an average accuracy of 89% and an average MCC value of 0.74 on the test sets. Molecular hydrophobicity and lipophilicity were found to be very important factors which lead to block the hERG potassium ion channel. Some other molecular properties such as electrostatic properties, features based on van der Waals surface area, the number of rigid bonds and molecular surface rugosity also played important roles in blocking bERG potassium ion channel.
