We prospectively studied long- term (5 years) effects of endoscopic papillar y balloon dilation (EPBD) on gallbladder motility. Thirteen patients with intact gallbladders (six with and seven without gallbladder stones...We prospectively studied long- term (5 years) effects of endoscopic papillar y balloon dilation (EPBD) on gallbladder motility. Thirteen patients with intact gallbladders (six with and seven without gallbladder stones) who had undergone EPBD for choledocholithiasis were enrolled in this study. Gallbladder volumes, w hile fasting and after dried egg yolk ingestion, were determined by ultrasonogra phy, before and at 7 days, 1 month, and 1, 2, and 5 years after EPBD. Before EPB D, the gallbladder had a larger fasting volume and lower yolk- stimulated maxim um contraction than in normal controls. Seven days after EPBD, fasting volume wa s decreased and maximum contraction was increased, regardless of whether the pat ient had gallbladder stones, showing significant differences from the pre- EPBD values. At 1 month to 5 years after EPBD, these changes were far less evident a nd gallbladder function did not differ significantly from baseline. EPBD does no t adversely affect gallbladder motility in the long- term (5 years).展开更多
Biomaterial will shrink during the drying process. The characteristics of shrinkage and rehydration of fresh peas were studied. Drying curves, shrinkage and rehydration curves of peas without seed coats and whole peas...Biomaterial will shrink during the drying process. The characteristics of shrinkage and rehydration of fresh peas were studied. Drying curves, shrinkage and rehydration curves of peas without seed coats and whole peas were compared. In addition, different volumetric shrinkage coefficients were obtained and discussed. The results show that seed coats resist moisture movement not only from inside to outside but also from outside to inside during different drying conditions. During a seed’s drying process, the drying curve is similar to the shrinkage curve. The higher the heat flux is, the less drying time is needed, and in the meantime, volume would shrink more and more intensively. Dried media will break easily at high heat flux. When we create a drying regime, both drying speed and the quality of dried media should be considered.展开更多
从手机市场的巨头,到All in VR,HTC的决策看似“超前”,实际上却谈不上什么成功。“跌跌不休”的营收2020年1月6日HTC发布了2019年财报,财报显示2019年12月HTC合并营收仅为1.38亿元人民币,全年收入为23.1亿元人民币,同比下滑了57.82%,比...从手机市场的巨头,到All in VR,HTC的决策看似“超前”,实际上却谈不上什么成功。“跌跌不休”的营收2020年1月6日HTC发布了2019年财报,财报显示2019年12月HTC合并营收仅为1.38亿元人民币,全年收入为23.1亿元人民币,同比下滑了57.82%,比2017年的总收入下降87%。要知道,早在2001年HTC的营收就已超过35.9亿元人民币,2019年不仅是19年来营收最差的一年,相比巅峰期,营收缩水更是超过40倍。展开更多
In view of different compressor adding ways in the ammonia-water absorption/compression combined refrigeration AWA /CCR cycle combining the Schulz state equation of the ammonia-water solution the theoretical analysis ...In view of different compressor adding ways in the ammonia-water absorption/compression combined refrigeration AWA /CCR cycle combining the Schulz state equation of the ammonia-water solution the theoretical analysis and calculations on two combination ways by adding the compressor in the high-pressure area and in the low-pressure area are conducted respectively.The effects of several factors including the evaporation temperature Te heat-source temperature Th as well as the cooling water temperature Tw on the equivalent heat consumption in compression qCW heat consumption in absorption qG and the system coefficient of performance COP are analyzed under the two combination configurations.The results show that the effect of the equivalent heat consumption in compression on the COP is less than that of the heat consumption in absorption.Besides the compressor set in the high-pressure area uses more energy than that in the low-pressure area. Moreover the compressor in the low-pressure area is superior to that in the high-pressure area with respect to the COP. Under the given intermediate pressure there is an optimum heat-source temperature corresponding to the maximum COP of the AWA/CCR cycle.展开更多
AIM: To evaluate the role of nitric oxide (NO) in the motor disorders of the dilated uninflamed mid-colon (DUMC) from trinitrobenzene sulfonic acid (TNBS)-induced acute distal colitis in rats. METHODS: Colitis...AIM: To evaluate the role of nitric oxide (NO) in the motor disorders of the dilated uninflamed mid-colon (DUMC) from trinitrobenzene sulfonic acid (TNBS)-induced acute distal colitis in rats. METHODS: Colitis was induced in male Sprague-Dawley rats by a single intracolonic administration of TNBS. Control rats received an enema of 0.9% saline. The rats were killed 48 h after TNBS or saline administration. Macroscopic and histologic lesions of the colon were evaluated. Myeloperoxidase (MPO) and nitric oxide synthase (NOS) activity were measured on the colonic tissue. In TNBS rats, we evaluated spontaneous and evoked contractile activity in circular muscle strips derived from DUMC in comparison to the same colonic segment of control rats, both in the presence and in the absence of a non-selective NOS isoforms inhibitor N-nitro-L- arginine (L-NNA). Pharmacological characterization of electric field stimulation (EFS)-evoked contractile responses was also performed. RESULTS: In TNBS rats, the distal colon showed severe histological lesions and a high MPO activity, while the DUMC exhibited normal histology and MPO activity. Constitutive NOS activity was similar in TNBS and control rats, whereas inducible NOS activity was significantly increased only in the injured distal colon of TNBS rats. Isometrically recorded mechanical activity of circular muscle strips from DUMC of TNBS rats showed a marked reduction of the force and frequency of spontaneous contractions compared to controls, as well as of the contractile responses to a contracting stimulus. In the presence of L-NNA, the contractile activity and responses displayed a significantly greater enhancement compared to controls. The pharmacological characterization of EFS contractile responses showed that a cooperative-like interaction between cholinergic muscarinic and tachyldnergic neurokinin 1 and 2 receptors mediated transmission in DUMC of TNBS rats vs a simple additive interaction in controls. CONCLUSION: The results of this study show that, during TNBS-induced acute distal colitis, circular muscle intrinsic contractile mechanisms and possible enteric neural excitatory activity are inhibited in the distended uninflamed mid-colon. Suppression of NO synthesis markedly improves spontaneous and evokes muscle contractions, in spite of any evident change in local NO activity. 2005 The WJG Press and Elsevier Inc. All rights reserved展开更多
Glacier variations in the Tibetan Plateau and surrounding mountain ranges in China affect the livelihood of over one billion people who depend on water from the Yellow, Yangtze, Brahmaputra, Ganges and Indus rivers or...Glacier variations in the Tibetan Plateau and surrounding mountain ranges in China affect the livelihood of over one billion people who depend on water from the Yellow, Yangtze, Brahmaputra, Ganges and Indus rivers originating in these areas. Based on the results of the present study and published literature, we found that the glaciers shrank :5.7% in area from 1963 to 20:0 with an annual area change of -0.33%. The shrinkage generally decreased from peripheral mountain ranges to the interior of Tibet. The linear trends of annual air temperature and precipitation at 147 stations were 0.36℃(10a)^-1 and 8.96 mm (10a)^-1 respectively from 1961 to 2010. The shrinkage of glaciers was well correlated with the rising temperature and the spatial patterns of the shrinkage were influenced by other factors superimposed on the rising temperature such as glacier size, type, elevation, debris cover and precipitation.展开更多
Currently,deformations along the central axis of specimens were usually measured under fixed environmental conditions. Seldom were the effects of environmental factors on the drying-shrinkage deformation of cement-bas...Currently,deformations along the central axis of specimens were usually measured under fixed environmental conditions. Seldom were the effects of environmental factors on the drying-shrinkage deformation of cement-based ma-terial considered. For this paper,the drying-shrinkage deformation at different w/b ratios and different additions to mor-tars was investigated under different environments at a temperature of 20 ℃ and humidity ranging from 100% to 50%. The specimens were cured in water for 28 days before measurement. The results illustrate that mortar shows much less shrinkage under various drying conditions when a lower w/b ratio is adopted. With a decrease in relative humidity the speed of drying-shrinkage becomes gradually lower. The addition of silica fume reduces the drying-shrinkage of mortar under higher relative humidity,because the pore structure of mortar with silica fume becomes more refined. The addi-tion of fly ash increases the total porosity and the volume of coarse pores in the mortar. The drying-shrinkage of mortar under different conditions increases with the addition of more of fly ash.展开更多
The kinetics of reductive leaching of manganese from low grade pyrolusite in dilute sulfuric acid in the presence of molasses alcohol wastewater was investigated. The shrinking core model was applied to quantify the e...The kinetics of reductive leaching of manganese from low grade pyrolusite in dilute sulfuric acid in the presence of molasses alcohol wastewater was investigated. The shrinking core model was applied to quantify the effects of reaction parameters on leaching rate. The leaching rate increases with reaction temperature, concentrations of H 2 SO 4 and organic matter in molasses alcohol wastewater increase and ore particle size decreases. The leaching process follows the kinetics of a shrinking core model and the apparent activation energy is 57.5 kJ·mol –1 . The experimental results indicate a reaction order of 0.52 for H2SO4 concentration and 0.90 for chemical oxygen demand (COD) of molasses alcohol wastewater. It is concluded that the reductive leaching of pyrolusite with molasses alcohol wastewater is controlled by the diffusion through the ash/inert layer composed of the associated minerals.展开更多
Swelling and shrinkage due to moisture-change is one of the characteristics of the expansive soil,which is similar to the behavior of most materials under thermal effect,If the deformation is restricted,stress in expa...Swelling and shrinkage due to moisture-change is one of the characteristics of the expansive soil,which is similar to the behavior of most materials under thermal effect,If the deformation is restricted,stress in expansive soil is caused by the swell-shrinking.The stress is defined as "moisture-change stress" and is adopted to analyze swell-shrinkage deformation based on the elasticity mechanics theory.The state when the total stress becomes equal to the soil tensile strength is considered as the cracking criterion as moisture-change increases.Then,the initial cracking mechanism due to evaporation is revealed as follows:Different rates of moisture loss at different depths result in greater shrinkage deformation on the surface while there is smaller shrinkage deformation at the underlayer in expansive soil;cracks will grow when the nonuniform shrinkage deformation increases to a certain degree.A theoretical model is established,which may be used to calculate the stress caused by moisture-change.The depth of initial cracks growing is predicted by the proposed model in expansive soil,A series of laboratory tests are carried out by exposing expansive soil samples with different moisture-changes.The process of crack propagation is investigated by resistivity method.The test results show good consistency with the predicted results by the proposed theoretical model.展开更多
Reservoir impoundment is related to several hydraulic engineering concerns,including irreversible valley contractions,landslides and reservoir-induced earthquakes.However,these phenomena,such as valley contractions,ar...Reservoir impoundment is related to several hydraulic engineering concerns,including irreversible valley contractions,landslides and reservoir-induced earthquakes.However,these phenomena,such as valley contractions,are hardly to be explained by the conventional method.The scientific understanding of water effects during impoundment and their hazards to hydraulic structure are needed.The effective stress law for fissured rock masses is introduced in the elasto-plastic model employing the Drucker-Prager criterion and implemented in the three dimension(3D)nonlinear finite element method(FEM)program Three-dimensional FINite Element(TFINE).The slope deforms towards river-way during impoundment since the increasing pore pressure in fissures changes stress state and leads to additional plastic deformation in the rock materials.The value of Biot coefficient and the influence of water on rock materials are discussed in detail.Thus,the mechanism of slope deformation during the impoundment of Jinping-I arch dam is revealed,and the deformation is accurately measured.The application of the effective stress law provides a method to consider stress assessment,deformation evaluation and stability estimate of hydraulic structures during the impoundment process.This is a beneficial exploration and an improvement of hydraulic engineering design.展开更多
AIM:To evaluate ursodeoxycholic acid (UDCA) therapy on the in vitro contraction of gallbladder smooth muscle strips from cholesterol gallstone patients. METHODS:The contraction forces of gallbladder smooth muscle stri...AIM:To evaluate ursodeoxycholic acid (UDCA) therapy on the in vitro contraction of gallbladder smooth muscle strips from cholesterol gallstone patients. METHODS:The contraction forces of gallbladder smooth muscle strips from 28 patients with cholesterol gallstones treated with UDCA were compared with contraction forces from 14 untreated patients. The strips were stimulated with increasing concentrations of cholecystokinin-8 (CCK-8). RESULTS:Although the contraction forces that developed in response to CCK-8 were higher in strips from specimens of UDCA treated patients compared to untreated patients,longer treatment periods (6-wk) caused more contraction responses than the short treatment period of 3-wk (F = 19.297,1.85 ± 0.22 g vs 1.70 ± 0.10 g,P < 0.01). Contraction forces developed with maximal stimulation with KCl in the 6-wk treatment group were also higher than contraction forces in the untreated group (F = 4.274,3.77 ± 0.45 g vs 3.30 ± 0.30 g,P < 0.05). CONCLUSION:Six-week UDCA treatment caused an increase in contractions of muscle strips from patients with cholesterol gallstones when compared to shorter treatment administration or controls. We suggest that extending UDCA treatment periods may cause more effective contractions in the gallbladder,and thereby increase the rate of response to treatment.展开更多
文摘We prospectively studied long- term (5 years) effects of endoscopic papillar y balloon dilation (EPBD) on gallbladder motility. Thirteen patients with intact gallbladders (six with and seven without gallbladder stones) who had undergone EPBD for choledocholithiasis were enrolled in this study. Gallbladder volumes, w hile fasting and after dried egg yolk ingestion, were determined by ultrasonogra phy, before and at 7 days, 1 month, and 1, 2, and 5 years after EPBD. Before EPB D, the gallbladder had a larger fasting volume and lower yolk- stimulated maxim um contraction than in normal controls. Seven days after EPBD, fasting volume wa s decreased and maximum contraction was increased, regardless of whether the pat ient had gallbladder stones, showing significant differences from the pre- EPBD values. At 1 month to 5 years after EPBD, these changes were far less evident a nd gallbladder function did not differ significantly from baseline. EPBD does no t adversely affect gallbladder motility in the long- term (5 years).
文摘Biomaterial will shrink during the drying process. The characteristics of shrinkage and rehydration of fresh peas were studied. Drying curves, shrinkage and rehydration curves of peas without seed coats and whole peas were compared. In addition, different volumetric shrinkage coefficients were obtained and discussed. The results show that seed coats resist moisture movement not only from inside to outside but also from outside to inside during different drying conditions. During a seed’s drying process, the drying curve is similar to the shrinkage curve. The higher the heat flux is, the less drying time is needed, and in the meantime, volume would shrink more and more intensively. Dried media will break easily at high heat flux. When we create a drying regime, both drying speed and the quality of dried media should be considered.
文摘从手机市场的巨头,到All in VR,HTC的决策看似“超前”,实际上却谈不上什么成功。“跌跌不休”的营收2020年1月6日HTC发布了2019年财报,财报显示2019年12月HTC合并营收仅为1.38亿元人民币,全年收入为23.1亿元人民币,同比下滑了57.82%,比2017年的总收入下降87%。要知道,早在2001年HTC的营收就已超过35.9亿元人民币,2019年不仅是19年来营收最差的一年,相比巅峰期,营收缩水更是超过40倍。
基金The National Natural Science Foundation of China(No.51176029)
文摘In view of different compressor adding ways in the ammonia-water absorption/compression combined refrigeration AWA /CCR cycle combining the Schulz state equation of the ammonia-water solution the theoretical analysis and calculations on two combination ways by adding the compressor in the high-pressure area and in the low-pressure area are conducted respectively.The effects of several factors including the evaporation temperature Te heat-source temperature Th as well as the cooling water temperature Tw on the equivalent heat consumption in compression qCW heat consumption in absorption qG and the system coefficient of performance COP are analyzed under the two combination configurations.The results show that the effect of the equivalent heat consumption in compression on the COP is less than that of the heat consumption in absorption.Besides the compressor set in the high-pressure area uses more energy than that in the low-pressure area. Moreover the compressor in the low-pressure area is superior to that in the high-pressure area with respect to the COP. Under the given intermediate pressure there is an optimum heat-source temperature corresponding to the maximum COP of the AWA/CCR cycle.
文摘AIM: To evaluate the role of nitric oxide (NO) in the motor disorders of the dilated uninflamed mid-colon (DUMC) from trinitrobenzene sulfonic acid (TNBS)-induced acute distal colitis in rats. METHODS: Colitis was induced in male Sprague-Dawley rats by a single intracolonic administration of TNBS. Control rats received an enema of 0.9% saline. The rats were killed 48 h after TNBS or saline administration. Macroscopic and histologic lesions of the colon were evaluated. Myeloperoxidase (MPO) and nitric oxide synthase (NOS) activity were measured on the colonic tissue. In TNBS rats, we evaluated spontaneous and evoked contractile activity in circular muscle strips derived from DUMC in comparison to the same colonic segment of control rats, both in the presence and in the absence of a non-selective NOS isoforms inhibitor N-nitro-L- arginine (L-NNA). Pharmacological characterization of electric field stimulation (EFS)-evoked contractile responses was also performed. RESULTS: In TNBS rats, the distal colon showed severe histological lesions and a high MPO activity, while the DUMC exhibited normal histology and MPO activity. Constitutive NOS activity was similar in TNBS and control rats, whereas inducible NOS activity was significantly increased only in the injured distal colon of TNBS rats. Isometrically recorded mechanical activity of circular muscle strips from DUMC of TNBS rats showed a marked reduction of the force and frequency of spontaneous contractions compared to controls, as well as of the contractile responses to a contracting stimulus. In the presence of L-NNA, the contractile activity and responses displayed a significantly greater enhancement compared to controls. The pharmacological characterization of EFS contractile responses showed that a cooperative-like interaction between cholinergic muscarinic and tachyldnergic neurokinin 1 and 2 receptors mediated transmission in DUMC of TNBS rats vs a simple additive interaction in controls. CONCLUSION: The results of this study show that, during TNBS-induced acute distal colitis, circular muscle intrinsic contractile mechanisms and possible enteric neural excitatory activity are inhibited in the distended uninflamed mid-colon. Suppression of NO synthesis markedly improves spontaneous and evokes muscle contractions, in spite of any evident change in local NO activity. 2005 The WJG Press and Elsevier Inc. All rights reserved
基金supported by the National Science Foundation of China (Grant Nos. 40871057 and 41271024)CAAS Project Innovation (2016-2020)+1 种基金IARRP (2016-637-1)Tianjin Philosophy and Social Science Planning Project (TJGL15-028)
文摘Glacier variations in the Tibetan Plateau and surrounding mountain ranges in China affect the livelihood of over one billion people who depend on water from the Yellow, Yangtze, Brahmaputra, Ganges and Indus rivers originating in these areas. Based on the results of the present study and published literature, we found that the glaciers shrank :5.7% in area from 1963 to 20:0 with an annual area change of -0.33%. The shrinkage generally decreased from peripheral mountain ranges to the interior of Tibet. The linear trends of annual air temperature and precipitation at 147 stations were 0.36℃(10a)^-1 and 8.96 mm (10a)^-1 respectively from 1961 to 2010. The shrinkage of glaciers was well correlated with the rising temperature and the spatial patterns of the shrinkage were influenced by other factors superimposed on the rising temperature such as glacier size, type, elevation, debris cover and precipitation.
基金Projects 2005AA332010 supported by the State High Technology Development Program (863) of China50408016 by the National Natural Science Foundation of China.
文摘Currently,deformations along the central axis of specimens were usually measured under fixed environmental conditions. Seldom were the effects of environmental factors on the drying-shrinkage deformation of cement-based ma-terial considered. For this paper,the drying-shrinkage deformation at different w/b ratios and different additions to mor-tars was investigated under different environments at a temperature of 20 ℃ and humidity ranging from 100% to 50%. The specimens were cured in water for 28 days before measurement. The results illustrate that mortar shows much less shrinkage under various drying conditions when a lower w/b ratio is adopted. With a decrease in relative humidity the speed of drying-shrinkage becomes gradually lower. The addition of silica fume reduces the drying-shrinkage of mortar under higher relative humidity,because the pore structure of mortar with silica fume becomes more refined. The addi-tion of fly ash increases the total porosity and the volume of coarse pores in the mortar. The drying-shrinkage of mortar under different conditions increases with the addition of more of fly ash.
基金Supported by the National Natural Science Foundation of China (20866001) the Natural Science Foundation of GuangxiProvince (0832035)
文摘The kinetics of reductive leaching of manganese from low grade pyrolusite in dilute sulfuric acid in the presence of molasses alcohol wastewater was investigated. The shrinking core model was applied to quantify the effects of reaction parameters on leaching rate. The leaching rate increases with reaction temperature, concentrations of H 2 SO 4 and organic matter in molasses alcohol wastewater increase and ore particle size decreases. The leaching process follows the kinetics of a shrinking core model and the apparent activation energy is 57.5 kJ·mol –1 . The experimental results indicate a reaction order of 0.52 for H2SO4 concentration and 0.90 for chemical oxygen demand (COD) of molasses alcohol wastewater. It is concluded that the reductive leaching of pyrolusite with molasses alcohol wastewater is controlled by the diffusion through the ash/inert layer composed of the associated minerals.
基金Project(2006BAB04A10) supported by the National Science and Technology Pillar Program during the 11th Five Year Plan of ChinaProject(51008117) supported by the National Natural Science Foundation of China
文摘Swelling and shrinkage due to moisture-change is one of the characteristics of the expansive soil,which is similar to the behavior of most materials under thermal effect,If the deformation is restricted,stress in expansive soil is caused by the swell-shrinking.The stress is defined as "moisture-change stress" and is adopted to analyze swell-shrinkage deformation based on the elasticity mechanics theory.The state when the total stress becomes equal to the soil tensile strength is considered as the cracking criterion as moisture-change increases.Then,the initial cracking mechanism due to evaporation is revealed as follows:Different rates of moisture loss at different depths result in greater shrinkage deformation on the surface while there is smaller shrinkage deformation at the underlayer in expansive soil;cracks will grow when the nonuniform shrinkage deformation increases to a certain degree.A theoretical model is established,which may be used to calculate the stress caused by moisture-change.The depth of initial cracks growing is predicted by the proposed model in expansive soil,A series of laboratory tests are carried out by exposing expansive soil samples with different moisture-changes.The process of crack propagation is investigated by resistivity method.The test results show good consistency with the predicted results by the proposed theoretical model.
基金Projects(51323014,51479097,51279086)supported by the National Natural Science Foundation of ChinaProject(2016-KY-2)supported by the State Key Laboratory of Hydroscience and Hydraulic Engineering,China
文摘Reservoir impoundment is related to several hydraulic engineering concerns,including irreversible valley contractions,landslides and reservoir-induced earthquakes.However,these phenomena,such as valley contractions,are hardly to be explained by the conventional method.The scientific understanding of water effects during impoundment and their hazards to hydraulic structure are needed.The effective stress law for fissured rock masses is introduced in the elasto-plastic model employing the Drucker-Prager criterion and implemented in the three dimension(3D)nonlinear finite element method(FEM)program Three-dimensional FINite Element(TFINE).The slope deforms towards river-way during impoundment since the increasing pore pressure in fissures changes stress state and leads to additional plastic deformation in the rock materials.The value of Biot coefficient and the influence of water on rock materials are discussed in detail.Thus,the mechanism of slope deformation during the impoundment of Jinping-I arch dam is revealed,and the deformation is accurately measured.The application of the effective stress law provides a method to consider stress assessment,deformation evaluation and stability estimate of hydraulic structures during the impoundment process.This is a beneficial exploration and an improvement of hydraulic engineering design.
文摘AIM:To evaluate ursodeoxycholic acid (UDCA) therapy on the in vitro contraction of gallbladder smooth muscle strips from cholesterol gallstone patients. METHODS:The contraction forces of gallbladder smooth muscle strips from 28 patients with cholesterol gallstones treated with UDCA were compared with contraction forces from 14 untreated patients. The strips were stimulated with increasing concentrations of cholecystokinin-8 (CCK-8). RESULTS:Although the contraction forces that developed in response to CCK-8 were higher in strips from specimens of UDCA treated patients compared to untreated patients,longer treatment periods (6-wk) caused more contraction responses than the short treatment period of 3-wk (F = 19.297,1.85 ± 0.22 g vs 1.70 ± 0.10 g,P < 0.01). Contraction forces developed with maximal stimulation with KCl in the 6-wk treatment group were also higher than contraction forces in the untreated group (F = 4.274,3.77 ± 0.45 g vs 3.30 ± 0.30 g,P < 0.05). CONCLUSION:Six-week UDCA treatment caused an increase in contractions of muscle strips from patients with cholesterol gallstones when compared to shorter treatment administration or controls. We suggest that extending UDCA treatment periods may cause more effective contractions in the gallbladder,and thereby increase the rate of response to treatment.