OBJECTIVES: To estimate the rates of and identify risk factors for disease in women with atypical glandular cells of undetermined significance (AGUS). METHODS: From 1998-2001, 477 Pap tests at Hartford Hospital were c...OBJECTIVES: To estimate the rates of and identify risk factors for disease in women with atypical glandular cells of undetermined significance (AGUS). METHODS: From 1998-2001, 477 Pap tests at Hartford Hospital were classified as AGUS and met the inclusion criteria of this study. Findings were evaluated for 2 years from the initial test. Disease was defined as histology results with a finding of high-grade squamous intraepithelial lesion or greater. RESULTS: Disease was diagnosed in 9%of the women, including malignancy in 3%. Women with malignant-appearing AGUS Pap tests had a higher rate of disease (29%) than women with benign-appearing (5%, P <.01) and unspecified AGUS Pap tests (13%, P <.03). Malignancies were associated with all subclassifications of AGUS Pap tests. Women aged less than 35 years were more likely to have disease than women aged 35 years or older (P <.02). Most women aged younger than 35 years had a squamous abnormality, whereas women aged 35 years or older had a greater diversity of squamous and glandular lesions and accounted for all cases of endometrial cancer, adenocarcinoma in situ, and cervical adenocarcinoma. Women with persistent AGUS Pap tests had a 31%rate of disease. The rate of disease among women with AGUS Pap tests collected by liquid-based cytology was 11%, compared with 6%among samples collected by the conventional method. CONCLUSION: These data suggest that women with atypical glandular cells are at substantial risk for dysplasia and malignancy. The rate of disease varies with the method of Pap test collection, age, presence of persistent AGUS Pap tests, and AGUS subclassification.展开更多
如果你想开发阿尔茨海默疾病、躁狂抑郁症或精神分裂症的诊断法或治疗法,你应该知道,市场将很快会提供以上患者的细胞有助你的研究.Coriell医学研究所从国立精神卫生研究所(National Institute of Mental Heath)收到为期五年的570万美...如果你想开发阿尔茨海默疾病、躁狂抑郁症或精神分裂症的诊断法或治疗法,你应该知道,市场将很快会提供以上患者的细胞有助你的研究.Coriell医学研究所从国立精神卫生研究所(National Institute of Mental Heath)收到为期五年的570万美元拨款,以建立细胞库冷冻保存患病者自愿献出的遗传样本. 将有十个地区研究中心为细胞贮藏库收集样本.展开更多
文摘OBJECTIVES: To estimate the rates of and identify risk factors for disease in women with atypical glandular cells of undetermined significance (AGUS). METHODS: From 1998-2001, 477 Pap tests at Hartford Hospital were classified as AGUS and met the inclusion criteria of this study. Findings were evaluated for 2 years from the initial test. Disease was defined as histology results with a finding of high-grade squamous intraepithelial lesion or greater. RESULTS: Disease was diagnosed in 9%of the women, including malignancy in 3%. Women with malignant-appearing AGUS Pap tests had a higher rate of disease (29%) than women with benign-appearing (5%, P <.01) and unspecified AGUS Pap tests (13%, P <.03). Malignancies were associated with all subclassifications of AGUS Pap tests. Women aged less than 35 years were more likely to have disease than women aged 35 years or older (P <.02). Most women aged younger than 35 years had a squamous abnormality, whereas women aged 35 years or older had a greater diversity of squamous and glandular lesions and accounted for all cases of endometrial cancer, adenocarcinoma in situ, and cervical adenocarcinoma. Women with persistent AGUS Pap tests had a 31%rate of disease. The rate of disease among women with AGUS Pap tests collected by liquid-based cytology was 11%, compared with 6%among samples collected by the conventional method. CONCLUSION: These data suggest that women with atypical glandular cells are at substantial risk for dysplasia and malignancy. The rate of disease varies with the method of Pap test collection, age, presence of persistent AGUS Pap tests, and AGUS subclassification.
文摘如果你想开发阿尔茨海默疾病、躁狂抑郁症或精神分裂症的诊断法或治疗法,你应该知道,市场将很快会提供以上患者的细胞有助你的研究.Coriell医学研究所从国立精神卫生研究所(National Institute of Mental Heath)收到为期五年的570万美元拨款,以建立细胞库冷冻保存患病者自愿献出的遗传样本. 将有十个地区研究中心为细胞贮藏库收集样本.
