To study the interactions of these compounds with calf thymus DNA(CT-DNA), seven b-carboline-3-carboxamides were designed and synthesized. The interactions of these compounds with CT-DNA were determined by the viscome...To study the interactions of these compounds with calf thymus DNA(CT-DNA), seven b-carboline-3-carboxamides were designed and synthesized. The interactions of these compounds with CT-DNA were determined by the viscometric titration assay and Tm (melting temperature) value assay. Binding strengths were evaluated by spectrophotometric titration experiment and microcalorimetric measurement. The interactions of these compounds were tested with CT-DNA. It was showed that all of these compounds were able to change the Tm value of CT-DNA. The results of viscometric titration assay indicated that these compounds interacted with CT-DNA by intercalation. Spectrophotometric titration experiment showed that the binding strengths of these compounds with CT-DNA were different, which was well in agreement with the cell culture results. The binding was driven by entropy according to the results of the microcalorimetric measurement. This series of b-carboline-3-carboxamides is DNA targeting compounds. Their obvious antitumor biological effect is based on the intercalation with DNA base-pairs.展开更多
A scoping review was conducted to report on the nature and extent of the literature addressing the transition through peri and post retirement for people living with chronic disorder（s）. The secondary purpose was to...A scoping review was conducted to report on the nature and extent of the literature addressing the transition through peri and post retirement for people living with chronic disorder（s）. The secondary purpose was to determine the extent that gender issues and the transition age （50-65） are specifically addressed. Of 3,256 titles identified, 111 articles meet the inclusion criteria. Information was often indirect but addressed varying health domains that significantly influence transitional stages toward retirement and illustrating the burden of chronic comorbid health problems, unequal gender positions with differences in labour force participation, retirement pensions, and changing social dynamics. Few studies directly addressed the complex interaction of chronic health outcomes, psychological well-being, social and financial health as a significant paradigm in determining a successful transition into retirement. Needed are prospective longitudinal studies that measure predictors and outcomes of retirement transitioning along with qualitative studies that define the decision-making process. Given the substantial differential impact in respect to retirement risk factors and opportunities, there must be consideration in design and analysis for future high quality research.展开更多
Nonlocal symmetry and explicit solution of the integrable Alice-Bob modified Korteweg-de Vries(ABm Kd V) equation is discussed, which has been established by the aid of the shifted parity and delayed time reversal to ...Nonlocal symmetry and explicit solution of the integrable Alice-Bob modified Korteweg-de Vries(ABm Kd V) equation is discussed, which has been established by the aid of the shifted parity and delayed time reversal to describe two-place events. Based on the Lax pair which contains the two-order partial derivative, the Lie symmetry group method is successfully applied to find the exact invariant solution for the AB-m Kd V equation with nonlocal symmetry by introducing one suitable auxiliary variable. Meanwhile, based on the prolonged system, the explicit analytic interaction solutions related to some specific functions are derived. Figures show the physical phenomenon, that is, "the shifted parity and delayed time reversal to describe two-place events".展开更多
基金This work was supported by National Natural Sciences Foundation of China (39870183) National Doctoral Foundation of China (9930)Natural Science Foundation of Beijing
文摘To study the interactions of these compounds with calf thymus DNA(CT-DNA), seven b-carboline-3-carboxamides were designed and synthesized. The interactions of these compounds with CT-DNA were determined by the viscometric titration assay and Tm (melting temperature) value assay. Binding strengths were evaluated by spectrophotometric titration experiment and microcalorimetric measurement. The interactions of these compounds were tested with CT-DNA. It was showed that all of these compounds were able to change the Tm value of CT-DNA. The results of viscometric titration assay indicated that these compounds interacted with CT-DNA by intercalation. Spectrophotometric titration experiment showed that the binding strengths of these compounds with CT-DNA were different, which was well in agreement with the cell culture results. The binding was driven by entropy according to the results of the microcalorimetric measurement. This series of b-carboline-3-carboxamides is DNA targeting compounds. Their obvious antitumor biological effect is based on the intercalation with DNA base-pairs.
文摘A scoping review was conducted to report on the nature and extent of the literature addressing the transition through peri and post retirement for people living with chronic disorder（s）. The secondary purpose was to determine the extent that gender issues and the transition age （50-65） are specifically addressed. Of 3,256 titles identified, 111 articles meet the inclusion criteria. Information was often indirect but addressed varying health domains that significantly influence transitional stages toward retirement and illustrating the burden of chronic comorbid health problems, unequal gender positions with differences in labour force participation, retirement pensions, and changing social dynamics. Few studies directly addressed the complex interaction of chronic health outcomes, psychological well-being, social and financial health as a significant paradigm in determining a successful transition into retirement. Needed are prospective longitudinal studies that measure predictors and outcomes of retirement transitioning along with qualitative studies that define the decision-making process. Given the substantial differential impact in respect to retirement risk factors and opportunities, there must be consideration in design and analysis for future high quality research.
基金Supported by the National Natural Science Foundation of China under Grant Nos.11705077 and 11775104Natural Science Foundation of Zhejiang Province under Grant No.LY14A010005Scientific Research Foundation of the First-Class Discipline of Zhejiang Province(B)(No.201601)
文摘Nonlocal symmetry and explicit solution of the integrable Alice-Bob modified Korteweg-de Vries(ABm Kd V) equation is discussed, which has been established by the aid of the shifted parity and delayed time reversal to describe two-place events. Based on the Lax pair which contains the two-order partial derivative, the Lie symmetry group method is successfully applied to find the exact invariant solution for the AB-m Kd V equation with nonlocal symmetry by introducing one suitable auxiliary variable. Meanwhile, based on the prolonged system, the explicit analytic interaction solutions related to some specific functions are derived. Figures show the physical phenomenon, that is, "the shifted parity and delayed time reversal to describe two-place events".
