Background: Tegaserod, a prokinetic 5-HT4 receptor agonist, has demonstrated efficacy and tolerability in irritable bowel syndrome (IBS) patients with constipation (IBS- C) in controlled clinical trials. Its use in pr...Background: Tegaserod, a prokinetic 5-HT4 receptor agonist, has demonstrated efficacy and tolerability in irritable bowel syndrome (IBS) patients with constipation (IBS- C) in controlled clinical trials. Its use in primary care has not been investigated. Aim: To determine whether tegaserod is effective and well tolerated by primary care IBS- C patients. Methods: Patients received tegaserod 6 mg b.i.d. for 12 weeks and were assessed for response, abdominal pain/discomfort, bloating, stool consistency/frequency and straining at weeks 4 and 12. Previous successful treatment with the withdrawn drug, cisapride, was noted. A 9- month study extension was offered to patients completing 12 weeks of tegaserod treatment. Results: 212 patients entered the 12- week treatment period; 166 completed as planned. Response rates were 64.2% at week 4 and 70.3% at week 12. After 12weeks, abdominal pain/discomfort and bloating were reduced from baseline (p< 0.0001; mean change - 1.02 and - 0.91 points, respectively), stool frequency increased (0.78- 0.97 stools/day) and stool consistency improved (2.45- 3.42; lumpy stools became softer). Tegaserod was well tolerated; the most common adverse events were headache (13.2% ) and diarrhea (9.4% ). One hundred and twenty patients entered the 9- month extension study, 85 completed and tegaserod continued to be well tolerated. Conclusions: In ambulatory primary care IBS- C patients, tegaserod is an effective and well- tolerated long- term treatment.展开更多
In order to overcome the phenomenon of image blur and edge loss in the process of collecting and transmitting medical image,a denoising method of medical image based on discrete wavelet transform(DWT)and modified medi...In order to overcome the phenomenon of image blur and edge loss in the process of collecting and transmitting medical image,a denoising method of medical image based on discrete wavelet transform(DWT)and modified median filter for medical image coupling denoising is proposed.The method is composed of four modules:image acquisition,image storage,image processing and image reconstruction.Image acquisition gets the medical image that contains Gaussian noise and impulse noise.Image storage includes the preservation of data and parameters of the original image and processed image.In the third module,the medical image is decomposed as four sub bands(LL,HL,LH,HH)by wavelet decomposition,where LL is low frequency,LH,HL,HH are respective for horizontal,vertical and in the diagonal line high frequency component.Using improved wavelet threshold to process high frequency coefficients and retain low frequency coefficients,the modified median filtering is performed on three high frequency sub bands after wavelet threshold processing.The last module is image reconstruction,which means getting the image after denoising by wavelet reconstruction.The advantage of this method is combining the advantages of median filter and wavelet to make the denoising effect better,not a simple combination of the two previous methods.With DWT and improved median filter coefficients coupling denoising,it is highly practical for high-precision medical images containing complex noises.The experimental results of proposed algorithm are compared with the results of median filter,wavelet transform,contourlet and DT-CWT,etc.According to visual evaluation index PSNR and SNR and Canny edge detection,in low noise images,PSNR and SNR increase by 10%–15%;in high noise images,PSNR and SNR increase by 2%–6%.The experimental results of the proposed algorithm achieved better acceptable results compared with other methods,which provides an important method for the diagnosis of medical condition.展开更多
文摘Background: Tegaserod, a prokinetic 5-HT4 receptor agonist, has demonstrated efficacy and tolerability in irritable bowel syndrome (IBS) patients with constipation (IBS- C) in controlled clinical trials. Its use in primary care has not been investigated. Aim: To determine whether tegaserod is effective and well tolerated by primary care IBS- C patients. Methods: Patients received tegaserod 6 mg b.i.d. for 12 weeks and were assessed for response, abdominal pain/discomfort, bloating, stool consistency/frequency and straining at weeks 4 and 12. Previous successful treatment with the withdrawn drug, cisapride, was noted. A 9- month study extension was offered to patients completing 12 weeks of tegaserod treatment. Results: 212 patients entered the 12- week treatment period; 166 completed as planned. Response rates were 64.2% at week 4 and 70.3% at week 12. After 12weeks, abdominal pain/discomfort and bloating were reduced from baseline (p< 0.0001; mean change - 1.02 and - 0.91 points, respectively), stool frequency increased (0.78- 0.97 stools/day) and stool consistency improved (2.45- 3.42; lumpy stools became softer). Tegaserod was well tolerated; the most common adverse events were headache (13.2% ) and diarrhea (9.4% ). One hundred and twenty patients entered the 9- month extension study, 85 completed and tegaserod continued to be well tolerated. Conclusions: In ambulatory primary care IBS- C patients, tegaserod is an effective and well- tolerated long- term treatment.
基金Project(2016JJ4074)supported by the Natural Science Foundation of Hunan Province,ChinaProject(14C0920)supported by the Hunan Provincial Education Department,ChinaProject(61771191)supported by the National Natural Science Foundation of China
文摘In order to overcome the phenomenon of image blur and edge loss in the process of collecting and transmitting medical image,a denoising method of medical image based on discrete wavelet transform(DWT)and modified median filter for medical image coupling denoising is proposed.The method is composed of four modules:image acquisition,image storage,image processing and image reconstruction.Image acquisition gets the medical image that contains Gaussian noise and impulse noise.Image storage includes the preservation of data and parameters of the original image and processed image.In the third module,the medical image is decomposed as four sub bands(LL,HL,LH,HH)by wavelet decomposition,where LL is low frequency,LH,HL,HH are respective for horizontal,vertical and in the diagonal line high frequency component.Using improved wavelet threshold to process high frequency coefficients and retain low frequency coefficients,the modified median filtering is performed on three high frequency sub bands after wavelet threshold processing.The last module is image reconstruction,which means getting the image after denoising by wavelet reconstruction.The advantage of this method is combining the advantages of median filter and wavelet to make the denoising effect better,not a simple combination of the two previous methods.With DWT and improved median filter coefficients coupling denoising,it is highly practical for high-precision medical images containing complex noises.The experimental results of proposed algorithm are compared with the results of median filter,wavelet transform,contourlet and DT-CWT,etc.According to visual evaluation index PSNR and SNR and Canny edge detection,in low noise images,PSNR and SNR increase by 10%–15%;in high noise images,PSNR and SNR increase by 2%–6%.The experimental results of the proposed algorithm achieved better acceptable results compared with other methods,which provides an important method for the diagnosis of medical condition.
