[^(18)F]FDOPA放射标记合成工艺研究进展

正电子发射断层扫描(positron emission tomography,PET)放射性示踪剂6-[^(18)F]氟-3,4-二羟基-L-苯丙氨酸([^(18)F]6-fluoro-3,4-dihydroxy-L-phenylalanine,[^(18)F]FDOPA)广泛用于中枢神经系统疾病的多巴胺代谢成像,然而以高产率放射性合成高比活度的[^(18)F]FDOPA极其困难。近年来随着[^(18)F]FDOPA在脑肿瘤、神经内分泌肿瘤和婴儿期局灶性高胰岛素血症等恶性疾病中的广泛应用,迫切需要开发更优的[^(18)F]FDOPA合成方法以满足日益增长的临床需求。该综述总结了[^(18)F]FDOPA放射合成工艺的研究进展,并且详细介绍了由不同放射标记方法所获得[^(18)F]FDOPA的放射性化学产率、比活度、对映体纯度和合成时间,为优化[^(18)F]FDOPA的放射性合成提供参考,以期获得适用于临床研究的高放射性化学放化产率和纯度以及高比活度的[^(18)F]FDOPA。

Molecular Identification of Gallibacterium from Hen and Analysis of Its 16S rRNA Gene

Two strains of Gallibacterium, isolated from one laying hen flock in Zhengzhou City of Henan Province, were identified by the morphological observation, genus -specific PCR, and analysis of 16S rRNA gene, which was used to generate the phylogenetic tree, with the 21 members of the 12 genera belonging to Pasteurellaceae to analyze the homology. Two strains were named Yu-ZZ-HL-I-SLG and Yu-ZZ-HL-II-GZ. The comparative result of the 16S rDNA sequence shows that the 2 isolated strains are identical in sequence; the highest identity （99.9%） was observed between the isolated strain and one of the strains of Gallibacterium anatis （AF22.8002）, the homologies between the isolated strain and 3 strains of gallibacterium accessed in NCBI （AF22.8016, Gallibacterium genomosp. 1, AF228017, Gallibacterium genomosp. 2, AF22.8018, Gal- libacterium genomosp. 1 ） were above 97.1%, higher than that of the isolated strain and the other strains of the other 11 genera which were between 90.7% -93.2%. It can be seen from the phylogenetic tree that the 2 isolated strains and the other 4 strain of gallibacterium fell into the same branch, furthermore the 2 isolated strains and the strain of Gallibacterium anatis locate in an internal branch, indicating that the 2 isolated strains belong to Gallibacterium anatis.

Emission Characteristics of Soil Nitrous Oxide from Typical Greenhouse Vegetable Fields in North China

To make clear the emission characteristics of soil N20 from typical green- house vegetable fields in North China, an experiment was conducted in greenhouse tomato field in Shouguang city, Shandong province, China＇s ＂Home of Vegetables＂. The N2O fluxes were observed in four experimental treatments, as follows： none N fertilizer （CK）, single organic fertilizer （OM）, conventional fertilization （FP） and opti- mized and reduced nitrogen fertilization （OPT）, by a close chamber-gas chromato- graph method. The effects of different fertilization treatments on N2O emission and tomato yield were analyzed. The results showed that following the fertilization and ir- rigation, the pulsed emissions of N2O were measured. The N2O emission peak ap- peared after basal fertilizer application and irrigation and could be maintained for about 20 days. While the N2O emission peak caused by topdressing was smaller and last only 3-5 days. The statistical analysis showed that the N2O fluxes were affected by air temperature, soil temperature and WFPS at soil depth of 3 cm. The total contents of soil N2O fluxes had significant differences among experimental groups. The total content orderly was FP of 14. 77 kg/hm^2, OPT of 9. 73 kg/hm^2, OM of 6.84 kg/hm^2 and CK of 2.37 kg/hm^2. The N~：~ emission coefficient ranged from 0.83%-1.10%,which was close to or more than the recommended value （1.0%） by IPCC. Compared with the FP treatment, the tomato yield in OPT treatment, whose application rate of chemical N fertilizer decreased by about 60%, increased by 2.2%. Under the current management measures, the reasonable reduction on ap- plicaUon rate of organic manure and chemical nitrogen fertilizer could effectively re- duce the N=O emissions in greenhouse vegetable fields.

Effect of Land Use History on Methane Emission and Methanogenic Flora in Flooded Soils

The characteristics of methane emission were compared among six types of upland and paddy soils developed from different parent materials with distinct physics and chemical properties after planting rice. The fluxes of methane emission in submerged soils from the upland were obviously lower than those from the paddy rice field. The flux of methane emission in the paddy soil developed from fluvo-aquic soil was the largest among all the types of soils. Planting of rice was helpful to emission of methane in soils. The amounts of various groups of methanogenic flora were conformed with the deferences among the fluxes of methane emission in various types of soils. Methane formation was observed in each type Of air-dried soils stored for a long time after addition of water and incubation at 35℃.

Survey on Natural Radiosensitizing Agents Since 2000

Actually, radiation alone is not enough to kill tumor cells efficientlybecause of the radioresistance of tumor cells. It is well known that tumors from the samehistolog-ical origin and of the same development stage are extremely heterogeneous in theirsensitivity to radiotherapy. One of the most resistant factors to radiation is that tumor cells arecommonly hypoxic. The study on radiosensitizing agents is one of the most interesting issues intumor radiotherapeutics. These radiosensitizing agents can be classified into three main categories:natural products, synthesized chemicals and gene therapeutic agents according to their origins andtherapeutic techniques. Many radiosensitizing agents have some side-effects when they are active;so, it is important and significant to do our best to find more radiosensitizing agents with higherefficiency and lower side-effects. On the other hand, the tumor cells are easy to become resistantto older radiosensitizing agents; hence, it is urgent to develop newer radiosensitizing agents forclinics. Natural products come from plants, animals and other living beings. When serving asradiosensitizing agents in tumor radiotherapy, they are more attractive and predominant than generaldrugs. The reasons include a great resource ( especially in China) , multifunctional regulation,higher effectiveness and safer clinical effects.

Prediction and control of rock burst of coal seam contacting gas in deep mining

By analyzing the characteristics and the production mechanism of rock burstthat goes with abnormal gas emission in deep coal seams,the essential method of eliminatingabnormal gas emission by eliminating the occurrence of rock burst or depressingthe magnitude of rock burst was considered.The No.237 working face was selected asthe typical working face contacting gas in deep mining;aimed at this working face,a systemof rock burst prediction and control for coal seam contacting gas in deep mining wasestablished.This system includes three parts:① regional prediction of rock burst hazardbefore mining,② local prediction of rock burst hazard during mining,and ③ rock burstcontrol.

Effects of pyrite on the spontaneous combustion of coal

Abstract Pyrite has a significant effect on the spontaneous combustion of coal. The presence of pyrite can change the propensity of coal towards spontaneous combustion. The influences of various pyrite contents on the parameters of spontaneous combustion, such as index gases, temperature and released heat etc., were investigated in this study, Coal samples with different pyrite contents （0 %, 3 %, 5 %, 7 % and 9 %） were made by mixing coal and pyrite. The oxidation experiments under temperature-programmed condition were carried out to test the release rate of gaseous oxidation products at different temperatures. Differential scanning calorimeter （DSC） was employed to measure the intensity of heat release during coal oxidation for various pyrite contents. The results indicate that pyrite can nonlinearly accelerate the process of spontaneous combustion. The coal sample with a pyrite content of 5 % has the largest CO release rate and oxygen adsorption as well. However, the coal sample with a pyrite content of ？ % has the largest rate of heat flow according to the results from the DSC tests. Pyrite contents of 5 %-7 % in coal has the most significant effects on spontaneous combustion within the range of this study. The conclusions are conducive to the evaluation and control for the spontaneous combustion of coal.

The role of cultural and creative industries in optimizing industrial structure under low-carbon emission constraint

In the post-financial crisis era,China is facing dual pressure from reducing carbon emissions and external demand stagnation.The industrial structure changing is in urgent needs.The cultural and creative industries can expand China's markets through creating and stimulating demands,and can reduce carbon emissions at the same time.By producing both demands and supplies,cultural and creative industries may lead the development of other industries.Since innovation plays a quite important role in the value chain,cultural and creative industries can promote the industrial upgrading and the industrial structure optimization by industrial convergence.

Design of intrinsically safe power supply

Aiming to make a high power direct current supply safely used in coal mine production, this paper made a deep research on characteristics of intrinsically safe power supply, using the mathematical model established according to coal mine intrinsic safety standards. It provides theory support for the application of high power intrinsically safe power supply. The released energy of output short circuit of switch power supply, and the close related factors that influence the biggest output short-circuit spark discharge energy are the theoretical basis of the power supply. It is shown how to make a high power intrinsically safe power supply using the calculated values in the mathematical model, and take values from intrinsically safe requirements parameters scope, then this theoretical calculation value can be developed as the ultimate basis for research of the power supply. It gets the identification method of intrinsically safe from mathematics model of intrinsically safe power supply characteristics study, which solves the problem of theory and application of designing different power intrinsically safe power supply, and designs a kind of high power intrinsically safe power supply through this method. energy, flyback

Impact of grazing on soil, vegetation and ewe production performances in a semi-arid rangeland

Controlled grazing is considered a good management strategy to maintain or increase the live weight of livestock and to reduce vegetation degradation of rangelands. The present study investigated soil characteristics, aboveground vegetation biomass dynamics and controlled grazinginduced changes in the live weight of local ewes in the semi-arid rangeland of Ahmadun, Ziarat, Balochistanprovince of Pakistan. An area of 115 ha was protected from livestock grazing in April 2014. In June 2015, soil characteristics within 0-30 cm depth i.e. soil organic matter(SOM), mineral nitrogen, p H and texture in controlled and uncontrolled grazing sites were assessed. Aboveground vegetation biomass measured in early(June) and late summer(August) in 2015 and 2016. The nutritional value i.e. crude protein, phosphorus(P), neutral detergent fiber(NDF), acid detergent fiber(ADF), calcium(Ca), magnesium(Mg) and potassium(K) of dominantplant species were assessed at the beginning of experiment in 2015. Vegetation cover of controlled and uncontrolled grazing sites was also measured during the two years of the study period using the Veg Measure software. From June to November in2015 and 2016, controlled and uncontrolled livestock grazing sites were grazed on a daily basis by local ewes with a stocking rate of 2 and 1 head ha^(-1) respectively. Results reveal that the organic matter contents of coarse-textured, slightly alkaline soil of the study site were in the range of 9.4-17.6 g kg^(-1) soil and showed a strong positive correlation with aboveground vegetation biomass. The biomass of plants was 56.5% and 33% greater at controlled than uncontrolled grazing site in 2015 and 2016 respectively and plant cover was also higher at controlled than uncontrolled grazing site in both years The nutrient contents were significantly(P<0.05)lower in grasses than shrubs. In both years, the controlled grazing increased the weight gain of ewes about two folds compared to the uncontrolled grazing.The results indicate that controlled grazing improved the vegetation biomass production and small ruminant productivity.

Spatial-temporal Heterogeneity of Industrial Structure Transformation and Carbon Emission Effects in Xuzhou Metropolitan Area

Employing decoupling index and industrial structure characteristic bias index methods, this study analyzed the spatial-temporal characteristics of industrial structure transformations and their resulting carbon emissions in the Xuzhou Metropolitan Area from 2000 to 2014, with a focus on their relationships and driving factors. Our research indicates that carbon emission intensity from industrial structures in the Xuzhou Metropolitan Area at first showed an increasing trend, which then decreased. Furthermore, the relationship between emissions and industrial economic growth has been trending toward absolute decoupling. From the perspective of the center-periphery, the Xuzhou Metropolitan Area formed a concentric pattern, where both progress towards low emissions and the level of technological advancement gradually diminished from the center to the periphery. In terms of variation across provinces, the ISCB index in the eastern Henan has decreased the slowest, followed by the southern Shandong and the northern Anhui, with the northern Jiangsu ranking last. During this period, resource-and labor-intensive industries were the primary growth industries in the northern Anhui and the eastern Henan, while labor-intensive industries dominated the southern Shandong and capital-intensive industries dominated the northern Jiangsu. In terms of city types, the spatial pattern for industrial structure indicates that recession resource-based cities had higher carbon emission intensities than mature resource-based cities, followed by non-resource-based cities and regenerative resource-based cities. Generally, the industrial structure in the Xuzhou Metropolitan Area has transformed from being resource-intensive to capital-intensive, and has been trending toward technology-intensive as resource availability has been exploited to exhaustion and then been regenerated. Industrial structure has been the leading factor causing heterogeneity of carbon emission intensities between metropolitan cities. Therefore, the key to optimizing the industrial structure and layout of metropolitan areas is to promote industrial structure transformation and improve the system controlling collaborative industrial development between cities.

Industrial transformation and green production to reduce environmental emissions: Taking cement industry as a case

Industrial transformation and green production(ITGP) is a new 10-year international research initiative proposed by the Chinese National Committee for Future Earth. It is also an important theme for adapting and responding to global environmental change. Aiming at a thorough examination of the implementation of ITGP in China, this paper presents its objectives, its three major areas, and their progress so far. It also identifies the key elements of its management and proposes new perspectives on managing green transformation. For instance, we introduce a case study on cement industry that shows the positive policy effects of reducing backward production capacity on PCDD/Fs emissions. Finally,to develop different transformation scenarios for a green future, we propose four strategies: 1) policy integration for promoting green industry, 2)system innovation and a multidisciplinary approach, 3) collaborative governance with all potential stakeholders, and 4) managing uncertainty,risks, and long-time horizons.

Vegetation and Community Changes of Elm (Ulmus pumila) Woodlands in Northeastern China in 1983-2011

Elm （Ulmus pumila）, widely distributed in the north temperate zone, contributes to a special savanna-like woodland in typical grassland region in the northeastern China. This woodland performs a variety of ecological functions and environmental signifi- cance, such as decreasing soil erosion, stabilizing sand dunes, preserving species diversity. However, in the last approximate 30 years, the species composition, productivity and distribution area of elm woodland has decreased severely. A series of studies have been carried out to find out whether the climate changes or human disturbances caused the degradation of elm woodland and how these factors af- fected elm woodland. In this study, undisturbed, plowing and grazing elm woodland were investigated in 1983 and 2011 by using Point-Centered Quarter method. The relationship between vegetation changes and environmental factors was analyzed by Bray-Curtis ordination. The results show that in 2011, species diversity and understory productivity of undisturbed elm woodland decrease slightly compared to those of undisturbed elm woodland in 1983. However, nearly 60% of the species is lost in the plowing and grazing elm woodland relative to the species undisturbed elm woodland in 1983. Interestingly, plowing stimulates the growth of elm and certain understory species through furrowing soil and accelerating soil nutrient turnover rate. Grazing disturbance not only leads to species loss and productivity decrease, but also induces changes in elm growth （small, short and twisted）. The mean age of the elm was 29 -4- 2 yr in undisturbed and plowing elm woodland, while only 15 yr in the grazing elm woodland. The results of Bray-Curtis ordination analysis show that all sample stands clustered to three groups： Group I including the undisturbed sample stands of 83UE （undisturbed elm wood- land in 1983） and l lUE （undisturbed elm woodland in 2011）; Group II including sample stands of PE （elm woodland disturbed by plowing）; Group III including samples stands of GE （elm woodland disturbed by grazing）. The results indicate that the long time distur- bance of the plowing and grazing have converted elm woodland to different community types. Climate change is not the primary reason causing the degradation of elm woodland, but plowing and grazing disturbance. Both plowing and grazing decrease the vegetation composition and species diversity. Grazing further decreases vegetation productivity and inhibits the growth of elm tree. Therefore, we suggest that reasonable plowing and exclusive grazing would be favorable for future regeneration of degraded elm woodland.

Review of Carbon Emissions Trading Production Model and Research on Its Applications in China

With the Kyoto Protocol entering into effect in many countries one after another,carbon trading has come into being and developed quickly.China is the main supplier of carbon emissions rights in the world,but such transactions are still in the stage of Clean Development Mechanism (CDM) projects without its own trading system,which is not conducive for China to win the rights of carbon pricing in the international market.Low-carbon and emissions reduction is the international trend nowadays,and therefore,it is particularly necessary and urgent to investigate the issue of carbon trading in China.In this paper,the authors have reviewed Putty-Clay Vintage,which is a model of production function for carbon trading,revealing the main points,contributions and shortcomings of the model.Combined with China's national conditions,the authors have investigated the application of this model in China's carbon trading from four different angles,including enterprise production optimization,financial market development,national macro-economy,and the allocation of emission quota.This study aims to provide China's enterprises with an analytical framework when participating in carbon trading in the future and it is beneficial for them to make optimal production planning when considering the cost of carbon emissions reduction.

Empirically Analysis of the CO_2 Emissions Embodied in Exports of China

In this paper,using the input-output model,the author first calculated the CO 2 emissions embodied in exports of China in 2002 and 2007.Then,the author empirically analyzed problems existing in the composition of exported products and analyzed its possible reasons.The research results of this paper are as follows:Since China's entry into WTO,the CO 2 emissions embodied in exports of China have been increasing rapidly;the value of exported products of high-carbon emissions industries accounts for a relatively higher proportion to China's total exports value because China's carbon intensive products have a certain competitive advantage.Additionally,this paper has put forward relevant suggestions based on these results.

Prevention of explosion in coal mine and management of coal mine gas

There are many problems in terms of safe coal production and the sound developmentof the coal industry.Accompanying the intensification and increasing efficiencyof coal production and the conducting of mining operations at deeper and more remoteareas of mines,the efficient recovery and utilization of Coal Mine Methane:(CMM) is animportant issue in improving and stabilizing the productivity in the coal mining industry withhigh levels of gas,where the incidence of gas outbursts is increasing.We plan to studyvarious aspects of the development of production technology and characteristics of themine site.This is to establish the technology for highly efficient coproduction coal and gasoperation rate.As a result,the productivity at the coal mine face will increase due to thereduction in gas emissions in the mining face.Effective use of recovered gas can be expectedto reduce global warming by reducing the amount of coal mine methane gas emissionin the air.

Assessment of energy release mechanisms contributing to coal burst

Coal burst is a dynamic release of energy within the rock （or coal） mass leading to high velocity expulsion of the broken/failed material into mine openings. This phenomenon has been recognised as one of the most catastrophic failures associated with the coal mining industry, which can often lead to injuries and fatalities of miners as well as significant production losses. This paper aims to examine the mecha- nisms contributing to coal burst occurrence, with an emphasis on the energy release concept. In this study, a numerical modelling study has been conducted to evaluate the roles and contributions of differ- ence energy components. The energy analysis presented in this paper can help to improve the under- standing of energy release mechanisms esoeciallv under Australian conditions.

A New Method of Producing Radionuclide-Labeled Microspheres for Radionuclide Therapy

This work is devoted to obtaining radionuclide-labeled microspheres for radionuclide therapy as a therapeutic drug with a selective method of delivery. The nature of magnetic microspheres and quantitative elemental composition radiopreparats was considered. We have developed a new method of producing radionuclide-labeled microspheres （radiopharmaceutical ^140Nd-microspheres） for radionuclide therapy.

Carbon emissions of China's industrial sectors based on input-output analysis

This study uses an input-output model presenting the embodied carbon emission in the importexport procedure, as well as the responsibility allocation between China's 35 sectors and 7 main trade partners from 1995 to 2011. Results indicate that the amount of carbon emissions in China's industrial sectors is immense and that the industrial sectors are in serious imbalance. Such imbalance exists mainly in textiles, basic and fabricated metal, electrical and optical equipment,and machinery, among others. Based on the consumer-responsibility principle, the responsibility of 29 departments is reduced. Correspondingly, foreign sectors become more responsible.America, as China's largest trading partner, should account for most of the total responsibility,followed by developed countries such as Japan, South Korea, and Germany.