With the characteristics of coal seam geology and gas occurrence,a'ground-underground' integrated gas drainage method was formed,which can relieve gaspressure and increase permeability by mining the protection...With the characteristics of coal seam geology and gas occurrence,a'ground-underground' integrated gas drainage method was formed,which can relieve gaspressure and increase permeability by mining the protection seams in conditional regions.After coal seam gas drainage,high gas outburst seam was converted to low gas safetyseam.In the coal face mining process,safety and high efficient coal mining were realizedby the measure of gas-suction over mining.In addition to the drainage gas for civil gasand gas power generation,the Huaibei Mining Group has actively carried out research onthe utilization technology of methane drainage by ventilation.On the one hand,it can saveprecious energy;on the other hand,it can protect the environment for people's survival.In2007,the amount of coal mine gas drainage was 120 hm3;the rate of coal mine gasdrainage was 44%.Compared with the year 2002,the amount of coal mine gas drainageincreased by two times.Meanwhile,the utilization rate of gas increased rapidly.展开更多
Solvent evaporation method for preparation of nanomatrix has the disadvantages,such as residual organic solvent,environmental pollution,explosion-proofing and so on.To overcome these shortcomings,a series of fenofibra...Solvent evaporation method for preparation of nanomatrix has the disadvantages,such as residual organic solvent,environmental pollution,explosion-proofing and so on.To overcome these shortcomings,a series of fenofibrate nanomatrix drug delivery system(NDDS)consisting of nano-porous silica Sylysia■350(S350)and pH sensitive material Eudragit■L100-55(EL100-55)were prepared using hot-melt extrusion(HME),and their in vitro dissolution and in vivo bioavailability were compared.Finally,the formulation with the highest in vivo bioavailability was selected as the optimized formulation for DSC and PXRD characterization.The results showed that the optimized NDDS showed a higher bioavailability than the reference formulation,although there was crystalline form drug remaining in NDDS.The relative bioavailability of the optimized formulation was 157.1%compared with the commercial product Lipanthyl■.In addition,the relative bioavailability of the optimized formulation was 124.8%in comparison with the formulation prepared by solvent evaporation method,showing that the NDDS prepared by the HME method was effective in improving the bioavailability of fenofibrate.In conclusion,HME was a promising method to prepare NDDS.展开更多
文摘With the characteristics of coal seam geology and gas occurrence,a'ground-underground' integrated gas drainage method was formed,which can relieve gaspressure and increase permeability by mining the protection seams in conditional regions.After coal seam gas drainage,high gas outburst seam was converted to low gas safetyseam.In the coal face mining process,safety and high efficient coal mining were realizedby the measure of gas-suction over mining.In addition to the drainage gas for civil gasand gas power generation,the Huaibei Mining Group has actively carried out research onthe utilization technology of methane drainage by ventilation.On the one hand,it can saveprecious energy;on the other hand,it can protect the environment for people's survival.In2007,the amount of coal mine gas drainage was 120 hm3;the rate of coal mine gasdrainage was 44%.Compared with the year 2002,the amount of coal mine gas drainageincreased by two times.Meanwhile,the utilization rate of gas increased rapidly.
基金National Basic Research Program of China(Grant No.2015CB932100)
文摘Solvent evaporation method for preparation of nanomatrix has the disadvantages,such as residual organic solvent,environmental pollution,explosion-proofing and so on.To overcome these shortcomings,a series of fenofibrate nanomatrix drug delivery system(NDDS)consisting of nano-porous silica Sylysia■350(S350)and pH sensitive material Eudragit■L100-55(EL100-55)were prepared using hot-melt extrusion(HME),and their in vitro dissolution and in vivo bioavailability were compared.Finally,the formulation with the highest in vivo bioavailability was selected as the optimized formulation for DSC and PXRD characterization.The results showed that the optimized NDDS showed a higher bioavailability than the reference formulation,although there was crystalline form drug remaining in NDDS.The relative bioavailability of the optimized formulation was 157.1%compared with the commercial product Lipanthyl■.In addition,the relative bioavailability of the optimized formulation was 124.8%in comparison with the formulation prepared by solvent evaporation method,showing that the NDDS prepared by the HME method was effective in improving the bioavailability of fenofibrate.In conclusion,HME was a promising method to prepare NDDS.
