放射与安瘤乳综合治疗食管癌——180例随机分组研究

食管癌治疗方法的效果均有待提高。因多数患者确诊时病期已晚,为提高疗效,很多学者主张采用综合治疗措施。我院自1986年11月至1990年3月对180例食管癌进行安瘤乳与放疗(放化组)和单纯放疗组(对照组)随机分组的对比研究,每组各90例。现总结如下:

乳腺癌根治术后合并放疗及放化疗的疗效

乳腺癌根治术后合并放疗及合并放化疗,二者对生存率有无显著意义。我们做了较系统的观察,现报告如下。 材料及方法病例选择及分组:1979年4月～1987年9月,在接收的乳腺癌根治术后病人中,经X线,B超和临床检查,无局部复发和远处转移的病人共81例,采用术后单独放疗44例(简称单放组)

Microstructure and mechanical properties of Ti-43Al-9V alloy fabricated by spark plasma sintering

A fine-grained TiAl alloy with the composition of Ti-43Al-9V was prepared by mechanical milling and spark plasma sintering（SPS）.The relationship among sintering temperature,microstructure and mechanical properties was studied.The results show that the morphology of mechanical milling powder is regular with size in a range of 5-30 μm.Main phases of γ-TiAl,α2-Ti3Al and few B2 phase are observed in the SPS bulk samples.For samples sintered at 1150 °C,equiaxed crystal grain microstructure is achieved with size in a range of 300 nm-1 μm.With increasing SPS temperature to 1250 °C,the size of equiaxed crystal grains obviously increases,the microhardness decreases from HV592 to HV535,and the bending strength decreases from 605 to 219 MPa.Meantime,the compression fracture strength also decreases from 2601 to 1905 MPa,and the strain compression decreases from 28.95% to 12.09%.

耳、鼻、喉

~~

Microstructure and mechanical properties of TiAl-based alloy prepared by double mechanical milling and spark plasma sintering

A fine-grained TiAl alloy with a composition of Ti-45Al-2Cr-2Nb-1B-0.5Ta-0.225Y （mole fraction, %） was prepared by double mechanical milling（DMM） and spark plasma sintering（SPS）. The relationship among sintering temperature, microstructure and mechanical properties was studied. The results show that the morphology of double mechanical milled powder is regular with size in the range of 20-40 μm and mainly composed of TiAl and Ti3Al phases. The main phase TiAl and few phases Ti3Al, Ti2Al and TiB2 were observed in the SPSed alloys. For samples sintered at 900 ℃ the equiaxed crystal grain microstructure is achieved with size in the range of 100-200 nm. With increasing the SPS temperature from 900 ℃to 1000 ℃ the size of equiaxed crystal grain obviously increases, the microhardness decreases from HV658 to HV616, and the bending strength decreases from 781 MPa to 652 MPa. In the meantime, the compression fracture strength also decreases from 2769 MPa to 2669 MPa, and the strain to fracture in compression increases from 11.69% to 17.76%. On the base of analysis of fractographies, it shows that the compression fracture transform of the SPSed alloys is intergranular rupture.

Distribution and generic composition of culturable marine actinomycetes from the sediments of Indian continental slope of Bay of Bengal

Actinomycetes population from continental slope sediment of the Bay of Bengal was studied. Samples were collected during two voyages of FORV Sagar Sampada in 2004 （May-June） and 2005 （July） respectively from 11 transects （each transect had ca. 200 m, 500 m, and 1 000 m depth stations）. The physicochemical parameters of overlying water, and sediment samples were also recorded. The actinomycete population ranged from 5.17 to 51.94 CFU/g dry sediment weight and 9.38 to 45.22 CFU/g dry sediment weight during the two cruises respectively. No actinomycete colony was isolated from stations in 1 000 m depth. Two-way analysis of variance showed significant variation among stations （ANOVA two-way, P〈0.05）, but no significance was found between the two cruises （ANOVA two-way, P〈0.05）. Populations in stations in 500 m depth in both cruises were higher than that of 200 m depth stations with statistically insignificant difference （ANOVA two-way, P〉0.05）. Three actinomycetes genera were identified. Streptomyces was found to be the dominating one in both the cruises, followed by Micromonospora, and Actinomyces. The spore of Streptomyces isolates showed the abundance in spiral spore chain. Spore surface was smooth. Multiple regression analysis revealed that the influencing physico-chemical factors were sediment pH, sediment temperature, TOC, porosity, salinity, and pressure. The media used in the present study was prepared with seawater. Thus, they may represent an autochthonous marine flora and deny the theory of land runoff carriage into the sea for adaptation to the salinity of the seawater and sediments.

Electron-induced rapid crosslinking in supramolecular metal-peptide assembly and chemically responsive disaggregation for catalytic application

The applications of supramolecular metal-peptide assemblies as catalyst or catalyst precursor have recent attracted increasing attentions.In this work,a fragment of the amyloid β-peptide,NH_(2)-KLVFF-COOH,was assembled into nanofilms with encapsulated Pd,Pt and Au nanoparticles(NPs)via a one-step room temperature electron induction method.The effects of building block,intermolecular interaction,driving force and side-chain on the assembly were investigated.The assembly mechanism was thereby proposed.The crosslinking of peptide monomers results in mainly random and unordered structures.The obtained metal-peptide assemblies are extremely stable in water at neutral pH for long term.However,the metal NPs are able to be responsively released under basic and reductive conditions.The released NPs show a high activity to catalyze the reduction of 4-nitrophenol.The present studies on assembly mechanism and responsive release will be helpful for the design of organic skeletons and also for the future development of peptide stabilized metallic NPs with applications beyond catalysts.

Expression and significance of ER and PR in differentiated thyroid carcinoma

Objective： The aim of the study was to investigate the relationship between expressions of estrogen receptor （ER）, progesterone receptor （PR） and gender, age, tumor size, lymph node metastasis, capsular invasion and histological type of differentiated thyroid carcinoma （DTC）. Methods： Seventy cases of DTC who received surgery in our hospital （No. 401 Hospital of People＇s Liberation Army, Qingdao, China） between January 2008 and December 2011 were selected. Among them, 61 cases were papillary carcinoma and 9 cases were follicular carcinoma. Twenty cases were normal thyroid tissue adjacent to the tumor which was used as control. Immunohistochemical SP method was employed to detect the expression of ER and PR. Results： The positive rates of ER and PR in tumor tissues of DTC patients were 21.4% （15/70） and 31.4% （22/70）, respectively, and no expression of ER or PR were founded in normal thyroid tissue （P 〈 0.01）. The expressions of ER and PR were related to the lymph node metastasis and capsular invasion （X2 = 16.913 and 6.327, P 〈 0.05; x2 = 7.516 and 12.727, P 〈 0.05）. No relationship was observed between the expressions of EPJPR and gender, age, and histological type （P 〉 0.05） of DTC patients. Conclusion： The expression levels of ER and PR in the tumor tissue of DTC patients were higher than those in the normal thyroid tissue nearby the tumor. Therefore, ER and PR expression might be clinical markers for DTC and its prognosis.

Study on the protein expression and amplification of HER2 gene in gastric cancer

Objective: The aim of the study was to investigate the human epidermal growth factor receptor 2(HER2) gene amplification and protein expression and interpretation points in the stomach mixed carcinomas. Methods: Immunohistochemistry(IHC) and fluorescence in situ hybridization(FISH) technique were used to detect HER2 gene amplification and expression of HER2 protein in 442 cases of gastric mixed carcinoma. Results: The expression rate of HER2 protein was 41.2%(182/442): the HER2 protein expression IHC 3+ extensive type in 18 cases, partial type in 21 cases, focal type in 8 cases, accounting for 10.6%(47/442); the HER2 protein expression IHC 2+ extensive type in 23 cases, partial type in 28 cases, focal type in 11 cases, accounting for 14.0%(62/442); the HER2 protein expression IHC 1+ extensive type in 27 cases, partial type in 31 cases, focal type in 15 cases, accounting for 16.5%(73/442). HER2 gene amplification rate of 442 cases was 16.1%(71/442). In 182 cases of HER2 protein positive expression, the HER2 gene cluster amplification rate was 14.8%(27/182), large granular amplification rate 11.0%(20/182), punctate amplification rate 6.0%(11/182) and high polysomy 7.1%(13/182). In 71 cases of HER2 gene amplification, there was 42 cases of HER2 protein expression IHC 3+, 22 cases of HER2 protein expression IHC 2+, and 7 cases of IHC 1+. Conclusion: HER2 detection of gastric mixed carcinoma has great heterogeneity, HER2 protein positive expression is divided into extensive type, partial type and focal type, and HER2 gene positive amplification is divided into cluster amplification, large granular amplification, punctate amplification and high polysomy. These typing of HER2 protein expression and HER2 gene amplification provide reference index to quantify for targeted therapeutic effect of anticancer drugs.

Variations in Laboratory-Scale Actinomycete Communities Exposed to Cadmium as Assessed by Denaturing Gradient Gel Electrophoresis Profiles

The actinomycete populations and functions in cadmium （Cd） contaminated soil were investigated by the cultivation- independent molecular methods. The genomic DNA was extracted and purified from soil adulterated with various con- centrations of Cd in the laboratory. The partial 16S rDNA genes were amplified by polymerase chain reaction （PCR） using specific primers bound to evolutionarily conserved regions within these actinomycete genes. The diversity in PCR- amplified products, as measured by denaturing gradient gel electrophoresis （EGGE）, was used as a genetic fingerprint of the population. Principle component analysis and Shannon-Weaver diversity index （H） analyses were used to analyze the DGGE results. Results showed that the two principal components accounted for only a low level of the total variance. The value H in contaminated soil was lower than that in the control at later stages of cultivation, whereas at earlier stages it was higher. Among the six sampling time points, the first, fifth and sixth weeks had the highest values of H. Significantly negative correlations between bioavallable Cd concentration and H values existed in the samples from weeks 2 （R = 0.929, P 〈 0.05） and 4 （R = 0.909, P 〈 0.05）. These results may shed light on the effect of Cd on the soil environment and the chemical behavior and toxicity of Cd to actinomycetes.

Step change approaches in coal technology and fugitive emissions research

Multi-factor productivity(MFP) in underground coal mining has been on the decline for the last decade.The mining industry requires a viable and sustainable approach to overcome the current downtrend. This is only possible by concurrently focussing on productivity improvement and operating costs reduction,delivered through both incremental and step change technology development. Four technologies are presented in this paper: fibre optic borehole sensing has been demonstrated to reveal detailed information about gas flow influx, water level and borehole blockage events occurring along the length of a surfaceto-inseam lateral. Fibre optic gas sensing has also been investigated, and this technology promises a remote, intrinsically safe, distributed solution. Recent developments in continuous water jet drilling technology have demonstrated a step change increase in drilling rates and flexibility for coal seam degassing,applicable in both surface-to-inseam and underground in-seam applications. The application of water jet technology to the cable bolt drilling problem offers potential to address a serious health and safety and productivity issue in the roadway development process.

Analyzing the Share Composition of C02 Emissions in Asian Countries

This paper is concerned with the fossil fuel composition of carbon emissions in 10 selected Asian countries. It assesses how economic development may affect this composition through various channels. This paper contributes to the debate on the EKC （environmental Kuznets curve） puzzle, which hypothesizes an inverted U-shaped relationship between per capita income and pollution. The paper examines the EKC hypothesis in an empirical analysis of channels that may allow for this effect. In particular, a specific subset of this general paradigm is investigated using a fractional multinomial logit model to assess how indicators associated with economic development and energy prices affect carbon emissions from coal relative to those of natural gas and oil.

Ⅱ期咽淋巴环非何杰金淋巴瘤综合治疗的近期疗效

从1987年6月至1990年8月,我院收治Ⅱ期咽淋巴环NHL50例,其中综合治疗27例,单纯放疗17例,单纯化疗6例,全部患者疗前行胸部X线和腹部B超检查,4例骨穿刺。采用Ann Arbor分期全部为Ⅱ期,除原发灶外,并有区域淋巴结受侵。原发灶或颈部病灶直经≥5cm者,定为Ⅱ期晚。病理诊断根据Working Formulation方案和Rapapor,分类法。三组临床资料见表1。

非小细胞肺癌的非手术治疗评价

非小细胞肺癌的非手术治疗评价郭汝涛，高永君，徐向英，李瑛，高春玲本文总结我院１９８７年１月至１９８９年１２月收治的３１０例非小细胞肺癌（ＮＳＣＬＣ）放疗、化疗的结果，并分析影响预后的因素及失败原因。１材料与方法全组病例均经病理和细胞学诊断证实，一般资...

Changhsingian radiolarian fauna from Anshun of Guizhou,and its relationship to TOC and paleo-productivity

Abundant siliceous micro-fossils were found from the Dalong Formation,Xinmin section,Guizhou,which include nine species of radiolarians belonging to seven genera as well as nine types of siliceous spongy spicules.The radiolarian fauna consists of all spherical radiolarians,without any species of Albaillellaria and Latentifistularia,indicating a relative shallow water sedimentary environment.The high relative co-efficient between the radiolarian abundance and total organic carbon(TOC)shows that the radiolarian assemblage represented by Copicyntra and Paracopicyntra can be used as a proxy to the paleo-productivity.However,the relative co-efficient between biogenic silica and the radiolarian and sponge spicule abundances is low.A possible explanation is that an oceanic circulation has changed the biogenic silica content after radiolarian test and siliceous spongy spicule were dissolved.

Approach for earth observation satellite real-time and playback data transmission scheduling

The scheduling of earth observation satellites(EOSs)data transmission is a complex combinatorial optimization problem. Current researches mainly deal with this problem on the assumption that the data transmission mode is fixed, either playback or real-time transmission. Considering the characteristic of the problem, a multi-satellite real-time and playback data transmission scheduling model is established and a novel algorithm based on quantum discrete particle swarm optimization(QDPSO)is proposed. Furthermore, we design the longest compatible transmission chain mutation operator to enhance the performance of the algorithm. Finally, some experiments are implemented to validate correctness and practicability of the proposed algorithm.

Well-aligned carbon nanotube array membrane and its field emission properties

Ensembles of aligned and monodispersed carbon nanotubes (CNTs)can be prepared by templating method which involves fabrication of porous anodic aluminum oxide (AAO) template, control of catalytic iron particle size and chemical vapor deposition of carbon in the cylindrical pores of AAO. Here we show that template-synthesized CNTs can be fabricated as well-aligned nanoporous CNTs membrane, which can be directly used as an electron field emitter. A low threshold electric field of 2-4 V/μm and maximum emission current density of ～12 mA/cm2 are observed. The results also show that the electron emission current is a function of the applied electrical field and the Fowler-Nordheim (F-N) plot almost follows a linear relationship which indicates a Fowler-Nordheim tunneling mechanism, and the field enhancement factor estimated is about 1100-7500. The simple and convenient approach should be significant for the development of nanotube devices integrated into field emission displays (FEDs) technology.