目的探讨围手术期放疗对于局部进展期直肠神经内分泌肿瘤患者的生存及治疗方式的影响,为该类患者的临床治疗策略和预后提供科学依据。方法本研究通过美国国家癌症研究所监测,流行病学和最终结果(Surveillance,Epidemiology,and End Resu...目的探讨围手术期放疗对于局部进展期直肠神经内分泌肿瘤患者的生存及治疗方式的影响,为该类患者的临床治疗策略和预后提供科学依据。方法本研究通过美国国家癌症研究所监测,流行病学和最终结果(Surveillance,Epidemiology,and End Result,SEER)数据库,收集了2010年至2019年接受根治性手术的新诊断的局部进展期直肠神经内分泌肿瘤患者数据,收集其临床特征、治疗相关信息与总生存等资料。根据病理结果将患者分为神经内分泌癌组及神经内分泌瘤组,并根据是否接受放疗及放疗时机等进行分层。组间比较采用卡方检验或Fisher确切概率法。使用Kaplan-Meier方法比较接受组间患者的生存情况。结果本项研究纳入了141例接受根治性手术治疗的局部进展期直肠神经内分泌肿瘤患者,其中86例患者病理诊断为神经内分泌癌。共有53例患者进行了围手术期放疗,其中术前新辅助放疗患者30例。白种人(46.2%vs.20.8%,P=0.006)、病理为神经内分泌癌(54.7%vs.10.9%,P<0.001)患者选择围手术期放疗的比例较高。在对合并治疗方式的影响上,大部分接受了围手术期放疗的患者未行保留肛门根治术(27.7%vs.62.5%,P<0.001)。与放疗患者相比,未放疗患者的中位生存期明显更长(87个月vs.34个月;P=0.01)。结论接受围手术期放疗的局部进展期直肠神经内分泌肿瘤患者有着更低的总生存,进行保留肛门括约肌手术的概率也没有因放疗而增加。展开更多
Prolactin (PRL) is a pleiotropic hormone associated with the progression of various cancers, including colorectal cancer (CRC). Here we investigate whether the association of serum PRL concentration and survival is af...Prolactin (PRL) is a pleiotropic hormone associated with the progression of various cancers, including colorectal cancer (CRC). Here we investigate whether the association of serum PRL concentration and survival is affected by tumor location and preoperative radiotherapy (PRERT) in patients with CRC cancer. Serum PRL was determined in 82 CRC patients without previous treatment. Patients with PRL concentrations at and above the 75th percentile (high PRL) or below this level (low PRL), had a significant correlation with overall survival determined using the Kaplan-Meier method. In colon cancer, there was an increased risk of mortality when PRL values were at and above the highest quartile (22%vs. 73%; P = 0.01). In contrast, in rectal cancer, high PRL values were associated with a significant overall survival advantage (88%vs. 44%; P = 0.05), which became more significant (100%vs. 34%; P = 0.005) when only rectal cancer patients receiving PRERT were compared. These findings suggest that tumor location and adjuvant radiotherapy influence the association between circulating PRL and survival in CRC.展开更多
文摘目的探讨围手术期放疗对于局部进展期直肠神经内分泌肿瘤患者的生存及治疗方式的影响,为该类患者的临床治疗策略和预后提供科学依据。方法本研究通过美国国家癌症研究所监测,流行病学和最终结果(Surveillance,Epidemiology,and End Result,SEER)数据库,收集了2010年至2019年接受根治性手术的新诊断的局部进展期直肠神经内分泌肿瘤患者数据,收集其临床特征、治疗相关信息与总生存等资料。根据病理结果将患者分为神经内分泌癌组及神经内分泌瘤组,并根据是否接受放疗及放疗时机等进行分层。组间比较采用卡方检验或Fisher确切概率法。使用Kaplan-Meier方法比较接受组间患者的生存情况。结果本项研究纳入了141例接受根治性手术治疗的局部进展期直肠神经内分泌肿瘤患者,其中86例患者病理诊断为神经内分泌癌。共有53例患者进行了围手术期放疗,其中术前新辅助放疗患者30例。白种人(46.2%vs.20.8%,P=0.006)、病理为神经内分泌癌(54.7%vs.10.9%,P<0.001)患者选择围手术期放疗的比例较高。在对合并治疗方式的影响上,大部分接受了围手术期放疗的患者未行保留肛门根治术(27.7%vs.62.5%,P<0.001)。与放疗患者相比,未放疗患者的中位生存期明显更长(87个月vs.34个月;P=0.01)。结论接受围手术期放疗的局部进展期直肠神经内分泌肿瘤患者有着更低的总生存,进行保留肛门括约肌手术的概率也没有因放疗而增加。
文摘Prolactin (PRL) is a pleiotropic hormone associated with the progression of various cancers, including colorectal cancer (CRC). Here we investigate whether the association of serum PRL concentration and survival is affected by tumor location and preoperative radiotherapy (PRERT) in patients with CRC cancer. Serum PRL was determined in 82 CRC patients without previous treatment. Patients with PRL concentrations at and above the 75th percentile (high PRL) or below this level (low PRL), had a significant correlation with overall survival determined using the Kaplan-Meier method. In colon cancer, there was an increased risk of mortality when PRL values were at and above the highest quartile (22%vs. 73%; P = 0.01). In contrast, in rectal cancer, high PRL values were associated with a significant overall survival advantage (88%vs. 44%; P = 0.05), which became more significant (100%vs. 34%; P = 0.005) when only rectal cancer patients receiving PRERT were compared. These findings suggest that tumor location and adjuvant radiotherapy influence the association between circulating PRL and survival in CRC.
