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枸橼酸莫沙必利口腔崩解片的制备及评价 被引量:6
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作者 孙运栋 张向荣 +3 位作者 付杰超 石晓磊 施路 李三鸣 《沈阳药科大学学报》 CAS CSCD 北大核心 2009年第3期176-180,共5页
目的制备枸橼酸莫沙必利口腔崩解片并对其进行评价。方法在预实验的基础上选择处方中所用辅料,以口腔中崩解时间为考察指标,综合运用效应面图和等高线图对口腔崩解片处方进行优化,直接压片法压片,并对枸橼酸莫沙必利口腔崩解片溶出度进... 目的制备枸橼酸莫沙必利口腔崩解片并对其进行评价。方法在预实验的基础上选择处方中所用辅料,以口腔中崩解时间为考察指标,综合运用效应面图和等高线图对口腔崩解片处方进行优化,直接压片法压片,并对枸橼酸莫沙必利口腔崩解片溶出度进行了考察。结果枸橼酸莫沙必利口腔崩解片的最佳处方为枸橼酸莫沙必利5 mg、微晶纤维素76 mg、甘露醇97 mg、低取代羟丙基纤维素20 mg、橘子香精1 mg、硬脂酸富马酸钠1 mg。口腔中崩解时间为19.4 s,溶出度为99.7%。结论采用直接压片法制备枸橼酸莫沙必利口腔崩解片,崩解时间短、溶出速度快、口感好。 展开更多
关键词 枸橼酸莫沙必利 口腔崩解片 口腔中崩解时间 效应面图 等高线 溶出度
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盐酸托烷司琼口腔崩解片的制备 被引量:3
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作者 陆军 黄晶晶 《华西药学杂志》 CAS CSCD 北大核心 2010年第6期668-671,共4页
目的制备并评价盐酸托烷司琼口腔崩解片。方法选择辅料,以口腔中崩解时间为考察指标,综合运用效应面图和等高线图对口腔崩解片处方进行优化,直接压片法压片后,考察盐酸托烷司琼口腔崩解片的溶出度。结果所用处方为5 mg盐酸托烷司琼、78... 目的制备并评价盐酸托烷司琼口腔崩解片。方法选择辅料,以口腔中崩解时间为考察指标,综合运用效应面图和等高线图对口腔崩解片处方进行优化,直接压片法压片后,考察盐酸托烷司琼口腔崩解片的溶出度。结果所用处方为5 mg盐酸托烷司琼、78 mg微晶纤维素、95 mg甘露醇、20 mg交联羧甲基纤维素钠、1.6 mg草莓香精、0.4 mg硬脂酸镁。口腔中崩解时间为22.8 s,溶出度为97.4%。结论采用直接压片法制备的盐酸托烷司琼口腔崩解片崩解时间短、溶出速度快。 展开更多
关键词 盐酸托烷司琼 口腔崩解片 崩解时间 效应面图 等高线 溶出度
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The spatial scaling effect of the discrete-canopy effective leaf area index retrieved by remote sensing 被引量:5
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作者 FAN WenJie GAI YingYing +1 位作者 XU XiRu YAN BinYan 《Science China Earth Sciences》 SCIE EI CAS 2013年第9期1548-1554,共7页
The leaf area index(LAI) is a critical biophysical variable that describes canopy geometric structures and growth conditions.It is also an important input parameter for climate,energy and carbon cycle models.The scali... The leaf area index(LAI) is a critical biophysical variable that describes canopy geometric structures and growth conditions.It is also an important input parameter for climate,energy and carbon cycle models.The scaling effect of the LAI has always been of concern.Considering the effects of the clumping indices on the BRDF models of discrete canopies,an effective LAI is defined.The effective LAI has the same function of describing the leaf density as does the traditional LAI.Therefore,our study was based on the effective LAI.The spatial scaling effect of discrete canopies significantly differed from that of continuous canopies.Based on the directional second-derivative method of effective LAI retrieval,the mechanism responsible for the spatial scaling effect of the discrete-canopy LAI is discussed and a scaling transformation formula for the effective LAI is suggested in this paper.Theoretical analysis shows that the mean values of effective LAIs retrieved from high-resolution pixels were always equal to or larger than the effective LAIs retrieved from corresponding coarse-resolution pixels.Both the conclusions and the scaling transformation formula were validated with airborne hyperspectral remote sensing imagery obtained in Huailai County,Zhangjiakou,Hebei Province,China.The scaling transformation formula agreed well with the effective LAI retrieved from hyperspectral remote sensing imagery. 展开更多
关键词 The spatial scaling effect of the discrete-canopy effective leaf area index retrieved by remote sensing
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Continuous Estimation of Wrist Torque from Surface EMG Signals Using Path-dependent Model
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作者 PAN Li-zhi ZHANG Ding-guo +1 位作者 SHENG Xin-jun ZHU Xiang-yang 《Chinese Journal of Biomedical Engineering(English Edition)》 2014年第4期159-164,共6页
Continuous estimation of wrist torque from surface electromyography(EMG) signals has been studied by some research institutes. Hysteresis effect is a phenomenon in EMG force relationship. In this work, a path-dependen... Continuous estimation of wrist torque from surface electromyography(EMG) signals has been studied by some research institutes. Hysteresis effect is a phenomenon in EMG force relationship. In this work, a path-dependent model based on hysteresis effect was used for continuously estimating wrist torque from surface EMG signals. The surface EMG signals of the flexor carpi ulnaris(FCU) and extensor carpi radialis(ECR) were collected along with wrist torque of flexion/extension degree-of-freedom. EMG signal of FCU was used to estimate the torque of wrist flexion and EMG signal of ECR to estimate the torque of wrist extension. The existence of hysteresis effect has been proven either during wrist flexion or extension on all subjects.And the estimation performance of path-dependent model is much better than the overall model. Thus, the path-dependent model is suitable to improve the wrist torque's estimation accuracy. 展开更多
关键词 electromyography (EMG) continuous estimation hysteresis effect path-dependent model
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