AIM: To study the preventive effects of Qianggan-Rongxian Decoction on liver fibrosis induced by dimethylnitrosamine (DMN) in rats. METHODS: Male Wistar rats were randomly divided into hepatic fibrosis model group, co...AIM: To study the preventive effects of Qianggan-Rongxian Decoction on liver fibrosis induced by dimethylnitrosamine (DMN) in rats. METHODS: Male Wistar rats were randomly divided into hepatic fibrosis model group, control group and 3 treatment groups (12 rats in each group). Except for the normal control group, all the rats received 1% DMN (10 μL/kg body weight, i.p), 3 times a week for 4 wk. The rats in the 3 treatment groups including a high-dose DMN group (10 mL/kg), a medium-dose DMN group (7 mL/kg), and a low-dose DMN group (4 mL/kg) were daily gavaged with Qianggan-Rongxian Decoction, and the rats in the model and normal control groups were given saline vehicle. Enzyme-linked immunosorbent assay (ELISA) was used to determine the changes in serum hyaluronic acid (HA), laminin (LN), and type IV collagen levels. Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were measured using routine laboratory methods. Pathologic changes, particularly fibrosis, were examined by hematoxylin and eosin (HE) and Sirius red staining. Hepatic stellate cells (HSC) were examined by transmission electron microscopy. RESULTS: Compared with the model control group, the serum levels of HA, LN, type Ⅳ collagen, ALT and AST were decreased markedly in the other groups after treatment with Qianggan-Rongxian Decoction, especially in the medium-dose DMN group (P < 0.05).Moreover, the area-density percentage of collagen fibrosis was lower in the Qianggan-Rongxian Decoction treatment groups than in the model group, and a more significant drop was observed in the medium-dose DMN group (P < 0.05). CONCLUSION: Qianggan-Rongxian Decoction can inhibit hepatic fibrosis due to chronic liver injury, delay the development of cirrhosis, and notably ameliorate liver function. It may be used as a safe and effective thera-peutic drug for patients with fibrosis.展开更多
The Fifth-Generation NCAR/Penn State Mesoscale Model (MM5) has been used to investigate the extra-area effects of silver iodide (AgI) seeding on stratiform clouds performed at the supercooled layer.A bulk two-moment m...The Fifth-Generation NCAR/Penn State Mesoscale Model (MM5) has been used to investigate the extra-area effects of silver iodide (AgI) seeding on stratiform clouds performed at the supercooled layer.A bulk two-moment microphysical scheme and the new software package for silver iodide are incorporated in MM5.Extra conservation equations are applied to trace the seeding agent,which is transported along the flow field and interacts with the supercooled cloud fields.In this study,the model was run using three nested grids,with 3.3 km × 3.3 km horizontal resolution in the finest grid.The model results showed that seeding with AgI at the 5 to 15℃ levels had microphysical effects on the simulated clouds and that the simulation produced a longer-lasting seeding effect because of the transport of the seeding agent by upper-level winds.Most of the AgI particles acted as deposition nuclei,and the deposition nucleation process contributed mostly to additional cloud ice formation in this study.The results showed that more precipitation results from seeded than unseeded case,and the precipitation was redistributed downwind of the target.Augmented precipitation (varying from 5% to 25% downwind) was confined in space to within 250 km of the seeding target and in time to the 3-h period after initial seeding.展开更多
The three-dimensional (3D) deformation effect of the slope engineering under the step-by-step excavation for the Antaibao surface mine was analyzed using the FLAC^3D technique. An optimal excavated scheme with a rel...The three-dimensional (3D) deformation effect of the slope engineering under the step-by-step excavation for the Antaibao surface mine was analyzed using the FLAC^3D technique. An optimal excavated scheme with a relatively steeper slope angle of 47° instead of 30° was successfully implemented at the west wall in the geological section 73200 of the mine area, where the 3D effect of the nonlinear large deformation of the slope was taken into account. Based on the above research conclusion, put forward the countermeasures of shortening mining length, excavating by different regions, timely foot backfilling to protect the excavated slope, and monitoring and feedback adjustment by studying the nonlinear effect. The results show that these countermeasures are effective in controlling maximum deformation and increasing the stability of the slope.展开更多
Prandtl’s lifting line theory was generalized to the lifting problem of a three-dimensional hydrofoil in the presence of a free surface. Similar to the classical lifting theory, the singularity distribution method wa...Prandtl’s lifting line theory was generalized to the lifting problem of a three-dimensional hydrofoil in the presence of a free surface. Similar to the classical lifting theory, the singularity distribution method was utilized to solve two-dimensional lifting problems for the hydrofoil beneath the free surface at the air-water interface, and a lifting line theory was developed to correct three-dimensional effects of the hydrofoil with a large aspect ratio. Differing from the classical lifting theory, the main focus was on finding the three-dimensional Green function of the free surface induced by the steady motion of a system of horseshoe vortices under the free surface. Finally, numerical examples were given to show the relationship between the lift coefficient and submergence Froude numbers for 2-D and 3-D hydrofoils. If the submergence Froude number is small free surface effect will be significant registered as the increase of lift coefficient. The validity of these approaches was examined in comparison with the results calculated by other methods.展开更多
In the reliability analysis of slope, the performance functions derived from the most available stability analysis procedures of slopes are usually implicit and cannot be solved by first-order second-moment approach. ...In the reliability analysis of slope, the performance functions derived from the most available stability analysis procedures of slopes are usually implicit and cannot be solved by first-order second-moment approach. A new reliability analysis approach was presented based on three-dimensional Morgenstem-Price method to investigate three-dimensional effect of landslide in stability analyses. To obtain the reliability index, Support Vector Machine (SVM) was applied to approximate the performance function. The time-consuming of this approach is only 0.028% of that using Monte-Carlo method at the same computation accuracy. Also, the influence of time effect of shearing strength parameters of slope soils on the long-term reliability of three-dimensional slopes was investigated by this new approach. It is found that the reliability index of the slope would decrease by 52.54% and the failure probability would increase from 0.000 705% to 1.966%. In the end, the impact of variation coefficients of c andfon reliability index of slopes was taken into discussion and the changing trend was observed.展开更多
Heat and mass transfer effects in three-dimensional flow of Maxwell fluid over a stretching surface were addressed.Analysis was performed in the presence of internal heat generation/absorption. Concentration and therm...Heat and mass transfer effects in three-dimensional flow of Maxwell fluid over a stretching surface were addressed.Analysis was performed in the presence of internal heat generation/absorption. Concentration and thermal buoyancy effects were accounted. Convective boundary conditions for heat and mass transfer analysis were explored. Series solutions of the resulting problem were developed. Effects of mixed convection, internal heat generation/absorption parameter and Biot numbers on the dimensionless velocity, temperature and concentration distributions were illustrated graphically. Numerical values of local Nusselt and Sherwood numbers were obtained and analyzed for all the physical parameters. It is found that both thermal and concentration boundary layer thicknesses are decreasing functions of stretching ratio. Variations of mixed convection parameter and concentration buoyancy parameter on the velocity profiles and associated boundary layer thicknesses are enhanced. Velocity profiles and temperature increase in the case of internal heat generation while they reduce for heat absorption. Heat transfer Biot number increases the thermal boundary layer thickness and temperature. Also concentration and its associated boundary layer are enhanced with an increase in mass transfer Biot number. The local Nusselt and Sherwood numbers have quite similar behaviors for increasing values of mixed convection parameter, concentration buoyancy parameter and Deborah number.展开更多
基金the Research Program of Department of Scienceand Technology of Hebei Province, No. 200721047
文摘AIM: To study the preventive effects of Qianggan-Rongxian Decoction on liver fibrosis induced by dimethylnitrosamine (DMN) in rats. METHODS: Male Wistar rats were randomly divided into hepatic fibrosis model group, control group and 3 treatment groups (12 rats in each group). Except for the normal control group, all the rats received 1% DMN (10 μL/kg body weight, i.p), 3 times a week for 4 wk. The rats in the 3 treatment groups including a high-dose DMN group (10 mL/kg), a medium-dose DMN group (7 mL/kg), and a low-dose DMN group (4 mL/kg) were daily gavaged with Qianggan-Rongxian Decoction, and the rats in the model and normal control groups were given saline vehicle. Enzyme-linked immunosorbent assay (ELISA) was used to determine the changes in serum hyaluronic acid (HA), laminin (LN), and type IV collagen levels. Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were measured using routine laboratory methods. Pathologic changes, particularly fibrosis, were examined by hematoxylin and eosin (HE) and Sirius red staining. Hepatic stellate cells (HSC) were examined by transmission electron microscopy. RESULTS: Compared with the model control group, the serum levels of HA, LN, type Ⅳ collagen, ALT and AST were decreased markedly in the other groups after treatment with Qianggan-Rongxian Decoction, especially in the medium-dose DMN group (P < 0.05).Moreover, the area-density percentage of collagen fibrosis was lower in the Qianggan-Rongxian Decoction treatment groups than in the model group, and a more significant drop was observed in the medium-dose DMN group (P < 0.05). CONCLUSION: Qianggan-Rongxian Decoction can inhibit hepatic fibrosis due to chronic liver injury, delay the development of cirrhosis, and notably ameliorate liver function. It may be used as a safe and effective thera-peutic drug for patients with fibrosis.
基金supported by the National Natural Science Foundation of China (Grant No. 40805056)the National Key Technologies R&D Program of China (Grant No. 2006BAC12B00)
文摘The Fifth-Generation NCAR/Penn State Mesoscale Model (MM5) has been used to investigate the extra-area effects of silver iodide (AgI) seeding on stratiform clouds performed at the supercooled layer.A bulk two-moment microphysical scheme and the new software package for silver iodide are incorporated in MM5.Extra conservation equations are applied to trace the seeding agent,which is transported along the flow field and interacts with the supercooled cloud fields.In this study,the model was run using three nested grids,with 3.3 km × 3.3 km horizontal resolution in the finest grid.The model results showed that seeding with AgI at the 5 to 15℃ levels had microphysical effects on the simulated clouds and that the simulation produced a longer-lasting seeding effect because of the transport of the seeding agent by upper-level winds.Most of the AgI particles acted as deposition nuclei,and the deposition nucleation process contributed mostly to additional cloud ice formation in this study.The results showed that more precipitation results from seeded than unseeded case,and the precipitation was redistributed downwind of the target.Augmented precipitation (varying from 5% to 25% downwind) was confined in space to within 250 km of the seeding target and in time to the 3-h period after initial seeding.
基金Supported by the National Natural Science Foundation of China(10572008)the Natural Science Foundation of Beijing(3063019)Doctor Foundation of Yanshan University(B245)
文摘The three-dimensional (3D) deformation effect of the slope engineering under the step-by-step excavation for the Antaibao surface mine was analyzed using the FLAC^3D technique. An optimal excavated scheme with a relatively steeper slope angle of 47° instead of 30° was successfully implemented at the west wall in the geological section 73200 of the mine area, where the 3D effect of the nonlinear large deformation of the slope was taken into account. Based on the above research conclusion, put forward the countermeasures of shortening mining length, excavating by different regions, timely foot backfilling to protect the excavated slope, and monitoring and feedback adjustment by studying the nonlinear effect. The results show that these countermeasures are effective in controlling maximum deformation and increasing the stability of the slope.
基金Supported by the National Natural Science Foundation of China under Grant No.50921001973 Program under Grant No. 2010CB83270
文摘Prandtl’s lifting line theory was generalized to the lifting problem of a three-dimensional hydrofoil in the presence of a free surface. Similar to the classical lifting theory, the singularity distribution method was utilized to solve two-dimensional lifting problems for the hydrofoil beneath the free surface at the air-water interface, and a lifting line theory was developed to correct three-dimensional effects of the hydrofoil with a large aspect ratio. Differing from the classical lifting theory, the main focus was on finding the three-dimensional Green function of the free surface induced by the steady motion of a system of horseshoe vortices under the free surface. Finally, numerical examples were given to show the relationship between the lift coefficient and submergence Froude numbers for 2-D and 3-D hydrofoils. If the submergence Froude number is small free surface effect will be significant registered as the increase of lift coefficient. The validity of these approaches was examined in comparison with the results calculated by other methods.
基金Project(50878082) supported by the National Natural Science Foundation of ChinaProject(200631880237) supported by the Science and Technology Program of West Transportation of the Ministry of Transportation of ChinaKey Project(09JJ3104) supported by the Natural Science Foundation of Hunan Province, China
文摘In the reliability analysis of slope, the performance functions derived from the most available stability analysis procedures of slopes are usually implicit and cannot be solved by first-order second-moment approach. A new reliability analysis approach was presented based on three-dimensional Morgenstem-Price method to investigate three-dimensional effect of landslide in stability analyses. To obtain the reliability index, Support Vector Machine (SVM) was applied to approximate the performance function. The time-consuming of this approach is only 0.028% of that using Monte-Carlo method at the same computation accuracy. Also, the influence of time effect of shearing strength parameters of slope soils on the long-term reliability of three-dimensional slopes was investigated by this new approach. It is found that the reliability index of the slope would decrease by 52.54% and the failure probability would increase from 0.000 705% to 1.966%. In the end, the impact of variation coefficients of c andfon reliability index of slopes was taken into discussion and the changing trend was observed.
文摘Heat and mass transfer effects in three-dimensional flow of Maxwell fluid over a stretching surface were addressed.Analysis was performed in the presence of internal heat generation/absorption. Concentration and thermal buoyancy effects were accounted. Convective boundary conditions for heat and mass transfer analysis were explored. Series solutions of the resulting problem were developed. Effects of mixed convection, internal heat generation/absorption parameter and Biot numbers on the dimensionless velocity, temperature and concentration distributions were illustrated graphically. Numerical values of local Nusselt and Sherwood numbers were obtained and analyzed for all the physical parameters. It is found that both thermal and concentration boundary layer thicknesses are decreasing functions of stretching ratio. Variations of mixed convection parameter and concentration buoyancy parameter on the velocity profiles and associated boundary layer thicknesses are enhanced. Velocity profiles and temperature increase in the case of internal heat generation while they reduce for heat absorption. Heat transfer Biot number increases the thermal boundary layer thickness and temperature. Also concentration and its associated boundary layer are enhanced with an increase in mass transfer Biot number. The local Nusselt and Sherwood numbers have quite similar behaviors for increasing values of mixed convection parameter, concentration buoyancy parameter and Deborah number.