中药方剂(traditional Chinese medicine formula,TCMF)是中医治疗的一种主要手段。然而一首方剂往往包含多种草药,这其中只有几种草药对治疗特定的病症起重要作用。因此,找出方剂中的核心药物和其配伍规律对研究中药方剂有非常重要的...中药方剂(traditional Chinese medicine formula,TCMF)是中医治疗的一种主要手段。然而一首方剂往往包含多种草药,这其中只有几种草药对治疗特定的病症起重要作用。因此,找出方剂中的核心药物和其配伍规律对研究中药方剂有非常重要的意义。针对该问题,提出了一种基于效用度(effect degree,ED)的核心药物及配伍规律发现方法。该方法包含三个主要步骤,分别是基于药物效用度的核心药物发现算法、基于带药对效用度的点式互信息(pointwise mutual information with herb pair ED,PMIED)的药物组网算法、基于重叠社团的高效药物配伍规律发现算法。通过实验,发现了肺痿方剂的42种核心药物和30种药物配伍,经分析和中医专家确认,42种核心药物对肺痿确有良好疗效,30组药物配伍中有26组符合药物配伍关系且对肺痿有良好疗效。展开更多
Preparation of high purity ruthenium nitrosyl nitrate using spent Ru-Zn/ZrO_(2)catalyst was studied,including melting and leaching to obtain potassium ruthenate solution,reduction,dissolving,concentrating and drying t...Preparation of high purity ruthenium nitrosyl nitrate using spent Ru-Zn/ZrO_(2)catalyst was studied,including melting and leaching to obtain potassium ruthenate solution,reduction,dissolving,concentrating and drying to obtain ruthenium trichloride,nitrosation and hydrolysis to obtain ruthenium nitrosyl hydroxide,removing of K^(+)and Cl^(-),and neutralization with nitric acid.The effects of temperature,concentration,time and pH on the yield and purity of intermediates and final product were studied,and the optimum process conditions were obtained.The yield of ruthenium nitrosyl nitrate is 92%,the content of ruthenium in high purity product is 32.16%,and the content of Cl^(-)and K^(+)are much less than 0.005%.The reaction kinetics of ruthenium nitrosyl chloride to ruthenium nitrosyl hydroxide was studied.The reaction orders of Ru(NO)Cl_(3)at 40,55 and 70℃are 0.39,0.37 and 0.39,respectively,while those of KOH are 0.16,0.15 and 0.17,respectively.The activation energy is-2.33 k J/mol.展开更多
The pharmacokinetics and absolute bioavailability of the sublingual naloxone tablet were studied with HPLC-electrochemical detection. Eight male dogs received single 5 mg dose of naloxone intravenously, the plasma con...The pharmacokinetics and absolute bioavailability of the sublingual naloxone tablet were studied with HPLC-electrochemical detection. Eight male dogs received single 5 mg dose of naloxone intravenously, the plasma concentration-time curves could be fitted to two-compartment open model, with 12.0 min of t1/2( , 143.4 min of t1/2( and 7.92 mg(min/L of AUC. The same eight dogs received 5 mg dose of the sublingual naloxone tablet after an interval of a week. The main pharmacokinetic parameters were: t1/2ka = 11.0 min, t1/2( = 15.4 min, t1/2( = 164.1 min, Tmax = 27.7 min, Cmax = 34.2 ng / ml, and AUC = 6.79 mg(min / L, respectively. The plasma concentration-time curves were fitted to the first order absorption two-compartment open model also. The mean absolute bioavailability of the sublingual naloxone tablet was 86.8 ( 10.9%. No statistically significant differences were found with t1/2(, t1/2(, ( and ( between the two routes of administration. These results indicated that the course of disposition for naloxone in dogs was similar for the two routes of administration, and the absolute bioavailability of the sublingual naloxone tablet was high. Thus satisfactory clinical effects could be expected.展开更多
文摘中药方剂(traditional Chinese medicine formula,TCMF)是中医治疗的一种主要手段。然而一首方剂往往包含多种草药,这其中只有几种草药对治疗特定的病症起重要作用。因此,找出方剂中的核心药物和其配伍规律对研究中药方剂有非常重要的意义。针对该问题,提出了一种基于效用度(effect degree,ED)的核心药物及配伍规律发现方法。该方法包含三个主要步骤,分别是基于药物效用度的核心药物发现算法、基于带药对效用度的点式互信息(pointwise mutual information with herb pair ED,PMIED)的药物组网算法、基于重叠社团的高效药物配伍规律发现算法。通过实验,发现了肺痿方剂的42种核心药物和30种药物配伍,经分析和中医专家确认,42种核心药物对肺痿确有良好疗效,30组药物配伍中有26组符合药物配伍关系且对肺痿有良好疗效。
基金Project(22178392)supported by the National Natural Science Foundation of China。
文摘Preparation of high purity ruthenium nitrosyl nitrate using spent Ru-Zn/ZrO_(2)catalyst was studied,including melting and leaching to obtain potassium ruthenate solution,reduction,dissolving,concentrating and drying to obtain ruthenium trichloride,nitrosation and hydrolysis to obtain ruthenium nitrosyl hydroxide,removing of K^(+)and Cl^(-),and neutralization with nitric acid.The effects of temperature,concentration,time and pH on the yield and purity of intermediates and final product were studied,and the optimum process conditions were obtained.The yield of ruthenium nitrosyl nitrate is 92%,the content of ruthenium in high purity product is 32.16%,and the content of Cl^(-)and K^(+)are much less than 0.005%.The reaction kinetics of ruthenium nitrosyl chloride to ruthenium nitrosyl hydroxide was studied.The reaction orders of Ru(NO)Cl_(3)at 40,55 and 70℃are 0.39,0.37 and 0.39,respectively,while those of KOH are 0.16,0.15 and 0.17,respectively.The activation energy is-2.33 k J/mol.
文摘The pharmacokinetics and absolute bioavailability of the sublingual naloxone tablet were studied with HPLC-electrochemical detection. Eight male dogs received single 5 mg dose of naloxone intravenously, the plasma concentration-time curves could be fitted to two-compartment open model, with 12.0 min of t1/2( , 143.4 min of t1/2( and 7.92 mg(min/L of AUC. The same eight dogs received 5 mg dose of the sublingual naloxone tablet after an interval of a week. The main pharmacokinetic parameters were: t1/2ka = 11.0 min, t1/2( = 15.4 min, t1/2( = 164.1 min, Tmax = 27.7 min, Cmax = 34.2 ng / ml, and AUC = 6.79 mg(min / L, respectively. The plasma concentration-time curves were fitted to the first order absorption two-compartment open model also. The mean absolute bioavailability of the sublingual naloxone tablet was 86.8 ( 10.9%. No statistically significant differences were found with t1/2(, t1/2(, ( and ( between the two routes of administration. These results indicated that the course of disposition for naloxone in dogs was similar for the two routes of administration, and the absolute bioavailability of the sublingual naloxone tablet was high. Thus satisfactory clinical effects could be expected.
